Yonsei Medical Journal最新文献

{"title":"Serum 25(OH)D Levels and Risk of Nonalcoholic Fatty Liver Disease in Nonobese and Lean Individuals.","authors":"Nam Hee Kim, Ji Hun Kang","doi":"10.3349/ymj.2024.0065","DOIUrl":"https://doi.org/10.3349/ymj.2024.0065","url":null,"abstract":"<p><strong>Purpose: </strong>The impact of vitamin D deficiency on nonalcoholic fatty liver disease (NAFLD) risk in individuals without obesity or insulin resistance has not been thoroughly evaluated. We aimed to identify whether low serum levels of 25(OH)D independently contribute to NAFLD risk in nonobese or lean individuals.</p><p><strong>Materials and methods: </strong>This study analyzed 241208 asymptomatic health check-up examinees who had abdominal ultrasonography. NAFLD risk was evaluated based on obesity status and serum 25(OH)D levels.</p><p><strong>Results: </strong>The overall NAFLD prevalence was 25.5%. Among the 178630 nonobese and 126909 lean participants, the prevalence rates were 13.4% and 6.7%, respectively. The multivariable adjusted odds ratios (ORs) [95% confidence intervals (CI)] for the prevalence of NAFLD, comparing serum 25(OH)D levels of 10-19 and ≥20 ng/mL with <10 ng/mL, were 0.96 (0.93-0.99) and 0.80 (0.77-0.83), respectively. Among nonobese participants, the corresponding adjusted ORs (95% CI) were 0.94 (0.90-0.99) and 0.77 (0.73-0.81), respectively. Similar results were observed among lean participants, with those having a 25(OH)D level of ≥20 ng/mL demonstrating a significantly lower odds of NAFLD (adjusted OR, 0.76; 95% CI, 0.70-0.83). Moreover, these results were consistent even among nonobese and lean individuals who showed no signs of insulin resistance.</p><p><strong>Conclusion: </strong>Insufficient 25(OH)D levels independently increased the risk of NAFLD, suggesting its role in the NAFLD pathogenesis, regardless of obesity or insulin resistance status. Considering the established relationship between vitamin D deficiency and nonobese/lean NAFLD, maintaining adequate 25(OH)D levels may aid in preventing the development of NAFLD, even among nonobese or lean individuals.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 5","pages":"269-276"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tocilizumab for Patients with Severe Fever with Thrombocytopenia Syndrome: Tocilizumab Observational SFTS Study-1.","authors":"Jeong Rae Yoo, Misun Kim, Myeong Jin Kang, Sora Kim, Keun Hwa Lee, Sang Taek Heo","doi":"10.3349/ymj.2024.0209","DOIUrl":"https://doi.org/10.3349/ymj.2024.0209","url":null,"abstract":"<p><p>There is no established treatment for severe fever with thrombocytopenia syndrome (SFTS). However, the potential role of tocilizumab (TCZ) in cytokine storm modulation warrants further investigation. In this study, we aimed to investigate the therapeutic potential of TCZ in adult patients with SFTS and provide valuable insights into the development of effective treatment strategies for this challenging infectious disease by assessing the impact of TCZ on cytokine dynamics and patient outcomes. This prospective longitudinal observational study included adult patients with SFTS at a teaching hospital in Korea between April 2013 and December 2023. Patients with SFTS and interleukin (IL)-6 levels ≥30 ng/mL received TCZ. The 14- and 28-day mortality rates were compared between the TCZ and therapeutic plasma exchange (TPE) groups during the study period. Among the total of 97 patients, the clinical characteristics showed no significant differences between the TCZ (n=10) and TPE groups (n=30). Compared with TPE, TCZ treatment showed a trend towards lower mortality rate (14-day mortality rate: 10.0% vs. 16.7%, <i>p</i>=0.608; 28-day mortality rate: 10.0% vs. 20.0%, <i>p</i>=0.480). Both treatments showed the potential to reduce the viral load and IL-6 levels, indicating their efficacy in managing the disease course. TCZ is a potential therapeutic option for SFTS as it modulates IL-6 levels and improves clinical outcomes.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 5","pages":"321-327"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors Associated with Middle Ear Barotrauma in Patients Undergoing Monoplace Hyperbaric Oxygen Therapy.","authors":"Yoon Sung Lee, Sang Won Ko, Hyoung Youn Lee, Kyung Hoon Sun, Tag Heo, Sung Min Lee","doi":"10.3349/ymj.2024.0068","DOIUrl":"https://doi.org/10.3349/ymj.2024.0068","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to identify independent risk factors for middle ear barotrauma (MEB) symptoms in patients undergoing monoplace hyperbaric oxygen therapy (HBOT).