Veterinary ophthalmology最新文献

Meta-Analysis of Tonometer Correction Formulae to Determine True Normal Intraocular Pressures Across a Diverse Range of Species.

IF 1.7 4区农林科学

Veterinary ophthalmology Pub Date : 2025-03-23 DOI: 10.1111/vop.70001

Andrew C Lewin, Caroline Rose, Xiaojuan Zhu, Paul E Miller

{"title":"Meta-Analysis of Tonometer Correction Formulae to Determine True Normal Intraocular Pressures Across a Diverse Range of Species.","authors":"Andrew C Lewin, Caroline Rose, Xiaojuan Zhu, Paul E Miller","doi":"10.1111/vop.70001","DOIUrl":"https://doi.org/10.1111/vop.70001","url":null,"abstract":"Objective: To utilize previously published tonometer correction formulae to investigate whether true intraocular pressure (IOP) is relatively conserved across a diverse range of vertebrate species.Animals studied: Tonometer correction formulae for 21 species.Procedures: A literature search was performed to identify prior studies containing correction formulae for non-invasive tonometers used in normal animal and human subjects. In all cases, direct manometry was compared to non-invasive tonometry values. Where necessary, multiple correction regression formulae were combined to generate a single representative formula using a meta-analysis generic inverse variance method. A subsequent literature search was then performed to collect uncorrected IOP values of normal animals and humans using a variety of non-invasive tonometers. These IOP values were then corrected using the relevant correction formula.Results: Sixty-five tonometer correction formulae and 104 studies containing IOP values in normal animals and humans acquired using non-invasive tonometry met the inclusion criteria. Corrected IOP values were calculated for 21 species using 13 types of non-invasive tonometers. Overall corrected and uncorrected mean IOP values were typically within a range of 10 to 25 mmHg (corrected: 16/21 species, uncorrected: 14/21 species). Differences between overall mean corrected and uncorrected IOP values ranged from 0.2 to 15.3 mmHg with an average of 6.1 mmHg difference.Conclusions: True normal IOP is relatively conserved across a diverse range of vertebrate species despite uncorrected values from individual tonometers suggesting otherwise. Maintaining true IOP between 10 and 25 mmHg appears to be important in ocular physiology in many vertebrates.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Rock Inhibitor (Y-27632) on the Corneal Endothelium in Dogs Undergoing Phacoemulsification: A Pilot Study.

IF 1.7 4区农林科学

Veterinary ophthalmology Pub Date : 2025-03-23 DOI: 10.1111/vop.13325

Marcella Rosa Filezio, Ivan R M Pádua, Gabriela Madruga, Fanchimery Fachini, Daniela Moura Dos Santos, Karina E H Bueno, José Luiz Laus, Paola Castro Moraes

{"title":"Effects of Rock Inhibitor (Y-27632) on the Corneal Endothelium in Dogs Undergoing Phacoemulsification: A Pilot Study.","authors":"Marcella Rosa Filezio, Ivan R M Pádua, Gabriela Madruga, Fanchimery Fachini, Daniela Moura Dos Santos, Karina E H Bueno, José Luiz Laus, Paola Castro Moraes","doi":"10.1111/vop.13325","DOIUrl":"https://doi.org/10.1111/vop.13325","url":null,"abstract":"Cataract is one of the most common ocular conditions in dogs, and phacoemulsification is the preferred therapeutic method among ophthalmologists. Of all postoperative complications, endothelial injuries stand out, potentially leading to permanent corneal decompensation and loss of transparency. In this study, we evaluated the effects of the ROCK inhibitor (Y-27632) on endothelial protection in dogs undergoing phacoemulsification. Twenty eyes of 10 dogs with bilateral senile cataracts were divided into two groups: Control Eyes (CE) (n = 10), which received balanced saline solution (BSS), and Treated Eyes (TE) (n = 10), which received 0.3 mL of intracameral Y-27632 at a concentration of 100 μmol/L immediately after corneal suturing. The corneal endothelium was evaluated through non-contact specular microscopy before and at different time points after phacoemulsification. We analyzed endothelial cell density (cells/mm2) and cell area (μm2), corneal thickness (mm), hexagonality (%), and coefficient of variation of cell size (%). P values equal to or < 0.05 were considered significant. Both groups showed a loss of endothelial cell density without statistical difference. Regarding corneal thickness and hexagonality, there was no difference. In the CE group, the cell area increased significantly between the evaluated time points, which was not observed in the TE group. It is assumed that the intracameral application of 0.3 mL containing 100 μmol/L of Y-27632 during phacoemulsification in dogs contributes to the stability of corneal endothelial cells, reducing their loss (7.4%), although no significant decrease in cell loss was observed compared to its non-use (11.8%).","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraocular Pressure Increase Induced by 0.5% Tropicamide-0.5% Phenylephrine in Dogs: An Analysis of Causes Using Ultrasound Biomicroscopy.

