World Journal of Gastroenterology最新文献

{"title":"Illuminating the black box: Machine learning enhances preoperative prediction in intrahepatic cholangiocarcinoma.","authors":"Eyad Gadour, Mohammed S AlQahtani","doi":"10.3748/wjg.v31.i17.106592","DOIUrl":"10.3748/wjg.v31.i17.106592","url":null,"abstract":"<p><p>The study by Huang <i>et al</i>, published in the <i>World Journal of Gastroenterology</i>, advances intrahepatic cholangiocarcinoma (ICC) management by developing a machine-learning model to predict textbook outcomes (TO) based on preoperative factors. By analyzing data from 376 patients across four Chinese medical centers, the researchers identified key variables influencing TO, including Child-Pugh classification, Eastern Cooperative Oncology Group score, hepatitis B status, and tumor size. The model, created using logistic regression and the extreme gradient boosting algorithm, demonstrated high predictive accuracy, with area under the curve values of 0.8825 for internal validation and 0.8346 for external validation. The integration of the Shapley additive explanation technique enhances the interpretability of the model, which is crucial for clinical decision-making. This research highlights the potential of machine learning to improve surgical planning and patient outcomes in ICC, opening possibilities for personalized treatment approaches based on individual patient characteristics and risk factors.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"106592"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vonoprazan and proton pump inhibitors: Which is superior for <i>Helicobacter pylori</i> eradication?","authors":"Mubin Ozercan, Ahmed Tawheed, Alaa Ismail, Mohab Sherif Amer, Mohamed El-Kassas","doi":"10.3748/wjg.v31.i17.103156","DOIUrl":"10.3748/wjg.v31.i17.103156","url":null,"abstract":"<p><p><i>Helicobacter pylori</i> is a worldwide health problem; therefore, eradicating this bacterium is important for the health and economic status of the whole world. There are a variety of anti-secretory and antibiotic combinations for this purpose; however, antibiotic resistance is a major barrier to achieving an appropriate eradication rate (> 90%). Blockage of gastric acid is the main supportive factor of the antibiotic effect on bacteria. Therefore, anti-secretory therapy with high efficacy and safety profiles should be used in eradication regimens. Vonoprazan (VPZ), a member of the potassium competitive acid blockers, is a novel agent with a potent anti-secretory effect. The present study aimed to summarize comparative and safety studies of VPZ and proton pump inhibitors (PPIs), especially the efficacy on <i>Helicobacter pylori</i> eradication. VPZ was reported to have a higher efficacy and safety profile in most studies that compared VPZ-based and PPI-based regimens for eradication therapy. Despite its greater cost, the effectiveness of VPZ emerges as a viable and cost-effective alternative to PPI on gastric acid-related pathologies.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"103156"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illuminating the black box: Machine learning enhances preoperative prediction in intrahepatic cholangiocarcinoma.","authors":"Eyad Gadour, Mohammed S AlQahtani","doi":"10.3748/wjg.v31.i17.106592","DOIUrl":"10.3748/wjg.v31.i17.106592","url":null,"abstract":"<p><p>The study by Huang <i>et al</i>, published in the <i>World Journal of Gastroenterology</i>, advances intrahepatic cholangiocarcinoma (ICC) management by developing a machine-learning model to predict textbook outcomes (TO) based on preoperative factors. By analyzing data from 376 patients across four Chinese medical centers, the researchers identified key variables influencing TO, including Child-Pugh classification, Eastern Cooperative Oncology Group score, hepatitis B status, and tumor size. The model, created using logistic regression and the extreme gradient boosting algorithm, demonstrated high predictive accuracy, with area under the curve values of 0.8825 for internal validation and 0.8346 for external validation. The integration of the Shapley additive explanation technique enhances the interpretability of the model, which is crucial for clinical decision-making. This research highlights the potential of machine learning to improve surgical planning and patient outcomes in ICC, opening possibilities for personalized treatment approaches based on individual patient characteristics and risk factors.