苯二氮卓类药物治疗乳腺癌诊断后抑郁症与痴呆风险之间的关系:一项基于全国人群的队列研究

IF 2.8 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Taehwan Kim, Hye Sun Lee, Soyoung Jeon, Dooreh Kim, Eunjoo Kim, Woo-Chan Park, Chang Ik Yoon, Jooyoung Oh
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引用次数: 0

摘要

目的:本研究调查乳腺癌患者诊断为抑郁症后2年内发生痴呆的风险,比较单独服用抗抑郁药与同时服用抗抑郁药和苯二氮卓类药物的患者。材料和方法:利用韩国国民健康保险索赔数据库中收集的超过14年的数据,我们纳入了197917名乳腺癌患者。其中,19170人在癌症诊断后2年内被诊断为抑郁症。在对合并症和年龄进行匹配后,每组1376例患者进行1:1匹配,其中仅服用抗抑郁药物的患者1326例,同时服用抗抑郁药物和苯二氮卓类药物的患者5304例进行1:4匹配。结果:在最初的1:1匹配分析中,仅服用抗抑郁药组与同时服用抗抑郁药和苯二氮卓类药物组痴呆发病率无显著差异。然而,进一步的详细分析显示,服用更高剂量或更长时间使用苯二氮卓类药物的患者患痴呆症的风险增加。在1:4匹配分析中,与仅服用抗抑郁药物的组相比,服用两种药物的组痴呆发病率明显更高(风险比为1.807;95%可信区间为1.263-2.583;p=0.0012)。结论:本研究强调了在诊断为抑郁症的乳腺癌患者中谨慎使用苯二氮卓类药物的重要性,因为它可能显著增加痴呆的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association between Benzodiazepine and Dementia Risk in Treating Depression after Breast Cancer Diagnosis: A Nationwide Population-Based Cohort Study.

Association between Benzodiazepine and Dementia Risk in Treating Depression after Breast Cancer Diagnosis: A Nationwide Population-Based Cohort Study.

Association between Benzodiazepine and Dementia Risk in Treating Depression after Breast Cancer Diagnosis: A Nationwide Population-Based Cohort Study.

Association between Benzodiazepine and Dementia Risk in Treating Depression after Breast Cancer Diagnosis: A Nationwide Population-Based Cohort Study.

Purpose: This study investigates the risk of developing dementia in breast cancer patients diagnosed with depression within 2 years of their cancer diagnosis, comparing those taking antidepressants alone versus those taking both antidepressants and benzodiazepines.

Materials and methods: Utilizing data from the Korean National Health Insurance claims database collected over 14 years, we included a cohort of 197917 breast cancer patients. Among them, 19170 were diagnosed with depression within 2 years of their cancer diagnosis. After matching for comorbidities and age, we included 1376 patients in each group for 1:1 matching, and 1326 patients taking only antidepressants and 5304 patients taking both antidepressants and benzodiazepines for 1:4 matching.

Results: In the initial 1:1 matched analysis, no significant difference in dementia incidence was observed between the group taking only antidepressants and the group taking both antidepressants and benzodiazepines. However, further detailed analysis revealed that patients taking higher doses or using benzodiazepines for longer durations had an increased risk of dementia. In the 1:4 matched analysis, the group taking both medications exhibited a significantly higher incidence of dementia compared to those taking only antidepressants (hazard ratio, 1.807; 95% confidence interval, 1.263-2.583; p=0.0012).

Conclusion: This study underscores the importance of cautious benzodiazepine use in breast cancer patients diagnosed with depression, given its potential to significantly increase dementia risk.

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来源期刊
Yonsei Medical Journal
Yonsei Medical Journal 医学-医学:内科
CiteScore
4.50
自引率
0.00%
发文量
167
审稿时长
3 months
期刊介绍: The goal of the Yonsei Medical Journal (YMJ) is to publish high quality manuscripts dedicated to clinical or basic research. Any authors affiliated with an accredited biomedical institution may submit manuscripts of original articles, review articles, case reports, brief communications, and letters to the Editor.
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