Veterinary ophthalmology最新文献

Successful Management of a Refractory Orbital Pseudocyst in a Chinese Goose Using Intraorbital Gentamicin Injection. 眼眶内注射庆大霉素成功治疗中华鹅眼眶难治性假性囊肿。

IF 1.3 4区农林科学

Veterinary ophthalmology Pub Date : 2025-10-15 DOI: 10.1111/vop.70101

Kristopher Houston, Chloe Fontaine, Natalia Dziedzic-Nyrka, David Donaldson

{"title":"Successful Management of a Refractory Orbital Pseudocyst in a Chinese Goose Using Intraorbital Gentamicin Injection.","authors":"Kristopher Houston, Chloe Fontaine, Natalia Dziedzic-Nyrka, David Donaldson","doi":"10.1111/vop.70101","DOIUrl":"https://doi.org/10.1111/vop.70101","url":null,"abstract":"Objective: To report the successful management of recurrent orbital swelling in a Chinese goose (Anser cygnoides ) following evisceration surgery, utilizing intraorbital gentamicin injection after multiple unsuccessful interventions.Animal studied: A 3-year-old, 4.58 kg male Chinese goose (Anser cygnoides ).Procedures: The goose was referred for evaluation of recurrent swelling of the right orbit following evisceration surgery performed after a severe corneal injury. Initial interventions included fluid drainage, revision surgeries with placement of Lyostypt and bone cement implants, sinus communication attempts, and placement of a Jackson-Pratt surgical drain. Diagnostic evaluation included physical examination, computed tomography (CT), cytology, histopathology, and bacterial culture. Despite these interventions, the orbital swelling recurred. Finally, an intraorbital injection of gentamicin (9 mg/kg) was administered following fluid drainage. Post-injection follow-up was conducted over 6 months.Results: Following the intraorbital gentamicin injection, the recurrent swelling resolved without any adverse effects. The goose remained clinically normal at a six-month follow-up, with no signs of recurrence.Conclusions: This case highlights the challenges of managing recurrent orbital swelling in avian species following evisceration surgery and the potential utility of intraorbital gentamicin injections. Gentamicin's cytotoxic effects on secretory tissue may offer an effective treatment option for refractory cases. Further studies are warranted to explore the safety and efficacy of this approach in avian species.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corneal Squamous Cell Carcinoma Arising From a Conjunctival Graft Scar in a Horse. 马结膜移植瘢痕引起的角膜鳞状细胞癌。

IF 1.3 4区农林科学

Veterinary ophthalmology Pub Date : 2025-10-15 DOI: 10.1111/vop.70102

Surita du Preez, Brittany Lynch, Scott Lindsay, Olivier Simon, Gustavo Ferlini Agne

{"title":"Corneal Squamous Cell Carcinoma Arising From a Conjunctival Graft Scar in a Horse.","authors":"Surita du Preez, Brittany Lynch, Scott Lindsay, Olivier Simon, Gustavo Ferlini Agne","doi":"10.1111/vop.70102","DOIUrl":"https://doi.org/10.1111/vop.70102","url":null,"abstract":"Objective: To describe the case details of an equine corneal squamous cell carcinoma (SCC) arising from the central scar of a previous conjunctival pedicle graft.Animal studied: An 18-year-old Thoroughbred gelding, showing a progressive increase in diameter, depth, opacity, and pigmentation of a conjunctival pedicle graft scar of the left eye, 34 months after surgery.Procedure(s): Complete ophthalmic examination, standard histologic and immunohistochemical evaluation of an incisional biopsy to formulate a definitive diagnosis. Carbon dioxide (CO2) laser photoablation combined with topical mitomycin C treatment.Results: Initial examination with slit-lamp biomicroscopic examination revealed a raised, pale pink and peripherally pigmented, ovoid corneal mass (25 × 20 mm, raised 5 mm) with a smooth to cobblestone contour, paraxial ventral at 6 o'clock of the left eye. Corneal neovascularization extended from the ventral limbus to the graft scar. The remaining ophthalmic examination was unremarkable. Histologic and immunohistochemical evaluation of an incisional biopsy were supportive of a diagnosis of corneal SCC. Two rounds of CO2 laser photoablation, 10 weeks apart, combined with topical mitomycin C chemotherapy, without surgical debulking, was successful in resolving the neoplastic lesion. The horse was euthanized 4 years later for unrelated reasons, with no evidence of SCC recurrence grossly or histologically.Conclusion: To the authors' knowledge, this is the first report in a horse of a SCC developing at the site of corneal scarring after a conjunctival pedicle graft.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of Recalibrated IOPVet in Canine Eyes Compared to Manometry and Recalibrated TONOVET Plus. 与测压法和重新校准的TONOVET Plus相比，重新校准的IOPVet在犬眼中的验证。

