Yonsei Medical Journal最新文献

{"title":"Interrupting Effect of Social Distancing on Ischemic Heart Disease, Asthma, Stroke, and Suicide Attempt Patients by PM_2.5 Exposure.","authors":"Minseo Choi, Mia Son, Sanghyuk Bae, Whanhee Lee, Kyung-Nam Kim, Jung K Hyun","doi":"10.3349/ymj.2023.0135","DOIUrl":"https://doi.org/10.3349/ymj.2023.0135","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine the interrupting effect of social distancing (SD) on emergency department (ED) patients with ischemic heart disease (IHD), stroke, asthma, and suicide attempts by PM_2.5 exposure in eight Korean megacities from 2017 to 2020.</p><p><strong>Materials and methods: </strong>The study used National Emergency Department Information System and AirKorea data. A total of 469014 patients visited EDs from 2017 to 2020. Interrupted time series analysis was employed to examine changes in the level and slope of the time series, relative risk, and confidence intervals (CIs) by PM_2.5 exposure. The SD level was added to the sensitivity analysis.</p><p><strong>Results: </strong>The interrupted time series analysis demonstrated a significant increase in the ratio of relative risk (RRR) of IHD patients in Seoul (RRR=1.004, 95% CI: 1.001, 1.006) and Busan (RRR=1.007, 95% CI: 1.002, 1.012) post-SD. Regarding stroke, only patients in Seoul exhibited a significant decrease post-SD (RRR=0.995, 95% CI: 0.991, 0.999). No significant changes were observed for asthma in any of the cities. In the case of suicide attempts, Ulsan demonstrated substantial pre-SD (RR=0.827, 95% CI: 0.732, 0.935) and post-SD (RRR=1.200, 95% CI: 1.057, 1.362) differences.</p><p><strong>Conclusion: </strong>While the interrupting effect of SD was not as pronounced as anticipated, this study did validate the effectiveness of SD in modifying health behaviors and minimizing avoidable visits to EDs in addition to curtailing the occurrence of infectious diseases.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"65 5","pages":"302-313"},"PeriodicalIF":2.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11045348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Treatment Approaches to Intestinal Behçet's Disease Complicated by Myelodysplastic Syndrome: The KASID and KSBD Multicenter Study.","authors":"Jung-Bin Park, So Jung Han, Seung Bum Lee, Dong Hyun Kim, Jae Hee Cheon, Sung Wook Hwang, Byong Duk Ye, Suk-Kyun Yang, Soo Jung Park, Sang Hyoung Park","doi":"10.3349/ymj.2023.0321","DOIUrl":"https://doi.org/10.3349/ymj.2023.0321","url":null,"abstract":"<p><strong>Purpose: </strong>Studies on intestinal Behçet's disease (BD) complicated by myelodysplastic syndrome (MDS) are rare, and no established therapeutic guidelines exist. This study aimed to evaluate the clinical presentation and outcomes of patients with intestinal BD complicated by MDS (intestinal BD-MDS) and suggest a treatment strategy.</p><p><strong>Materials and methods: </strong>Data from patients with intestinal BD-MDS from four referral centers in Korea who were diagnosed between December 2000 and December 2022 were retrospectively analyzed. Clinical features and prognosis of intestinal BD-MDS compared with age-, sex-matched intestinal BD without MDS were investigated.</p><p><strong>Results: </strong>Thirty-five patients with intestinal BD-MDS were included, and 24 (70.6%) had trisomy 8. Among the 35 patients, 23 (65.7%) were female, and the median age at diagnosis for intestinal BD was 46.0 years (range, 37.0-56.0 years). Medical treatments only benefited eight of the 32 patients, and half of the patients underwent surgery due to complications. Compared to 70 matched patients with intestinal BD alone, patients with intestinal BD-MDS underwent surgery more frequently (51.4% vs. 24.3%; <i>p</i>=0.010), showed a poorer response to medical and/or surgical treatment (75.0% vs. 11.4%; <i>p</i><0.001), and had a higher mortality (28.6% vs. 0%; <i>p</i><0.001). Seven out of 35 patients with intestinal BD-MDS underwent hematopoietic stem cell transplantation (HSCT), and four out of the seven patients had a poor response to medical treatment prior to HSCT, resulting in complete remission of both diseases.</p><p><strong>Conclusion: </strong>Patients with intestinal BD-MDS frequently have refractory diseases with high mortalities. HSCT can be an effective treatment modality for medically refractory patients with intestinal BD-MDS.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"65 5","pages":"265-275"},"PeriodicalIF":2.