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"106592"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone controls the metabolism of tryptophan protecting against sepsis-induced intestinal damage by activating aryl hydrocarbon receptor.","authors":"Qing Wang, Chun-Zheng Liu, Bai-Tian Li, Xiu-Qin Yu, Jin-Yuan Zhang, Ze-Tian Wang, Li-Jun Liao, Xiao-Dong Liu","doi":"10.3748/wjg.v31.i17.105411","DOIUrl":"10.3748/wjg.v31.i17.105411","url":null,"abstract":"<p><strong>Background: </strong>Intestinal injury is the most common complication of sepsis, and the mitigation of intestinal damage is crucial for treating sepsis.</p><p><strong>Aim: </strong>To examine the use of ozone-rich water and its action in preventing intestinal damage caused by sepsis.</p><p><strong>Methods: </strong>Through histological analysis, immunohistochemistry, immunofluorescence assays, and Western blot detection, we evaluated the therapeutic efficacy of ozone in mitigating intestinal injury during sepsis. Additionally, by conducting 16S rRNA sequencing and untargeted metabolomics analysis on fecal samples, we identified alterations in the gut microbiota and specific metabolites in septic mice following ozone treatment. This comprehensive approach aims to further elucidate the mechanistic underpinnings of ozone therapy in alleviating sepsis-induced intestinal damage.</p><p><strong>Results: </strong>Our results demonstrate that ozonated water significantly ameliorates pathological damage in intestinal tissues, enhances the expression of tight junction proteins, and inhibits the polarization of intestinal macrophages, thereby reducing the expression of inflammatory cytokines in intestinal tissues of cecal ligation and puncture-induced septic mice. 16S rRNA sequencing analysis revealed that ozonated water increased the abundance of beneficial bacteria and alleviated gut microbiota dysbiosis. Studies using broad-spectrum antibiotic-treated mice indicated that the protective effects of ozonated water on intestinal injury are dependent on the gut microbiota. Furthermore, metabolomic analysis identified an increase in the tryptophan metabolite DL-tryptophan in the ozonated water treatment group. This suggests that ozonated water protects against intestinal injury by activating the aryl hydrocarbon receptor and suppressing necroptosis in intestinal epithelial cells.</p><p><strong>Conclusion: </strong>Ozone protected against sepsis-induced intestinal injury through regulation of the gut microbiota and tryptophan metabolism, inhibiting necrotic apoptosis of intestinal epithelial cells through activation of the aryl hydrocarbon receptor.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"105411"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein-losing enteropathy and multiple vasculature dysplasia in <i>LZTR1</i>-related Noonan syndrome: A case report and review of literature.","authors":"Qiu-Ju Tian, Lu-Jia Zhang, Qun Zhang, Feng-Chao Liu, Man Xie, Jin-Zhen Cai, Wei Rao","doi":"10.3748/wjg.v31.i17.105347","DOIUrl":"10.3748/wjg.v31.i17.105347","url":null,"abstract":"<p><strong>Background: </strong>Protein-losing enteropathy (PLE) is a rare cause of hypoalbuminemia that can be attributed to intestinal lymphangiectasia. Patients with Noonan syndrome may present with disorder of lymph vessel formation. However, PLE is rarely reported with Noonan syndrome.</p><p><strong>Case summary: </strong>A 15-year-old female was hospitalized multiple times for recurrent edema and diarrhea secondary to hypoalbuminemia. Additional manifestations included a ventricular septal defect at birth, intermuscular hemangioma, slightly wide interocular and intermammary distances, and absence of the distal phalanx of the left little finger since birth. Abdominal computed tomography revealed cavernous transformation of the portal vein, and liver biopsy indicated \"porto-sinusoidal vascular disease\". Whole exome and Sanger sequencing revealed a heterozygous mutation (exon9: C.850C>T:P.R284C) in leucine zipper-like transcription regulator 1, suggesting Noonan syndrome type 10. Further examinations revealed thoracic duct dysplasia and intestinal lymphangiectasia causing PLE in this patient. A multidisciplinary team decided to address thoracic duct dysplasia with outlet obstruction. Approximately two years after the microsurgical relief of the thoracic duct outlet obstruction, the patient achieved persistent normal serum albumin level without edema or diarrhea. Furthermore, the relevant literatures on Noonan syndrome and PLE were reviewed.</p><p><strong>Conclusion: </strong>Herein, we reported the first case of PLE associated with Noonan syndrome caused by a rare genetic mutation in leucine zipper-like transcription regulator 1 (c.850C>T:P.R284C) with newly reported manifestations. This case presented the successful treatment of clinical hypoalbuminemia attributed to thoracic duct dysplasia, intestinal lymphangiectasia and PLE.