IF 1.3 4区农林科学

Veterinary ophthalmology Pub Date : 2025-10-13 DOI: 10.1111/vop.70100

Bertrand Michaud, Inès Desquiens

{"title":"Validation of Recalibrated IOPVet in Canine Eyes Compared to Manometry and Recalibrated TONOVET Plus.","authors":"Bertrand Michaud, Inès Desquiens","doi":"10.1111/vop.70100","DOIUrl":"https://doi.org/10.1111/vop.70100","url":null,"abstract":"Objective: To evaluate the clinical and manometric accuracy of a recalibrated version of the IOPVet indentation tonometer in dogs, and to compare its performance to a recalibrated TonoVet Plus (rTVP) and in situ direct manometry.Animals studied: A total of 97 eyes from 49 client-owned dogs were enrolled and divided into three groups: a glaucomatous group of 34 dogs (67 eyes: 41 glaucomatous, 26 fellow normotensive eyes), a control group of 10 healthy dogs (20 eyes), and a manometric group of 10 eyes from 5 euthanized dogs.Procedures: IOP was measured using both the rTVP and the recalibrated IOPVet, each device being used by a separate examiner. IOPVet readings were recorded as semi-quantitative intervals: < 10, 10-29, 30-49, and ≥ 50 mmHg. Agreement with rTVP and manometric values was assessed through sensitivity, specificity, and Chi-square analysis. Manometry was performed post-mortem using dual-needle in situ cannulation over a range of pressures (10-70 mmHg).Results: All glaucomatous eyes (rTVP ≥ 30 mmHg, n = 41) were correctly classified by the IOPVet (sensitivity 100%). Among normotensive eyes (rTVP ≤ 29 mmHg, n = 46), 78.3% were correctly categorized, with 21.7% overestimated (specificity 84.8%). The association between rTVP and IOPVet categories was significant (χ2 = 50.2, df = 4, p < 0.0001). In manometric validation, accuracy was 95% (10-29 mmHg), 100% (30-49 mmHg), and 94% (≥ 50 mmHg), with no misclassification below 30 mmHg.Conclusions: The recalibrated IOPVet demonstrates markedly improved accuracy, excellent sensitivity, and acceptable specificity in detecting elevated IOP in dogs. Its affordability and ease of use support its integration into clinical practice and owner-assisted glaucoma monitoring.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pseudophakia Is Associated With an Increased Risk of Post-Operative Fibrin Formation in Dogs Undergoing Phacoemulsification Compared to Elective Aphakia. 与选择性无晶状体相比，接受超声乳化术的犬的假晶状体与术后纤维蛋白形成的风险增加有关。

