Veterinary ophthalmology最新文献

{"title":"Predictors of Postoperative Corneal Clarity After Corneal Reconstruction for Deep Corneal Ulcers and Perforations in Dogs.","authors":"Shingo Otaki, Yuichiro Muramatsu, Ushio Fukushima","doi":"10.1111/vop.70258","DOIUrl":"10.1111/vop.70258","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify factors associated with postoperative corneal clarity in dogs undergoing corneal transplantation for deep stromal or perforating corneal defects.</p><p><strong>Animals studied: </strong>A total of 76 dogs (78 eyes) treated surgically for deep stromal or perforating corneal defects were evaluated.</p><p><strong>Methods: </strong>The medical records of dogs who underwent corneal reconstruction between January 2019 and August 2025, anonymized for review, were retrospectively reviewed. A total of 78 eyes were evaluated; surgical techniques included autologous corneal grafting (23 eyes), corneo-limbo-conjunctival transposition (CLCT; 13 eyes), and xenogeneic corneal grafting (42 eyes). The corneal clarity score (CCS) was used to grade postoperative corneal clarity. Associations between CCS and potential prognostic factors, including the graft type, brachycephalic conformation, corneal perforation, graft size, and bacterial infection, were assessed using the Mann-Whitney U test and logistic regression analysis.</p><p><strong>Results: </strong>Corneal perforations were observed in 31 eyes, with a median graft size of 5 mm. Seven eyes required revision surgery, all of which had previously undergone xenogeneic corneal grafting. Corneal opacities were identified in 71 eyes. The graft type, brachycephalic conformation, graft size, and bacterial infection were not significantly associated with postoperative corneal clarity (p > 0.05). Conversely, corneal perforation was considerably associated with increased graft opacity (p = 0.04). However, no independent predictors of postoperative corneal clarity were identified in the multivariable logistic regression analysis.</p><p><strong>Conclusions: </strong>Postoperative corneal clarity in dogs is influenced more by disease severity, particularly corneal perforation, than by graft material.</p>","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70258"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Advanced Imaging and Long-Term Follow-Up of Peters Anomaly Type 2, With Presumed Lenticular Material in the Cornea, in a Scottish Terrier.","authors":"Yu Sato, Tomer Shua-Haim, Eric C Ledbetter, Ralph E Hamor, Bret A Moore","doi":"10.1111/vop.70240","DOIUrl":"10.1111/vop.70240","url":null,"abstract":"<p><strong>Objective: </strong>To describe the clinical findings and advanced in vivo imaging features of a bilateral case of peters anomaly type 2 in a dog.</p><p><strong>Animal studied: </strong>An 8-week-old male scottish terrier presented with bilateral central corneal leukomas and was followed clinically for 3 years.</p><p><strong>Procedures: </strong>Complete ophthalmic examination was performed at multiple time points. Ocular ultrasonography, optical coherence tomography (OCT), and in vivo confocal microscopy (IVCM) were performed under sedation at 37 weeks of age to further evaluate anterior segment structures obscured by corneal opacity.</p><p><strong>Results: </strong>Both eyes displayed central leukoma and iridocorneal adhesions consistent with anterior segment dysgenesis. The left eye had a keratolenticular adhesion, progressive cataract formation, microphthalmia, goniodysgenesis, and secondary glaucoma. A defect involving the posterior corneal stroma, descemet's membrane, and endothelium, with extension of the keratolenticular adhesion into the mid-stroma was demonstrated in detail with OCT. Endothelial cell loss, endothelial polymegathism and pleomorphism, stromal fibrosis, vascularization, and multiple highly refractile structures within the mid-stroma consistent with presumed lenticular material were visualized with IVCM. The right eye had a mild central corneal leukoma and incipient cataract, with spontaneous separation of the keratolenticular adhesion and no further clinically significant abnormalities.</p><p><strong>Conclusions: </strong>This report documents peters anomaly type 2 in a dog using OCT and IVCM. Advanced imaging allowed detailed evaluation of anterior segment abnormalities that were not fully appreciable on clinical examination and revealed presumed lenticular remnants within the corneal stroma, a finding not previously described in veterinary medicine.</p>","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70240"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13491414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Topical Omidenepag Isopropyl on Intraocular Pressure and Pupil Diameter in Normal Dogs.","authors":"Hikaru Tsujimura, Tomoaki Kameda, Kazuya Oikawa, Hiroki Takahashi","doi":"10.1111/vop.70239","DOIUrl":"10.1111/vop.70239","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the effects of 0.002% omidenepag isopropyl (OMDI) ophthalmic solution on intraocular pressure (IOP) and pupil diameter (PD) in clinically normal dogs.