Nan Tang, Kang-Ming Li, Hao-Ran Li, Qing-Dui Zhang, Ji Hao, Chun-Mei Qi
{"title":"Advances in the diagnosis and management of post-percutaneous coronary intervention coronary microvascular dysfunction: Insights into pathophysiology and metabolic risk interactions.","authors":"Nan Tang, Kang-Ming Li, Hao-Ran Li, Qing-Dui Zhang, Ji Hao, Chun-Mei Qi","doi":"10.4330/wjc.v17.i2.103950","DOIUrl":"10.4330/wjc.v17.i2.103950","url":null,"abstract":"<p><p>Percutaneous coronary intervention (PCI), as an essential treatment for coronary artery disease, has significantly improved the prognosis of patients with large coronary artery lesions. However, some patients continue to experience myocardial ischemic symptoms post-procedure, largely due to coronary microvascular dysfunction (CMD). The pathophysiological mechanisms of CMD are complex and involve endothelial dysfunction, microvascular remodeling, reperfusion injury, and metabolic abnormalities. Moreover, components of metabolic syndrome, including obesity, hyperglycemia, hypertension, and dyslipidemia, exacerbate the occurrence and progression of CMD through multiple pathways. This review systematically summarizes the latest research advancements in CMD after PCI, including its pathogenesis, diagnostic techniques, management strategies, and future research directions. For diagnosis, invasive techniques such as coronary flow reserve and the index of microcirculatory resistance, as well as non-invasive imaging modalities (positron emission tomography and cardiac magnetic resonance), provide tools for early CMD detection. In terms of management, a multi-level intervention strategy is emphasized, incorporating lifestyle modifications (diet, exercise, and weight control), pharmacotherapy (vasodilators, hypoglycemic agents, statins, and metabolic modulators), traditional Chinese medicine, and specialized treatments (enhanced external counterpulsation, metabolic surgery, and lipoprotein apheresis). However, challenges remain in CMD treatment, including limitations in diagnostic tools and the lack of personalized treatment strategies. Future research should focus on the complex interactions between CMD and metabolic risks, aiming to optimize diagnostic and therapeutic strategies to improve the long-term prognosis of patients post-PCI.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 2","pages":"103950"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Large left atrial myxoma with synchronous laryngeal squamous cell carcinoma: A case report.","authors":"Ling Zhu, Jax Yuan-Zhe Neo, Lavisha S Punjabi, Siang-Hui Lai, Yeow-Leng Chua","doi":"10.4330/wjc.v17.i2.100952","DOIUrl":"10.4330/wjc.v17.i2.100952","url":null,"abstract":"<p><strong>Background: </strong>Cardiac myxoma is a benign neoplasm and one of the most common types of primary cardiac tumors. Synchronous cardiac myxoma and other malignancies are extremely rare, and only limited cases have been reported.</p><p><strong>Case summary: </strong>We describe a young patient with newly diagnosed locally advanced laryngeal cancer, with a synchronous cardiac tumor detected on staging scans. An echocardiogram showed the typical appearance of myxoma in the left atrium. Early cardiac surgery was performed in view of its obstructive features and post cardiac surgery recovery was uneventful. The patient was scheduled for subsequent oncological treatment for the laryngeal cancer. However, due to rapid progression of the advanced laryngeal malignancy, he was placed on supportive care.</p><p><strong>Conclusion: </strong>To our knowledge, this is the first reported case of synchronous cardiac myxoma with laryngeal malignancy. Individualized treatment strategy should be adopted to manage synchronous tumors in a multidisciplinary approach. The most life-threatening condition needs be treated first. Single resection, staged operations or simultaneous resection of both tumors have been reported with good outcomes.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 2","pages":"100952"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From surgery to recovery: Measuring success through quality of life and functional improvements after cardiac surgery.","authors":"Peng Li, Hui-Ping Zhang","doi":"10.4330/wjc.v17.i2.100213","DOIUrl":"10.4330/wjc.v17.i2.100213","url":null,"abstract":"<p><p>Coronary artery disease and aortic valve stenosis are highly prevalent cardiovascular diseases worldwide, resulting in substantial morbidity and mortality. Surgical interventions, such as coronary artery bypass grafting and surgical aortic valve replacement, offer significant therapeutic benefits, including enhanced postoperative quality of life (QoL) and functional capacity, which are key indicators of surgical success. This editorial reviews recent studies on postoperative QoL and functional outcomes in patients undergoing cardiac surgery. Factors such as preoperative health, age, intensive care unit stay duration, surgical risk, and perioperative complications could influence these outcomes. Cardiac rehabilitation is pivotal in enhancing patient function, reducing frailty and improving long-term QoL.