World Journal of Cardiology最新文献

{"title":"Structural radial artery modifications following transradial access: Mechanisms, clinical implications, and preventive strategies.","authors":"Xenofon M Sakellariou, Dimitrios Ν Nikas, Panagiotis Papanagiotou, Evangelos Liberopoulos, Matilda Florentin, Aris Bechlioulis, Eleftheria M Mastoridou, Theofilos M Kolettis","doi":"10.4330/wjc.v17.i7.107772","DOIUrl":"10.4330/wjc.v17.i7.107772","url":null,"abstract":"<p><p>Transradial access (TRA) has emerged as the preferred vascular access route for coronary angiography and percutaneous coronary interventions due to its superior safety profile compared to transfemoral access. However, its widespread adoption raises concerns regarding structural alterations in the radial artery, which may impact long-term vascular health and future procedural feasibility. TRA is associated with histopathologic changes in the arterial wall, such as intimal injury and hyperplasia, medial remodeling and adventitial inflammation, collectively contributing to radial artery remodeling. Moreover, TRA can induce changes in radial artery lumen diameter driven by an inflammatory response due to arterial puncture and mechanical friction during the procedure. Nonetheless, a more clinically significant consequence is radial artery occlusion, which is influenced by various procedural and patient-related factors. Strategies to minimize remodeling include meticulous pre-procedural ultrasound assessment to ensure appropriate sheath-to-artery size matching, periprocedural pharmacological interventions and implementation of patent hemostasis techniques. This review synthesizes current knowledge regarding the mechanisms, clinical implications, and preventive strategies related to radial artery remodeling following TRA. Further research is needed to elucidate the long-term consequences of radial artery remodeling and to refine preventive strategies for preserving radial artery patency and its suitability for future interventions.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 7","pages":"107772"},"PeriodicalIF":2.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter aortic valve replacement or surgical aortic valve replacement: Establishing a middle ground.","authors":"Sukhdeep Bhogal, Tarun Bhandari, Akash Batta, Bishav Mohan","doi":"10.4330/wjc.v17.i7.109690","DOIUrl":"10.4330/wjc.v17.i7.109690","url":null,"abstract":"<p><p>Transcatheter aortic valve replacement (TAVR) has emerged as an established standard of care for patients with severe aortic stenosis (AS), irrespective of their surgical risk. However, despite the continuous advancements over last two decades, there are still significant challenges in field in terms of appropriate selection of patients as well as the valves. While there is no doubt that TAVR has now become the leading mode of treatment for severe AS patients, surgical aortic valve replacement (SAVR) still holds its value for the selective group of patients who are not ideal candidate for the minimally invasive procedure: TAVR. The dilemma is palpable in the clinical field that warrants best approach focusing on the lifetime management of these patients. In the recent metanalysis by Moradi <i>et al</i>, the authors provide a comprehensive insight into TAVR <i>vs</i> SAVR in terms of mortality, procedural complications, and post-procedure adverse events. In this editorial, we shed light on comparative analysis of both modalities to establish a middle ground.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 7","pages":"109690"},"PeriodicalIF":2.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-enabled single-lead electrocardiogram in early detection of ischemic heart disease.","authors":"Wen-Hua Song, Gary Tse, Kang-Yin Chen, Tong Liu","doi":"10.4330/wjc.v17.i7.108510","DOIUrl":"10.4330/wjc.v17.i7.108510","url":null,"abstract":"<p><p>With the rapid advancement and widespread adoption of new artificial intelligence (AI) technologies, personalized medicine and more accurate diagnosis using medical imaging are now possible. Among its many applications, AI has shown remarkable potential in the analysis of electrocardiograms (ECGs), which provide essential insights into the electrical activity of the heart and allowing early detection of ischemic heart disease (IHD). Notably, single-lead ECG (SLECG) analysis has emerged as a key focus in recent research due to its potential for widespread and efficient screening. This editorial focuses on the latest research progress of AI-enabled SLECG utilized in the diagnosis of IHD.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 7","pages":"108510"},"PeriodicalIF":2.