IF 1.3 4区农林科学

Veterinary ophthalmology Pub Date : 2025-10-13 DOI: 10.1111/vop.70099

Elizabeth J Stevens, V J Adams, Christine L Heinrich, Rachael A Grundon

{"title":"Pseudophakia Is Associated With an Increased Risk of Post-Operative Fibrin Formation in Dogs Undergoing Phacoemulsification Compared to Elective Aphakia.","authors":"Elizabeth J Stevens, V J Adams, Christine L Heinrich, Rachael A Grundon","doi":"10.1111/vop.70099","DOIUrl":"https://doi.org/10.1111/vop.70099","url":null,"abstract":"Objective: To evaluate the occurrence and effect of fibrin formation following phacoemulsification in dogs with pseudophakia and elective aphakia.Animal studied: A total of 193 eyes (116 dogs) undergoing phacoemulsification with or without intraocular lens implantation.Procedures: Retrospective evaluation of medical records (2016-2020) from a private referral clinic in the United Kingdom. Signalment, pre-operative ophthalmic findings, surgical parameters, postoperative complications, and duration of follow-up were evaluated. All surgeries were performed by one surgeon using one hydrophobic acrylic lens (LOKI; Cristalens). Cross-tabulations and Fisher's exact tests were used to evaluate associations between lens implantation, fibrin formation, and visual outcome at 6 months postoperatively.Results: Records of 193 eyes from 116 dogs were reviewed. Postoperative fibrin formation was recorded in 31/72 (43%) pseudophakic eyes and 18/121 (15%) aphakic eyes. Pseudophakic eyes were three times more likely to experience fibrin formation compared to aphakic eyes (p < 0.001). Signalment, diabetic status, presence of concurrent ocular or systemic disease, cataract stage, or development of postoperative ocular hypertension were not associated with fibrin formation (p > 0.1). At 6 months postoperatively fibrin formation was significantly associated with vision loss in pseudophakic eyes (p = 0.003), but there was no association between fibrin formation and vision loss in aphakic eyes (p = 0.6). There was no direct association between the presence of an intraocular lens and vision loss (p > 0.4).Conclusion: In this study, pseudophakia was associated with increased occurrence of postoperative fibrin formation. Although pseudophakia was not directly associated with vision loss, fibrin formation in pseudophakic eyes was associated with a poorer visual outcome.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bovine Amniotic Membrane Transplantation in Feline Corneal Sequestrum: A Retrospective Study of 52 Cases (56 Eyes). 牛羊膜移植治疗猫角膜残症52例（56眼）的回顾性研究。

IF 1.3 4区农林科学

Veterinary ophthalmology Pub Date : 2025-10-13 DOI: 10.1111/vop.70098

Jennifer Anne, Anaïs Cathelin, Anne-Sandrine Augsburger

{"title":"Bovine Amniotic Membrane Transplantation in Feline Corneal Sequestrum: A Retrospective Study of 52 Cases (56 Eyes).","authors":"Jennifer Anne, Anaïs Cathelin, Anne-Sandrine Augsburger","doi":"10.1111/vop.70098","DOIUrl":"https://doi.org/10.1111/vop.70098","url":null,"abstract":"Objective: To evaluate visual and transparency outcomes using the Royal Veterinary College Corneal Clarity Score (RVC-CCS) following bovine amniotic membrane transplantation (BAMT) in cats with large feline corneal sequestrum (FCS).Methods: Fifty-two cats (56 eyes) were treated with BAMT with freezing storage, between June 2016 and May 2023. Breed, age, sex of the cats, size, and location of the FCS were reported. For the removal of the corneal sequestrum, a lamellar keratectomy was performed, and one or more layers of BAMT were sutured. The success of the surgery was assessed by functional and esthetic outcomes, as well as the rate of recurrence. The RVC-CCS was used to evaluate the degree of persistent corneal opacity.Results: Twenty-three females and twenty-nine males underwent surgery. Brachycephalic cats were over-represented (32/52), with the majority being Persian (28/52). The mean age of the cats was 5 years. The median follow-up time was 89.5 days with an average of 400 days (range 21-2590 days). There were no complications in forty-five cases. Twelve eyes had recurrence of FCS, seven of them early, i.e., < 2 months postoperatively. One cat had a partial suture dehiscence, and another had a postoperative corneal infection. Rare complications occurred in two cases: a hemorrhage and a poor adhesion between two layers of amniotic membrane. 90% of cases had RVC-CCS scores better than or equal to G2 at median follow-up.Conclusions: BAMT with freezing storage was a good option to maintain corneal transparency after surgical management of large FCS.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound Biomicroscopic Study of the Effects of 1% Tropicamide on the Anterior Segment and Ciliary Body in Cats. 1%托品酰胺对猫前段和纤毛体影响的超声生物显微镜研究。

