World Journal of Cardiology最新文献

{"title":"Initial decrease in the lipoprotein(a) level is a novel prognostic biomarker in patients with acute coronary syndrome.","authors":"Yasuhiko Saeki, Jun Sawaguchi, Satori Akita, Taka-Aki Takamura, Kosuke Fujibayashi, Minoru Wakasa, Hironobu Akao, Michihiko Kitayama, Yasuyuki Kawai, Kouji Kajinami","doi":"10.4330/wjc.v16.i6.329","DOIUrl":"10.4330/wjc.v16.i6.329","url":null,"abstract":"<p><strong>Background: </strong>Lipoprotein(a) [Lp(a)] is a causal risk factor for atherosclerotic cardiovascular diseases; however, its role in acute coronary syndrome (ACS) remains unclear.</p><p><strong>Aim: </strong>To investigate the hypothesis that the Lp(a) levels are altered by various conditions during the acute phase of ACS, resulting in subsequent cardiovascular events.</p><p><strong>Methods: </strong>From September 2009 to May 2016, 377 patients with ACS who underwent emergent coronary angiography, and 249 who completed ≥ 1000 d of follow-up were enrolled. Lp(a) levels were measured using an isoform-independent assay at each time point from before percutaneous coronary intervention (PCI) to 48 h after PCI. The primary endpoint was the occurrence of major adverse cardiac events (MACE; cardiac death, other vascular death, ACS, and non-cardiac vascular events).</p><p><strong>Results: </strong>The mean circulating Lp(a) level decreased significantly from pre-PCI (0 h) to 12 h after (19.0 mg/dL to 17.8 mg/dL, <i>P</i> < 0.001), and then increased significantly up to 48 h after (19.3 mg/dL, <i>P</i> < 0.001). The changes from 0 to 12 h [Lp(a)Δ0-12] significantly correlated with the basal levels of creatinine [Spearman's rank correlation coefficient (SRCC): -0.181, <i>P</i> < 0.01] and Lp(a) (SRCC: -0.306, <i>P</i> < 0.05). Among the tertiles classified according to Lp(a)Δ0-12, MACE was significantly more frequent in the lowest Lp(a)Δ0-12 group than in the remaining two tertile groups (66.2% <i>vs</i> 53.6%, <i>P</i> = 0.034). A multivariate analysis revealed that Lp(a)Δ0-12 [hazard ratio (HR): 0.96, 95% confidence interval (95%CI): 0.92-0.99] and basal creatinine (HR: 1.13, 95%CI: 1.05-1.22) were independent determinants of subsequent MACE.</p><p><strong>Conclusion: </strong>Circulating Lp(a) levels in patients with ACS decreased significantly after emergent PCI, and a greater decrease was independently associated with a worse prognosis.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 6","pages":"329-338"},"PeriodicalIF":1.9,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Massive inferior wall aneurysm presenting with ventricular tachycardia and refractory cardiomyopathy requiring multiple interventions: A case report.","authors":"Anderson Anuforo, Jake Charlamb, Dan Draytsel, Mark Charlamb","doi":"10.4330/wjc.v16.i6.363","DOIUrl":"10.4330/wjc.v16.i6.363","url":null,"abstract":"<p><strong>Background: </strong>Inferior wall left ventricular aneurysms are rare, they develop after transmural myocardial infarction (MI) and may be associated with poorer prognosis. We present a unique case of a large aneurysm of the inferior wall complicated by ventricular tachycardia (VT) and requiring surgical resection and mitral valve replacement.</p><p><strong>Case summary: </strong>A 59-year-old male was admitted for VT one month after he had a delayed presentation for an inferior ST-segment elevation MI and was discovered to have a large true inferior wall aneurysm on echocardiography and confirmed on coronary computed tomography (CT) angiography. Due to the sustained VT, concern for aneurysm expansion, and persistent heart failure symptoms, the patient was referred for surgical resection of the aneurysm with patch repair, mitral valve replacement, and automated implantable cardioverter defibrillator insertion with significant improvement in functional and clinical status.</p><p><strong>Conclusion: </strong>Inferior wall aneurysms are rare and require close monitoring to identify electrical or contractile sequelae. Coronary CT angiography can outline anatomic details and guide surgical intervention to ameliorate life-threatening complications and improve performance status.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 6","pages":"363-369"},"PeriodicalIF":1.9,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of D-dimer on in-hospital mortality following aortic dissection: A systematic review and meta-analysis.","authors":"Sashwath Srikanth, Shabnam Abrishami, Lakshmi Subramanian, Ashwini Mahadevaiah, Ankit Vyas, Akhil Jain, Sangeetha Nathaniel, Subramanian Gnanaguruparan, Rupak Desai","doi":"10.4330/wjc.v16.i6.355","DOIUrl":"10.4330/wjc.v16.i6.355","url":null,"abstract":"<p><strong>Background: </strong>The utility of D-dimer (DD) as a biomarker for acute aortic dissection (AD) is recognized. Yet, its predictive value for in-hospital mortality remains uncertain and subject to conflicting evidence.