World Journal of Cardiology最新文献

{"title":"Circulating microRNAs in predicting fibrosis in hypertrophic cardiomyopathy: A systematic review.","authors":"Maneeth Mylavarapu, Lakshmi Sai Meghana Kodali, Roopeessh Vempati, Jai Sivanandan Nagarajan, Ankit Vyas, Rupak Desai","doi":"10.4330/wjc.v17.i5.106123","DOIUrl":"10.4330/wjc.v17.i5.106123","url":null,"abstract":"<p><strong>Background: </strong>Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy and interstitial fibrosis, which contribute to adverse outcomes such as heart failure and sudden cardiac death. While cardiac magnetic resonance (CMR) imaging is commonly used to detect myocardial fibrosis, circulating microRNAs (miRNAs) have emerged as promising noninvasive biomarkers for this condition due to their stability in blood plasma and resistance to pH and temperature variance.</p><p><strong>Aim: </strong>To explore the role of specific circulating miRNAs in identifying myocardial fibrosis in patients with HCM.</p><p><strong>Methods: </strong>Using PubMed/MEDLINE and Google Scholar, we reviewed studies from 2014 to 2024 examining the link between circulating miRNAs and myocardial fibrosis in HCM. We included studies measuring miRNA expression in blood samples from HCM patients and assessing fibrosis <i>via</i> imaging, mostly CMR. Data extraction concentrated on the population, methodology, and findings related to the correlation between miRNA levels and fibrosis.</p><p><strong>Results: </strong>Seven studies involving 365 HCM patients with a mean age of 49.37 ± 10.5 years, 116 (31.78%) females, and one animal study identified miR-21, miR-29a, miR-133, miR-4454, and miR-221 as frequently dysregulated markers associated with fibrosis. Elevated levels of miR-21 and miR-29a correlated with more extensive fibrosis, as assessed by late gadolinium enhancement in CMR imaging, with miR-29a consistently linked to both fibrosis and hypertrophy across the studies.</p><p><strong>Conclusion: </strong>Circulating miRNAs, particularly miR-21, miR-29a, and miR-221, show significant potential as biomarkers for myocardial fibrosis in HCM. Further research should validate these findings and investigate the clinical application of miRNA-based diagnostics in HCM.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"106123"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of myocardial damage induced by doxorubicin <i>via</i> calumenin-regulated mitochondrial dynamics and the calcium-Cx43 pathway.","authors":"He Shi, Song-Ao Yang, Ling-Yu Bai, Jian-Jun Du, Zhe Wu, Zhi-Hui He, Hao Liu, Jia-Yue Cui, Ming Zhao","doi":"10.4330/wjc.v17.i5.104839","DOIUrl":"10.4330/wjc.v17.i5.104839","url":null,"abstract":"<p><strong>Background: </strong>The clinical application of doxorubicin (DOX) is limited by its potential to cause cardiac cardiotoxicity.</p><p><strong>Aim: </strong>To investigate the correlation between calumenin (CALU) and mitochondrial kinetic-related proteins in rats with DOX cardiomyopathy.</p><p><strong>Methods: </strong>A rat model of DOX-induced cardiomyopathy was used to evaluate the effects of DOX. We observed the effect of DOX on electrical conduction in cardiomyocytes using the electromapping technique. Masson staining was performed to evaluate myocardium fibrosis. Electron microscopy was used to observe the changes in pathological ultrastructure of the myocardium. Western blotting and ELISAs were performed to detect protein levels and intracellular free Ca²⁺ concentration.</p><p><strong>Results: </strong>DOX slowed conduction and increased conduction dispersion in cardiomyocytes. The myocardial pathology in rats treated with DOX exhibited a significant deterioration, as demonstrated by an increase in mitochondrial Ca²⁺ concentration and a decrease in the expression of CALU, optic atrophy-1, and Bcl-2. Additionally, there was an increase in the expression of connexin 43 (Cx43) and the mitochondrial mitotic proteins dynamin-related protein 1, CHOP, Cytochrome C, and Bax in DOX rats. Decreased expression of CALU in cardiomyocytes triggered an increase in cytoplasmic free calcium concentration, which would normally be taken up by mitochondria, but decreased expression of mitochondrial outer membrane fusion proteins triggered a decrease in mitochondrial Ca²⁺ uptake, and the increase in cytoplasmic free calcium concentration triggered cell apoptosis.</p><p><strong>Conclusion: </strong>Increased cytoplasmic free calcium ion concentration induces calcium overload in ventricular myocytes, leading to decreased Cx43 protein, slowed conduction in myocytes, and increased conduction dispersion, resulting in arrhythmias.