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 2","pages":"100213"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk stratification for future cardiac arrest after COVID-19 vaccination.","authors":"Peter A McCullough, Nicolas Hulscher","doi":"10.4330/wjc.v17.i2.103909","DOIUrl":"10.4330/wjc.v17.i2.103909","url":null,"abstract":"<p><p>Unheralded cardiac arrest among previously healthy young people without antecedent illness, months or years after coronavirus disease 2019 (COVID-19) vaccination, highlights the urgent need for risk stratification. The most likely underlying pathophysiology is subclinical myopericarditis and reentrant ventricular tachycardia or spontaneous ventricular fibrillation that is commonly precipitated after a surge in catecholamines during exercise or the waking hours of terminal sleep. Small patches of inflammation and/or edema can be missed on cardiac imaging and autopsy, and the heart can appear grossly normal. This paper reviews evidence linking COVID-19 vaccines to cardiac arrest where unfortunately the majority of victims have had no antecedent clinical evaluation. We propose a comprehensive strategy for evaluating cardiovascular risk post-vaccination, incorporating detailed patient history, antibody testing, and cardiac diagnostics in the best attempt to detect abnormalities before sudden cardiac death. This approach aims to identify individuals at higher risk of cardiac events after COVID-19 vaccination and guide appropriate clinical management. It is prudent for each primary care physician to have a pre-established plan when addressing this issue in their practice.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 2","pages":"103909"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Updates in breathomics behavior in ischemic heart disease and heart failure, mass-spectrometry.","authors":"Basheer Abdualah Marzoog, Peter Chomakhidze, Daria Gognieva, Alena Yurievna Parunova, Snezhana Nikolaevna Demchuk, Artemiy Silantyev, Natalia Kuznetsova, Anastasia Kostikova, Dmitrii Podgalo, Evgeny Nagornov, Aida Gadzhiakhmedova, Philipp Kopylov","doi":"10.4330/wjc.v17.i2.102851","DOIUrl":"10.4330/wjc.v17.i2.102851","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) and associated sequalae remain the leading cause of disability worldwide. Ischemic heart disease (IHD) and heart failure are the most common etiologies of morbidity and mortality worldwide. This is due to the poor diagnostic and management methods for heart failure and IHD. Early detection of related risk factors through modern strategies is underestimated and requires further research.</p><p><strong>Aim: </strong>To interpret data from the published literature on volatile organic compounds (VOC), including all the methods used to analyze exhaled breath in patients with IHD and heart failure.</p><p><strong>Methods: </strong>Searches for specific keywords were performed on Scopus and PubMed. A total of 20 studies were identified in breath analysis and IHD and heart failure. The study is registered in PROSPERO (Registration No. CRD42023470556).</p><p><strong>Results: </strong>Considering the articles found, more research is required to gain a full understanding of the role of VOCs in IHD and heart failure. However, the existing literature demonstrates that cardiac metabolic changes can be expressed in exhaled air. The number of papers found is extremely low, making interpretation extremely difficult.</p><p><strong>Conclusion: </strong>Exhaled breath analysis can be a novel biomarker for the diagnosis and prevention of heart failure and IHD. Exhaled breath analysis can be used as a mirror to reflect the metabolic changes related to IHD and heart failure.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 2","pages":"102851"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emerging roles of the acid sphingomyelinase/ceramide pathway in metabolic and cardiovascular diseases: Mechanistic insights and therapeutic implications.","authors":"Hong-Ni Wang, Ye Wang, Si-Yao Zhang, Lan Bai","doi":"10.4330/wjc.v17.i2.102308","DOIUrl":"10.4330/wjc.v17.i2.102308","url":null,"abstract":"<p><p>Metabolic diseases have emerged as a leading cause of mortality from non-communicable diseases, posing a significant global public health challenge. Although the association between ceramides (Cers) and metabolic diseases is well-established, the role of the acid sphingomyelinase (ASMase)/Cer pathway in these diseases remains underexplored. This review synthesizes recent research on the biological functions, regulatory mechanisms, and targeted therapies related to the ASMase/Cer pathway in metabolic conditions, including obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. The effects of the ASMase/Cer pathway on metabolic disease-related indicators, such as glycolipid metabolism, insulin resistance, inflammation, and mitochondrial homeostasis are elucidated. Moreover, this article discusses the therapeutic strategies using ASMase/Cer inhibitors for inverse prevention and treatment of these metabolic diseases in light of the possible efficacy of blockade of the ASMase/Cer pathway in arresting the progression of metabolic diseases. These insights offered herein should provide insight into the contribution of the ASMase/Cer pathway to metabolic diseases and offer tools to develop therapeutic interventions for such pathologies and their severe complications.