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11045345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trend in the Incidence of Severe Partial Edentulism among Adults Using the Korean National Health Insurance Service Claim Data, 2014-2018.","authors":"Hyeonjeong Go, Hoi-In Jung, Song Vogue Ahn, Jeonghoon Ahn, Hosung Shin, Atsuo Amano, Youn-Hee Choi","doi":"10.3349/ymj.2023.0380","DOIUrl":"10.3349/ymj.2023.0380","url":null,"abstract":"<p><strong>Purpose: </strong>Missing teeth is one of the most important indicators of oral health behavior and the result of dental caries, periodontal disease, and injuries. This study examined a trend in the incidence of severe partial edentulism (SPE) using the Korean National Health Insurance Service (KNHIS) data.</p><p><strong>Materials and methods: </strong>Data of adults aged ≥20 years were obtained from the KNHIS for the 2014-2018 period. SPE was defined in dental information within a population with a treatment history of dental scaling as having 1 to 8 natural teeth. Crude incidence rates (CIRs) and age-standardized incidence rates (AIRs) with 95% confidence interval were calculated per 100000 persons. The Cochran Armitage trend (CAT) test and average annual percentage change were used to analyze SPE trends.</p><p><strong>Results: </strong>The CIRs among Korean adults were from 346.29 to 391.11 in 2014-2016 and from 391.11 to 354.09 in 2016-2018. The AIRs trend statistically increased by 4.31% from 346.29 to 376.80 and decreased by 4.72% from 376.80 to 342.10. The AIRs in men increased by 4.00% and decreased by 3.01%. The AIRs in women decreased by 2.18% and increased by 2.11% (CAT; <i>p</i><0.01). The AIRs by region and income also showed trends of increase and decrease.</p><p><strong>Conclusion: </strong>The study showed that the incidence trend of SPE increased and decreased from 2014 to 2018. This result would be able to aid in the planning of public oral health, and may also serve as fundamental data for verifying the impact of the public oral health policies implemented.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"65 4","pages":"234-240"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Dietary Habits on Alzheimer's Disease Progression.","authors":"So Hyun Ahn, Jee Hyang Jeong, Kyung Won Park, Eun-Joo Kim, Soo Jin Yoon, Bora Yoon, Jae-Won Jang, Yangki Minn, Seong Hye Choi","doi":"10.3349/ymj.2023.0119","DOIUrl":"10.3349/ymj.2023.0119","url":null,"abstract":"<p><strong>Purpose: </strong>Research on the relationship between diet and dementia among Koreans are lacking. This study investigated the association between dietary habits and dementia progression over 3 years in patients with Alzheimer's disease dementia (ADD).</p><p><strong>Materials and methods: </strong>This study included 705 patients with mild-to-moderate ADD. Dietary habits were assessed using the Mini Dietary Assessment Index, comprising 10 questions. Outcome measures included the Clinical Dementia Rating scale-Sum of Boxes (CDR-SB), Seoul-Instrumental Activities of Daily Living, Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI), and neuropsychological test battery (NTB) z-scores, which were evaluated annually over 3 years.</p><p><strong>Results: </strong>In Q10 (eat all food evenly without being picky), the 3-year mean differences in CDR-SB (increases in scores represent worsening) compared to the \"rarely\" group were -1.86 [95% confidence interval (CI)=-3.64 - -0.09, <i>p</i>=0.039] for the \"usually\" group and -2.23 (95% CI=-4.40 - -0.06, <i>p</i>=0.044) for the \"always\" group. In Q7 (add salt or soy sauce to food when eating), the 3-year mean differences in CDR-SB compared to the \"always\" group were -2.47 (95% CI=-4.70 - -0.24, <i>p</i>=0.030) for the \"usually\" group and -3.16 (95% CI=-5.36 - -0.96, <i>p</i>=0.005) for the \"rarely\" group. The \"rarely\" and \"usually\" groups in Q7 showed significantly less decline in NTB z-score and CGA-NPI compared to the \"always\" group.</p><p><strong>Conclusion: </strong>Eating a balanced diet and reducing salt intake were associated with a slower decline in dementia severity, cognition, and behavioral alterations in patients with ADD.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"65 4","pages":"217-226"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The First Case of a Korean Patient with a Mutation-Confirmed Tumor Necrosis Factor Receptor-Associated Periodic Syndrome.","authors":"Seok-Jin Lee, Jee Yeon Baek, Ji Young Lee, Ji-Man Kang, Jong Gyun Ahn","doi":"10.3349/ymj.2023.0366","DOIUrl":"10.3349/ymj.2023.0366","url":null,"abstract":"<p><p>Tumor necrosis factor receptor-associated periodic syndrome (TRAPS, OMIM: #142680) is a rare autoinflammatory disease (AID) with recurrent febrile episodes. To our knowledge, we report herein the first case of a patient with TRAPS in South Korea whose symptoms included fever, arthralgia, abdominal pain, rash, myalgia, cough, and lymphadenopathy. A pathogenic de novo mutation, c.175T>C (p.Cys59Arg), in the tumor necrosis factor receptor superfamily member 1A (<i>TNFRSF1A</i>) gene, was