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of glucagon-like peptide-1 receptor agonists on the incidence of atrial fibrillation.","authors":"Krzysztof Glaser, Wojciech Glaser, Luca Marino, Marek Ruchala, Federico Bilotta","doi":"10.4330/wjc.v17.i7.107510","DOIUrl":"10.4330/wjc.v17.i7.107510","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) stands as the most prevalent type of arrhythmia, affecting approximately 60 million individuals world-wide. Although antiarrhythmic drugs (AADs) remain the gold standard for AF treatment, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are arising as potential therapeutic alternatives.</p><p><strong>Aim: </strong>To evaluate the impact of GLP-1 RAs on the incidence of AF.</p><p><strong>Methods: </strong>Inclusion criteria included systematic reviews (SRs) that based their analyses on clinical trials, observational studies, controlled trials and network meta-analyses. A total of 8 SRs were selected for data extraction, focusing on semaglutide, liraglutide and dulaglutide. Additionally, the effects of GLP-1 RAs on AF incidence were compared with those of sodium-glucose co-transporter 2 (SGLT2) inhibitors.</p><p><strong>Results: </strong>Findings indicate that semaglutide, evaluated in the largest patient cohort across the 8 SRs, consistently reduced AF incidence. However, dulaglutide and liraglutide exhibited inconsistent effects. Notably, as opposed to variable outcomes associated with GLP-1 RAs, SGLT2 inhibitors a class of antidiabetic agents with weight-reducing properties exhibit significant cardiovascular benefits, including reductions in both AF and atrial flutter.</p><p><strong>Conclusion: </strong>GLP-1 RAs emerge as a promising and potential alternative for AADs in reduction of incidence of AF. However, further research is required to fully determine their therapeutic potential and long-term cardiovascular effects.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 7","pages":"107510"},"PeriodicalIF":2.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel cardiac biomarkers and multiple-marker approach in the early detection, prognosis, and risk stratification of cardiac diseases.","authors":"Syed Faqeer Hussain Bokhari, Muhammad Umais, Syed Muhammad Faizan Sattar, Umair Mehboob, Asma Iqbal, Maaz Amir, Danyal Bakht, Khawar Ali, Abdul Haseeb Hasan, Muhammad Arsham Javed, Wahidullah Dost","doi":"10.4330/wjc.v17.i7.106561","DOIUrl":"10.4330/wjc.v17.i7.106561","url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, necessitating innovative diagnostic and prognostic strategies. Traditional biomarkers like C-reactive protein, uric acid, troponin, and natriuretic peptides play crucial roles in CVD management, yet they are often limited by sensitivity and specificity constraints. This narrative review critically examines the emerging landscape of cardiac biomarkers and advocates for a multiple-marker approach to enhance early detection, prognosis, and risk stratification of CVD. In recent years, several novel biomarkers have shown promise in revolutionizing CVD diagnostics. Gamma-glutamyltransferase, microRNAs, endothelial microparticles, placental growth factor, trimethylamine N-oxide, retinol-binding protein 4, copeptin, heart-type fatty acid-binding protein, galectin-3, growth differentiation factor-15, soluble suppression of tumorigenicity 2, fibroblast growth factor 23, and adrenomedullin have emerged as significant indicators of CV health. These biomarkers provide insights into various pathophysiological processes, such as oxidative stress, endothelial dysfunction, inflammation, metabolic disturbances, and myocardial injury. The integration of these novel biomarkers with traditional ones offers a more comprehensive understanding of CVD mechanisms. This multiple-marker approach can improve diagnostic accuracy, allowing for better risk stratification and more personalized treatment strategies. This review underscores the need for continued research to validate the clinical utility of these biomarkers and their potential incorporation into routine clinical practice. By leveraging the strengths of both traditional and novel biomarkers, precise therapeutic plans can be developed, thereby improving the management and prognosis of patients with CVDs. The ongoing exploration and validation of these biomarkers are crucial for advancing CV care and addressing the limitations of current diagnostic tools.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 7","pages":"106561"},"PeriodicalIF":2.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Bothrops</i> bite and cardiac complications: A case report and review of literature.","authors":"Juan S Acosta, Jennifer Cifuentes Tarquino, Joshua E Arteaga","doi":"10.4330/wjc.v17.i7.106828","DOIUrl":"10.4330/wjc.v17.i7.106828","url":null,"abstract":"<p><strong>Background: </strong><i>Bothrops</i> envenomation is a common medical emergency in tropical areas and is characterized by local and systemic complications, such as edema, coagulopathy, and tissue necrosis. Cardiovascular manifestations are rare and poorly documented, contributing to the complexity of its clinical management.