World Journal of Gastroenterology最新文献

{"title":"Application of aggregation-induced emission materials in gastrointestinal diseases.","authors":"Yi-Rong Li, Gang Wang, Wen-Ting He, Tao Liu","doi":"10.3748/wjg.v31.i16.105378","DOIUrl":"https://doi.org/10.3748/wjg.v31.i16.105378","url":null,"abstract":"<p><p>Aggregation-induced emission (AIE) is a phenomenon characterized by certain fluorescent molecules that exhibit weak or no luminescence in solution but demonstrate significantly enhanced luminescence upon aggregation. Accordingly, AIE materials have successfully addressed the limitations associated with aggregation-caused quenching effects and have made significant progress in the application of various fields of medicine in recent years. At present, the application of AIE materials in gastrointestinal (GI) diseases is mainly in GI imaging, diagnosis and treatment. In this review, we summarize the applications of AIE materials in GI pathogens and GI diseases, including inflammatory bowel disease and GI tumors, and outline combined treatment methods of AIE materials in GI tumor therapy.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 16","pages":"105378"},"PeriodicalIF":4.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duodenal mucosal ablation with irreversible electroporation reduces liver lipids in rats with non-alcoholic fatty liver disease.","authors":"Jia-Wei Yu, Qi Zhao, Pei-Xi Li, Ya-Xuan Zhang, Bi-Xuan Gao, Lin-Biao Xiang, Xiao-Yu Liu, Lei Wang, Yi-Jie Sun, Ze-Zhou Yang, Yu-Jia Shi, Yun-Fei Chen, Meng-Bo Yu, Hong-Ke Zhang, Lei Zhang, Qin-Hong Xu, Lu Ren, Dan Li, Yi Lyu, Feng-Gang Ren, Qiang Lu","doi":"10.3748/wjg.v31.i16.105188","DOIUrl":"https://doi.org/10.3748/wjg.v31.i16.105188","url":null,"abstract":"<p><strong>Background: </strong>Duodenal mucosal ablation (DMA) using irreversible electroporation (IRE) with a glucagon-like peptide-1 receptor agonist has been clinically shown to reduce liver lipid deposition in non-alcoholic fatty liver disease (NAFLD). However, the specific metabolic contributions of DMA using IRE in NAFLD remain unclear.</p><p><strong>Aim: </strong>To assess the feasibility and effectiveness of DMA using IRE in NAFLD rat models.</p><p><strong>Methods: </strong>Seven-week-old male Sprague-Dawley rats underwent DMA using IRE after 8 weeks on a high-fat diet. Two weeks post-treatment, duodenal and liver tissues and blood samples were collected. We evaluated differences in the duodenal wall structure, liver lipid deposition, enteroendocrine, claudin, and zonula ocludens-1 in the duodenal mucosa.</p><p><strong>Results: </strong>DMA using IRE could be safely performed in rats with NAFLD without duodenal bleeding, perforation, or stenosis. The duodenum healed well 2 weeks after DMA and was characterized by slimmer villi, narrower and shallower crypts, and thicker myenterons compared with the sham-control setting. Liver lipid deposition was reduced and serum lipid index parameters were considerably improved in the DMA setting. However, these improvements were independent of food intake and weight loss. In addition, enteroendocrine parameters, such as claudin, and zonula ocludens-1 levels in the duodenal mucosa, differed between the different settings in the DMA group.</p><p><strong>Conclusion: </strong>By altering enteroendocrine and duodenal permeability, simple DMA using IRE ameliorated liver lipid deposition and improved serum lipid parameters in NAFLD rats.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 16","pages":"105188"},"PeriodicalIF":4.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning algorithms reveal gut microbiota signatures associated with chronic hepatitis B-related hepatic fibrosis.","authors":"Ying Zhu, Shi-Yu Geng, Yao Chen, Qing-Jing Ru, Yi Zheng, Na Jiang, Fei-Ye Zhu, Yong-Sheng Zhang","doi":"10.3748/wjg.v31.i16.105985","DOIUrl":"https://doi.org/10.3748/wjg.v31.i16.105985","url":null,"abstract":"<p><strong>Background: </strong>Hepatic fibrosis (HF) represents a pivotal stage in the progression and potential reversal of cirrhosis, underscoring the importance of early identification and therapeutic intervention to modulate disease trajectory.</p><p><strong>Aim: </strong>To explore the complex relationship between chronic hepatitis B (CHB)-related HF and gut microbiota to identify microbiota signatures significantly associated with HF progression in CHB patients using advanced machine learning algorithms.</p><p><strong>Methods: </strong>This study included patients diagnosed with CHB and classified them into HF and non-HF groups based on liver stiffness measurements. The HF group was further subdivided into four subgroups: F1, F2, F3, and F4. Data on clinical indicators were collected. Stool samples were collected for 16S rRNA sequencing to assess the gut microbiome. Microbiota diversity, relative abundance, and linear discriminant analysis effect size (LEfSe) were analyzed in different groups. Correlation analysis between clinical indicators and the relative abundance of gut microbiota was performed. The random forest and eXtreme gradient boosting algorithms were used to identify key differential gut microbiota. The Shapley additive explanations were used to evaluate microbiota importance.