IF 1.7 4区农林科学

Veterinary ophthalmology Pub Date : 2025-03-16 DOI: 10.1111/vop.70015

Donghee Kim, Sang-Eun Park, Haerin Yoon, Jiyi Hwang, Ji Seung Jung, Soohyun Kim, Kyung-Mee Park

{"title":"Intraocular Pressure Increase Induced by 0.5% Tropicamide-0.5% Phenylephrine in Dogs: An Analysis of Causes Using Ultrasound Biomicroscopy.","authors":"Donghee Kim, Sang-Eun Park, Haerin Yoon, Jiyi Hwang, Ji Seung Jung, Soohyun Kim, Kyung-Mee Park","doi":"10.1111/vop.70015","DOIUrl":"https://doi.org/10.1111/vop.70015","url":null,"abstract":"Purpose: To determine whether the differences in intraocular pressure (IOP) change after the topical application of 0.5% tropicamide and 0.5% phenylephrine (TP) are due to anatomical variations in the anterior chamber using ultrasound biomicroscopy (UBM).Methods: Prospective clinical data from 27 eyes of 14 dogs with normal eye conditions were analyzed. IOP and UBM measurements were taken before and 30 min after administering a topical TP. Dogs were categorized into two groups based on an IOP increase criterion of 4 mmHg: the high group and the stable group. Parameters measured included the iridocorneal angle (ICA), angle-opening distance (AOD), ciliary cleft width (CCW), length (CCL), area (CCA), ciliary body axial length (CBAXL), and ciliary process-sclera angle (CPSA).Results: Both groups showed a statistically significant decrease in ICA and an increase in AOD. However, in the stable group, CPSA increased, CBAXL decreased, and CCA increased, whereas in the high group, CPSA and CBAXL did not change significantly, and CCA decreased.Conclusion: In the stable group, although the pupil dilated, the ciliary body relaxed, leading to an increase in the CCA. Conversely, in the high group, the pupil dilated, and the ciliary body remained unrelaxed, resulting in a reduction in the CCA. These iridociliary changes with pupil dilation increase the risk of elevated IOP. Therefore, an increase in IOP following TP administration may serve as a prognostic indicator for possible glaucoma risk.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Eye of the Largest Forest Raptor, the Harpy Eagle (Harpia harpyja): Morphologic Observations and Reference Values for Selected Ophthalmic Tests.

IF 1.7 4区农林科学

Veterinary ophthalmology Pub Date : 2025-03-16 DOI: 10.1111/vop.70014

Andressa Lopes Grego, Wanderlei de Moraes, Bret A Moore, André T Somma, Thiago Alegre Coelho Ferreira, Ana Carolina Veiga Rodarte-Almeida, Arianne Pontes Oriá, Fabiano Montiani-Ferreira

