Yonsei Medical Journal最新文献_第2页

Comparative Safety of Intravenous Sedatives for Bronchoscopy: A Bayesian Network Meta-Analysis. 静脉注射镇静剂用于支气管镜检查的比较安全性：贝叶斯网络荟萃分析。

IF 2.8 4区医学

Yonsei Medical Journal Pub Date : 2026-04-01 DOI: 10.3349/ymj.2025.0275

Jonghoo Lee, Jae-Uk Song

{"title":"Comparative Safety of Intravenous Sedatives for Bronchoscopy: A Bayesian Network Meta-Analysis.","authors":"Jonghoo Lee, Jae-Uk Song","doi":"10.3349/ymj.2025.0275","DOIUrl":"10.3349/ymj.2025.0275","url":null,"abstract":"Purpose: The selection of sedatives for bronchoscopy procedures remains debated. This study evaluates the safety of intravenous midazolam, propofol, dexmedetomidine, and remimazolam as sedative agents during flexible bronchoscopy.Materials and methods: We conducted a Bayesian network meta-analysis (NMA) using PubMed, Embase, and the Cochrane Central Register. Between-group comparisons were estimated using odds ratios (ORs) with 95% credible intervals (95% CIs). Surface under the cumulative rank curve (SUCRA) plots were produced. The rate of hypoxemia was the primary outcome.Results: Twenty-four randomized controlled trials involving 4010 patients were included. Baseline variables were generally well balanced across sedative agents in the transitivity analysis, and the node-splitting approach demonstrated a high degree of concordance among the comparisons. The NMA results indicate that remimazolam was significantly associated with a lower rate of hypoxemia than midazolam (OR 0.36, 95% CI 0.18 to 0.79) and propofol (OR 0.33, 95% CI 0.16 to 0.69). Based on their SUCRA values, the ranking of the four sedative agents from most to least favorable was intravenous remimazolam, followed by dexmedetomidine, midazolam, and propofol. The probability of intravenous remimazolam being the most effective treatment was 93.4%. The SUCRA values also showed that midazolam had the lowest risk of hypotension (79.6%), and propofol had the lowest risk of bradycardia (90.4%).Conclusion: These NMA findings suggest that, in terms of reducing the risk of hypoxemia, intravenous remimazolam is the safest sedative agent for patients undergoing bronchoscopy.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"67 4","pages":"322-333"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep Learning for Automated Tumor Segmentation of Rectal Cancer on T2-Weighted Magnetic Resonance Images. 基于t2加权磁共振图像的直肠癌肿瘤自动分割的深度学习。

IF 2.8 4区医学

Yonsei Medical Journal Pub Date : 2026-04-01 DOI: 10.3349/ymj.2025.0133

Miri Seo, YongDae Lee, Myung-Won You

{"title":"Deep Learning for Automated Tumor Segmentation of Rectal Cancer on T2-Weighted Magnetic Resonance Images.","authors":"Miri Seo, YongDae Lee, Myung-Won You","doi":"10.3349/ymj.2025.0133","DOIUrl":"10.3349/ymj.2025.0133","url":null,"abstract":"Purpose: To develop a deep learning (DL)-based automated segmentation model for rectal cancer on T2-weighted (T2W) magnetic resonance (MR) images.Materials and methods: A total of 458 patients who underwent baseline rectal MR imaging were retrospectively enrolled. An experienced radiologist labeled the tumor on each slice of the selected T2W axial images covering the entire tumor mass, and tumor volume was measured during labeling. Another radiologist labeled the rectum on the same images. Attention U-Net was trained on the T2W images from the training dataset to classify each voxel as tumor or non-tumor. Segmentation with or without rectum guidance was compared using evaluation metrics, including the Dice similarity coefficient (DSC), in the test dataset.Results: The tumor segmentation DSC without rectum guidance was 73.35% (71.97-74.71); that with the predicted rectum was 71.79% (70.53-73.05); and that with the overlaid rectum was 75.52% (74.32-76.62), which was the highest among the three segmentation models. Tumor volume showed a positive correlation with tumor segmentation accuracy with the predicted rectum (r=0.333, p=0.001; overlaid rectum, r=0.319, p=0.002) and without rectum guidance (r=0.219, p=0.036).Conclusion: A DL-based automated segmentation model can predict RC with over 70% accuracy, which was further improved with overlaid rectum, and larger tumor volume.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"67 4","pages":"358-367"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short- and Long-Term Outcomes of Offspring According to Cerclage Placement in Twin Pregnancy: A National Cohort Study Over 15 Years. 双胎妊娠中环扎位置对后代的短期和长期影响：一项超过15年的国家队列研究。