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"105347"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological characteristics and prognostic outcomes of pregnancy-associated colorectal cancer: A 24-year experience.","authors":"Li-Wen Fan, Chao Shang, Qi Lin, Yan-Tao Tian, Dong-Kui Xu","doi":"10.3748/wjg.v31.i17.106508","DOIUrl":"10.3748/wjg.v31.i17.106508","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) during pregnancy poses significant risks to both maternal and fetal health; however, this topic remains under researched globally.</p><p><strong>Aim: </strong>To investigate the impacts of clinical features, pathology type, treatment strategies, and tumor stage on maternal and fetal outcomes in pregnant patients with pregnancy-associated CRC (pCRC).</p><p><strong>Methods: </strong>To address this research gap, we analyzed the clinical and pathological characteristics of pCRC by collecting and evaluating clinicopathological data from 43 patients treated at the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, between 1999 and 2023 using descriptive statistical methods.</p><p><strong>Results: </strong>Treatment for pCRC was initiated with surgery and/or chemotherapy. Among 43 patients, 37 underwent surgery, including 21 radical resections (5 prenatal and 16 postpartum resections) and 16 palliative surgeries. Chemotherapy (with regimens such as CapeOx or FOLFOX4) was administered to 37 patients. Six advanced-stage patients received chemotherapy alone. The gestational outcomes among the patients varied. Specifically, 5 patients who were diagnosed in early pregnancy chose abortion. Additionally, in mid-pregnancy, 3 patients underwent abortion, 1 required induced labor, and 2 underwent cesarean delivery with healthy neonates. Among the 3 late-pregnancy diagnoses, 1 patient underwent induced abortion, 1 delivered <i>via</i> cesarean section with a healthy fetus, and 1 underwent stillbirth management. The 5-year survival rate was 59.8%, with a rate of 100% for stage I/II patients, 75% for stage III patients, and 21.1% for stage IV patients.</p><p><strong>Conclusion: </strong>Patients with poorly differentiated tumors exhibited worse outcomes than those with moderately and highly differentiated tumors. Early-stage diagnosis and timely treatment significantly improved maternal survival and fetal outcomes in pregnant patients with CRC. Advanced tumor stages and delayed diagnosis were observed to be associated with poorer maternal prognoses and may require interventions that compromise fetal survival. Fetal outcomes depend on the pathological stage of the mother's cancer, the gestational age at diagnosis, and treatment strategies.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"106508"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation.","authors":"Xiao-Mei Wang, Ze Dai, Dai-Jun Lu, Chao-Qun Bao, Nai-Bin Yang, Yu-Ping Zhou","doi":"10.3748/wjg.v31.i17.105438","DOIUrl":"10.3748/wjg.v31.i17.105438","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a prominent and pervasive global health challenge. Bicuculline (BIC), which is a key active component of the anti-MASLD prescription \"Eight Zhes Decoction\", has been preliminarily shown by our research team to have significant potential in treating MASLD.</p><p><strong>Aim: </strong>To determine BIC's efficacy in treating MASLD by regulating lipid metabolism and suppressing hepatic inflammation <i>via</i> nuclear factor-kappa B (NF-κB) pathway, identifying it as a therapeutic candidate.</p><p><strong>Methods: </strong>This study explored the potential of BIC in preventing and treating MASLD using zebrafish, cellular (HepG2 and AML12), and mouse models.</p><p><strong>Results: </strong>Our results indicate that BIC significantly reduces lipid accumulation and inflammation both <i>in vivo</i> and <i>in vitro</i>. Transcriptomic analysis suggested that the anti-MASLD effects of BIC are linked to the inhibition of the NF-κB pathway, which plays a critical role in mitigating inflammation and lipid deposition.</p><p><strong>Conclusion: </strong>This study is the first to demonstrate that BIC specifically alleviates lipid accumulation and hepatic steatosis in MASLD models <i>via</i> the NF-κB signaling pathway. Overall, BIC has emerged as a promising candidate for treating MASLD.