IF 1.3 4区农林科学

Veterinary ophthalmology Pub Date : 2025-10-06 DOI: 10.1111/vop.70083

Donghee Kim, Yunji Her, Ji Seung Jung, Jiyi Hwang, Sooyeon Lee, Mirae Lee, Haemi Seol, Soohyun Kim, Kyung-Mee Park

{"title":"Ultrasound Biomicroscopic Study of the Effects of 1% Tropicamide on the Anterior Segment and Ciliary Body in Cats.","authors":"Donghee Kim, Yunji Her, Ji Seung Jung, Jiyi Hwang, Sooyeon Lee, Mirae Lee, Haemi Seol, Soohyun Kim, Kyung-Mee Park","doi":"10.1111/vop.70083","DOIUrl":"https://doi.org/10.1111/vop.70083","url":null,"abstract":"Objective: To investigate the effects of 1% tropicamide on intraocular pressure (IOP), anterior chamber morphology, and ciliary body dynamics in cats using ultrasound biomicroscopy (UBM).Methods: A total of 28 eyes from 14 clinically healthy cats were evaluated before and 30 min after unilateral instillation of 1% tropicamide in the right eye (OD), with the left eye (OS) serving as a control. Parameters assessed included pupil size, IOP, and UBM-derived measurements of the iridocorneal angle (ICA), angle opening distance (AOD), ciliary cleft width (CCW), length (CCL), area (CCA), ciliary body axial length (CBAXL), and ciliary process-scleral angle (CPSA).Results: Tropicamide significantly increased IOP in the treated eye (OD) but not in the control eye (OS). UBM analysis revealed significant reductions in ICA and CCW in OD, while other anterior chamber and ciliary body parameters showed no meaningful changes. In contrast, no significant alterations were observed in any anterior chamber or ciliary body parameters in OS.Conclusion: These findings suggest that tropicamide-induced IOP elevation in cats results from anterior chamber angle narrowing, emphasizing the need for caution when using mydriatics in patients at risk for ocular hypertension.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Pilot Investigation of Transforming Growth Factor-β2 and Total Protein Concentrations in Aqueous Humor of Canine Glaucomatous Eyes With and Without Ahmed Glaucoma Valve Surgery. 经阿迈德青光眼瓣膜手术的犬青光眼房水中转化生长因子-β2和总蛋白浓度的初步研究。