</p><p><strong>Methods: </strong>Five healthy dogs (10 eyes) were included in this prospective randomized, observer-masked, placebo-controlled study. An initial pilot study was conducted to evaluate IOP and ocular irritation up to 48 h after a single instillation of OMDI. For the subsequent main study, each dog received one drop of 0.002% OMDI in one randomly selected eye and placebo in the contralateral eye once daily. IOP, PD, and conjunctival hyperemia scores were measured five times daily during the baseline (3 days), treatment (5 days), and recovery (3 days) periods.</p><p><strong>Results: </strong>A single instillation of topical OMDI significantly lowered IOP by a maximal IOP reduction of 7.2 mmHg (60%). In the repeated-dose study, once-daily administration of topical OMDI significantly reduced average daily IOP ± SD by 4.8 ± 0.68 mmHg (38.6%) and 6.1 ± 0.75 mmHg (44.3%), relative to baseline and contralateral controls, respectively. No clinically relevant miosis was observed in OMDI-treated eyes. Adverse events were limited to mild-to-moderate conjunctival hyperemia in OMDI-treated eyes.</p><p><strong>Conclusions: </strong>Once-daily administration of 0.002% OMDI resulted in a robust reduction in IOP without inducing miosis and was well-tolerated in normal dogs. Further studies are warranted to assess its therapeutic potential and long-term safety in dogs with glaucoma.</p>","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70239"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Evaluation of Chromatic Pupillometry and Retinal Thickness in Dogs With Sudden Acquired Retinal Degeneration Syndrome.","authors":"Soohyun Kim, Ann E Cooper, David J Maggs, Ariana D Marangakis, Tran Nguyen, Monica Motta, Sara M Thomasy","doi":"10.1111/vop.70248","DOIUrl":"10.1111/vop.70248","url":null,"abstract":"<p><strong>Objective: </strong>To determine longitudinal changes in chromatic pupillary light reflexes (cPLR) and retinal layers in dogs with sudden acquired retinal degeneration syndrome (SARDS).</p><p><strong>Animals studied: </strong>Clinical evaluation: Fifteen SARDS-affected and nine control dogs.</p><p><strong>Histology: </strong>Achieved globes from five SARDS-affected (1-7 years post-diagnosis) and eight age-matched controls.</p><p><strong>Procedures: </strong>Dogs underwent ophthalmic examination and electroretinography to confirm SARDS. Chromatic pupillometry and Fourier-domain optical coherence tomography (FD-OCT) were performed at baseline (once for control; < 1-month post-blindness for SARDS-affected dogs), and follow-up (3, 6 and 12 months post-diagnosis). The extent, velocity and latency of pupil constriction were evaluated. Retinal thickness was measured from the FD-OCT images. Ganglion cell counts were determined from histologic sections stained with hematoxylin and eosin.</p><p><strong>Results: </strong>At baseline, SARDS-affected dogs showed significantly reduced extent and velocity of red light PLR, and reduced extent with prolonged latency of white light PLR, relative to controls; white light velocity and all blue light parameters did not differ. White light PLR velocity significantly decreased over time in SARDS-affected dogs. FD-OCT in SARDS-affected dogs revealed progressive total retinal thinning but stable inner retinal thickness. Histology of SARDS-affected eyes identified diffuse outer retinal atrophy with relative inner retinal preservation; ganglion cell counts were not different between groups.</p><p><strong>Conclusions: </strong>Chromatic pupillometry reflects the selective preservation of melanopsin-containing retinal ganglion cell function despite progressive photoreceptor degeneration in SARDS. The combined longitudinal use of chromatic pupillometry and FD-OCT provides a comprehensive assessment of the evolving functional and structural changes in SARDS-affected dogs.</p>","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70248"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ex Vivo Validation of the TONOVET Plus and TONOVET Pro in Cynomolgus Monkeys (Macaca fascicularis): Comparison of Canine and Lapine Calibration Modes.","authors":"Wontae Kim, Seonmi Kang, Jiwon Lee, Jun Young Lee, Kangmoon Seo","doi":"10.1111/vop.70265","DOIUrl":"10.1111/vop.70265","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the accuracy of the TONOVET Plus (TVP) and TONOVET Pro (TVPR) in measuring intraocular pressure (IOP) in ex vivo cynomolgus monkey eyes compared to manometry, and to determine the accuracy of Canine and Lapine calibration modes: ANIMALS STUDIED: Five enucleated eyes from three cynomolgus monkeys.</p><p><strong>Procedures: </strong>The anterior chambers were cannulated to regulate IOP manometrically from 5 to 80 mmHg. Agreement between tonometric and manometric readings was analyzed using a linear mixed-effects model (LMM), Lin's concordance correlation coefficient (CCC), and repeated-measures Bland-Altman analysis. Data points at the 80 mmHg manometric setting were excluded to prevent artificial distortion from the devices' maximum display limits.