confirmed by gene sequencing. The patient has been with tocilizumab (an interleukin-6 inhibitor); tocilizumab administration every other week has completely alleviated the patient's symptoms. Our report further expands the clinical spectrum of patients with TRAPS and reaffirms the use of tocilizumab as a viable alternative treatment option for those patients who are unsatisfactorily responsive to other commonly used biologics, such as canakinumab, anakinra, infliximab, and etanercept. Furthermore, our report may aid in increasing awareness about the existence of mutation-confirmed TRAPS in South Korea in addition to emphasizing the importance of actively pursuing genetic testing to correctly diagnose rare AID.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"65 4","pages":"241-245"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Data Mining Technology in the Screening for Gallbladder Stones: A Cross-Sectional Retrospective Study of Chinese Adults.","authors":"Shuang Wang, Chenhui Bao, Dongmei Pei","doi":"10.3349/ymj.2023.0246","DOIUrl":"10.3349/ymj.2023.0246","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to use data mining methods to establish a simple and reliable predictive model based on the risk factors related to gallbladder stones (GS) to assist in their diagnosis and reduce medical costs.</p><p><strong>Materials and methods: </strong>This was a retrospective cross-sectional study. A total of 4215 participants underwent annual health examinations between January 2019 and December 2019 at the Physical Examination Center of Shengjing Hospital Affiliated to China Medical University. After rigorous data screening, the records of 2105 medical examiners were included for the construction of J48, multilayer perceptron (MLP), Bayes Net, and Naïve Bayes algorithms. A ten-fold cross-validation method was used to verify the recognition model and determine the best classification algorithm for GS.</p><p><strong>Results: </strong>The performance of these models was evaluated using metrics of accuracy, precision, recall, F-measure, and area under the receiver operating characteristic curve. Comparison of the F-measure for each algorithm revealed that the F-measure values for MLP and J48 (0.867 and 0.858, respectively) were not statistically significantly different (<i>p</i>>0.05), although they were significantly higher than the F-measure values for Bayes Net and Naïve Bayes (0.824 and 0.831, respectively; <i>p</i><0.05).</p><p><strong>Conclusion: </strong>The results of this study showed that MLP and J48 algorithms are effective at screening individuals for the risk of GS. The key attributes of data mining can further promote the prevention of GS through targeted community intervention, improve the outcome of GS, and reduce the burden on the medical system.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"65 4","pages":"210-216"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Cell-Mediated Autoimmune Responses in Severe Asthma.","authors":"Thi Bich Tra Cao, Quang Luu Quoc, Jae-Hyuk Jang, Hae-Sim Park","doi":"10.3349/ymj.2023.0432","DOIUrl":"10.3349/ymj.2023.0432","url":null,"abstract":"<p><p>Severe asthma (SA) has heterogeneous inflammatory phenotypes characterized by persistent airway inflammation (eosinophilic and/or neutrophilic inflammation) and remodeling. Various immune cells (eosinophils, neutrophils, and macrophages) become more activated and release inflammatory mediators and extracellular traps, damaging the protective barrier of airway epithelial cells and further activating other immune and structural cells. These cells play a role in autoimmune responses in asthmatic airways, where the adaptive immune system generates autoantibodies, inducing immunoglobulin G-dependent airway inflammation. Recent studies have suggested that adult asthmatics had high titers of autoantibodies associated with asthma severity, although pathogenic factors or diagnostic criteria are not well-defined. This challenge is further compounded by asthmatics with the autoimmune responses showing therapy insensitivity or failure to current pharmacological and biological treatment. This review updates emerging mechanisms of autoimmune responses in asthmatic airways and provides insights into their roles, proposing potential biomarkers and therapeutic targets for SA.