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"104839"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal analgesia in cardiac surgery: Impact on postoperative medication consumption and cognitive function.","authors":"Qin Wang, Xiao-Qiong Yan, Xiao-Mei Ma, Rui Yan, Zhi-Hua Wang, Yu-Jie Ma, Hai-Bin Wang","doi":"10.4330/wjc.v17.i5.103168","DOIUrl":"10.4330/wjc.v17.i5.103168","url":null,"abstract":"<p><strong>Background: </strong>Patients who undergo cardiac surgery often face postoperative pain and potential cognitive issues. Multimodal analgesia may address these problems. We hypothesized that multimodal analgesia can reduce opioid use and improve cognitive recovery.</p><p><strong>Aim: </strong>To investigate the effects of multimodal analgesia on postoperative opioid consumption and cognitive recovery in patients who underwent cardiac surgery.</p><p><strong>Methods: </strong>A prospective, randomized controlled trial at General Hospital from January 2020 to April 2023 recruited a total of 150 adult patients who underwent elective cardiac surgery. The patients were randomly divided into two groups. Group A had patient-controlled intravenous analgesia with sufentanil and flurbiprofen axil. Group B had flurbiprofen axil and paravertebral nerve block. Data were analyzed with appropriate statistical methods.</p><p><strong>Results: </strong>Group B had lower postoperative patient-controlled intravenous analgesia drug consumption (2.21 mL/hour <i>vs</i> 4.26 mL/hour, <i>P</i> < 0.001), shorter extubation time (2.32 hours <i>vs</i> 3.81 hours, <i>P</i> < 0.001), and intensive care unit stay (15.32 h <i>vs</i> 28.63 h, <i>P</i> < 0.001). Visual Analogue Scale pain scores were lower in group B (<i>P</i> < 0.001). Group B had fewer postoperative complications (no respiratory depression <i>vs</i> 37.9% in group A, <i>P</i> < 0.05), a lower postoperative cognitive dysfunction incidence (16.0% <i>vs</i> 28.0%, <i>P</i> < 0.05), and higher Barthel Index scores (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Multimodal analgesia with paravertebral nerve block and flurbiprofen axil reduces opioid use and improves cognitive outcomes in patients who underwent cardiac surgery.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"103168"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between heart rate variability and cancer management.","authors":"Takashi Kikuchi, Takatoshi Kasai","doi":"10.4330/wjc.v17.i5.107434","DOIUrl":"10.4330/wjc.v17.i5.107434","url":null,"abstract":"<p><p>In patients with advanced cancer, the prevalence rate of cardiac autonomic neuropathy (CAN) is high, and the prognosis of patients with CAN is generally poor. Although mechanisms including inflammation, infection, metabolism, neurodegeneration, toxic processes, and cancer treatment have been proposed as etiologies of CAN in cancer patients, these mechanisms have not been completely elucidated, and their relationship has only been described indirectly. A study involving 127 cancer patients revealed that both the disease and its treatments can lead to a decrease in heart rate variability (HRV) indicating the autonomic imbalance. Because managing CAN is essential for improving the survival and quality of life of patients with cancer, patients and specialists can work together to customize cancer treatment and management using HRV as an index.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"107434"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversible dilated cardiomyopathy caused by primary hyperparathyroidism: A case report.","authors":"Wei Jiang, Yu-Zhi Qiu, Hu-Tao Xi, Hui-Hui Ma, Xin Wu, Xiao-Mei Yuan, Wen-Yan Wang, Hong Kong, Xiao-Ping Li","doi":"10.4330/wjc.v17.i5.105670","DOIUrl":"10.4330/wjc.v17.i5.105670","url":null,"abstract":"<p><strong>Background: </strong>Dilated cardiomyopathy (DCM) is a common cause of systolic heart failure, and is the most prevalent type of non-ischemic cardiomyopathy. Primary hyperparathyroidism (PHPT) is characterized by hypercalcemia and excessive secretion of parathyroid hormone (PTH). Generally, PHPT is asymptomatic and is incidentally identified during routine laboratory assessments.