IF 2.8 4区医学

Yonsei Medical Journal Pub Date : 2026-04-01 DOI: 10.3349/ymj.2025.0007

Ji-Hee Sung, Sooji Ham, Youri Lee, Danbee Kang, Hyejeong Park, Juhee Cho, Suk-Joo Choi, Cheong-Rae Roh, Soo-Young Oh

{"title":"Short- and Long-Term Outcomes of Offspring According to Cerclage Placement in Twin Pregnancy: A National Cohort Study Over 15 Years.","authors":"Ji-Hee Sung, Sooji Ham, Youri Lee, Danbee Kang, Hyejeong Park, Juhee Cho, Suk-Joo Choi, Cheong-Rae Roh, Soo-Young Oh","doi":"10.3349/ymj.2025.0007","DOIUrl":"10.3349/ymj.2025.0007","url":null,"abstract":"Purpose: To evaluate the short- and long-term outcomes of the offspring of twin pregnancies undergoing cerclage.Materials and methods: Using the Korean National Health Insurance Service database, we identified primigravid women who delivered live twins between January 2005 and December 2019. Women with a history of miscarriage, stillbirth, or prolonged hospitalization (>7 days post-cerclage) were excluded. The participants were grouped by gestational age at cerclage placement as follows: <16 weeks, 16-24 weeks, and >24 weeks. We calculated the adjusted odds ratios (OR) and hazard ratios (HR) for offspring outcomes, controlling for factors such as maternal age and Charlson index.Results: Among 89617 twin pregnancies, cerclage was associated with increased odds of preterm birth compared to no cerclage: OR: 2.45 [95% confidence interval (CI): 2.09-2.88] for <16 weeks, 1.35 (95% CI: 1.19-1.53) for 16-24 weeks, and 3.00 (95% CI: 2.43-3.69) for >24 weeks. The >24 week-group showed the highest neonatal composite morbidities (OR: 3.66; 95% CI: 2.93-4.56) and significantly elevated rates of bronchopulmonary dysplasia (OR: 11.64; 95% CI: 8.22-16.49) and intraventricular hemorrhage (OR: 8.36; 95% CI: 3.40-20.56). Regarding long-term outcomes, the >24 week-group also had higher HR for autism (2.44), attention-deficit/hyperactivity disorder (2.23), and cerebral palsy (6.39).Conclusion: Cerclage performed after 24 weeks in twin pregnancies is linked to adverse short- and long-term outcomes in offspring, suggesting that late cerclage should be avoided when possible.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"67 4","pages":"341-348"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adequacy Criteria for Thyroid Fine-Needle Aspiration in the Era of the Bethesda Reporting System. Bethesda报告系统时代甲状腺细针穿刺的充分性标准。

IF 2.8 4区医学

Yonsei Medical Journal Pub Date : 2026-04-01 DOI: 10.3349/ymj.2025.0257

Jin Young Kwak, Sangwoo Cho, Hye Sun Lee, Jung Hyun Yoon, Syed Z Ali, Soon Won Hong

{"title":"Adequacy Criteria for Thyroid Fine-Needle Aspiration in the Era of the Bethesda Reporting System.","authors":"Jin Young Kwak, Sangwoo Cho, Hye Sun Lee, Jung Hyun Yoon, Syed Z Ali, Soon Won Hong","doi":"10.3349/ymj.2025.0257","DOIUrl":"10.3349/ymj.2025.0257","url":null,"abstract":"Purpose: There is a lack of consensus and data validating lower cell counts for sample adequacy of thyroid fine-needle aspiration (FNA). We investigated less stringent adequacy thresholds under the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) and evaluated malignancy risks for \"nondiagnostic\" nodules by ultrasound features.Materials and methods: A total of 2459 nodules with initial FNA were included. We built 11 new adequacy criteria based on the number of cell groups and total follicular epithelial cells. Diagnostic performance of each criterion was compared with the original criterion using the general estimating equation. Nondiagnostic nodules under each criterion were categorized by the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TIRADS), and malignancy rates of each ACR TIRADS category were compared.Results: Malignancy rates of nondiagnostic nodules were under 3.5% across all criteria, and showed no significant differences compared with the original. More than 40 cells, regardless of cell group, or more than three cell groups showed no significant difference in diagnostic accuracy and false negative rates compared with the original criterion. Malignancy rates of nondiagnostic nodules were above 28.6% for ACR TIRADS 5, and below 5% for ACR TIRADS 1 to 4, in all criteria.Conclusion: Less stringent thresholds for sample adequacy can show comparable diagnostic performances to the original criterion of the TBSRTC. Given their markedly higher malignancy rates, nondiagnostic ACR TIRADS 5 nodules may warrant more active management than lower category nodules.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"67 4","pages":"314-321"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunological Basis of Chronic Spontaneous Urticaria: Immunoglobulin E and Beyond. 慢性自发性荨麻疹的免疫学基础：免疫球蛋白E及以上。