</p><p><strong>Case summary: </strong>We described a rare cardiac complication in a 65-year-old female patient, who initially presented with mild <i>Bothrops</i> envenomation. She experienced localized edema and erythema but with a lack of systemic symptoms. During the evaluation we detected asymptomatic sinus bradycardia and QTc prolongation (523 milliseconds) that progressed to severe arrhythmias that required implantation of a permanent pacemaker. Management included the administration of polyvalent antiphonic serum, fresh frozen plasma transfusions, and intensive care unit monitoring. Imaging and laboratory studies ruled out ischemic, metabolic, or electrolytic etiologies for the cardiac alterations. The patient recovered favorably after the intervention and was discharged without further complications.</p><p><strong>Conclusion: </strong>This case underscored the need for cardiac monitoring after snakebite envenomation as well as further research on venom-induced cardiotoxic mechanisms.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 7","pages":"106828"},"PeriodicalIF":2.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute myocardial infarction with ventricular septal rupture: Clinical characteristics, prognosis factors, and treatment strategies.","authors":"Jian Zu, Lu Cheng, Jing-Jing Lu, Hui Xu, Rong Zhang, Xue-Rui Ye, Qian Qiao, Li-Hong Zhang, Hao-Ling Zhang, Jing-Jing Zhang","doi":"10.4330/wjc.v17.i7.109787","DOIUrl":"10.4330/wjc.v17.i7.109787","url":null,"abstract":"<p><p>This review comprehensively examines acute myocardial infarction with ventricular septal rupture (VSR), a rare yet lethal complication. We analyze its epidemiological, pathophysiological, clinical, and therapeutic aspects, emphasizing innovative strategies like bioabsorbable occluders and tissue engineering to reduce complications and improve prognosis. The integration of artificial intelligence and big data analytics for treatment decision-making and personalized surgical timing models is highlighted as transformative. Our analysis underscores the need for early diagnosis and tailored interventions, proposing future research directions in molecular mechanisms, multidisciplinary collaboration, and technology integration. These innovations promise to enhance VSR management and extend to other cardiovascular diseases, heralding a new era of precision and regenerative cardiovascular medicine.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 7","pages":"109787"},"PeriodicalIF":2.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating liver and heart health: Cardiovascular risk reduction in patients with metabolic-associated steatotic liver disease.","authors":"Thang Viet Luong, Hoa Tran, Bich Ngoc Hoang Thi, Hung Minh Vu, The Trung Le, Tien Thi Le, Huyen Trang Tran Thi, Hung Minh Nguyen, Thang Chi Doan, Binh Anh Ho, Tien Anh Hoang, Hai Nguyen Ngoc Dang","doi":"10.4330/wjc.v17.i7.107751","DOIUrl":"10.4330/wjc.v17.i7.107751","url":null,"abstract":"<p><p>Metabolic-associated steatotic liver disease (MASLD) is a global health burden intricately linked to cardiovascular disease (CVD) through shared pathways-insulin resistance, dyslipidemia, and chronic inflammation. CVD has become the leading cause of mortality in MASLD, necessitating integrated management strategies. This review synthesizes evidence on bidirectional MASLD-CVD interactions and evaluates therapeutic approaches: Lifestyle modifications, pharmacotherapy (<i>e.g.</i>, GLP-1 receptor agonists, SGLT2 inhibitors, statins), and metabolic interventions. Despite progress, critical gaps persist in risk stratification tools, personalized treatment algorithms, and long-term outcomes of novel agents like resmetirom. A multidisciplinary care model, bridging hepatology and cardiology, is essential to address these challenges and improve patient outcomes.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 7","pages":"107751"},"PeriodicalIF":2.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol is a predictor for cardiovascular mortality in patients with diabetes mellitus.","authors":"Deng Pan, Peng-Fei Chen, Si-Yan Ji, Tie-Long Chen, He Zhang","doi":"10.4330/wjc.v17.i7.101434","DOIUrl":"10.4330/wjc.v17.i7.101434","url":null,"abstract":"<p><strong>Background: </strong>The non-high-density lipoprotein cholesterol (non-HDL-C)/HDL-C ratio (NHHR) is linked to cardiovascular event risk, but its prognostic value in diabetes mellitus (DM) patients remains unclear.</p><p><strong>Aim: </strong>To explore the association of NHHR and cardiovascular mortality in patients with DM and generate predictive model.