</p><p><strong>Results: </strong>Integrating the results from univariate analysis, LEfSe, and machine learning, we identified that the presence of <i>Dorea</i> in gut microbiota may be a key feature associated with CHB-related HF. <i>Dorea</i> possibly serves as a core differential feature of the gut microbiota that distinguishes HF from non-HF patients, and the presence of <i>Dorea</i> shows significant variations across different stages of HF (<i>P</i> < 0.05). The relative abundance of <i>Dorea</i> significantly decreases with increasing HF severity (<i>P =</i> 0.041). Moreover, the gut microbiota composition in patients with different stages of HF was found to correlate with several liver function indicators, such as γ-glutamyl transferase, alkaline phosphatase, total bilirubin, and the aspartate aminotransferase/alanine transaminase ratio (<i>P <</i> 0.05). The associated pathways were predominantly enriched in biosynthesis, degradation/utilization/assimilation, generation of precursors, metabolites, and energy, among other categories.</p><p><strong>Conclusion: </strong>HF affects the composition of the gut microbiota, indicating that the gut microbiota plays a crucial role in its pathophysiological processes. The abundance of <i>Dorea</i> varies significantly across various stages of HF, making it a potential microbial marker for identifying HF onset and progression.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 16","pages":"105985"},"PeriodicalIF":4.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventional effect of hesperetin on N-methyl-N'-nitro-N-nitrosoguanidine-induced exosomal circ008274 in affecting normal cells to promote gastric carcinogenesis.","authors":"Zhao-Feng Liang, Yu-Meng Xu, Jia-Jia Song, Zi-Han Gao, Hui Qian, Xue-Zhong Xu","doi":"10.3748/wjg.v31.i16.104920","DOIUrl":"https://doi.org/10.3748/wjg.v31.i16.104920","url":null,"abstract":"<p><strong>Background: </strong>Hesperetin, a flavonoid predominantly present in citrus fruits, exhibits significant intervention effects on both the initiation and progression of gastric cancer. However, the specific mechanisms underlying this effect remain unclear.</p><p><strong>Aim: </strong>To investigate the interventional role of hesperetin on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced exosomes in inducing gastric carcinogenesis.</p><p><strong>Methods: </strong>Bioinformatics technology was used to identify the critical molecular components underlying hesperetin-mediated inhibition of MNNG induced gastric carcinogenesis through exosomal circular RNA. Biological experiments were conducted to validate these findings.</p><p><strong>Results: </strong>Exosomes derived from TGES-1 cells (TGES-1-EX) significantly enhanced the proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and stemness of GES-1 cells. The oncogenic potential of TGES-1-EX was significantly diminished following hesperetin pretreatment. TGES-1-EX with overexpressed or knocked down circ0008274 was extracted and GES-1 cells were treated in combination with hesperetin or alone. Our investigation revealed that hesperetin exerted significant inhibitory effects on MNNG-induced gastric carcinogenesis by exosomal circ0008274. Bioinformatics prediction identified microRNA (miR)-526b-5p as a potential miRNA binding to circ0008274. Functional experiments demonstrated that hesperetin may mediate its intervention in MNNG-induced gastric cancer initiation by targeting miR-526b-5p through exosomal circ0008274. TGES-1-EX circ0008274 promoted the proliferation, EMT, and cancer stem cell-like characteristics in GES-1 cells through miR-526b-5p-mediated regulatory mechanisms.</p><p><strong>Conclusion: </strong>Hesperetin exerted an interventional effect on the gastric carcinogenesis process, particularly through the modulation of exosomal circ0008274 and its interaction with miR-526b-5p.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 16","pages":"104920"},"PeriodicalIF":4.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA FTX promotes colorectal cancer radioresistance through disturbing redox balance and inhibiting ferroptosis <i>via</i> miR-625-5p/SCL7A11 axis.","authors":"Qing Dai, Tian-Yin Qu, Jin-Lan Yang, Jing Leng, Lin Fang, Qian-Qian Zhu, Ke-Bi Wu, Jie Wu, Jing-Jing Ma, Huang-Fei Yu","doi":"10.3748/wjg.v31.i16.104305","DOIUrl":"https://doi.org/10.3748/wjg.v31.i16.104305","url":null,"abstract":"<p><strong>Background: </strong>Radiotherapy is widely employed in colorectal cancer (CRC) treatment, but the occurrence of radioresistance severely limits the clinical benefit to patients and significantly contributes to treatment failure and recurrent metastasis.</p><p><strong>Aim: </strong>To explore the role and underlying mechanism of the lncRNA FTX in radiotherapy resistance in CRC.