World Journal of Gastroenterology最新文献

{"title":"Role of artificial intelligence in gastric diseases.","authors":"Eun Jeong Gong, Jieun Woo, Jae Jun Lee, Chang Seok Bang","doi":"10.3748/wjg.v31.i37.111327","DOIUrl":"10.3748/wjg.v31.i37.111327","url":null,"abstract":"<p><p>The integration of artificial intelligence (AI) in gastroenterology has evolved from basic computer-aided detection to sophisticated multimodal frameworks that enable real-time clinical decision support. This study presents AI applications in gastric disease diagnosis and management, highlighting the transition from domain-specific deep learning to general-purpose large language models. Our research reveals a key finding: AI effectiveness demonstrates an inverse relationship with user expertise, with moderate-expertise practitioners benefiting the most, whereas experts and novices show limited performance gains. We developed a clinical decision support system achieving 96% lesion detection internally and 82%-87% classification accuracy in external validation. Multimodal integration, which combines endoscopic images, clinical histories, laboratory results, and genomic data, enables comprehensive disease assessment and personalized treatment. The emergence of large language models with expanding context windows and multiagent architectures represents a paradigm shift in medical AI. Furthermore, emerging technologies are expanding AI's potential applications, and feasibility studies on smart glasses in endoscopy training suggest opportunities for hands-free assistance, although clinical implementation challenges persist. This minireview addresses persistent limitations including geographic bias in training data, regulatory hurdles, ethical considerations regarding patient privacy and AI accountability, and the concentration of AI development among technology giants. Successful integration requires balancing innovation with patient safety, while preserving the irreplaceable role of human clinical judgment.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 37","pages":"111327"},"PeriodicalIF":5.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute intestinal obstruction caused by endoscopic submucosal dissection: A case report.","authors":"Qiang Zhang, Dan Hong, Yi-Chi Zhou, Guo-Xin He, Teng Jiang","doi":"10.3748/wjg.v31.i37.111081","DOIUrl":"10.3748/wjg.v31.i37.111081","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic submucosal dissection (ESD) is considered one of the effective and minimally invasive methods for managing lateral spreading tumors of the intestine. However, with the widespread adoption of this technique, the incidence of complications is expected to increase. The most common complications of ESD are hemorrhage and perforation. Rare cases of obstruction after colorectal ESD have been reported, which are often easily misdiagnosed. Therefore, clinicians should maintain heightened awareness of this complication.</p><p><strong>Case summary: </strong>We report the case of a 50-year-old male who developed bowel obstruction following ESD. On the second day after the procedure, the patient presented with fever and a mild left lower abdominal pain. Physical examination revealed tenderness and rebound tenderness in the left lower quadrant. Plain abdominal radiographs demonstrated air-fluid levels and dilatation of the proximal bowel. The patient continued to fast and was treated with intravenous antibiotics. On the third postoperative day, he developed abdominal distension in the lower abdomen and vomited approximately 200 mL of greenish-yellow fluid, with no bowel movement for two days after the procedure. A diagnosis of obstruction after ESD was made. Continuous gastrointestinal decompression was initiated on the fourth day, resulting in symptomatic improvement. Follow-up abdominal radiographs showed marked improvement in the obstruction compared with prior imaging. The patient resumed oral intake and was discharged uneventfully on the eighth postoperative day.</p><p><strong>Conclusion: </strong>Acute intestinal obstruction after ESD is a rare complication. Delayed diagnosis or misdiagnosis may be life-threatening. Clinicians should be vigilant for this condition following ESD.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 37","pages":"111081"},"PeriodicalIF":5.