</p><p><strong>Case summary: </strong>This case report details a 52-year-old man diagnosed with DCM and refractory hypercalcemia, who presented with clinical manifestations including dyspnea, recurrent anorexia, and abdominal distention. Laboratory investigations indicated an elevated serum PTH level, and the sestamibi scan suggested the presence of a parathyroid adenoma. Hence, the patient underwent a parathyroidectomy, which pathologically confirmed the diagnosis of a parathyroid adenoma. Postoperatively, the patient's hypercalcemia was corrected, the dimensions of the cardiac chambers were reduced, and there was a marked improvement in cardiac function.</p><p><strong>Conclusion: </strong>Our findings emphasize the importance of PTH assessment in patients with DCM and concurrent hypercalcemia.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"105670"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of nocturnal duty on cardiometabolic health: Insights across professions.","authors":"Elie Bou Sanayeh, Oday Salman, Georges Khattar, Dmitriy Nevelev","doi":"10.4330/wjc.v17.i5.105669","DOIUrl":"10.4330/wjc.v17.i5.105669","url":null,"abstract":"<p><p>This editorial explores the significant cardiometabolic outcomes of nocturnal sentry duty and its broader implications for other professions with overnight work. Highlighting the paradox of essential nighttime labor and its adverse physiological effects, we discuss how occupations like healthcare, hospitality, and emergency services are similarly affected. The study by Lin <i>et al</i> provides critical insights into these dynamics and lays the groundwork for understanding nocturnal duty's multifaceted impact on human health.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"105669"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-pressure tamponade due to hemothorax after transcatheter edge-to-edge repair of the mitral valve.","authors":"Nicholas Seidler, Shyamal R Asher, Tzonghuei Chen, Paul Gordon, Neel Sodha, Andrew Maslow","doi":"10.4330/wjc.v17.i5.106567","DOIUrl":"10.4330/wjc.v17.i5.106567","url":null,"abstract":"<p><strong>Background: </strong>The use of percutaneous transcatheter edge-to-edge repair (TEER) for mitral regurgitation (MR) has increased, including an increased application to older, frailer, and higher risk patients.</p><p><strong>Case summary: </strong>A 74 year-old woman with severe MR, a left ventricular ejection fraction of 45%, and a small circumferential pericardial effusion underwent TEER of the mitral valve. After the placement of two MitraClips, the MR was assessed as mild to moderate. Within 10-20 minutes after the completion of the case, the patient was dyspneic and hypotensive despite volume resuscitation. Point-of-care ultrasound (POCUS) showed no changes in cardiac contractility, valve function, or the pericardial space. The right heart chambers appeared small with right atrial (RA) diastolic collapse. There was no evidence of venous congestion. Further exam showed a large right pleural fluid collection. Given the clinical scenario of dyspnea, hypotension, and diastolic RA collapse, low-pressure tamponade was suspected. A thoracentesis expelled 1200 mL of blood with immediate hemodynamic improvement. The patient made an uneventful recovery.</p><p><strong>Conclusion: </strong>The application of POCUS is crucial for detecting, diagnosing, and properly managing cardiac dysfunction and procedural complications associated with TEER. While tamponade is classically associated with a pericardial effusion and vena caval plethora, their absence does not dismiss the suspicion or diagnosis of tamponade. This case highlights the value of POCUS in assessing low-pressure tamponade caused by a large, pressurized pleural effusion. Clinical suspicion, supported by POCUS findings, was confirmed by a thoracentesis that resulted in immediate hemodynamic improvement.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"106567"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National adult mortality trends due to chronic kidney disease-related atrial fibrillation in the United States from year 2011-2020.","authors":"Muhammad Abdullah Naveed, Faizan Ahmed, Ahila Ali, Sherif Eltawansy, Zaima Afzaal, Bazil Azeem, Muhammad Kashan, Omar Kamel, Hritvik Jain, Mushood Ahmed, Kainat Aman, Hira Zahid, Rabia Iqbal, Aman Ullah, Muhammad Naveed Zafar, Pawel Lajczak, Ogechukwu Obi, Raheel Ahmed","doi":"10.4330/wjc.v17.i5.105919","DOIUrl":"10.4330/wjc.v17.i5.105919","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) associated with chronic kidney disease (CKD) is a prevalent condition in the United States, significantly impacting global morbidity and mortality. Understanding temporal patterns in AF-related mortality among CKD patients is crucial for effective clinical and public health strategies.</p><p><strong>Aim: </strong>To investigate AF-CKD comorbidity and mortality on the national level.