</p><p><strong>Aim: </strong>To conduct a meta-analysis of AD-related in-hospital mortality (ADIM) with elevated DD levels.</p><p><strong>Methods: </strong>We searched PubMed, Scopus, Embase, and Google Scholar for AD and ADIM literature through May 2022. Heterogeneity was assessed using <i>I</i> ² statistics and effect size (hazard or odds ratio) analysis with random-effects models. Sample size, study type, and patients' mean age were used for subgroup analysis. The significance threshold was <i>P</i> < 0.05.</p><p><strong>Results: </strong>Thirteen studies (3628 patients) were included in our study. The pooled prevalence of ADIM was 20% (95%CI: 15%-25%). Despite comparable demographic characteristics and comorbidities, elevated DD values were associated with higher ADIM risk (unadjusted effect size: 1.94, 95%CI: 1.34-2.8; adjusted effect size: 1.12, 95%CI: 1.05-1.19, <i>P</i> < 0.01). Studies involving patients with a mean age of < 60 years exhibited an increased mortality risk (effect size: 1.43, 95%CI: 1.23-1.67, <i>P</i> < 0.01), whereas no significant difference was observed in studies with a mean age > 60 years. Prospective and larger sample size studies (<i>n</i> > 250) demonstrated a heightened likelihood of ADIM associated with elevated DD levels (effect size: 2.57, 95%CI: 1.30-5.08, <i>P</i> < 0.01 <i>vs</i> effect size: 1.05, 95%CI: 1.00-1.11, <i>P</i> = 0.05, respectively).</p><p><strong>Conclusion: </strong>Our meta-analysis shows elevated DD increases in-hospital mortality risk in AD patients, highlighting the need for larger, prospective studies to improve risk prediction models.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 6","pages":"355-362"},"PeriodicalIF":1.9,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of a patient with an unusual trajectory of a temporary trans-venous pacing lead.","authors":"Metesh Acharya, Ethan Kavanagh, Sheena Garg, Davorin Sef, Fabio de Robertis","doi":"10.4330/wjc.v16.i6.314","DOIUrl":"10.4330/wjc.v16.i6.314","url":null,"abstract":"<p><p>Perforation of the right ventricle during placement of pacing wires is a well-documented complication and can be potentially fatal. Use of temporary pacemaker, helical screw leads and steroids use prior to implant are recognised as risk factors for development of post-permanent pacemaker effusion. We reported an unusual case of pacing wire perforating interventricular septum into the left ventricle that occurred during the implant procedure performed in another institution. After the preoperative work-up and transfer to our tertiary cardiothoracic centre, the patient underwent successful surgical management. In conclusion, early recognition and timely diagnosis using advanced multimodality imaging can guide surgical intervention and prevent unfavourable consequences of device-related complications.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 6","pages":"314-317"},"PeriodicalIF":1.9,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound unveiling: Decoding venous congestion in heart failure for precision management of fluid status.","authors":"Davide Ramoni, Federico Carbone, Fabrizio Montecucco","doi":"10.4330/wjc.v16.i6.306","DOIUrl":"10.4330/wjc.v16.i6.306","url":null,"abstract":"<p><p>This editorial discusses the manuscript by Di Maria <i>et al</i>, published in the recent issue of the <i>World Journal of Cardiology</i>. We here focus on the still elusive pathophysiological mechanisms underlying cardio-renal syndrome (CRS), despite its high prevalence and the substantial worsening of both kidney function and heart failure. While the measure of right atrial pressure through right cardiac catheterization remains the most accurate albeit invasive and costly procedure, integrating bedside ultrasound into diagnostic protocols may substantially enhance the staging of venous congestion and guide therapeutic decisions. In particular, with the assessment of Doppler patterns across multiple venous districts, the Venous Excess Ultrasound (VExUS) score improves the management of fluid overload and provides insight into the underlying factors contributing to cardio-renal interactions. Integrating specific echocardiographic parameters, particularly those concerning the right heart, may thus improve the VExUS score sensitivity, offering perspective into the nuanced comprehension of cardio-renal dynamics. A multidisciplinary approach that consistently incorporates the use of ultrasound is emerging as a promising advance in the understanding and management of CRS.