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of serum alpha-fetoprotein kinetics in liver failure on artificial liver support.","authors":"Wei-Bo Guo, Lu-Yao Wang, Xi-Ju Guo, Jing Yang, Wen Li, Fa-Yao Shen, Yu-Ting Li, Jin-Hui Yang, Wen-Lin Tai","doi":"10.3748/wjg.v31.i37.111914","DOIUrl":"10.3748/wjg.v31.i37.111914","url":null,"abstract":"<p><strong>Background: </strong>Liver failure, particularly acute-on-chronic liver failure, is associated with high mortality (50%-90%). The plasma exchange (PE) mode of the artificial liver support system has been shown to improve clinical outcomes, although its efficacy may vary depending on the regenerative capacity of the liver. Alpha-fetoprotein (AFP), an oncofetal glycoprotein, is reactivated during liver regeneration and may serve as a prognostic biomarker. Previous studies have reported significantly higher post-PE AFP levels in survivors than in non-survivors (286.5 ng/mL <i>vs</i> 82.3 ng/mL at day 7). However, the predictive value of baseline AFP stratification and serial AFP kinetics during PE therapy remains unestablished. This study investigated whether serial AFP measurements predict clinical outcomes in liver failure patients receiving PE.</p><p><strong>Aim: </strong>To evaluate the predictive value of serial AFP measurements in liver failure patients receiving PE.</p><p><strong>Methods: </strong>This retrospective study included 194 liver failure patients with complete AFP data, excluding those with tumors, bleeding disorders, allergies, or unstable conditions. Patients were stratified by baseline AFP into low-AFP (< 100 ng/mL, <i>n</i> = 60), medium-AFP (100-200 ng/mL, <i>n</i> = 70), and high-AFP (> 200 ng/mL, <i>n</i> = 64) groups. AFP was measured before PE and on days 1, 10, 20, and 25.</p><p><strong>Results: </strong>Stratification by baseline AFP revealed significant gradients. The high-AFP group required fewer PE sessions than the low-AFP group (2.8 ± 1.0 <i>vs</i> 4.2 ± 1.5) but exhibited greater post-PE AFP elevation (75.1 ± 20.3 ng/mL <i>vs</i> 33.1 ± 10.2 ng/mL; <i>P</i> < 0.001). The high-AFP group demonstrated optimal values, including the lowest ammonia, bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transferase, and the highest albumin and prothrombin activity (all post hoc <i>P</i> < 0.05 <i>vs</i> low-AFP). The medium-AFP group showed intermediate values except for prothrombin activity (35.2% ± 8.6%), which was significantly lower than in both other groups (<i>P</i> < 0.001). The high-AFP group had a reduced incidence of spontaneous bacterial peritonitis (9.4% <i>vs</i> 25.0%; <i>P</i> = 0.003), superior three-month survival (90.6% <i>vs</i> 56.7%; <i>P</i> < 0.001), and a higher post-treatment three-month receiver operating characteristic area under the curve (0.8851 <i>vs</i> 0.7051).</p><p><strong>Conclusion: </strong>AFP dynamics correlate with regenerative capacity and clinical outcomes in liver failure. Serial AFP monitoring may enhance risk stratification and support personalized therapeutic strategies.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 37","pages":"111914"},"PeriodicalIF":5.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic retrograde cholangiopancreatography in elderly patients: Is age just a number or something more?","authors":"Theodoros A Voulgaris, George Tribonias, Ioannis S Papanikolaou, Georgios P Karamanolis, Ioannis A Vezakis, Aspasia Louta, Orfeas Petros Varvarelis, Leonidas Chardalias, Andreas Polydorou, Antonios Vezakis","doi":"10.3748/wjg.v31.i37.110269","DOIUrl":"10.3748/wjg.v31.i37.110269","url":null,"abstract":"<p><strong>Background: </strong>Data suggest that elderly patients may have a lower risk of complications after endoscopic retrograde cholangiopancreatography (ERCP), especially post-ERCP pancreatitis (PEP).</p><p><strong>Aim: </strong>To validate these findings in a large, real-world clinical setting.</p><p><strong>Methods: </strong>Clinical, epidemiological, and procedural data collected from a prospectively maintained database were gathered over a 20-year period (2001-2021) from consecutive patients undergoing their first ERCP. Patients were grouped based on age: < 80 years and ≥ 80 years.