IF 1.3 4区农林科学

Veterinary ophthalmology Pub Date : 2025-10-05 DOI: 10.1111/vop.70077

Songhui Lee, Kangmoon Seo, Seonmi Kang

{"title":"A Pilot Investigation of Transforming Growth Factor-β2 and Total Protein Concentrations in Aqueous Humor of Canine Glaucomatous Eyes With and Without Ahmed Glaucoma Valve Surgery.","authors":"Songhui Lee, Kangmoon Seo, Seonmi Kang","doi":"10.1111/vop.70077","DOIUrl":"https://doi.org/10.1111/vop.70077","url":null,"abstract":"Objective: To investigate responses to surgical interventions in concentrations of transforming growth factor-β2 (TGF-β2) and total protein (TP) in the aqueous humor (AH) of primary angle-closure glaucoma (PACG) eyes, with and without Ahmed glaucoma valve surgery in dogs.Animal studied: Nineteen eyes diagnosed with PACG from client-owned dogs and nine non-glaucomatous eyes from both client-owned dogs and research Beagles.Procedures: AH samples were collected and analyzed for TP and TGF-β2 via bicinchoninic acid assay and an enzyme-linked immunosorbent assay. The samples included AH from pre-surgical eyes that had aqueous paracentesis for intraocular pressure (IOP) management (pre-surgical group; n = 6) and from post-surgical eyes when tissue plasminogen activator was injected (post-surgery group; n = 7); fluid aspirated from blebs during surgical revision (bleb group; n = 6), and normal control AH samples from both client-owned dogs undergoing ocular surgery for non-glaucomatous conditions and research Beagles (control group; n = 9).Results: TP and TGF-β2 concentrations were significantly higher in all PACG groups compared to normal AH (p < 0.01). Bleb fluid exhibited the highest TP and TGF-β2 concentrations among glaucomatous groups. Post-surgical AH had significantly lower TGF-β2 concentrations than both pre-surgical and bleb fluid (p = 0.0168, p = 0.0023, respectively). No significant correlation was found between IOP and either TP or TGF-β2 in any group (p > 0.05).Conclusions: Elevated TGF-β2 in PACG could contribute to disease progression and post-surgical fibrosis. These findings support future studies to examine the potential of TGF-β2 modulation as a therapeutic approach to improving long-term surgical outcomes following Ahmed glaucoma valve surgery in canine PACG.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Omidenepag Isopropyl Versus Latanoprost Eye Drops on Intraocular Pressure, Pupil Diameter, and Anterior Chamber Parameters in Normal Feline Eyes: A Pilot Study. 奥米尼帕格异丙酯与拉坦前列素滴眼液对正常猫眼眼压、瞳孔直径和前房参数的影响：一项初步研究

IF 1.3 4区农林科学

Veterinary ophthalmology Pub Date : 2025-10-05 DOI: 10.1111/vop.70078

Sang-Eun Park, Jiyi Hwang, Nanyoung Kang, Jiseung Jung, Heung-Myong Woo, Kyung-Mee Park

{"title":"Effects of Omidenepag Isopropyl Versus Latanoprost Eye Drops on Intraocular Pressure, Pupil Diameter, and Anterior Chamber Parameters in Normal Feline Eyes: A Pilot Study.","authors":"Sang-Eun Park, Jiyi Hwang, Nanyoung Kang, Jiseung Jung, Heung-Myong Woo, Kyung-Mee Park","doi":"10.1111/vop.70078","DOIUrl":"https://doi.org/10.1111/vop.70078","url":null,"abstract":"Objectives: This study aimed to compare the effect of the newly developed selective prostaglandin E2 receptor agonist, omidenepag isopropyl (OMDI), and latanoprost on intraocular pressure (IOP), pupil diameter (PD), and anterior chamber parameters in normal feline eyes.Animal studied: Twenty-two client-owned cats (n = 44 normal eyes) were included in the study.Procedure: IOP and PD were evaluated at baseline (0), 2, and 4 h after drug administration. Ultrasound biomicroscopy was employed to assess parameters such as the iridocorneal angle (ICA), area of the ciliary cleft (CCA), width of the ciliary cleft, mid-width of the ciliary cleft (mid-CCW), angle-opening distance, length of the ciliary cleft, ciliary muscle thickness (CMT), and scleral ciliary process angle.Results: The OMDI-treated eyes showed a significant reduction in IOP compared with normal control eyes, unlike latanoprost-treated eyes. Compared with the control eyes, latanoprost-treated eyes showed a significantly greater decrease in PD than OMDI-treated eyes. The OMDI-treated eyes demonstrated a statistically significant increase in mid-CCW and CCA compared with the latanoprost-treated eyes. Both the OMDI- and latanoprost-treated eyes showed an increase in ICA and CMT compared with the control eyes.Conclusion: OMDI effectively reduced IOP in cats for at least 4 h without reducing PD. An increase in the CCA and mid-CCW, observed exclusively with OMDI, suggests that the hypotensive effect may be mediated by the conventional outflow pathway. Additionally, an increase in CMT in both the OMDI- and latanoprost-treated eyes may indicate an effect on the uveoscleral outflow pathway.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial Activity of Ultraviolet C Light as a Potential Novel Treatment for Moraxella bovis Infection-An In Vitro Study. 紫外线C光治疗牛莫拉菌感染的体外研究