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 2","pages":"102308"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Coronary heart disease with pulmonary embolism: A case report.","authors":"Jun-Qing Xu, Meng-Xin Jiang, Feng Wang, Kai-Qiang Yang, Ying-Jiang Xu, Yu-Jiu Wang, Sheng-Jun Dong","doi":"10.4330/wjc.v17.i2.101588","DOIUrl":"10.4330/wjc.v17.i2.101588","url":null,"abstract":"<p><strong>Background: </strong>Coronary heart disease (CHD) and pulmonary embolism (PE) are thrombotic diseases. Patients with CHD and PE are common in clinical practice. However, the clinical diagnosis of PE is challenging due to overlapping primary symptoms, such as chest tightness and dyspnea. This confluence frequently leads to the misdiagnosis of PE, thus precipitating treatment delays and compromising patient outcomes. Herein, we report the case of a patient with both diseases who underwent surgery and medication therapy.</p><p><strong>Case summary: </strong>A 51-year-old man with a history of hypertension for 2 years visited a local hospital because of paroxysmal chest tightness for 1 d and was diagnosed with CHD. However, he refused hospitalization. He visited our hospital for the treatment of recurring symptoms. A comprehensive examination after admission revealed elevated D-dimer levels, and computed tomography pulmonary angiography was performed to confirm the diagnosis of PE. The patient successfully underwent coronary artery bypass grafting with anticoagulant and antiplatelet drugs and had a prognosis.</p><p><strong>Conclusion: </strong>D-dimer is useful in screening for PE, whereas computed tomography pulmonary angiography is important for diagnosis. For patients with CHD and PE, coronary artery bypass grafting combined with anticoagulant and antiplatelet therapy is feasible.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 2","pages":"101588"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Left bundle branch pacing cardiac resynchronization therapy <i>vs</i> biventricular pacing cardiac resynchronization therapy-time to write a requiem for biventricular pacing-cardiac resynchronization therapy.","authors":"Akshyaya Pradhan, Daljeet Saggu, Monika Bhandari","doi":"10.4330/wjc.v17.i2.103356","DOIUrl":"10.4330/wjc.v17.i2.103356","url":null,"abstract":"<p><p>Cardiac resynchronization therapy (CRT) reduces heart failure (HF) hospitalizations and all-cause mortality in patients with HF with reduced ejection fraction with left bundle branch (LBB) block. Biventricular pacing (BVP) is considered the gold standard for achieving CRT; however, approximately 30%-40% of patients do not respond to BVP-CRT. Recent studies have demonstrated that LBB pacing (LBBP) produces remarkable results in CRT. In this meta-analysis, LBBP-CRT showed better outcomes than conventional BVP-CRT, including greater QRS duration reduction and left ventricular ejection fraction improvement, along with consistently lower pacing thresholds on follow-up. Additionally, there was a greater reduction in New York Heart Association class and brain natriuretic peptide levels. This study contributes to the growing body of encouraging data on LBBP-CRT from recent years. With ongoing technological advancements and increasing operator expertise, the day may not be far when LBBP-CRT becomes the standard of care rather than the exception.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 2","pages":"103356"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Outcomes of patients with acute ST-segment elevation myocardial infarction treated by a prolonged \"Deferred\" percutaneous coronary intervention strategy.","authors":"Akshyaya Pradhan, Shivam Uppal, Pravesh Vishwakarma, Abhishek Singh, Monika Bhandari, Ayush Shukla, Akhil Sharma, Gaurav Chaudhary, Sharad Chandra, Rishi Sethi, Sudhanshu Kumar Dwivedi","doi":"10.4330/wjc.v17.i2.99074","DOIUrl":"10.4330/wjc.v17.i2.99074","url":null,"abstract":"<p><strong>Background: </strong>Primary percutaneous coronary intervention (PCI) is the preferred treatment for ST-segment elevation myocardial infarction (STEMI). However, in patients with high thrombus burden, immediate stenting during PCI can lead to poor outcomes due to the risk of thrombus migration and subsequent microvascular occlusion, resulting in no-reflow phenomena. Deferred stenting offers a potential advantage by allowing for the reduction of thrombus load, which may help to minimize the incidence of slow-flow and no-reflow complications. This study explores the effectiveness of a deferred stenting strategy in improving outcomes for STEMI patients.</p><p><strong>Aim: </strong>To evaluate the effectiveness and safety of deferred PCI in a real-world setting in acute STEMI patients.