</p><p><strong>Results: </strong>A total of 3147 patients were included in the study, with 70.3% < 80 years old and 28.7% ≥ 80 years. The most common indication for ERCP was biliary colic with or without elevated liver enzymes (39.6%). Periampullary diverticula were more frequently observed in elderly patients (<i>P</i> < 0.001). Successful cannulation of the common bile duct was achieved in 96.1% of cases and did not differ significantly between age groups (<i>P</i> = 0.148). Complete common bile duct clearance during the first ERCP was accomplished in 90.1%, and stone size was the only independent predictor of success. Use of antiplatelet or anticoagulant therapy was independently associated with intraprocedural bleeding (odds ratio [OR] = 1.333; <i>P</i> = 0.03 and OR = 1.275; <i>P</i> = 0.041, respectively). Overall, post-ERCP complications occurred in 6% of cases, with similar rates between elderly and younger patients. The most common complication was PEP. The incidences of clinical bleeding and PEP did not differ significantly between groups (<i>P</i> = 0.290 and <i>P</i> = 0.128, respectively). Clinical bleeding was independently associated with anticoagulant use and intraprocedural bleeding.</p><p><strong>Conclusion: </strong>Our findings highlight that elderly patients do not experience higher complication rates or lower success rates with ERCP, supporting the procedure's safety and efficacy in this population.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 37","pages":"110269"},"PeriodicalIF":5.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-derived organoids in hepatobiliary pancreatic cancer research: Their uses and limitations.","authors":"Sam Jacobs, William Butterworth, Ewen A Griffiths","doi":"10.3748/wjg.v31.i36.110684","DOIUrl":"10.3748/wjg.v31.i36.110684","url":null,"abstract":"<p><p>In this letter, we discuss the highlights of the paper by Hu <i>et al</i>, including how patient-derived organoids may be beneficial to hepatobiliary pancreatic research. The article provides a review of how organoids can be used in drug sensitivity testing; looking at ways in which successful organoids are created. The literature included in the review revealed heterogeneity in organoid establishment including some differences between organoids from resected tumours compared with liquid biopsies. Additional research is required in creating organoids from liquid biopsies and optimizing these techniques for widespread clinical practice. The article raises awareness of limitations of organoids with suggestions of how co-culture or microfluid platforms may help to simulate the tumour microenvironment for better model fidelity. The article provides a comprehensive review of how organoids are being used in drug testing and ideas about how to harvest or produce these in future.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 36","pages":"110684"},"PeriodicalIF":5.4,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peroxiredoxin 1 inhibits tumorigenesis by activating the NLRP3/GSDMD pathway to induce pyroptosis of colorectal cancer cells.","authors":"Ying He, Jing Liu, Ning Zhou, Ling-Xiang Xie, Yong-Fang Jiang, Chun-Lan Chen","doi":"10.3748/wjg.v31.i36.111557","DOIUrl":"10.3748/wjg.v31.i36.111557","url":null,"abstract":"<p><strong>Background: </strong>Damage associated molecular patterns (DAMPs) are vital for the immunogenic cell death of cancer cells and can enhance the anti-tumor activity of immune cells in colorectal cancer (CRC). Peroxiredoxin 1 (Prdx1), an important DAMP, is highly expressed in various tumor tissues including CRC. However, the role of Prdx1 in CRC remains unknown.</p><p><strong>Aim: </strong>To investigate the effect and mechanisms of Prdx1 on CRC.</p><p><strong>Methods: </strong>Patients diagnosed with CRC in our medical center were included in this study to verify the expression of Prdx1 in cancer tissues. Recombinant Prdx1 (rPrdx1) was used to stimulate RKO and SW480 colon cancer cells. The cell survival rate, migration, proliferation and invasion ability were assessed. Transmission electron microscopy, TUNEL assay, lactate dehydrogenase release assay, and Western blot were used to determine the effect of Prdx1 on pyroptosis. NLRP3 inflammasome inhibitor and gasdermin D (GSDMD) inhibitor were used to explore the mechanism of Prdx1-induced pyroptosis.</p><p><strong>Results: </strong>The mRNA and protein levels of Prdx1 were significantly increased in the tumor tissues of patients with CRC. rPrdx1 inhibited the viability, proliferation, migration and invasion of RKO and SW480 colon cancer cells. Further study found that rPrdx1 inhibited the malignant biological behaviors of CRC cells by inducing pyroptosis rather than apoptosis and necroptosis. Mechanistically, rPrdx1 induces pyroptosis of CRC cells by activating the NLRP3 inflammasome/GSDMD pathway.</p><p><strong>Conclusion: </strong>Prdx1 induces pyroptosis by activating the NLRP3 inflammasome/GSDMD pathway, thereby inhibiting the malignant biological behavior of RKO and SW480 colon cancer cells.