{"title":"The Eye of the Largest Forest Raptor, the Harpy Eagle (Harpia harpyja): Morphologic Observations and Reference Values for Selected Ophthalmic Tests.","authors":"Andressa Lopes Grego, Wanderlei de Moraes, Bret A Moore, André T Somma, Thiago Alegre Coelho Ferreira, Ana Carolina Veiga Rodarte-Almeida, Arianne Pontes Oriá, Fabiano Montiani-Ferreira","doi":"10.1111/vop.70014","DOIUrl":"https://doi.org/10.1111/vop.70014","url":null,"abstract":"Objective: To carry out a descriptive investigation of the most relevant morphological features of the harpy eagle eye and to provide normative data for selected ophthalmic diagnostic tests.Animals studied: Twenty-nine clinically normal harpy eagles (Harpia harpyja).Procedures: Selected morphological ocular observations were made in live animals under physical restraint: Schirmer tear test (STT), culture of normal conjunctival flora, slit lamp biomicroscopic examination of adnexa and anterior segment, rebound tonometry, applanation tonometry, central corneal thickness (CCT), palpebral fissure length (PFL), B-mode ultrasound, and ocular biometry. Eyelid histology was evaluated from previously deceased individuals.Results: STT type I 17.48 ± 5.476 mm/min; Rebound tonometry 14.00 IQR 4.00 mmHg; Applanation tonometry 15.00 IQR 6.00 mmHg; CCT 0.563 ± 0.041 mm; PFL 26.42 ± 2.13 mm; Axial globe length 29.43 IQR 0.42 mm; Anterior chamber depth 5.00 IQR 0.22 mm; Axial length of the lens 6.60 IQR 0.97 mm; Vitreous chamber depth 16.50 IQR 0.80 mm, and pecten length 8.80 IQR 1.47 mm. The conjunctiva of the lower eyelid has a distinct cartilaginous plate adjacent to the conjunctival epithelium. The most frequent conjunctival bacterial isolates were E. coli (32.76%) followed by Enterobacter spp. (15.52%) and Streptococcus spp. (10.34%).Conclusion: Reference data and morphologic observations obtained in this investigation might aid in the understanding and diagnosis of eye diseases in harpy eagles and improve the clinical management of ocular disease.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Tear Film Concentrations of Cefazolin and Chloramphenicol Using Cross-Linked Hyaluronic Acid in Canine Eyes.

IF 1.7 4区农林科学

Veterinary ophthalmology Pub Date : 2025-03-16 DOI: 10.1111/vop.70013

Dikla Arad, Ella Margot Mordechai, Yulia Goncharov, Ron Ofri, Lionel Sebbag

{"title":"Enhanced Tear Film Concentrations of Cefazolin and Chloramphenicol Using Cross-Linked Hyaluronic Acid in Canine Eyes.","authors":"Dikla Arad, Ella Margot Mordechai, Yulia Goncharov, Ron Ofri, Lionel Sebbag","doi":"10.1111/vop.70013","DOIUrl":"https://doi.org/10.1111/vop.70013","url":null,"abstract":"Objective: To evaluate the impact of two excipients, 1.4% polyvinyl alcohol (PVA) and 0.75% cross-linked hyaluronic acid (XHA), on tear film concentrations of cefazolin and chloramphenicol.Animals studied: Ten ophthalmologically healthy dogs.Procedures: Cefazolin and chloramphenicol were compounded into 5.5% and 0.5% solutions, respectively, using either 1.4% PVA or 0.75% XHA. In the first trial, each dog received cefazolin-PVA in one randomly assigned eye and cefazolin-XHA in the contralateral eye. One month later, the experiment was repeated using chloramphenicol formulations. Tear fluid was sampled at 0, 1, 5, 10, 15, 30, 60, 120, 240, 360, and 480 min following eyedrop administration using 2 μL capillary tubes. Tear concentrations of cefazolin and chloramphenicol were measured using UV-Vis spectrophotometry.Results: Tear film concentrations of cefazolin and chloramphenicol were significantly higher with XHA compared to PVA at all time points (p ≤ 0.020), except for baseline (both antibiotics), times 1 min, 60 min, and 120 min for cefazolin. The tear film kinetics exhibited a biphasic pattern, with drug levels decreasing from 0 to 120 min, then slightly increasing between 120 and 360 min before declining again until 480 min. The area under the time-concentration curve (AUC0-480) was significantly greater with XHA versus PVA formulations (p = 0.002), with a median 2.4 and 4.2 times higher for cefazolin and chloramphenicol, respectively.Conclusion: The cross-linked hyaluronic acid significantly enhanced the retention and overall exposure of both cefazolin and chloramphenicol in the canine tear film. These findings suggest that XHA could serve as a superior delivery vehicle for ocular antibiotics, potentially improving treatment outcomes for ophthalmic infections.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycotic Sphenopalatine Sinusitis With Concurrent Compression of the Optic Nerves and Chiasm and Severe Visual Impairment in A Horse.