</p><p><strong>Materials and methods: </strong>We analyzed data from a single-center study involving 296 patients who received monoplace HBOT. Through multivariable logistic regression analysis, we examined the relationship between various factors and the occurrence of MEB to identify significant independent risk factors.</p><p><strong>Results: </strong>The multivariable logistic regression analysis indicated that an altered mental state was associated with increased odds of MEB occurrence [odds ratio (OR) 2.50; 95% confidence interval (CI): 1.13-5.51]. Furthermore, patients in the emergency treatment group for HBOT, as defined by the national health insurance in Korea, were found to be 6.75 times more likely to experience MEB (95% CI: 1.33-34.20).</p><p><strong>Conclusion: </strong>This study identified altered mental status and classification in the emergency treatment group for monoplace HBOT as independent risk factors for MEB. These findings can aid in developing safer protocols for monoplace HBOT chamber operations.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 5","pages":"302-309"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Failure to Eradicate Infection after Single Arthroscopic Debridement in Septic Arthritis of a Native Knee Joint.","authors":"Junwoo Byun, Min Jung, Kwangho Chung, Se-Han Jung, Hyeokjoo Jang, Chong-Hyuk Choi, Sung-Hwan Kim","doi":"10.3349/ymj.2024.0190","DOIUrl":"https://doi.org/10.3349/ymj.2024.0190","url":null,"abstract":"<p><strong>Purpose: </strong>To identify the risk factors and effect of empirical glycopeptide on the failure of single arthroscopic debridement for septic knee arthritis in a native knee joint.</p><p><strong>Materials and methods: </strong>Patients who underwent arthroscopic debridement for septic knee arthritis from March 2005 to December 2022 at one institution were included in this study. Demographic data, comorbidities, preoperative factors including history of previous surgery, history of injection, laboratory data including preoperative C-reactive protein (CRP) and white blood cell (WBC) count, isolated pathogens from synovial fluid culture, and Gachter stage were analyzed. Statistical analyses using univariate and logistic regression were performed.</p><p><strong>Results: </strong>Out of 132 patients, 17 patients (12.9%) had more than one additional arthroscopic debridement. History of diabetes mellitus (DM) (<i>p</i><0.001), previous injection (<i>p</i>=0.041), isolated <i>Staphylococcus aureus</i> in synovial fluid (<i>p</i>=0.010), and high Gachter stage (<i>p</i>=0.002) were identified as risk factors, whereas age, history of previous knee surgery at the affected knee, CRP level, preoperative WBC, and preoperative neutrophil count of synovial fluid had no significant relation. Logistic regression analysis showed significant increase of risk in patients with DM [odds ratio (OR) 12.002, 95% confidence interval (CI) 3.243-44.418, <i>p</i><0.001], previous injection history (OR 4.812, 95% CI 1.367-16.939, <i>p</i>=0.017), and isolation of <i>Staphylococcus aureus</i> in synovial fluid (OR 4.804, 95% CI 1.282-18.001, <i>p</i>=0.031) as independent risk factors for failure of infection eradication after single arthroscopic debridement.</p><p><strong>Conclusion: </strong>Comorbidity of DM, history of previous injection, isolated <i>Staphylococcus aureus</i> in synovial fluid, and high Gachter stage were associated with a higher risk of failure to eradicate infection with a single arthroscopic procedure. Empirical glycopeptide administration also showed no significant benefit in reducing the risk of additional surgical procedures for infection control, suggesting against the routine administration of glycopeptide.