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 6","pages":"306-309"},"PeriodicalIF":1.9,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic predictors and associated outcomes of multiple vegetations in infective endocarditis: A pilot study.","authors":"Ajay Kumar Mishra, Kannu Bansal, Ibragim Al-Seykal, Pradnya B Bhattad, Anu Anna George, Anil Jha, Nitish Sharma, Jennifer Sargent, Mark J Kranis","doi":"10.4330/wjc.v16.i6.318","DOIUrl":"10.4330/wjc.v16.i6.318","url":null,"abstract":"<p><strong>Background: </strong>Infective endocarditis (IE) is a life-threatening infection with an annual mortality of 40%. Embolic events reported in up to 80% of patients. Vegetations of > 10 mm size are associated with increased embolic events and poor prognosis. There is a paucity of literature on the association of multiple vegetations with outcome.</p><p><strong>Aim: </strong>To study the echocardiographic (ECHO) features and outcomes associated with the presence of multiple vegetations.</p><p><strong>Methods: </strong>In this retrospective, single-center, cohort study patients diagnosed with IE were recruited from June 2017 to June 2019. A total of 84 patients were diagnosed to have IE, of whom 67 with vegetation were identified. Baseline demographic, clinical, laboratory, and ECHO parameters were reviewed. Outcomes that were studied included recurrent admission, embolic phenomenon, and mortality.</p><p><strong>Results: </strong>Twenty-three (34%) patients were noted to have multiple vegetations, 13 (56.5%) were male and 10 (43.5%) were female. The mean age of these patients was 50. Eight (35%) had a prior episode of IE. ECHO features of moderate to severe valvular regurgitation [odds ratio (OR) = 4], presence of pacemaker lead (OR = 4.8), impaired left ventricle (LV) relaxation (OR = 4), and elevated pulmonary artery systolic pressure (PASP) (OR = 2.2) are associated with higher odds of multiple vegetations. Of these moderate to severe valvular regurgitation (<i>P</i> = 0.028), pacemaker lead (<i>P</i> = 0.039) and impaired relaxation (<i>P</i> = 0.028) were statistically significant. These patients were noted to have an increased association of recurrent admissions (OR = 3.6), recurrent bacteremia (OR = 2.4), embolic phenomenon (OR = 2.5), intensive care unit stay (OR = 2.8), hypotension (OR = 2.1), surgical intervention (OR = 2.8) and device removal (OR = 4.8). Of this device removal (<i>P</i> = 0.039) and recurrent admissions (<i>P</i> = 0.017) were statistically significant.</p><p><strong>Conclusion: </strong>This study highlights the associations of ECHO predictors and outcomes in patients with IE having multiple vegetations. ECHO features of moderate to severe regurgitation, presence of pacemaker lead, impaired LV relaxation, and elevated PASP and outcomes including recurrent admissions and device removal were found to be associated with multiple vegetations.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 6","pages":"318-328"},"PeriodicalIF":1.9,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound based estimate of central venous pressure: Are we any closer?","authors":"Atit A Gawalkar, Akash Batta","doi":"10.4330/wjc.v16.i6.310","DOIUrl":"10.4330/wjc.v16.i6.310","url":null,"abstract":"<p><p>Central venous pressure (CVP) serves as a direct approximation of right atrial pressure and is influenced by factors like total blood volume, venous compliance, cardiac output, and orthostasis. Normal CVP falls within 8-12 mmHg but varies with volume status and venous compliance. Monitoring and managing disturbances in CVP are vital in patients with circulatory shock or fluid disturbances. Elevated CVP can lead to fluid accumulation in the interstitial space, impairing venous return and reducing cardiac preload. While pulmonary artery catheterization and central venous catheter obtained measurements are considered to be more accurate, they carry risk of complications and their usage has not shown clinical improvement. Ultrasound-based assessment of the internal jugular vein (IJV) offers real-time, non-invasive measurement of static and dynamic parameters for estimating CVP. IJV parameters, including diameter and ratio, has demonstrated good correlation with CVP. Despite significant advancements in non-invasive CVP measurement, a reliable tool is yet to be found. Present methods can offer reasonable guidance in assessing CVP, provided their limitations are acknowledged.