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"105438"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vonoprazan and proton pump inhibitors: Which is superior for <i>Helicobacter pylori</i> eradication?","authors":"Mubin Ozercan, Ahmed Tawheed, Alaa Ismail, Mohab Sherif Amer, Mohamed El-Kassas","doi":"10.3748/wjg.v31.i17.103156","DOIUrl":"10.3748/wjg.v31.i17.103156","url":null,"abstract":"<p><p><i>Helicobacter pylori</i> is a worldwide health problem; therefore, eradicating this bacterium is important for the health and economic status of the whole world. There are a variety of anti-secretory and antibiotic combinations for this purpose; however, antibiotic resistance is a major barrier to achieving an appropriate eradication rate (> 90%). Blockage of gastric acid is the main supportive factor of the antibiotic effect on bacteria. Therefore, anti-secretory therapy with high efficacy and safety profiles should be used in eradication regimens. Vonoprazan (VPZ), a member of the potassium competitive acid blockers, is a novel agent with a potent anti-secretory effect. The present study aimed to summarize comparative and safety studies of VPZ and proton pump inhibitors (PPIs), especially the efficacy on <i>Helicobacter pylori</i> eradication. VPZ was reported to have a higher efficacy and safety profile in most studies that compared VPZ-based and PPI-based regimens for eradication therapy. Despite its greater cost, the effectiveness of VPZ emerges as a viable and cost-effective alternative to PPI on gastric acid-related pathologies.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"103156"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride-glucose index as a prognostic indicator in advanced gastric cancer: Insights and future research.","authors":"Cheng-Fei Zhao, Xiao-Ling Liu, Ning-Bi Wu, Zhi-Feng Xu","doi":"10.3748/wjg.v31.i17.104794","DOIUrl":"10.3748/wjg.v31.i17.104794","url":null,"abstract":"<p><p>Gastric cancer (GC), the fifth most common malignancy worldwide, poses a substantial challenge in clinical oncology, particularly in its advanced stages. Despite advancements in immunotherapy, patient prognosis remains poor, underscoring the need for reliable prognostic tools to refine treatment strategies. A study by Yao <i>et al</i> explores the role of the triglyceride-glucose (TyG) index as a prognostic marker for advanced GC patients receiving immunotherapy combined with chemotherapy. The results of the study demonstrate that the TyG index correlates with improved survival outcomes, including better progression-free survival and overall survival. This editorial critically evaluates the significance of these findings, discusses their implications for future research, and highlights innovative directions that could drive further breakthroughs in the application of the TyG index to cancer therapy. This editorial also highlights the potential of TyG in advancing precision oncology and advocates for global validation and mechanistic investigations to further solidify its clinical utility. Future research should focus on validating the TyG index across various malignancies, exploring its potential to influence immunotherapy through metabolic interventions, and developing multi-biomarker models that integrate TyG with immune and genomic profiles.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"104794"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study.","authors":"Yan-Ping Wu, Jia-Xuan Zhou, Hong-Bo Wu, Di-Ping Wu, Ling-Zhi Qin, Bin Qin, Xiao-Yu Xu, Saleh Abdulaziz Abdulgani Yehya, Yan Cheng","doi":"10.3748/wjg.v31.i17.105281","DOIUrl":"10.3748/wjg.v31.i17.105281","url":null,"abstract":"<p><strong>Background: </strong>Reflux hypersensitivity (RH) constitutes roughly 14% of patients with heartburn and 34% of those with refractory heartburn, yet it is inadequately comprehended.</p><p><strong>Aim: </strong>To investigate the clinical characteristics and risk factors associated with RH.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 109 patients with RH and 384 healthy controls from three medical centers between January 2022 and December 2023. Comprehensive data encompassing symptoms, motility, impedance-pH monitoring, and psychological evaluations were collected.</p><p><strong>Results: </strong>RH patients encountered a greater frequency of weakly acidic reflux (WAR) events compared to acidic reflux or nonacidic reflux (NAR) events. Upright reflux time (1.22%) exceeds supine reflux time (0.54%) (<i>P</i> < 0.05). Extraesophageal symptoms were more prevalent among younger patients and those with elevated NAR (<i>P</i> < 0.05). The acidic reflux, WAR, NAR, and peristaltic contraction break length in male patients exceeded those in female patients (<i>P</i> < 0.05). Age [odds ratio (OR) = 5.633], hiatal hernia (OR = 13.103), and anxiety (OR = 17.342) constituted independent risk factors for RH.</p><p><strong>Conclusion: </strong>WAR and NAR are pivotal in RH. Patients with increased NAR are more likely to experience extraesophageal symptoms. Age, hiatal hernia, and anxiety are significant independent risk factors for RH.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 17","pages":"105281"},"PeriodicalIF":4.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}