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 5","pages":"295-301"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Approaches in Tracheal Resection and Anastomosis Surgery: Integrating Extracorporeal Membrane Oxygenation for Enhanced Safety.","authors":"Joohyung Son, Bong Soo Son, Jong Myung Park, Jeong Su Cho, Yeongdae Kim, Hoseok I, Do Hyung Kim","doi":"10.3349/ymj.2024.0236","DOIUrl":"https://doi.org/10.3349/ymj.2024.0236","url":null,"abstract":"<p><strong>Purpose: </strong>Tracheal resection with end-to-end anastomosis (TREE) has many advantages over conservative treatment in terms of long-term results; however, this method requires improved safety and accessibility. We aimed to combine expanded venovenous extracorporeal membrane oxygenation (ECMO) during TREE surgery.</p><p><strong>Materials and methods: </strong>Between May 2006 and December 2022, 41 patients diagnosed with tracheal stenosis or tracheal tumors underwent TREE. The non-ECMO and ECMO groups were classified based on the presence or absence of intraoperative ECMO support.</p><p><strong>Results: </strong>Reconstruction length was slightly longer in the ECMO group than in the non-ECMO group, but there was no statistical significance (<i>p</i>=0.082). There was no significant difference between the two groups in terms of operative time (<i>p</i>=0.698), estimated blood loss (<i>p</i>=0.210), and duration of mechanical ventilation (<i>p</i>=0.713). There was a significant difference in intensive care unit stay between the two groups (<i>p</i>=0.013) due to the postoperative maintenance of ECMO. There were no cases of early mortality in either group during hospitalization (<i>p</i>>0.999).</p><p><strong>Conclusion: </strong>ECMO support could assist in more challenging cases as it makes surgery easier in difficult patient scenarios.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 5","pages":"289-294"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixture of Mastic Gum and Peppermint Extracts Promotes Hair Growth and Health in Vitro and in C57BL/6 Mice.","authors":"Seoyoon Ham, Young In Lee, Yujin Jang, Sang Gu Lee, Jangmi Suk, Inhee Jung, Jae Hyun Park, Ju Hee Lee","doi":"10.3349/ymj.2024.0100","DOIUrl":"https://doi.org/10.3349/ymj.2024.0100","url":null,"abstract":"<p><strong>Purpose: </strong>Hair disorders, which are often attributed to conditions associated with a shortened anagen growth phase, oxidative stress, and hormonal dysregulation, especially during aging, have profound psychological implications. Currently, only minoxidil has been approved as a topical hair growth solution; thus, alternative therapies for treating hair loss and promoting hair health are urgently needed. Herein, we aimed to develop and assess a novel method to promote hair growth and health using mastic (Pistacia lentiscus) gum and peppermint (Mentha piperita L.) extracts.</p><p><strong>Materials and methods: </strong>After determining the optimal ratio of mastic gum and peppermint extracts, we performed in vitro and in vivo experiments to verify the efficacy of the 7:3 mastic gum-peppermint mixture (MP73; FHH-MG) for enhancing hair growth and health.</p><p><strong>Results: </strong>Mastic gum significantly promoted cell proliferation and demonstrated synergistic benefits when combined with peppermint extract. In vitro, FHH-MG increased human dermal follicle papilla cell proliferation and demonstrated anti-inflammatory and antioxidant effects. In vivo, treatment with FHH-MG dose-dependently enhanced hair growth and gloss and increased the expression of vascular endothelial growth factor, epidermal growth factor, β-catenin, and insulin-like growth factor-1 in C57BL/6 mice compared to the negative control.</p><p><strong>Conclusion: </strong>The novel mixture exhibited hair growth-promoting effects in C57BL/6 mice; thus, FHH-MG may serve as a botanical alternative for hair growth and health promotion.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 5","pages":"310-320"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Learning-Based Computer-Aided Diagnosis in Coronary Artery Calcium-Scoring CT for Pulmonary Nodule Detection: A Preliminary Study.","authors":"Seung Yun Lee, Ji Weon Lee, Jung Im Jung, Kyunghwa Han, Suyon Chang","doi":"10.3349/ymj.2024.0050","DOIUrl":"10.3349/ymj.2024.0050","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the feasibility and utility of deep learning-based computer-aided diagnosis (DL-CAD) for the detection of pulmonary nodules on coronary artery calcium (CAC)-scoring computed tomography (CT).