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 6","pages":"310-313"},"PeriodicalIF":1.9,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 and cardiac complications: Myocarditis and multisystem inflammatory syndrome in children","authors":"Muhammed Güneş, Öner Özdemir","doi":"10.4330/wjc.v16.i5.260","DOIUrl":"https://doi.org/10.4330/wjc.v16.i5.260","url":null,"abstract":"Coronavirus is an important pathogen causing disease in humans and animals. At the end of 2019, an investigation into an increase in pneumonia cases in Wuhan, Hubei Province, China, found that the cause was a new coronavirus. This disease, which spread rapidly across China and caused an outbreak worldwide, resulted in a pandemic. Although this virus has previously been referred to as 2019-nCoV, which causes coronavirus disease 2019 (COVID-19), later it was named severe acute respiratory syndrome coronavirus 2. Children were usually asymptomatic and rarely severely affected. In April 2020, reports from the United Kingdom indicated that children may have Kawasaki disease or a clinical condition similar to toxic shock syndrome. This clinical picture was later defined as multisystem inflammatory syndrome in children. Since then, similarly affected children as well as cases with other cardiac complications have been reported in other parts of the world. In this review, we aimed to evaluate COVID-19 in terms of cardiac involvement by reviewing the literature.","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"30 12","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141098084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of titanium-nitride-oxide coated stents and drug-eluting stents in acute coronary syndrome: A systematic review and meta-analysis","authors":"Muhammad Ahmed Ali Fahim, Afia Salman, Hira Anas Khan, Syed Muhammad Hasan, Muskan Fatima Bhojani, Sarah Aslam, Amna Zia Ul Haq, Vishal Reddy Bejugam, Beena Muntaha Nasir, Wajiha Gul, Abdul Moeed, A. S. Abdalla, Muhammad Majid, Muhammad Sohaib Asghar, Md Al Hasibuzzaman","doi":"10.4330/wjc.v16.i5.293","DOIUrl":"https://doi.org/10.4330/wjc.v16.i5.293","url":null,"abstract":"BACKGROUND\u0000 In severe cases of coronary artery disease, percutaneous coronary intervention provide promising results. The stent used could be a drug-eluting stent (DES) or a titanium-nitride-oxide coated stent (TiNOS).\u0000 AIM\u0000 To compare the 5-year effectiveness and safety of the two stent types.\u0000 METHODS\u0000 The following systematic review and meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines, and PubMed/MEDLINE, Scopus, and Cochrane Central were searched from inception till August 2023. Primary outcomes were major adverse cardiac events (MACE), cardiac death, myocardial infarction (MI), cardiac death or MI, and ischemia-driven total lesion revascularization (ID-TLR).\u0000 RESULTS\u0000 Four randomized controlled trials (RCT), which analyzed a sum total of 3045 patients with acute coronary syndrome (ACS) after a median follow-up time of 5 years were included. Though statistically insignificant, an increase in the ID-TLR was observed in patients receiving TiNOSs vs DESs. In addition, MI, cardiac death and MI, and definite stent thrombosis (DST) were significantly decreased in the TiNOS arm. Baseline analysis revealed no significant results with meta-regression presenting non-ST elevated MI (NSTEMI) as a statistically significant covariate in the outcome of MACE.\u0000 CONCLUSION\u0000 TiNOS was found to be superior to DES in terms of MI, cardiac death or MI, and DST outcomes, however, the effect of the two stent types on ID-TLR and MACE was not significant. A greater number of studies are required to establish an accurate comparison of patient outcomes in TiNOS and DES.","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"30 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141098159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium glucose cotransporter-2 inhibitors and heart disease: Current perspectives.","authors":"Sunetra Mondal, Subhodip Pramanik, Vibhu Ranjan Khare, Cornelius James Fernandez, Joseph M Pappachan","doi":"10.4330/wjc.v16.i5.240","DOIUrl":"10.4330/wjc.v16.i5.240","url":null,"abstract":"<p><p>Sodium glucose cotransporter-2 inhibitors (SGLT-2i) are antidiabetic medications with remarkable cardiovascular (CV) benefits proven by multiple randomised controlled trials and real-world data. These drugs are also useful in the prevention of CV disease (CVD) in patients with diabetes mellitus (DM). Although DM as such is a huge risk factor for CVD, the CV benefits of SGLT-2i are not just because of antidiabetic effects. These molecules have proven beneficial roles in prevention and management of nondiabetic CVD and renal disease as well. There are various molecular mechanisms for the organ protective effects of SGLT-2i which are still being elucidated. Proper understanding of the role of SGLT-2i in prevention and management of CVD is important not only for the cardiologists but also for other specialists caring for various illnesses which can directly or indirectly impact care of heart diseases. This clinical review compiles the current evidence on the rational use of SGLT-2i in clinical practice.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"16 5","pages":"240-259"},"PeriodicalIF":1.9,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}