</p><p><strong>Methods: </strong>This cohort study analyzed data from 8425 DM patients in National Health and Nutrition Examination Survey. NHHR was calculated as (total cholesterol - HDL-C)/HDL-C. Cardiovascular mortality was determined <i>via</i> the National Death Index. Feature selection was performed using the Boruta algorithm and least absolute shrinkage and selection operator regression, followed by Cox proportional hazards models to evaluate NHHR's relationship with cardiovascular mortality. Stratified and sensitivity analyses assessed the findings' robustness. A nomogram was developed to predict cardiovascular mortality, with model performance evaluated using receiver operating characteristic curves and calibration plots.</p><p><strong>Results: </strong>Over an average follow-up of 94.2 months, 671 cardiovascular deaths (8.0%) occurred. Six key features including age, education, ethnicity, poverty-income ratio, history of heart failure, and NHHR, were selected. A non-linear association was found, with the highest NHHR quartile showing a 39% higher risk of cardiovascular death compared to the lowest quartile (Q4, hazard ratio: 1.39, 95% confidence interval: 1.11-1.73). Stratified analyses confirmed the increased risk across all subgroups. Sensitivity analyses supported the stability of the results. The nomogram for predicting cardiovascular mortality demonstrated high accuracy.</p><p><strong>Conclusion: </strong>Elevated NHHR is associated with increased cardiovascular mortality risk in DM patients. NHHR could be a valuable prognostic marker, aiding in identifying high-risk patients and guiding targeted lipid management strategies.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 7","pages":"101434"},"PeriodicalIF":2.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond initial recovery: Heart failure with transient <i>vs</i> sustained improvement in left ventricular ejection fraction.","authors":"Rasha Kaddoura, Ammar Chapra, Jassim Shah, Mohamed Izham, Rajvir Singh, Haisam Alsadi, Maha Al-Amri, Tahseen Hamamyh, Manar Fallouh, Farras Elasad, Mohamed Abdelghani, Sumaya Alsaadi Alyafei, Amr Badr, Ashfaq Patel","doi":"10.4330/wjc.v17.i6.106717","DOIUrl":"10.4330/wjc.v17.i6.106717","url":null,"abstract":"<p><strong>Background: </strong>There is no available data about the trajectory of heart failure (HF) with improved ejection fraction (EF) and patient clinical outcomes in Qatar.</p><p><strong>Aim: </strong>To explore the difference in characteristics and outcomes between patients with transient and sustained improvement in left ventricular ejection fraction (LVEF) and to determine the independent predictors for sustained improvement in LVEF.</p><p><strong>Methods: </strong>This is a retrospective cohort study that was conducted at the advanced HF clinic of a tertiary care hospital in Qatar between January 2017 and December 2018. This study included adult patients with improved LVEF and had at least three echocardiographic studies. The patients were divided into two groups: HF with transient improvement in EF (HFtimpEF) and HF with sustained improvement in EF (HFsimpEF).</p><p><strong>Results: </strong>A total of 175 patients with HF and improved EF were included. Among them 136 (77.7%) patients showed sustained improvement in LVEF. The remaining patients with HFtimpEF were predominantly males [37 (94.9%) <i>vs</i> 101 (74.3%), <i>P</i> = 0.005] with a higher incidence of ischemic cardiomyopathy [32 (82.1%) <i>vs</i> 68 (50.4%), <i>P</i> = 0.002], dyslipidemia [24 (61.5%) <i>vs</i> 54 (39.7%), <i>P</i> = 0.03], and hypertension [34 (87.2%) <i>vs</i> 93 (68.4%), <i>P</i> = 0.03] than those with HFsimpEF. The latter experienced significantly lower rates of hospitalization [39 (28.7%) <i>vs</i> 20 (51.3%), <i>P</i> = 0.01] and diagnosis of new cardiovascular conditions during the follow-up (<i>e.g.</i>, acute coronary syndrome, stroke, decompensated HF, and atrial fibrillation) [14 (10.3%) <i>vs</i> 10 (25.6%), <i>P</i> = 0.03] without a difference in emergency department visits or in-hospital death. Sustained improvement in LVEF was positively associated with being female [adjusted odds ratio (aOR) = 6.8, 95% confidence interval (CI): 1.4-32.3, <i>P</i> = 0.02], having non-ischemic etiology of HF (aOR = 3.1, 95%CI: 1.03-9.3, <i>P</i> = 0.04), and using a mineralocorticoid receptor antagonist (aOR = 7.0, 95%CI: 1.50-31.8, <i>P</i> = 0.01).</p><p><strong>Conclusion: </strong>Patients with HFsimpEF experienced significantly lower rates of hospitalization and diagnosis of new cardiovascular conditions than patients with HFtimpEF. Sustained improvement in LVEF was positively associated with being a female, having non-ischemic etiology of HF, and using a mineralocorticoid receptor antagonist.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 6","pages":"106717"},"PeriodicalIF":1.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}