World Journal of Gastroenterology最新文献

{"title":"Triglyceride-glucose index as a prognostic indicator in advanced gastric cancer: Insights and future research.","authors":"Cheng-Fei Zhao, Xiao-Ling Liu, Ning-Bi Wu, Zhi-Feng Xu","doi":"10.3748/wjg.v31.i17.104794","DOIUrl":"10.3748/wjg.v31.i17.104794","url":null,"abstract":"<p><p>Gastric cancer (GC), the fifth most common malignancy worldwide, poses a substantial challenge in clinical oncology, particularly in its advanced stages. Despite advancements in immunotherapy, patient prognosis remains poor, underscoring the need for reliable prognostic tools to refine treatment strategies. A study by Yao <i>et al</i> explores the role of the triglyceride-glucose (TyG) index as a prognostic marker for advanced GC patients receiving immunotherapy combined with chemotherapy. The results of the study demonstrate that the TyG index correlates with improved survival outcomes, including better progression-free survival and overall survival. This editorial critically evaluates the significance of these findings, discusses their implications for future research, and highlights innovative directions that could drive further breakthroughs in the application of the TyG index to cancer therapy. This editorial also highlights the potential of TyG in advancing precision oncology and advocates for global validation and mechanistic investigations to further solidify its clinical utility. Future research should focus on validating the TyG index across various malignancies, exploring its potential to influence immunotherapy through metabolic interventions, and developing multi-biomarker models that integrate TyG with immune and genomic profiles.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"104794"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein-losing enteropathy and multiple vasculature dysplasia in <i>LZTR1</i>-related Noonan syndrome: A case report and review of literature.","authors":"Qiu-Ju Tian, Lu-Jia Zhang, Qun Zhang, Feng-Chao Liu, Man Xie, Jin-Zhen Cai, Wei Rao","doi":"10.3748/wjg.v31.i17.105347","DOIUrl":"10.3748/wjg.v31.i17.105347","url":null,"abstract":"<p><strong>Background: </strong>Protein-losing enteropathy (PLE) is a rare cause of hypoalbuminemia that can be attributed to intestinal lymphangiectasia. Patients with Noonan syndrome may present with disorder of lymph vessel formation. However, PLE is rarely reported with Noonan syndrome.</p><p><strong>Case summary: </strong>A 15-year-old female was hospitalized multiple times for recurrent edema and diarrhea secondary to hypoalbuminemia. Additional manifestations included a ventricular septal defect at birth, intermuscular hemangioma, slightly wide interocular and intermammary distances, and absence of the distal phalanx of the left little finger since birth. Abdominal computed tomography revealed cavernous transformation of the portal vein, and liver biopsy indicated \"porto-sinusoidal vascular disease\". Whole exome and Sanger sequencing revealed a heterozygous mutation (exon9: C.850C>T:P.R284C) in leucine zipper-like transcription regulator 1, suggesting Noonan syndrome type 10. Further examinations revealed thoracic duct dysplasia and intestinal lymphangiectasia causing PLE in this patient. A multidisciplinary team decided to address thoracic duct dysplasia with outlet obstruction. Approximately two years after the microsurgical relief of the thoracic duct outlet obstruction, the patient achieved persistent normal serum albumin level without edema or diarrhea. Furthermore, the relevant literatures on Noonan syndrome and PLE were reviewed.</p><p><strong>Conclusion: </strong>Herein, we reported the first case of PLE associated with Noonan syndrome caused by a rare genetic mutation in leucine zipper-like transcription regulator 1 (c.850C>T:P.R284C) with newly reported manifestations. This case presented the successful treatment of clinical hypoalbuminemia attributed to thoracic duct dysplasia, intestinal lymphangiectasia and PLE.