IF 1.3 4区农林科学

Veterinary ophthalmology Pub Date : 2025-10-05 DOI: 10.1111/vop.70087

Bactelius Turicea, Dipak K Sahoo, Rachel A Allbaugh, Chloe C Stinman, Melissa A Kubai

{"title":"Antimicrobial Activity of Ultraviolet C Light as a Potential Novel Treatment for Moraxella bovis Infection-An In Vitro Study.","authors":"Bactelius Turicea, Dipak K Sahoo, Rachel A Allbaugh, Chloe C Stinman, Melissa A Kubai","doi":"10.1111/vop.70087","DOIUrl":"https://doi.org/10.1111/vop.70087","url":null,"abstract":"Objective: To investigate the antimicrobial effect of 275 nm wavelength ultraviolet C (UV-C) light on M. bovis using an affordable, broadly available modified handheld device and to determine if photoreactivation plays a role in bacterial resistance to UV-C.Methods: UV-C therapy (UVCT) was evaluated in vitro using triplicates of 3 M. bovis isolates from clinical cases. The UVCT was performed at a distance of 10, 15, and 20 mm with 1 or 2 doses (4 h apart) for 5, 15, or 30 s (s); the photoreactivation plates were exposed to 12 h of light at different times (T): T0, T4, T6, and T12 after the treatment.Results: In vitro results showed all plates treated with UVCT had a 100% bactericidal effect for all the isolates with a single dose of 15 s at a 10 mm distance. At 15 and 20 mm of distance, 2 doses, 4 h apart, were needed for the same effect, or a single dose of 30 s, which had an 88.8% bactericidal effect. No bacterial regrowth was noticed macroscopically after exposure of the treated plates to artificial light at any time point.Conclusions: The therapeutic potential for killing M. bovis was confirmed in vitro for all tested isolates using a single exposure of 15 s. UVCT can reduce the need for antibiotics, thereby shortening withdrawal periods for animal-derived food products, having a major impact on the cattle industry. Photoreactivation might not play a role in bacterial resistance to UV-C. While safety studies are underway, clinical trials are warranted.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elemental Composition Analysis of Sheep Tears Using Particle-Induced X-Ray Emission. 用粒子诱导x射线发射分析羊眼泪的元素组成。

IF 1.3 4区农林科学

Veterinary ophthalmology Pub Date : 2025-10-01 DOI: 10.1111/vop.70096

Alon Zahavi, Oren Pe'er, Noa Cohen Sinai, Yoav Vardizer, Lionel Sebbag, Ron Ofri, Olga Girshevitz, Nitza Goldenberg-Cohen

{"title":"Elemental Composition Analysis of Sheep Tears Using Particle-Induced X-Ray Emission.","authors":"Alon Zahavi, Oren Pe'er, Noa Cohen Sinai, Yoav Vardizer, Lionel Sebbag, Ron Ofri, Olga Girshevitz, Nitza Goldenberg-Cohen","doi":"10.1111/vop.70096","DOIUrl":"https://doi.org/10.1111/vop.70096","url":null,"abstract":"Objective: To identify the elemental composition of ovine tears using particle-induced X-ray emission (PIXE).Animals studied: Ten physically healthy female sheep.Procedures: Tear samples were collected using Schirmer tear test strips. Tear samples were collected once daily over five consecutive days to assess reproducibility. Elemental analysis was performed with PIXE. Data were processed with GUPIX software. Median values of the elements identified were calculated and statistically analyzed with Kruskal-Wallis and post hoc Dunn's tests.Results: The analysis demonstrated consistent elemental concentrations over the 5-day sampling period. Among the elements detected, chloride (Cl) and sodium (Na) exhibited the highest concentrations.Conclusions: This study establishes PIXE as a valuable technique for detecting and analyzing the elemental composition of the tear film in sheep. By providing a precise method for elemental analysis in small biological samples, this approach lays the groundwork for future research exploring its reliability and sensitivity in tear analysis and potential as a biomarker for ocular and systemic health. The impact of variables including age, diet, and environmental exposure on tear film constituents should be studied, potentially extending the methodology to other species.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0