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 36","pages":"111557"},"PeriodicalIF":5.4,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-processed foods: Implications for gastrointestinal health.","authors":"Anupam Kumar Singh, Akash Gandotra, Shubham Kumar, Arjun Singh, Rakesh Kochhar, Manish Manrai","doi":"10.3748/wjg.v31.i36.109143","DOIUrl":"10.3748/wjg.v31.i36.109143","url":null,"abstract":"<p><p>Ultra-processed foods (UPFs) are believed to contribute to the development of multiple chronic inflammatory diseases, including inflammatory bowel diseases and metabolic syndrome, based on epidemiological studies and emerging preclinical and clinical research. Several aspects of food processing and formulation in the development of chronic inflammatory diseases are currently being studied. Ongoing research emphasizes epidemiological evidence and mechanistic insights regarding UPFs and their interaction with the intestinal microbiota. In this review, we explore UPFs, their interaction with the intestinal microbiota, and the implications for gastrointestinal health.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 36","pages":"109143"},"PeriodicalIF":5.4,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastroenterology in the age of artificial intelligence: Bridging technology and clinical practice.","authors":"Yagna Mehta, Saumya Mehta, Vishwa Bhayani, Sankalp Parikh, Rajiv Mehta","doi":"10.3748/wjg.v31.i36.110549","DOIUrl":"10.3748/wjg.v31.i36.110549","url":null,"abstract":"<p><p>The integration of artificial intelligence (AI), deep learning (DL), and radiomics is rapidly reshaping gastroenterology and hepatology. Advanced computational models including convolutional neural networks, recurrent neural networks, transformers, artificial neural networks, and support vector machines are revolutionizing both clinical practice and biomedical research. This review explores the broad applications of AI in managing patient data, developing disease-specific algorithms, and performing literature mining. In drug discovery, AI-driven computational chemistry is significantly speeding up drug discovery and development by accelerating hit identification, lead optimization, and formulation development. Machine learning models enable the precise prediction of molecular interactions and drug-target binding, thereby improving screening efficiency and reducing reliance on conventional experimental methods. AI also plays a central role in structure-based drug design, molecular docking, and absorption, distribution, metabolism, excretion, and toxicity simulations, while facilitating excipient selection and optimizing formulation stability and bioavailability. In clinical endoscopy, DL-enhanced computer vision is advancing ambient intelligence by enabling real-time image interpretation and procedural guidance. AI-based predictive analytics further support personalized medicine by forecasting treatment response in inflammatory bowel disease. Remote monitoring systems powered by AI are proving vital in managing high-risk populations, including patients with acute-on-chronic liver failure, liver transplant recipients, and individuals with cirrhosis requiring individualized diuretic titration. Despite its promise, AI potential in gastroenterology faces challenges stemming from data inconsistencies, ethical concerns, algorithmic biases, and data privacy issues including health insurance portability and accountability act and general data protection regulation compliance. Establishing standardized protocols for data collection, labeling, and sharing, alongside robust multicenter databases and regulatory oversight, are essential for ensuring safe, ethical, and effective AI integration into clinical workflows.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 36","pages":"110549"},"PeriodicalIF":5.4,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translational artificial intelligence in gastrointestinal and hepatic disorders: Advancing intelligent clinical decision-making for diagnosis, treatment, and prognosis.","authors":"Shu-Qi Ren, Jin-Man Chen, Chuang Cai","doi":"10.3748/wjg.v31.i36.110742","DOIUrl":"10.3748/wjg.v31.i36.110742","url":null,"abstract":"<p><p>Gastrointestinal and hepatic disorders exhibit significant heterogeneity, characterized by complex and diverse clinical phenotypes. Most lesions present without typical symptoms in their early stages, which poses substantial challenges