</p><p><strong>Materials and methods: </strong>This retrospective study included 273 patients (aged 63.9±13.2 years; 129 men) who underwent CAC-scoring CT. A DL-CAD system based on thin-section images was used for pulmonary nodule detection, and two independent junior readers reviewed the standard CAC-scoring CT scans with and without referencing DL-CAD results. A reference standard was established through the consensus of two experienced radiologists. Sensitivity, positive predictive value, and F1-score were assessed on a per-nodule and per-patient basis. The patients' medical records were monitored until November 2023.</p><p><strong>Results: </strong>A total of 269 nodules were identified in 129 patients. With DL-CAD assistance, the readers' sensitivity significantly improved (65% vs. 80% for reader 1; 82% vs. 86% for reader 2; all <i>p</i><0.001), without a notable increase in the number of false-positives per case (0.11 vs. 0.13, <i>p</i>=0.078 for reader 1; 0.11 vs. 0.11, <i>p</i>>0.999 for reader 2). Per-patient analysis also enhanced sensitivity with DL-CAD assistance (73% vs. 84%, <i>p</i><0.001 for reader 1; 89% vs. 91%, <i>p</i>=0.250 for reader 2). During follow-up, lung cancer was diagnosed in four patients (1.5%). Among them, two had lesions detected on CAC-scoring CT, both of which were successfully identified by DL-CAD.</p><p><strong>Conclusion: </strong>DL-CAD based on thin-section images can assist less experienced readers in detecting pulmonary nodules on CAC-scoring CT scans, improving detection sensitivity without significantly increasing false-positives.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 4","pages":"240-248"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Factors for Increased Bone Density Following Romosozumab Administration Based on Pre-Administration Blood Test Results.","authors":"Akira Kuwabara, Kazuhide Inage, Masaomi Yamashita, Sumihisa Orita, Yawara Eguchi, Yasuhiro Shiga, Masahiro Inoue, Miyako Suzuki-Narita, Takahisa Hishiya, Takahito Arai, Noriyasu Toshi, Kohei Okuyama, Soichiro Tokeshi, Susumu Tashiro, Shuhei Ohyama, Noritaka Suzuki, Seiji Ohtori","doi":"10.3349/ymj.2023.0535","DOIUrl":"10.3349/ymj.2023.0535","url":null,"abstract":"<p><strong>Purpose: </strong>Romosozumab reportedly increases bone density in patients with severe osteoporosis; however, data on its clinical effects are limited. We conducted a multicenter retrospective survey to study the bone density-increasing effects of romosozumab and blood test-based predictive factors in patients with severe osteoporosis, examining its effects in clinical practice.</p><p><strong>Materials and methods: </strong>This was a multicenter retrospective observational study. The subjects were patients with severe osteoporosis who were treated with romosozumab at the participating facilities. The increase in bone density was assessed by comparing bone density changes (as a percentage) in the lumbar spine, femoral neck, and total femur before and 12 months after administration using dual-energy X-ray absorptiometry. The association between changes in bone density at each site and pre-treatment bone metabolism markers (Tracp 5b, P1NP), serum calcium levels, nutritional status [Conut score: albumin, total cholesterol (T-Cho), and total lymphocyte count], and kidney function (eGFR) was assessed.</p><p><strong>Results: </strong>In both naïve patients and those switching from bone resorption inhibitors, the bone density increased significantly. In naïve patients, eGFR were positively associated with bone density in the total femur. In cases of switching from bone resorption inhibitors, correlations were found between Tracp 5b and lumbar spine bone mineral density (BMD), as well as between Tracp 5b, Alb, T-Cho, and eGFR in the total femur BMD.</p><p><strong>Conclusion: </strong>Romosozumab administration significantly increases bone density in osteoporosis, and assessing key predictive factors is necessary to ensure clinical effectiveness.