</p><p><strong>Methods: </strong>LncRNA FTX expression in colorectal parent cells (HT29 and HCT116) and radioresistant cells (HT29R and HCT116R) was determined by real-time quantitative PCR, and the viability of HT29R-shFTX and HCT116R-shFTX cells under ionizing radiation was evaluated using the cell counting kit-8 assay and colony formation experiment. The levels of glutathione and reactive oxygen species in cells after irradiation were determined, and the association between ferroptosis and lncRNA FTX expression in cancer cells was tested. A dual-luciferase assay was used to validate gene interactions. A xenotransplantation mouse model was established to explore the effects of FTX on the CRC tumor radiosensitivity <i>in vivo</i>.</p><p><strong>Results: </strong>FTX was upregulated in radioresistant CRC cells, and FTX knockdown inhibited cell survival and increased cell ferroptotic death in response to ionizing radiation. Moreover, lncRNA FTX restricted the SLC7A11 expression by sponging with miR-625-5p, and inhibition of the lncRNA FTX or SLC7A11 significantly increased cellular oxidant levels and DNA damage to ionizing radiation in cancer cells. However, SLC7A11 overexpression reversed the effects of decreased FTX levels on ferroptosis and high oxidation levels in cancer cells exposed to ionizing radiation.</p><p><strong>Conclusion: </strong>Inhibition of the lncRNA FTX/miR-625-5p/SLC7A11 axis can induce ferroptosis and disturb intracellular redox balance, further sensitizing CRC cells to ionizing radiation, suggesting its potential as a therapeutic target for improving CRC response to radiation therapy.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 16","pages":"104305"},"PeriodicalIF":4.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic intersection of human leukocyte antigen-DP/DQ and hepatitis B virus-related liver disease: Insights from a multi-clustering study.","authors":"Jin-Wei Zhang","doi":"10.3748/wjg.v31.i16.102511","DOIUrl":"https://doi.org/10.3748/wjg.v31.i16.102511","url":null,"abstract":"<p><p>Hepatitis B virus infection remains a significant global health challenge, particularly in endemic regions like Vietnam. This article examines the groundbreaking study by Nguyen <i>et al</i>, which investigates the relationship between human leukocyte antigen-DP/DQ polymorphisms and hepatitis B virus-related liver disease progression. Through advanced multi-clustering analysis, the study reveals that the A-A-A haplotype (rs2856718-rs3077-rs9277535) provides protection against disease progression, while the G-G-G haplotype correlates with increased hepatocellular carcinoma susceptibility. The integration of machine learning approaches with genetic data offers promising avenues for refined disease prediction and personalized therapeutic strategies. This article discusses the implications for expanding study populations, implementing longitudinal cohort studies, and leveraging artificial intelligence for improved patient outcomes.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 16","pages":"102511"},"PeriodicalIF":4.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creeping fat: A promising radiological predictor in small bowel Crohn's disease.","authors":"Hong Wei, Zi-Ling Mai, Bo-Tong Ma, Bing Chang","doi":"10.3748/wjg.v31.i16.105186","DOIUrl":"https://doi.org/10.3748/wjg.v31.i16.105186","url":null,"abstract":"<p><p>In this manuscript, we comment on the article by Hasnaoui <i>et al</i>. Specifically, we delve into the characteristic manifestation of Crohn's disease (CD) known as creeping fat (CF). Our primary focus is to investigate the potential of imaging features of CF in predicting the response of small bowel CD to biologic therapies and fecal microbiota transplantation. We believe that further research should be dedicated to developing methods for quantifying CF in order to provide more accurate predictive tools for the treatment of small bowel CD.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 16","pages":"105186"},"PeriodicalIF":4.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in liver cancer surgery: Predicting success before the first incision.","authors":"Shu-Yen Chan, Patrick Twohig","doi":"10.3748/wjg.v31.i16.107221","DOIUrl":"https://doi.org/10.3748/wjg.v31.i16.107221","url":null,"abstract":"<p><p>Advancements in machine learning have revolutionized preoperative risk assessment. In this article, we comment on the article by Huang <i>et al</i>, which presents a recent multicenter cohort study demonstrated that machine learning algorithms effectively stratify recurrence-free survival, providing a robust predictive framework for maximizing surgical outcomes in intrahepatic cholangiocarcinoma. By leveraging interpretable models, the research enhances clinical decision-making, allowing for more precise patient selection and personalized surgical strategies. These findings highlight the growing role of artificial intelligence in optimizing surgical outcomes and improving prognostic accuracy in hepatobiliary oncology.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 16","pages":"107221"},"PeriodicalIF":4.