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"65 4","pages":"194-201"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ssangcheon, Life of Lee Young-Choon (1903-1980).","authors":"Kang-Hyu Lee, Joo-Min Lee, Soon-Jae Yoon, Chang-Seop Lee","doi":"10.3349/ymj.2023.0445","DOIUrl":"10.3349/ymj.2023.0445","url":null,"abstract":"","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"65 4","pages":"189-193"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Activity-Induced Modification of the Association of Long-Term Air Pollution Exposure with the Risk of Depression in Older Adults.","authors":"Woongbi Park, Heeseon Jang, Juyeon Ko, Jungwoo Sohn, Young Noh, Sun-Young Kim, Sang-Baek Koh, Changsoo Kim, Jaelim Cho","doi":"10.3349/ymj.2023.0292","DOIUrl":"10.3349/ymj.2023.0292","url":null,"abstract":"<p><strong>Purpose: </strong>Evidence suggests that long-term air pollution exposures may induce depression; however, the influence of physical activity on this effect is unclear. We investigated modification of the associations between air pollution exposures and depression by the intensity of physical activity.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 1454 Korean adults. Depression was defined as a Geriatric Depression Scale score ≥8. Concentrations of particulate matter (PM₁₀ and PM_2.5: diameter ≤10 µm and ≤2.5 µm, respectively) and nitrogen dioxide (NO₂) level at each participant's residential address were estimated. Based on metabolic equivalents, physical activity intensity was categorized as inactive, minimally active, or health-enhancing physical activity (HEPA).</p><p><strong>Results: </strong>Each 1-part per billion (ppb) NO₂ concentration increase was significantly associated with a 6% [95% confidence interval (CI), 4%-8%] increase in depression risk. In older adults (≥65 years), a 1-ppb NO₂ increase was associated (95% CI) with a 4% (1%-7%), 9% (5%-13%), and 21% (9%-33%) increase in depression risk in the inactive, minimally active, and HEPA groups, respectively. Compared with the inactive group, the minimally active (<i>p</i>=0.039) and HEPA groups (<i>p</i>=0.004) had higher NO₂ exposure-associated depression risk. Associations of PM₁₀ and PM_2.5 with depression did not significantly differ by the intensity of physical activity.</p><p><strong>Conclusion: </strong>We suggest that older adults who vigorously exercise outdoors may be susceptible to air pollution-related depression.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"65 4","pages":"227-233"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence of Placental Villous Inflammation and Apoptosis in Third-Trimester Symptomatic SARS-CoV-2 Maternal Infection.","authors":"Manggala Pasca Wardhana, Kuntaman Kuntaman, Budi Utomo, Rozi Aditya Aryananda, Salsabila Nabilah Rifdah, Ifan Ali Wafa, Almira Aulia Shahnaz, Dahlia Ningrum, Nareswari Imanadha Cininta, Grace Ariani, Jan Mm Van Lith, Erry Gumilar Dachlan","doi":"10.3349/ymj.2023.0309","DOIUrl":"10.3349/ymj.2023.0309","url":null,"abstract":"<p><strong>Purpose: </strong>In view of conflicting reports on the ability of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) to infect placental tissue, this study aimed to further evaluate the impact of inflammation and placental damage from symptomatic third-trimester maternal COVID-19 infection.</p><p><strong>Materials and methods: </strong>This case-control study included 32 placenta samples each from symptomatic COVID-19 pregnancy and normal non-COVID-19 pregnancy. The villous placental area's inflammatory expression [angiotensin converting enzyme-2 (ACE-2), transmembrane protease serine-2 (TMPRSS2), interferon-γ (IFN-γ), interleukin-6 (IL-6), and SARS-CoV-2 spike protein] and apoptotic rate were examined using immunohistochemistry and Terminal deoxynucleotidyl transferase dUTP Nick-End Labeling (TUNEL) assay. Comparison and correlation analysis were used based on COVID-19 infection, placental SARS-CoV-2 spike protein evidence, and maternal severity status.</p><p><strong>Results: </strong>Higher expressions of TMPRSS2, IFN-γ, and trophoblast apoptotic rate were observed in the COVID-19 group (<i>p</i><0.001), whereas ACE-2 and IL-6 expressions were not significantly different from the control group (<i>p</i>>0.05). Additionally, SARS-CoV-2 spike protein was detected in 8 (25%) placental samples of COVID-19 pregnancy. COVID-19 subgroup analysis revealed increased IFN-γ, trophoblast, and stromal apoptosis (<i>p</i><0.01). Moreover, the results of the current study revealed no correlation between maternal COVID-19 severity and placental inflammation as well as the apoptotic process.</p><p><strong>Conclusion: </strong>The presence of SARS-CoV-2 spike protein as well as altered inflammatory and apoptotic processes may indicate the presence of placental disturbance in third-trimester maternal COVID-19 infection. The lack of correlation between placental disruption and maternal severity status suggests the need for more research to understand the infection process and any potential long-term impacts on all offsprings born to COVID-19-infected pregnant women.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"65 4","pages":"202-209"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}