IF 1.7 4区农林科学

Veterinary ophthalmology Pub Date : 2025-03-07 DOI: 10.1111/vop.70003

Niklas Holz, José Suárez, Udo Hetzel, Antonella Rampazzo, Riccardo Stoppini

{"title":"Mycotic Sphenopalatine Sinusitis With Concurrent Compression of the Optic Nerves and Chiasm and Severe Visual Impairment in A Horse.","authors":"Niklas Holz, José Suárez, Udo Hetzel, Antonella Rampazzo, Riccardo Stoppini","doi":"10.1111/vop.70003","DOIUrl":"https://doi.org/10.1111/vop.70003","url":null,"abstract":"A 15-year-old Swiss Warmblood gelding was presented to the ophthalmology service of Zurich University due to severe visual impairment. Ophthalmic and neurologic examinations were performed, raising suspicion of post-retinal blindness. Standing contrast computed tomography (CT) of the head revealed a partially calcified, soft tissue attenuating mass in the sphenopalatine sinus with concurrent compression of the optic nerves and chiasm. Differential diagnosis included neoplasia and granulomatous disease. The horse was euthanized, and the head was subsequently examined by magnetic resonance imaging (MRI) followed by gross and histopathology. MRI showed compression of the optic nerves and chiasm. Histopathology revealed the formation of fibrous granulation tissue, osseous metaplasia, and pyogranulomatous inflammation in the sphenopalatine sinus. Periodic acid-Schiff reaction and Grocott silver staining demonstrated branching septated filament hyphae and fungal spores. The optic nerves and chiasm were evident of mild neuronal atrophy, showing mild gliosis, vacuolation, and mild lympho-plasmacytic inflammation. Mycotic sphenopalatine sinusitis should be considered as a more specific diagnosis for post-retinal blindness in horses due to the compression of the optic nerve(s) and chiasm.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trace Element Levels in Canine Tear Film.

IF 1.7 4区农林科学

Veterinary ophthalmology Pub Date : 2025-03-05 DOI: 10.1111/vop.70004

Oren Pe'er, Lionel Sebbag, Alon Zahavi, Olga Girshevitz, Nitza Goldenberg-Cohen, Ron Ofri

{"title":"Trace Element Levels in Canine Tear Film.","authors":"Oren Pe'er, Lionel Sebbag, Alon Zahavi, Olga Girshevitz, Nitza Goldenberg-Cohen, Ron Ofri","doi":"10.1111/vop.70004","DOIUrl":"https://doi.org/10.1111/vop.70004","url":null,"abstract":"Objective: To evaluate the levels of trace elements in the tear film of healthy dogs.Animals studied: Twenty-five healthy Labrador retrievers.Procedures: Tear samples were collected from the ventral conjunctival fornix of each dog using a Schirmer tear test strip. Elemental analysis was conducted using the particle-induced X-ray emission (PIXE) method with a 1.7 MV Pelletron accelerator. Trace element levels were compared across all dogs using the Kruskal-Wallis test with post hoc Tukey analysis and between male and female dogs using the Mann-Whitney test.Results: The study included 14 neutered males and 11 spayed females, with a mean (±SD) age of 19.8 ± 3.1 months (range 14.3-26.5, median 18.8 months). Elemental analysis of tear samples revealed the presence of calcium (Ca), chloride (Cl), iron (Fe), phosphorus (P), potassium (K), sodium (Na), and sulfur (S). The median ± SEM peak area levels were highest for Cl (69 530 ± 1432) and K (5782 ± 514), followed by S (3545 ± 772), Na (3387 ± 159), P (1408 ± 160), Ca (593 ± 85), and Fe (276 ± 206). Compared to males, female dogs had significantly higher peak areas for S (2272 ± 549 vs. 4389 ± 1484, p = 0.037) and Ca (536 ± 76 vs. 800 ± 148, p = 0.029).Conclusions: This study provides a detailed assessment of the trace element composition in the tear film of healthy dogs. These findings enhance our understanding of canine ocular surface physiology and may have potential implications for the diagnosis and management of ocular surface diseases in dogs.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultraviolet C (UV-C) Light Therapy for Equine Ulcerative Keratomycosis-An In Vitro Study.