</p><p><strong>Results: </strong>Strong linear relationships were observed between manometric and tonometric IOPs for all modes. However, the Lapine mode demonstrated proportional overestimation with steeper regression slopes compared to the Canine mode. The Canine mode showed excellent agreement (CCC: 0.967 for TVP, 0.971 for TVPR) with minimal mean bias. In contrast, the Lapine mode exhibited significant positive bias and wider limits of agreement, particularly at higher pressures.</p><p><strong>Conclusions: </strong>Both TVP and TVPR provided accurate and reliable IOP measurements in cynomolgus monkeys when using the Canine calibration mode. Despite the central corneal thickness of cynomolgus monkeys being closer to that of rabbits, the Lapine mode resulted in significant overestimation and is not recommended. Among the tested settings, the Canine mode provided highly accurate IOP measurements with minimal bias, whereas the Lapine mode significantly overestimated IOP.</p>","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70265"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13550816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of Anions in Dog Tear Fluid Using Ion Chromatography.","authors":"Tomohiko Saito, Takashi Suzuki, Yukina Kato, Takanori Narita, Ken Okabayashi, Yuichi Hori","doi":"10.1111/vop.70262","DOIUrl":"10.1111/vop.70262","url":null,"abstract":"<p><strong>Objective: </strong>Anions in tears may be related to the pathogenesis of ocular surface diseases. A comprehensive method that can detect small quantities of anions in human tears has been developed. However, the differences in individual anion concentrations between tears and plasma remain unclear. This study investigated anion concentrations in dog tears.</p><p><strong>Methods: </strong>To compare anion concentrations between tear and plasma samples in canines, 12 eyes of six healthy purpose-bred research Beagles (unneutered males, 3 years old) were investigated. Additionally, the tears of canines with various diseases were examined.</p><p><strong>Procedure: </strong>Anion concentrations were assessed using a commercially available ion chromatography system. For this, at least 10 μL of tears were collected in a glass capillary tube and diluted with 300 μL of distilled water; plasma was obtained by centrifuging collected blood samples, which were then diluted 100-fold before chromatography.</p><p><strong>Results: </strong>Anion concentrations differed significantly between the tears and plasma of Beagles. The average concentrations (mg/L) of anions in tears of Beagles were as follows: Cl^-, 5374.06 ± 157.06; Br^-, 27.84 ± 1.43; NO₃ ^-, 0.70 ± 0.65; HPO₄ ^2-, 77.54 ± 14.36; and SO₄ ^2-, 16.41 ± 8.17. In plasma, the values were as follows: Cl^-, 4603.81 ± 542.52; Br^-, 18.34 ± 2.78; NO₃ ^-, 1.31 ± 0.87; HPO₄ ^2-, 83.63 ± 21.04; and SO₄ ^2-, 105.14 ± 21.86. No statistically significant differences in anion concentrations were observed between tears from diseased and non-diseased eyes of canines.</p><p><strong>Conclusions: </strong>Herein, we observed that certain anions, such as Br^- and Cl^-, were consistently elevated in tear fluid than in the plasma.</p>","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70262"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Trace Elements in the Formation of Feline Corneal Sequestra.","authors":"O Pe'er, L Sebbag, R Ofri","doi":"10.1111/vop.70242","DOIUrl":"10.1111/vop.70242","url":null,"abstract":"<p><strong>Objective: </strong>To characterize the trace element composition of feline corneal sequestra (FCS) and provide insights into their pathophysiology.</p><p><strong>Methods: </strong>FCS samples were collected from 11 eyes of 9 cats following keratectomy and compared with corneal samples from four clinically normal control cats euthanized for reasons unrelated to the study. Excised corneal tissues were immediately frozen at -80°C and analyzed using particle-induced X-ray emission (PIXE) with a 1.7 MV Pelletron accelerator to determine relative elemental abundance. Trace element levels between groups were compared using Mann-Whitney tests, and results were expressed as peak area units.</p><p><strong>Results: </strong>Affected cats were predominantly brachycephalic or predisposed breeds, including Sphynx, Persian, and British Shorthair. Lesions measured 1-8 mm in diameter and involved approximately 20%-70% stromal depth. Across all samples, sulfur demonstrated the highest elemental signal, followed by phosphorus, potassium, chloride, sodium, calcium, magnesium, zinc, iron, and bromine. Iron (median ± SEM: 751 ± 336 vs. 0 ± 0; p = 0.047) and bromine (110 ± 50 vs. 0 ± 0; p = 0.004) were consistently detected in sequestral tissue but were absent in control corneas. No statistically significant differences were observed between groups for sodium, potassium, chloride, magnesium, phosphorus, calcium, sulfur, or zinc.</p><p><strong>Conclusion: </strong>Feline corneal sequestra exhibited a distinct elemental profile characterized by the detection of iron and bromine, which were not detected in the normal corneal samples analyzed. These findings demonstrate measurable differences in trace element composition between sequestral and healthy corneas and provide novel insights into the biochemical characteristics of this disease.