IF 2.8 4区医学

Yonsei Medical Journal Pub Date : 2026-04-01 DOI: 10.3349/ymj.2025.0369

Hyo-In Rhyou, Young-Hee Nam, Jung-Won Park, Hae-Sim Park

{"title":"Immunological Basis of Chronic Spontaneous Urticaria: Immunoglobulin E and Beyond.","authors":"Hyo-In Rhyou, Young-Hee Nam, Jung-Won Park, Hae-Sim Park","doi":"10.3349/ymj.2025.0369","DOIUrl":"10.3349/ymj.2025.0369","url":null,"abstract":"Chronic spontaneous urticaria (CSU) is associated with a substantial disease burden due to its prolonged course and significant impairment of quality of life. The diagnostic process for CSU involves confirming the diagnosis itself and identifying disease phenotypes or endotypes, cofactors, and comorbid conditions, which may affect disease activity and severity. Immunoglobulin E (IgE) and non-IgE-mediated mast cell degranulation are the major pathogenic mechanisms of CSU, where FcεRIα, a high-affinity IgE receptor, is the critical therapeutic target. Although the first-line treatment for CSU is typically second-generation H1-antihistamines, anti-IgE antibodies are recommended for patients who are refractory to up-dosed antihistamines. However, some patients with autoimmune phenotypes show incomplete responses. Recently, dupilumab, an anti-interleukin (IL)-4/IL-13 receptor antibody that inhibits type 2 inflammation, was approved by the US Food and Drug Administration. Patients with autoimmune phenotypes treated with Bruton's tyrosine kinase inhibitors have shown promising efficacy. Additionally, emerging biological agents, such as anti-KIT antibodies targeting mast cell activation and survival, and novel anti-IgE therapies (e.g., YH35324), are currently under investigation and are anticipated to become potential therapeutic options. This review provides an update on the pathogenic mechanisms of CSU, including IgE- and non-IgE-mediated mechanisms, and suggests potential therapeutic targets for improving clinical remission rates.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"67 4","pages":"287-296"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Rabeprazole for Gastrointestinal Protection in Acute Coronary Syndrome Patients Treated with Aspirin and Ticagrelor: A Pilot Study. 评价雷贝拉唑对阿司匹林和替格瑞洛联合治疗的急性冠脉综合征患者胃肠道保护作用：一项初步研究。

IF 2.8 4区医学

Yonsei Medical Journal Pub Date : 2026-04-01 DOI: 10.3349/ymj.2025.0232

Hye Kyung Hyun, Oh-Hyun Lee, Ji Woong Roh, Seok-Jae Heo, Cheal Wung Huh, Yongcheol Kim