IF 1.7 4区农林科学

Veterinary ophthalmology Pub Date : 2025-03-05 DOI: 10.1111/vop.70012

Mona Hoerdemann, Dipak K Sahoo, Rachel A Allbaugh, Melissa A Kubai

{"title":"Ultraviolet C (UV-C) Light Therapy for Equine Ulcerative Keratomycosis-An In Vitro Study.","authors":"Mona Hoerdemann, Dipak K Sahoo, Rachel A Allbaugh, Melissa A Kubai","doi":"10.1111/vop.70012","DOIUrl":"https://doi.org/10.1111/vop.70012","url":null,"abstract":"Objectives: To assess if an affordable, commercially available 275 nm ultraviolet C (UV-C) device can inhibit fungal pathogens associated with equine keratomycosis and to establish the optimal exposure time/dose required in vitro.Methods: Fungal inhibition zone surface areas of isolates from two fungal genera (Aspergillus and Fusarium spp.) were compared in triplicates after UV-C exposure at distances of 10, 15, and 20 mm with single or repeat doses (4 h apart) of 5, 10, 15, or 30 s duration after 24, 48, and 72 h of incubation. Inhibition zones were microscopically assessed, and regrowth checks were performed.Results: Fungal inhibition was achieved with the lowest exposures/doses of 5 s/7.5 mJ/cm2 and 10 s/7 mJ/cm2 at distances of 10 and 20 mm, respectively. At 10 mm, the fungal inhibition zone was statistically significantly enlarged by increasing exposure/dose from 5 s to 15 s/22.5 mJ/cm2 for all isolates. Only Aspergillus flavus showed a further significant zone enlargement after a 30 s/45 mJ/cm2 exposure/dose. Fungal inhibition zone sizes did not differ significantly between isolates after 15 s exposure regardless of distance, but an increased distance led to a subjective increase in fungal regrowth. While inhibition zones decreased over time, no central growth was noted despite the lack of complete fungal eradication.Conclusions: For Aspergillus and Fusarium spp., an exposure/dose of 15 s at a 10 mm distance/22.5 mJ/cm2 may optimally align antifungal efficacy with previously reported corneal safety data. Further preclinical and safety studies are required to ensure that this effect translates into clinical practice.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nodular Keratitis Associated With a Previous Diagnosis of Chronic Superficial Keratitis in a German Shepherd Dog: A First Case Report. 德国牧羊犬结节性角膜炎与之前诊断的慢性浅表性角膜炎有关：首例病例报告。

IF 1.7 4区农林科学

Veterinary ophthalmology Pub Date : 2025-03-05 DOI: 10.1111/vop.70009

Natalia Ziółkowska, Katarzyna Paździor-Czapula, Aleksandra Rawicka

{"title":"Nodular Keratitis Associated With a Previous Diagnosis of Chronic Superficial Keratitis in a German Shepherd Dog: A First Case Report.","authors":"Natalia Ziółkowska, Katarzyna Paździor-Czapula, Aleksandra Rawicka","doi":"10.1111/vop.70009","DOIUrl":"https://doi.org/10.1111/vop.70009","url":null,"abstract":"Objective: To describe the clinical and morphological features of a case of superficial nodular keratitis in a dog.Case description: A German shepherd dog previously diagnosed with chronic superficial keratitis (CSK) presented with a nonpainful, unilateral corneal nodule. After a complete ophthalmic examination, topical treatment with dexamethasone (0.1% dexamethason, WZW) was prescribed. However, the patient did not respond to this treatment; thus, a superficial keratectomy was performed. The lesion was examined histologically and immunohistochemically.Results: The ophthalmic examination revealed a round, pink, solid nodule, approximately 0.5 cm in diameter, located in the ventral, paracentral cornea. Results from the Schirmer tear test I, tonometry, and fluorescein staining were in the normal ranges. A small amount of mucous discharge and moderate hyperemia of the bulbar conjunctiva were present. The histological examination revealed a solid mass in the superficial corneal stroma under the corneal epithelium. Hematoxylin and eosin (HE) staining showed that the mass was supplied with blood vessels; HE and immunohistochemistry revealed it consisted of a mixture of plasma cells (MUM+ cells), B lymphocytes (CD79+, CD20+ cells), T lymphocytes (CD3+), and macrophages (Iba1+ cells). Mitotic figures were absent. Some nuclei in inflammatory infiltrates displayed a Ki76+ reaction. Inflammatory infiltrates were present in the superficial stroma and the corneal epithelium.Conclusion: These novel results demonstrate that the features of nodular keratitis in a German shepherd dog previously diagnosed with CSK differ from the features of xanthogranulomas, nodular episcleritis, corneal granulomas, pyogranulomatous keratitis, corneal epithelial inclusion cysts, protozoal keratitis, and corneal squamous cell carcinoma.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

55th annual meeting of the American College of Veterinary Ophthalmologists, Savannah, Georgia, USA, October 23-26, 2024.

IF 1.7 4区农林科学

Veterinary ophthalmology Pub Date : 2025-03-03 DOI: 10.1111/vop.13323

引用次数: 0