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"105347"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological characteristics and prognostic outcomes of pregnancy-associated colorectal cancer: A 24-year experience.","authors":"Li-Wen Fan, Chao Shang, Qi Lin, Yan-Tao Tian, Dong-Kui Xu","doi":"10.3748/wjg.v31.i17.106508","DOIUrl":"10.3748/wjg.v31.i17.106508","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) during pregnancy poses significant risks to both maternal and fetal health; however, this topic remains under researched globally.</p><p><strong>Aim: </strong>To investigate the impacts of clinical features, pathology type, treatment strategies, and tumor stage on maternal and fetal outcomes in pregnant patients with pregnancy-associated CRC (pCRC).</p><p><strong>Methods: </strong>To address this research gap, we analyzed the clinical and pathological characteristics of pCRC by collecting and evaluating clinicopathological data from 43 patients treated at the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, between 1999 and 2023 using descriptive statistical methods.</p><p><strong>Results: </strong>Treatment for pCRC was initiated with surgery and/or chemotherapy. Among 43 patients, 37 underwent surgery, including 21 radical resections (5 prenatal and 16 postpartum resections) and 16 palliative surgeries. Chemotherapy (with regimens such as CapeOx or FOLFOX4) was administered to 37 patients. Six advanced-stage patients received chemotherapy alone. The gestational outcomes among the patients varied. Specifically, 5 patients who were diagnosed in early pregnancy chose abortion. Additionally, in mid-pregnancy, 3 patients underwent abortion, 1 required induced labor, and 2 underwent cesarean delivery with healthy neonates. Among the 3 late-pregnancy diagnoses, 1 patient underwent induced abortion, 1 delivered <i>via</i> cesarean section with a healthy fetus, and 1 underwent stillbirth management. The 5-year survival rate was 59.8%, with a rate of 100% for stage I/II patients, 75% for stage III patients, and 21.1% for stage IV patients.</p><p><strong>Conclusion: </strong>Patients with poorly differentiated tumors exhibited worse outcomes than those with moderately and highly differentiated tumors. Early-stage diagnosis and timely treatment significantly improved maternal survival and fetal outcomes in pregnant patients with CRC. Advanced tumor stages and delayed diagnosis were observed to be associated with poorer maternal prognoses and may require interventions that compromise fetal survival. Fetal outcomes depend on the pathological stage of the mother's cancer, the gestational age at diagnosis, and treatment strategies.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"106508"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of sex on the outcomes of peroral endoscopic myotomy for the treatment of achalasia.","authors":"Chen-Yi Zhao, Ning Xu, Hao Dong, Ning-Li Chai, En-Qiang Linghu","doi":"10.3748/wjg.v31.i17.104579","DOIUrl":"10.3748/wjg.v31.i17.104579","url":null,"abstract":"<p><strong>Background: </strong>Peroral endoscopic myotomy (POEM) has emerged as the first-line therapy for achalasia. However, large-scale studies which examine sex-related differences in symptoms and outcomes remain limited.</p><p><strong>Aim: </strong>To evaluate the impact of sex on achalasia symptoms, diagnostic findings, and postoperative improvement following POEM.</p><p><strong>Methods: </strong>We conducted a retrospective review of achalasia patients who underwent POEM at a large center between 2010 and 2020, analyzing demographics and variables collected before, during, and after the procedure for both female and male cases.</p><p><strong>Results: </strong>Our study included 526 cases in total, with the female group experiencing more severe chest pain (<i>P</i> = 0.008). After stratifying age, we found that women aged 40 to 60 showed higher chest pain scores compared to their male counterparts. In female cases, the severity of dysphagia before POEM was lowest among those aged 60 and older (<i>P</i> = 0.033). Preoperatively, the integrated relaxation pressure (IRP) and resting lower esophageal sphincter pressure (LESP) were higher in the female group compared to the male group (<i>P</i> < 0.001 and <i>P</i> = 0.001, respectively). However, no differences in postoperative IRP and LESP were observed between two groups. The overall efficiency of POEM was 96.52%, with a significant improvement in chest pain scores noted in female cases (<i>P</i> = 0.043).