{"title":"Evaluation of Rabeprazole for Gastrointestinal Protection in Acute Coronary Syndrome Patients Treated with Aspirin and Ticagrelor: A Pilot Study.","authors":"Hye Kyung Hyun, Oh-Hyun Lee, Ji Woong Roh, Seok-Jae Heo, Cheal Wung Huh, Yongcheol Kim","doi":"10.3349/ymj.2025.0232","DOIUrl":"10.3349/ymj.2025.0232","url":null,"abstract":"Purpose: Patients with acute coronary syndrome (ACS) on ticagrelor-based dual antiplatelet therapy (DAPT) have an increased risk of gastrointestinal (GI) bleeding. However, evidence supporting the protective role of proton pump inhibitors against DAPT-induced gastric mucosal injury remains limited.Materials and methods: This was a single-center, prospective, open-label, observational trial enrolling patients with ACS who were treated with DAPT, specifically aspirin and ticagrelor, following percutaneous coronary intervention in South Korea. Participants received 20 mg rabeprazole once daily for 8 weeks. The primary outcome was the proportion of patients exhibiting a modified Lanza score (MLS) of 0-5 on upper endoscopy at 8 weeks compared to baseline endoscopy results. The secondary outcomes included GI symptom scores and safety assessments.Results: Among the 50 patients included in the per-protocol analysis, the median MLS at baseline and 8 weeks was 2.0 (1.0-2.0) and 2.0 (1.0-2.0), respectively, with no significant change (p=0.69). Similarly, in patients at high-risk for GI bleeding (76.0%, 38/50), there was no significant difference in MLS after 8 weeks of treatment with rabeprazole compared to the baseline MLS, consistent with the results of the overall study population. GI symptom scores, including the Nepean Dyspepsia Index-Korean, Gastroesophageal Reflux Disease (GERD) Questionnaire, and GERD Health-Related Quality of Life Questionnaires, showed no significant changes from baseline in the overall cohort and high-risk groups. No major bleeding or adverse cardiac events were observed.Conclusion: In this pilot study, rabeprazole was associated with maintained gastric mucosal integrity in patients with ACS receiving ticagrelor-based DAPT.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"67 4","pages":"306-313"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of Type 2 Diabetes Mellitus in New Users of 5-Alpha Reductase Inhibitors: A Nationwide Historical Cohort Study. 5- α还原酶抑制剂新使用者患2型糖尿病的风险：一项全国历史队列研究

IF 2.8 4区医学

Yonsei Medical Journal Pub Date : 2026-04-01 DOI: 10.3349/ymj.2025.0056

Minh-Ha Nguyen, Juyeon Ko, Jaelim Cho

{"title":"Risk of Type 2 Diabetes Mellitus in New Users of 5-Alpha Reductase Inhibitors: A Nationwide Historical Cohort Study.","authors":"Minh-Ha Nguyen, Juyeon Ko, Jaelim Cho","doi":"10.3349/ymj.2025.0056","DOIUrl":"10.3349/ymj.2025.0056","url":null,"abstract":"Purpose: Recent large-scale studies have investigated the risk of type 2 diabetes mellitus (T2DM) associated with the use of 5-alpha reductase inhibitors (5-ARIs) in benign prostatic hyperplasia (BPH) patients, but heterogeneous findings have been reported. This study aimed to examine the risk of T2DM associated with 5-ARIs (finasteride and dutasteride) compared to tamsulosin.Materials and methods: We identified nationwide cohorts of new users of finasteride, dutasteride, and tamsulosin without a history of prescriptions for 5-ARIs or tamsulosin within the previous 3 years among patients covered by national health insurance between 2010 to 2020 in South Korea. Patients were free of T2DM and had received at least 90 days of dispensation of the medications. We balanced cohorts on risk factors for T2DM based on age, health insurance status, index year, comorbidities, and co-medications using stabilized inverse probability of treatment weighting. Adjusted hazard ratios (HRs) were estimated using Cox proportional hazards models, with censoring for treatment discontinuation, switching, or augmentation, end of enrollment, and death.Results: A total of 34874 tamsulosin users, 16953 finasteride users, and 19480 dutasteride users were included. The adjusted HR for finasteride was 1.06 [95% confidence interval (CI), 1.01-1.11] and that for dutasteride was 0.97 (95% CI, 0.92-1.02), when compared with tamsulosin users. These estimates were consistent in lag time analyses and attenuated among patients with good compliance.Conclusion: This study suggests minimal effects of finasteride and dutasteride on the risk of T2DM when compared with tamsulosin among patients with BPH.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"67 4","pages":"368-376"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined Effect of Toothbrushing and Interdental Cleaning on the Risk of Dementia. 刷牙和牙间清洁对痴呆风险的联合作用。

IF 2.8 4区医学

Yonsei Medical Journal Pub Date : 2026-03-01 DOI: 10.3349/ymj.2025.0156

Yong-Jin Lee, Hyeonjeong Go, Kyunghun Kang, Masae Kuboniwa, Young-Eun Lee, Youn-Hee Choi