for early clinical identification and intervention. As an interdisciplinary field at the forefront of technology, artificial intelligence (AI) integrates theoretical innovation, algorithm development, and engineering applications, triggering paradigm shifts within the medical field. Current research trends indicate that AI technology is progressively permeating the entire diagnostic and therapeutic process for gastrointestinal and hepatic disorders, facilitating intelligent transformations in precise lesion detection, optimization of treatment decisions, and prognosis evaluation through the integration of different modal data, construction of intelligent algorithms, and establishment of clinical verification systems. This article systematically reviews the latest advancements in AI technology concerning the diagnosis and treatment of gastrointestinal diseases (such as inflammatory bowel disease and digestive system tumors) and hepatic diseases (including hepato-cirrhosis and liver cancer), emphasizing its application value and transformative potential in critical areas such as imaging omics analysis, endoscopic intelligent identification, and personalized treatment prediction.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 36","pages":"110742"},"PeriodicalIF":5.4,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Meridian flow injection acupoint application combined with transcutaneous electrical acupoint stimulation in patients undergoing gastroenteroscopy.","authors":"Xian Hong, Xiao-Yan Wu, Qing-Li Xu","doi":"10.3748/wjg.v31.i36.110583","DOIUrl":"10.3748/wjg.v31.i36.110583","url":null,"abstract":"<p><strong>Background: </strong>Although gastroscopy is a commonly used diagnostic and therapeutic technique, postoperative gastrointestinal dysfunction is prone to occur. Traditional Chinese medicine theory suggests that postoperative gastrointestinal disorders are related to spleen and stomach weakness. This study hypothesizes that the combination of acupoint application at the Ziwu Liuzhu acupoint and percutaneous acupoint electrical stimulation can promote postoperative gastrointestinal function recovery and alleviate stress reactions.</p><p><strong>Aim: </strong>To investigate the effects of acupoint application of Ziwu Liuzhu combined with percutaneous acupoint electrical stimulation on postoperative gastrointestinal function recovery and stress response in patients undergoing gastrointestinal endoscopy surgery.</p><p><strong>Methods: </strong>A total of 120 patients who underwent gastroscopy surgery were selected and treated between October 2024 and January 2025. This study used a stratified block randomization method, and then allocated groups using computer-generated random number sequences (SAS 9.4 software). The groups were divided into two groups: A control group of 60 patients who received routine postoperative intervention measures, and an observation group of 60 patients who received acupuncture point application combined with transcutaneous acupoint electrical stimulation therapy. The therapeutic effects were compared after 3 days of treatment.</p><p><strong>Results: </strong>The mean time of first defecation was 3.20 ± 1.04 days, the mean first eating time was 2.55 ± 0.72 days, and the mean length of hospital stay was 5.57 ± 0.09 days (<i>P</i> < 0.05) after treatment. Gastrin levels were found to be (161.15 ± 16.75) pg/mL, norepinephrine (125.53 ± 17.78) pg/mL, cortisol (142.16 ± 19.55) μg/L, aldosterone (51.14 ± 5.39) pg/mL demonstrated superiority in comparison to the control group (<i>P</i> < 0.05). Conversely, the observation group exhibited superior outcomes, with an 93.33% success rate as opposed to the control group's 75.00%, and an overall satisfaction rate of 91.67% as compared to the control group's 68.33%. Moreover, the postoperative complication rate in the observation group was 16.67%, significantly lower than the 38.33% rate observed in the control group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The combination of percutaneous acupoint electrical stimulation in gastroscopy patients has been demonstrated to be both highly safe and effective. The benefits of this approach include the promotion of postoperative gastrointestinal function, the reduction of stress response, the attainment of optimal results, and the enhancement of patient satisfaction.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 36","pages":"110583"},"PeriodicalIF":5.4,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}