</p><p><strong>Conclusion: </strong>Sex may influence the severity and frequency of chest pain, with female cases exhibiting higher LESP and IRP compared to male cases. POEM is proven to be a safe and effective procedure for both sexes, with female cases potentially experiencing greater benefits.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"104579"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone controls the metabolism of tryptophan protecting against sepsis-induced intestinal damage by activating aryl hydrocarbon receptor.","authors":"Qing Wang, Chun-Zheng Liu, Bai-Tian Li, Xiu-Qin Yu, Jin-Yuan Zhang, Ze-Tian Wang, Li-Jun Liao, Xiao-Dong Liu","doi":"10.3748/wjg.v31.i17.105411","DOIUrl":"10.3748/wjg.v31.i17.105411","url":null,"abstract":"<p><strong>Background: </strong>Intestinal injury is the most common complication of sepsis, and the mitigation of intestinal damage is crucial for treating sepsis.</p><p><strong>Aim: </strong>To examine the use of ozone-rich water and its action in preventing intestinal damage caused by sepsis.</p><p><strong>Methods: </strong>Through histological analysis, immunohistochemistry, immunofluorescence assays, and Western blot detection, we evaluated the therapeutic efficacy of ozone in mitigating intestinal injury during sepsis. Additionally, by conducting 16S rRNA sequencing and untargeted metabolomics analysis on fecal samples, we identified alterations in the gut microbiota and specific metabolites in septic mice following ozone treatment. This comprehensive approach aims to further elucidate the mechanistic underpinnings of ozone therapy in alleviating sepsis-induced intestinal damage.</p><p><strong>Results: </strong>Our results demonstrate that ozonated water significantly ameliorates pathological damage in intestinal tissues, enhances the expression of tight junction proteins, and inhibits the polarization of intestinal macrophages, thereby reducing the expression of inflammatory cytokines in intestinal tissues of cecal ligation and puncture-induced septic mice. 16S rRNA sequencing analysis revealed that ozonated water increased the abundance of beneficial bacteria and alleviated gut microbiota dysbiosis. Studies using broad-spectrum antibiotic-treated mice indicated that the protective effects of ozonated water on intestinal injury are dependent on the gut microbiota. Furthermore, metabolomic analysis identified an increase in the tryptophan metabolite DL-tryptophan in the ozonated water treatment group. This suggests that ozonated water protects against intestinal injury by activating the aryl hydrocarbon receptor and suppressing necroptosis in intestinal epithelial cells.</p><p><strong>Conclusion: </strong>Ozone protected against sepsis-induced intestinal injury through regulation of the gut microbiota and tryptophan metabolism, inhibiting necrotic apoptosis of intestinal epithelial cells through activation of the aryl hydrocarbon receptor.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"105411"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of sex on the outcomes of peroral endoscopic myotomy for the treatment of achalasia.","authors":"Chen-Yi Zhao, Ning Xu, Hao Dong, Ning-Li Chai, En-Qiang Linghu","doi":"10.3748/wjg.v31.i17.104579","DOIUrl":"10.3748/wjg.v31.i17.104579","url":null,"abstract":"<p><strong>Background: </strong>Peroral endoscopic myotomy (POEM) has emerged as the first-line therapy for achalasia. However, large-scale studies which examine sex-related differences in symptoms and outcomes remain limited.</p><p><strong>Aim: </strong>To evaluate the impact of sex on achalasia symptoms, diagnostic findings, and postoperative improvement following POEM.</p><p><strong>Methods: </strong>We conducted a retrospective review of achalasia patients who underwent POEM at a large center between 2010 and 2020, analyzing demographics and variables collected before, during, and after the procedure for both female and male cases.