</p><p><strong>Methods: </strong>Death certificates from the Centers for Disease Control Wide-Ranging Online Data for Epidemiologic Research database spanning 2011-2020 were analyzed to investigate AF-related CKD mortality in adults aged 35 to 85 or more years. Age-adjusted mortality rates (AAMRs) per 100000 persons and annual percent change (APC) were calculated, stratified by year, sex, race/ethnicity, and geographic region.</p><p><strong>Results: </strong>A total of 110733 deaths occurred among adults (aged 35-85 or more years) related to AF associated with CKD in the United States. Overall AAMR declined from 8.1 in 2011 to 5.5 in 2014 (APC: -14.89; 95% confidence interval (CI): -30.44 to -4.06), followed by an increase to 10.3 in 2020 (APC: 9.91; 95%CI: 6.1-19.62). Men had higher AAMRs than women (men: 7.6, 95%CI: 7.6-7.7). Non-Hispanic White adults had the highest AAMR (7.8), followed by non-Hispanic Black (5). States in the top 90^th percentile had approximately four times higher AAMRs than those in the lower 10^th percentile. AAMR also varied by region (Midwest: 7.6, West: 6.7, Northeast: 6.3, South: 5.6), with nonmetropolitan areas exhibiting higher AF-associated CKD mortality.</p><p><strong>Conclusion: </strong>Temporal trends in AF-related mortality among CKD patients showed fluctuations over the study period, with notable disparities across demographic and geographic factors. Targeted interventions are warranted to mitigate the burden of AF associated with CKD and reduce mortality rates in the United States.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"105919"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in risk stratification and treatment of acute pulmonary embolism.","authors":"George Latsios, Emmanouil Mantzouranis, Ioannis Kachrimanidis, Panagiotis Theofilis, Sotirios Dardas, Evaggelia Stroumpouli, Constantina Aggeli, Costas Tsioufis","doi":"10.4330/wjc.v17.i5.104983","DOIUrl":"10.4330/wjc.v17.i5.104983","url":null,"abstract":"<p><p>Pulmonary embolism (PE) represents the third leading cause of cardiovascular death, despite the implementation of European Society of Cardiology guidelines, the establishment of PE response teams and advances in diagnosis and treatment modalities. Unfavorable prognosis may be attributed to the increasing incidence of the disease and pitfalls in risk stratification using the established risk stratification tools that fail to recognize patients with intermediate-high risk PE at normotensive shock in order to prevent further deterioration. In this light, research has been focused to identify novel risk stratification tools, based on the hemodynamic impact of PE on right ventricular function. Furthermore, a growing body of evidence has demonstrated that novel interventional treatments for PE, including catheter directed thrombolysis, mechanical thrombectomy and computer-assisted aspiration, are promising solutions in terms of efficacy and safety, when targeted at specific populations of the intermediate-high- and high-risk spectrum. Various therapeutic protocols have been suggested worldwide, regarding the indications and proper timing for interventional strategies. A ST-elevation myocardial infarction-like timing approach has been suggested in high-risk PE with contraindications for fibrinolysis, while optimal timing of the procedure in intermediate-high risk patients is still a matter of debate; however, early interventions, within 24-48 hours of presentation, are associated with more favorable outcomes.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"104983"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finerenone and semaglutide: Role in heart failure with reduced ejection fraction.","authors":"Muhammad Abdul Rehman Gulzar","doi":"10.4330/wjc.v17.i5.105822","DOIUrl":"10.4330/wjc.v17.i5.105822","url":null,"abstract":"<p><p>Obesity and type 2 diabetes mellitus commonly coexist with heart failure (HF) and may contribute to the pathogenesis of HF with preserved ejection fraction. With progression in management therapies for HF with preserved ejection fraction, the mechanism behind beneficial actions of finerenone and semaglutide remains enigmatic. For decades, the cardiorenal protective effects of aldosterone blockage in patients with chronic kidney disease have been of significant interest. But due to multiple side effects, these trials were likely to stop.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 5","pages":"105822"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}