</p><p><strong>Methods: </strong>This study was conducted at King George's Medical University, Lucknow, from October 1, 2018, to October 30, 2019 and included a total of 55 participants. Patients with acute STEMI who underwent coronary angiography were selected for a deferred PCI strategy based on specific angiographic features.</p><p><strong>Results: </strong>Anterior wall myocardial infarction was the predominant type of STEMI in 62% of the selected 55 patients (mean age: 54 years; 70% males), and diabetes mellitus was the most common risk factor (18.2%), followed by hypertension (16.2%). On the second angiogram of these patients measures of thrombus grade, thrombolysis in myocardial infarction flow grade, myocardial blush grade, and severity of stenosis of culprit lesion were considerably improved compared to the first angiogram, and the average culprit artery diameter had increased by 7.8%. Most patients (60%) had an uneventful hospital stay during the second angiogram and an uneventful intraprocedural course (85.19%), with slow-flow/no-reflow occurring only in 7.4% of the patients; these patients recovered after taking vasodilator drugs. In 29.3% of patients, the culprit artery was recanalized, preventing unnecessary stent deployment.</p><p><strong>Conclusion: </strong>Deferred PCI strategy is safe and reduces the thrombus burden, improves thrombolysis in myocardial infarction (TIMI) flow, improves myocardial blush grade, and prevents unwarranted stent deployment.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 2","pages":"99074"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diana Maria Morariu-Briciu, Sorin Lucian Bolintineanu, Andreea Rata, Alexandra Denisa Semenescu, Alina Anton, Robert Jijie, Andreea Kis, Ingrid Hrubaru, Alina Heghes
{"title":"Assessment of the biosafety profile of <i>Galium verum in vitro</i> on myoblasts and <i>in ovo</i> on chorioallantoic membrane.","authors":"Diana Maria Morariu-Briciu, Sorin Lucian Bolintineanu, Andreea Rata, Alexandra Denisa Semenescu, Alina Anton, Robert Jijie, Andreea Kis, Ingrid Hrubaru, Alina Heghes","doi":"10.4330/wjc.v17.i2.102310","DOIUrl":"10.4330/wjc.v17.i2.102310","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular diseases are the first cause of death in the world. Ischemic heart disease is the main cause of heart failure. New approaches are continuously sought to identify better therapeutic success. Thereby, current research has been drawn to identifying and completing the therapeutic profile of natural sources. <i>Galium</i> species are representatives exhibiting diuretic and antibacterial potential in living organisms and can treat burns, wounds, and skin diseases. Moreover, it was also observed that these plants manifest cardioprotective effects as well as having antihemolytic, antioxidant, antibacterial, anti-inflammatory, immunomodulatory, and antiproliferative potential. In ischemic heart disease, <i>Galium verum</i> (<i>G. verum)</i> extract manifested preservative properties in terms of contractility, systolic and diastolic function maintenance, and reduced damage to the heart after ischemia. In addition, <i>G. verum</i> extract upregulated the activity of antioxidant enzymes alleviating the production of pro-oxidants.</p><p><strong>Aim: </strong>To test the ethanolic extract of <i>G. verum</i> on the H9C2(2-1) cell line by evaluating the <i>in vitro</i> biosafety profile and <i>in ovo</i> irritative potential.</p><p><strong>Methods: </strong>Cells were tested <i>in vitro</i> for viability (using the MTT test), cellular morphology, cell number, confluence, nuclear morphology (by immunofluorescence staining of cell nuclei and F-actin assay) and <i>in ovo</i> by the hen's egg chorioallantoic membrane (CAM) test and CAM anti-irritant methods to study the irritation potential on the CAM.</p><p><strong>Results: </strong>The extract demonstrated a dose-dependent stimulatory activity. The viability increased to 170% for the dose of 55 µg/mL and decreased to 135% at 200 µg/mL. The results of cell number, confluence, and morphological analysis did not present significant changes compared with control untreated cells. The immunofluorescence assay showed insignificant apoptotic potential, and the hen's egg CAM test revealed that the extract was in the weak to moderately irritating category with an irritation score of 5.3. When applying the sample to the CAM, only slight coagulation was observed (128 s). The anti-irritant test revealed the protective potential of the extract in the vascular plexus.</p><p><strong>Conclusion: </strong>The ethanolic extract of <i>G. verum</i> manifests a stimulating effect on cardiomyocytes, enhancing cell viability, and maintaining a normal elongated shape, cell number, and confluence, without significant signs of apoptosis and with a weak irritative effect <i>in ovo</i>. In addition, the extract demonstrated a protective effect against hemorrhage, lysis, and coagulation of blood vessels induced by sodium dodecyl sulfate on the CAM.</p>","PeriodicalId":23800,"journal":{"name":"World Journal of Cardiology","volume":"17 2","pages":"102310"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}