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epstein-Barr virus infection is an independent risk factor for surgery in patients with moderate-to-severe ulcerative colitis.","authors":"Hui Zhang, Xi Gu, Wei He, Shu-Liang Zhao, Zhi-Jun Cao","doi":"10.3748/wjg.v31.i16.104758","DOIUrl":"https://doi.org/10.3748/wjg.v31.i16.104758","url":null,"abstract":"<p><strong>Background: </strong>Epstein-Barr virus (EBV) infection of the intestinal mucosa is associated with surgical risk in ulcerative colitis (UC); however, the exact effect remains unclear.</p><p><strong>Aim: </strong>To determine whether EBV infection can predict the need for colectomy and to develop a surgical risk predictive model.</p><p><strong>Methods: </strong>This was a single-center retrospective study of 153 patients with moderate-to-severe UC between September 2012 and May 2023. EBV-encoded small RNA (EBER) <i>in situ</i> hybridization and immunohistochemistry (IHC) were used for EBV testing and assessment. Cytomegalovirus (CMV) was detected by IHC. Logistic regression analysis was conducted to identify risk factors for colectomy and develop a predictive risk model.</p><p><strong>Results: </strong>EBER-positivity in the intestinal mucosa was present in 40.4% (19/47) and 4.7% (5/106) of patients in the surgery and non-surgery groups, respectively, with significant differences between the groups (<i>P</i> < 0.01, odds ratio = 13.707). The result of multivariate logistic regression revealed that age, EBV infection in the colonic mucosa, CMV infection in the colonic mucosa, and treatment with three or more immunosuppressive agents before admission were significant independent predictors of colectomy. A nomogram incorporating these variables demonstrated good discriminative ability, and exhibited good calibration and clinical utility. IHC showed that EBV-infected cells mainly included B and T lymphocytes in patients with high EBER concentrations.</p><p><strong>Conclusion: </strong>EBV infection of the intestinal mucosa is a significant independent risk factor for colectomy in patients with moderate-to-severe UC. The nomogram model, which includes EBV infection, effectively predicts colectomy risk.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 16","pages":"104758"},"PeriodicalIF":4.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding prognosis in dengue-induced hepatitis: Model for end-stage liver disease <i>vs</i> albumin-bilirubin for predicting liver failure and survival.","authors":"Linda Galasso, Giorgio Esposto, Irene Mignini, Maria Elena Ainora, Maria Assunta Zocco","doi":"10.3748/wjg.v31.i16.102778","DOIUrl":"https://doi.org/10.3748/wjg.v31.i16.102778","url":null,"abstract":"<p><p>In this editorial, we comment on the article by Teerasarntipan <i>et al</i> published in a recent issue of the <i>World Journal of Gastroenterology</i>. Dengue infection is a major mosquito-borne disease with global significance. Dengue-induced severe hepatitis (DISH) is a rare complication though severe, as it can lead to acute liver failure (ALF) with an incidence rate between 0.7% and 2.0% and mortality rates from 47.0% to 58.8%. In this context, the identification of patients at risk of ALF could improve prognosis in DISH patients. Teerasarntipan <i>et al</i> retrospectively enrolled 2532 dengue patients, counting 193 DISH and 20 ALF. The authors explored the prognostic role of liver-specific scores, as the model for end-stage liver disease (MELD) score, albumin-bilirubin (ALBI) score, easy (EZ)-ALBI score, and platelet-ALBI (PALBI) score. Univariate analysis identified international normalized ratio (INR), total bilirubin, albumin, and creatinine as independent laboratory factors associated with ALF, while age, gender, and liver comorbidities were not linked to in-hospital mortality. The presence of dengue shock syndrome significantly increased mortality, with an odds ratio (OR) of 28.05 (95%CI: 7.21-109.18, <i>P</i> < 0.001). High INR and low albumin were laboratory markers associated with death from DISH, with ORs of 5.83 (95%CI: 2.59-13.12, <i>P</i> < 0.001) and 0.15 (95%CI: 0.05-0.44, <i>P</i> < 0.001), respectively. Multivariate analysis confirmed that INR remained the only significant predictor of both ALF and death, with adjusted ORs of 19.54 (95%CI: 3.37-113.38, <i>P</i> < 0.001) and 3.86 (95%CI: 1.13-13.18, <i>P</i> = 0.031), respectively. Among prognostic models, the MELD score performed best in predicting ALF, with a very high accuracy [area under the receiver operating characteristic curve (AUROC) of 0.929, 87.5% sensitivity, 89.3% specificity at a cutoff of 16], followed by the EZ-ALBI, ALBI, and PALBI scores, with AUROCs of 0.865, 0.832, and 0.797, respectively. As MELD remains the best scoring system for predicting poor outcomes in DISH-related ALF, EZ-ALBI is a valid adjunct tool that could improve medical care in these patients.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 16","pages":"102778"},"PeriodicalIF":4.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}