</p>","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70242"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- and Post-Phacoemulsification Morphologic Iridocorneal Angle Analysis by Anterior Segment Gonioscopic Imaging as a Predictor of Postoperative Glaucoma in Dogs.","authors":"Steven R Hanes, Renata V Ramos, Ian P Herring, Roxanne M Rodriguez-Galarza","doi":"10.1111/vop.70246","DOIUrl":"10.1111/vop.70246","url":null,"abstract":"<p><strong>Objective: </strong>To serially assess iridocorneal angle (ICA) gonioscopic morphology following phacoemulsification in dogs and to determine whether postoperative changes are associated with the development aphakic/pseudophakic glaucoma.</p><p><strong>Animals studied: </strong>Client-owned dogs presented for cataract removal by phacoemulsification.</p><p><strong>Procedures: </strong>All enrolled eyes underwent preoperative and serial postoperative gonioscopic ICA imaging using a retinal imaging camera (RetCam), with images acquired from all four quadrants at baseline and at scheduled postoperative timepoints up to 1 year. Images were evaluated for angle width and pectinate ligament dysplasia (PLD) severity, which were integrated into a ZibWest Angle Index score for each eye at each timepoint. Clinical outcomes, including the development of glaucoma, were recorded throughout the study period.</p><p><strong>Results: </strong>Thirty-nine dogs (74 eyes) were included, and 29 dogs (74.3%) completed the study through the final 1-year follow-up. Iridocorneal angle morphology changed significantly over time, including angle width, PLD, and Zibwest Angle Index score. Despite these changes, no statistically significant associations were found between pre- or postoperative ICA morphology and the subsequent development of aphakic/pseudophakic glaucoma.</p><p><strong>Conclusion: </strong>Gonioscopically visible aspects of the canine ICA undergo significant morphologic change following phacoemulsification. However, within this study population and study period, no association was identified between preoperative ICA morphology and postoperative glaucoma. Larger longitudinal studies and imaging modalities that assess deeper angle structures may help refine postoperative glaucoma risk prediction.</p>","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70246"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Comparison of Diagnostic Performance Between Large Language Models and Veterinary Evaluators in Feline Ocular Diseases Based on Clinical Summaries and Anterior Segment Photographs\".","authors":"","doi":"10.1111/vop.70252","DOIUrl":"10.1111/vop.70252","url":null,"abstract":"","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70252"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13495654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential Photodynamic Therapy and Electrochemotherapy for Bilateral Palpebral Squamous Cell Carcinoma in a Cat: A Case Report.","authors":"Tarcísio Guerra Guimarães, Karla Menezes Cardoso, Luciana Almeida Lopes, Carlos Roberto Daleck, Nuno Alexandre, Maria Filomena Botelho, Mafalda Laranjo","doi":"10.1111/vop.70241","DOIUrl":"10.1111/vop.70241","url":null,"abstract":"<p><strong>Objectives: </strong>To report the clinical outcomes of photodynamic therapy (PDT), alone and in combination with electrochemotherapy (ECT), in the conservative treatment of bilateral palpebral squamous cell carcinoma (SCC) in a cat, involving the right and left eyelids, with functional preservation and local tumor control.</p><p><strong>Methods: </strong>A domestic shorthair cat with histologically confirmed squamous cell carcinoma affecting both eyelid margins underwent different therapeutic protocols. The left eye received a single PDT session with topical a lipophilic methyl ester derivative of 5-aminolevulinic acid (160 mg/g) and red LED light, while the right eye received two sessions, followed by adjuvant ECT with intravenous bleomycin.</p><p><strong>Results: </strong>The lesion in the left eye presented with pallor associated with mild inflammation after the PDT session, with complete resolution in the following days and recovery of its normal clinical appearance. In the right eye, the first two PDT sessions resulted in significant regression of the neoplastic lesions. However, a lesion in the medial canthus showed partial response, requiring adjuvant treatment with ECT, which led to complete clinical resolution, despite the presence of mild eyelid deformity.</p><p><strong>Conclusions: </strong>In this single case report, PDT was associated with clinical regression of superficial lesions, while adjuvant ECT was followed by complete clinical resolution of the residual lesion. The combination of these modalities represents a viable conservative alternative to extensive surgical excision, enabling the tumor remission while preserving the aesthetic appearance and functional integrity of the eyelid.</p>","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":"29 5","pages":"e70241"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}