</p><p><strong>Results: </strong>Our study included 526 cases in total, with the female group experiencing more severe chest pain (<i>P</i> = 0.008). After stratifying age, we found that women aged 40 to 60 showed higher chest pain scores compared to their male counterparts. In female cases, the severity of dysphagia before POEM was lowest among those aged 60 and older (<i>P</i> = 0.033). Preoperatively, the integrated relaxation pressure (IRP) and resting lower esophageal sphincter pressure (LESP) were higher in the female group compared to the male group (<i>P</i> < 0.001 and <i>P</i> = 0.001, respectively). However, no differences in postoperative IRP and LESP were observed between two groups. The overall efficiency of POEM was 96.52%, with a significant improvement in chest pain scores noted in female cases (<i>P</i> = 0.043).</p><p><strong>Conclusion: </strong>Sex may influence the severity and frequency of chest pain, with female cases exhibiting higher LESP and IRP compared to male cases. POEM is proven to be a safe and effective procedure for both sexes, with female cases potentially experiencing greater benefits.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"104579"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation.","authors":"Xiao-Mei Wang, Ze Dai, Dai-Jun Lu, Chao-Qun Bao, Nai-Bin Yang, Yu-Ping Zhou","doi":"10.3748/wjg.v31.i17.105438","DOIUrl":"10.3748/wjg.v31.i17.105438","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a prominent and pervasive global health challenge. Bicuculline (BIC), which is a key active component of the anti-MASLD prescription \"Eight Zhes Decoction\", has been preliminarily shown by our research team to have significant potential in treating MASLD.</p><p><strong>Aim: </strong>To determine BIC's efficacy in treating MASLD by regulating lipid metabolism and suppressing hepatic inflammation <i>via</i> nuclear factor-kappa B (NF-κB) pathway, identifying it as a therapeutic candidate.</p><p><strong>Methods: </strong>This study explored the potential of BIC in preventing and treating MASLD using zebrafish, cellular (HepG2 and AML12), and mouse models.</p><p><strong>Results: </strong>Our results indicate that BIC significantly reduces lipid accumulation and inflammation both <i>in vivo</i> and <i>in vitro</i>. Transcriptomic analysis suggested that the anti-MASLD effects of BIC are linked to the inhibition of the NF-κB pathway, which plays a critical role in mitigating inflammation and lipid deposition.</p><p><strong>Conclusion: </strong>This study is the first to demonstrate that BIC specifically alleviates lipid accumulation and hepatic steatosis in MASLD models <i>via</i> the NF-κB signaling pathway. Overall, BIC has emerged as a promising candidate for treating MASLD.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"105438"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study.","authors":"Yan-Ping Wu, Jia-Xuan Zhou, Hong-Bo Wu, Di-Ping Wu, Ling-Zhi Qin, Bin Qin, Xiao-Yu Xu, Saleh Abdulaziz Abdulgani Yehya, Yan Cheng","doi":"10.3748/wjg.v31.i17.105281","DOIUrl":"10.3748/wjg.v31.i17.105281","url":null,"abstract":"<p><strong>Background: </strong>Reflux hypersensitivity (RH) constitutes roughly 14% of patients with heartburn and 34% of those with refractory heartburn, yet it is inadequately comprehended.</p><p><strong>Aim: </strong>To investigate the clinical characteristics and risk factors associated with RH.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 109 patients with RH and 384 healthy controls from three medical centers between January 2022 and December 2023. Comprehensive data encompassing symptoms, motility, impedance-pH monitoring, and psychological evaluations were collected.</p><p><strong>Results: </strong>RH patients encountered a greater frequency of weakly acidic reflux (WAR) events compared to acidic reflux or nonacidic reflux (NAR) events. Upright reflux time (1.22%) exceeds supine reflux time (0.54%) (<i>P</i> < 0.05). Extraesophageal symptoms were more prevalent among younger patients and those with elevated NAR (<i>P</i> < 0.05). The acidic reflux, WAR, NAR, and peristaltic contraction break length in male patients exceeded those in female patients (<i>P</i> < 0.05). Age [odds ratio (OR) = 5.633], hiatal hernia (OR = 13.103), and anxiety (OR = 17.342) constituted independent risk factors for RH.