{"title":"Combined Effect of Toothbrushing and Interdental Cleaning on the Risk of Dementia.","authors":"Yong-Jin Lee, Hyeonjeong Go, Kyunghun Kang, Masae Kuboniwa, Young-Eun Lee, Youn-Hee Choi","doi":"10.3349/ymj.2025.0156","DOIUrl":"10.3349/ymj.2025.0156","url":null,"abstract":"Purpose: Systemic inflammation contributes to dementia risk by promoting amyloid beta production and enhancing brain neurotoxicity. While oral hygiene is key in managing inflammation, few studies have assessed the combined effect of toothbrushing frequency and interdental cleaning on dementia risk. This study examined the association between oral hygiene behaviors and dementia onset among older Korean adults.Materials and methods: A retrospective cohort study followed participants for 11 years using data from the National Health Insurance Service-National Health Information Database. Kaplan-Meier estimates computed cumulative incidence probabilities, and differences between oral hygiene groups were evaluated using the log-rank test. Cox proportional hazards models were applied to evaluate the impact of oral hygiene behaviors on dementia incidence, estimating the hazard ratio (HR) and 95% confidence interval (CI).Results: Higher frequency of toothbrushing and interdental cleaning device use were each significantly associated with reduced dementia risk [\"≥3 times toothbrushing daily,\" adjusted HR (aHR)=0.85; \"always using interdental cleaning devices,\" aHR=0.89], though no clear linear dose-response pattern was observed. Combined frequent toothbrushing and interdental cleaning showed a further risk reduction [\"≥2 times toothbrushing with interdental cleaning (always or sometimes),\" aHR=0.75], regardless of dementia type. Professional dental cleaning within 1 year (aHR=0.88) and always brushing before sleep (aHR=0.82) were also associated with lower risk.Conclusion: Proper oral hygiene practices, especially toothbrushing combined with interdental cleaning, were associated with a lower risk of dementia.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"67 3","pages":"259-268"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12936508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Sarcopenia on Renal Outcomes in Patients with Septic Acute Kidney Injury: A Retrospective Cohort Study. 脓毒性急性肾损伤患者肌肉减少症对肾脏预后的影响：一项回顾性队列研究。

IF 2.8 4区医学

Yonsei Medical Journal Pub Date : 2026-03-01 DOI: 10.3349/ymj.2024.0495

Hyung Jung Oh, Jung Ho Kim, Yun Ho Roh, Jin Young Ahn, Su Jin Jeong, Jun Yong Choi, Joon-Sup Yeom, Nam Su Ku

{"title":"Impact of Sarcopenia on Renal Outcomes in Patients with Septic Acute Kidney Injury: A Retrospective Cohort Study.","authors":"Hyung Jung Oh, Jung Ho Kim, Yun Ho Roh, Jin Young Ahn, Su Jin Jeong, Jun Yong Choi, Joon-Sup Yeom, Nam Su Ku","doi":"10.3349/ymj.2024.0495","DOIUrl":"10.3349/ymj.2024.0495","url":null,"abstract":"Purpose: Despite the high prevalence of sarcopenia and the significant burden of septic acute kidney injury (AKI), the impact of sarcopenia on renal outcomes in patients with septic AKI has not been studied. Therefore, we aimed to evaluate the effect of sarcopenia on the renal prognosis of patients with septic AKI.Materials and methods: This retrospective study enrolled patients with septic AKI between July 2008 and March 2019. Sarcopenia was identified by measuring the total abdominal muscle area using abdominal CT. Patients were divided into sarcopenia and non-sarcopenia groups. The effect of sarcopenia on 90-day renal outcomes, including a >50% decrease in the estimated glomerular filtration rate, dialysis dependence, and requirement for continuous renal replacement therapy within 90 days, was analysed. Additionally, the effect of sarcopenia on 90-day mortality was assessed.Results: Of the 608 enrolled patients with septic AKI, 273 (44.9%) were assigned to the sarcopenia group. At baseline, there were no significant differences in the severity score and distribution of AKI stages between the two groups. There was no significant between-group difference in the 90-day renal outcomes. Moreover, sarcopenia was not associated with 90-day renal outcomes across all AKI stages in stratified multivariable logistic analysis. In contrast, the 90-day mortality rates were significantly higher in the sarcopenia group than in the non-sarcopenia group (30.0% vs. 17.3%, respectively; p<0.001).Conclusion: Sarcopenia was significantly associated with an increased 90-day mortality rate; however, no significant association with 90-day renal progression was observed in patients with septic AKI.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"67 3","pages":"198-205"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12936507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Work of Oliver R. Avison and His Ecumenical Spirit. 奥利弗·艾维森的著作和他的大公精神。

IF 2.8 4区医学

Yonsei Medical Journal Pub Date : 2026-03-01 DOI: 10.3349/ymj.2025.0086

Meehyun Chung

引用次数: 0