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 4","pages":"226-232"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the Administration of Cautionary Drugs on the Risk of Worsening Myasthenia Gravis: A Retrospective Matched Case-Control Study.","authors":"Hee Jo Han, Seung Woo Kim, Myeongjee Lee, Hye Rim Kim, Yun Ho Roh, Ha Young Shin","doi":"10.3349/ymj.2024.0017","DOIUrl":"10.3349/ymj.2024.0017","url":null,"abstract":"<p><strong>Purpose: </strong>Although some medications trigger the worsening of myasthenia gravis (MG), their clinical influence on patients with MG has not been significantly evaluated. We aimed to investigate whether the risk of clinical worsening of MG increases after administering cautionary drugs in patients with MG.</p><p><strong>Materials and methods: </strong>This retrospective case-control study was based on the medical records of patients diagnosed with MG between 2007 and 2020. We analyzed the risk of MG worsening in patients exposed to cautionary drugs during the risk period, defined as 6 months from the first exposure to cautionary drugs. The risk of MG worsening in the exposed patients was compared to that in the non-exposed patients, who were individually matched in a 1:1 ratio with exposed cases for sex, age, thymoma, and autoantibodies.</p><p><strong>Results: </strong>Of the 2002 patients diagnosed with MG, 552 (27.6%) were exposed to cautionary drugs. Neuromuscular blocking agents (320 patients) and beta blockers (66123 person-days) were the most frequently prescribed medications. After exact matching, 220 exposed and 220 non-exposed patients were enrolled. The incidence rate of clinical worsening during the risk period was significantly higher in the exposed patients than in the non-exposed patients (odds ratio=4.09; 95% confidence interval, 1.88-8.90; <i>p</i><0.001). Clinical worsening was observed in 31 (14.1%) of the exposed patients and in 8 (3.6%) of the non-exposed patients.</p><p><strong>Conclusion: </strong>The administration of cautionary drugs increased the risk of clinical worsening in patients with MG. Clinicians should be aware of this risk when cautionary drugs need to be administered.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 4","pages":"218-225"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pericapsular Nerve Group Block with Periarticular Injection for Pain Management after Total Hip Arthroplasty: A Randomized Controlled Trial.","authors":"Hun Sik Cho, Bo Ra Lee, Hyuck Min Kwon, Jun Young Park, Hyeong Won Ham, Woo-Suk Lee, Kwan Kyu Park, Tae Sung Lee, Yong Seon Choi","doi":"10.3349/ymj.2024.0098","DOIUrl":"10.3349/ymj.2024.0098","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to compare the effectiveness of pericapsular nerve group (PENG) block with periarticular multimodal drug injection (PMDI) on postoperative pain management and surgical outcomes in patients who underwent total hip arthroplasty (THA). We hypothesized that PENG block with PMDI would exhibit superior effects on postoperative pain control after THA compared to PMDI alone.</p><p><strong>Materials and methods: </strong>From April 2022 to February 2023, 58 patients who underwent THA were randomly assigned into two groups: PENG block with PMDI group (n=29) and PMDI-only group (n=29). Primary outcomes were postoperative numeric rating scale (NRS) at rest and during activity at 6, 24, and 48 hours postoperatively. Secondary outcomes were postoperative complications (nausea and vomiting), Richards-Campbell Sleep Questionnaire (RCSQ) score, length of hospital stay, Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, Harris Hip Score (HHS), and total morphine usage after surgery.</p><p><strong>Results: </strong>There was no significant difference in postoperative pain for either resting NRS or active NRS. Postoperative nausea and vomiting, RCSQ score, length of hospital stay, WOMAC index, HHS, and total morphine usage exhibited no significant differences between the two groups.</p><p><strong>Conclusion: </strong>Both groups showed no significant differences in postoperative pain and clinical outcomes, indicating that the addition of PENG block to PMDI does not improve pain management after applying the posterolateral approach of THA. PMDI alone during THA would be an efficient, fast, and safe method for managing postoperative pain. This article was registered with ClinicalTrials. gov (Gov ID: NCT05320913).</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 4","pages":"233-239"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}