</p><p><strong>Conclusion: </strong>WAR and NAR are pivotal in RH. Patients with increased NAR are more likely to experience extraesophageal symptoms. Age, hiatal hernia, and anxiety are significant independent risk factors for RH.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"105281"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of aggregation-induced emission materials in gastrointestinal diseases.","authors":"Yi-Rong Li, Gang Wang, Wen-Ting He, Tao Liu","doi":"10.3748/wjg.v31.i16.105378","DOIUrl":"https://doi.org/10.3748/wjg.v31.i16.105378","url":null,"abstract":"<p><p>Aggregation-induced emission (AIE) is a phenomenon characterized by certain fluorescent molecules that exhibit weak or no luminescence in solution but demonstrate significantly enhanced luminescence upon aggregation. Accordingly, AIE materials have successfully addressed the limitations associated with aggregation-caused quenching effects and have made significant progress in the application of various fields of medicine in recent years. At present, the application of AIE materials in gastrointestinal (GI) diseases is mainly in GI imaging, diagnosis and treatment. In this review, we summarize the applications of AIE materials in GI pathogens and GI diseases, including inflammatory bowel disease and GI tumors, and outline combined treatment methods of AIE materials in GI tumor therapy.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 16","pages":"105378"},"PeriodicalIF":4.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duodenal mucosal ablation with irreversible electroporation reduces liver lipids in rats with non-alcoholic fatty liver disease.","authors":"Jia-Wei Yu, Qi Zhao, Pei-Xi Li, Ya-Xuan Zhang, Bi-Xuan Gao, Lin-Biao Xiang, Xiao-Yu Liu, Lei Wang, Yi-Jie Sun, Ze-Zhou Yang, Yu-Jia Shi, Yun-Fei Chen, Meng-Bo Yu, Hong-Ke Zhang, Lei Zhang, Qin-Hong Xu, Lu Ren, Dan Li, Yi Lyu, Feng-Gang Ren, Qiang Lu","doi":"10.3748/wjg.v31.i16.105188","DOIUrl":"https://doi.org/10.3748/wjg.v31.i16.105188","url":null,"abstract":"<p><strong>Background: </strong>Duodenal mucosal ablation (DMA) using irreversible electroporation (IRE) with a glucagon-like peptide-1 receptor agonist has been clinically shown to reduce liver lipid deposition in non-alcoholic fatty liver disease (NAFLD). However, the specific metabolic contributions of DMA using IRE in NAFLD remain unclear.</p><p><strong>Aim: </strong>To assess the feasibility and effectiveness of DMA using IRE in NAFLD rat models.</p><p><strong>Methods: </strong>Seven-week-old male Sprague-Dawley rats underwent DMA using IRE after 8 weeks on a high-fat diet. Two weeks post-treatment, duodenal and liver tissues and blood samples were collected. We evaluated differences in the duodenal wall structure, liver lipid deposition, enteroendocrine, claudin, and zonula ocludens-1 in the duodenal mucosa.</p><p><strong>Results: </strong>DMA using IRE could be safely performed in rats with NAFLD without duodenal bleeding, perforation, or stenosis. The duodenum healed well 2 weeks after DMA and was characterized by slimmer villi, narrower and shallower crypts, and thicker myenterons compared with the sham-control setting. Liver lipid deposition was reduced and serum lipid index parameters were considerably improved in the DMA setting. However, these improvements were independent of food intake and weight loss. In addition, enteroendocrine parameters, such as claudin, and zonula ocludens-1 levels in the duodenal mucosa, differed between the different settings in the DMA group.</p><p><strong>Conclusion: </strong>By altering enteroendocrine and duodenal permeability, simple DMA using IRE ameliorated liver lipid deposition and improved serum lipid parameters in NAFLD rats.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 16","pages":"105188"},"PeriodicalIF":4.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}