Yonsei Medical Journal最新文献_第9页

Diagnosis of Primary Ciliary Dyskinesia via Whole Exome Sequencing and Histologic Findings. 通过全外显子组测序和组织学发现诊断原发性睫状肌运动障碍症

IF 2.4 4区医学

Yonsei Medical Journal Pub Date : 2024-01-01 DOI: 10.3349/ymj.2023.0238

Jiyoung Oh, Jin-Sung Lee, Moo Suk Park, Young Ae Kang, Hyung-Ju Cho, Song Yee Kim, Jinsei Jung, Sun Och Yoon, Kyung Won Kim

{"title":"Diagnosis of Primary Ciliary Dyskinesia via Whole Exome Sequencing and Histologic Findings.","authors":"Jiyoung Oh, Jin-Sung Lee, Moo Suk Park, Young Ae Kang, Hyung-Ju Cho, Song Yee Kim, Jinsei Jung, Sun Och Yoon, Kyung Won Kim","doi":"10.3349/ymj.2023.0238","DOIUrl":"10.3349/ymj.2023.0238","url":null,"abstract":"Purpose: To assess the diagnostic potential of whole-exome sequencing (WES) and elucidate the clinical and genetic characteristics of primary ciliary dyskinesia (PCD) in the Korean population.Materials and methods: Forty-seven patients clinically suspected of having PCD were enrolled at a tertiary medical center. WES was performed in all patients, and seven patients received biopsy of cilia and transmission electron microscopy (TEM).Results: Overall, PCD was diagnosed in 10 (21.3%) patients: eight by WES (8/47, 17%), four by TEM. Among patients diagnosed as PCD based on TEM results, two patients showed consistent results with WES and TEM of PCD (2/4, 50%). In addition, five patients, who were not included in the final PCD diagnosis group, had variants of unknown significance in PCD-related genes (5/47, 10.6%). The most frequent pathogenic (P)/likely pathogenic (LP) variants were detected in DNAH11 (n=4, 21.1%), DRC1 (n=4, 21.1%), and DNAH5 (n=4, 21.1%). Among the detected 17 P/LP variants in PCD-related genes in this study, 8 (47.1%) were identified as novel variants. Regarding the genotype-phenotype correlation in this study, the authors experienced severe PCD cases caused by the LP/P variants in MCIDAS, DRC1, and CCDC39.Conclusion: Through this study, we were able to confirm the value of WES as one of the diagnostic tools for PCD, which increases with TEM, rather than single gene tests. These results will prove useful to hospitals with limited access to PCD diagnostic testing but with relatively efficient in-house or outsourced access to genetic testing at a pre-symptomatic or early disease stage.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to "Bone Flap Changes after Cranioplasty Using Frozen Autologous Bone Flaps: A Three-Dimensional Volumetric Reconstruction Study" by Lee JH, et al. (Yonsei Med J 2019 Nov;60(11):1067-1073). Lee JH等人的“冷冻自体骨瓣颅骨成形术后骨瓣变化:三维体积重建研究”的更正(延世医学杂志2019年11月;60(11):1067-1073)。

IF 2.4 4区医学

Yonsei Medical Journal Pub Date : 2023-12-01 DOI: 10.3349/ymj.2019.0141.er

引用次数: 0

Erratum to "National Trends in Hospitalization for Ambulatory Care Sensitive Conditions among Korean Adults between 2008 and 2019" by Park H, et al. (Yonsei Med J 2022 Oct;63(10):948-955). Park H等人对“2008年至2019年韩国成年人门诊护理敏感条件住院的全国趋势”的勘误(延世医学杂志2022年10月;63(10):948-955)。

IF 2.4 4区医学

Yonsei Medical Journal Pub Date : 2023-12-01 DOI: 10.3349/ymj.2022.0110.er

引用次数: 0

The Effect of Model for End-Stage Liver Disease 3.0 on Disparities between Patients with and without Hepatocellular Carcinoma in Korea. 终末期肝病模型3.0对韩国肝癌和非肝癌患者差异的影响。

IF 2.4 4区医学

Yonsei Medical Journal Pub Date : 2023-11-01 DOI: 10.3349/ymj.2023.0163

Kunhee Kim, Deok-Gie Kim, Jae Geun Lee, Dong Jin Joo, Hye Won Lee

{"title":"The Effect of Model for End-Stage Liver Disease 3.0 on Disparities between Patients with and without Hepatocellular Carcinoma in Korea.","authors":"Kunhee Kim, Deok-Gie Kim, Jae Geun Lee, Dong Jin Joo, Hye Won Lee","doi":"10.3349/ymj.2023.0163","DOIUrl":"10.3349/ymj.2023.0163","url":null,"abstract":"Purpose: The model for end-stage liver disease (MELD) 3.0 has recently been suggested for determining liver allocation. We aimed to apply MELD 3.0 to a Korean population and to discover differences between patients with and without hepatocellular carcinoma (HCC).Materials and methods: This study is a retrospective study of 2203 patients diagnosed with liver cirrhosis at Severance Hospital between 2016-2022. Harrell's concordance index was used to validate the ability of MELD scores to predict 90-day survival.Results: During a mean follow-up of 12.9 months, 90-day survival was 61.9% in all patients, 50.4% in the HCC patients, and 74.8% in the non-HCC patients. Within the HCC patients, the concordance index for patients on the waitlist was 0.653 using MELD, which increased to 0.753 using MELD 3.0. Among waitlisted patients, the 90-day survival of HCC patients was worse than that of non-HCC patients with MELD scores of 31-37 only (69.7% vs. 30.0%, p=0.001). Applying MELD 3.0, the 90-day survival of HCC patients was worse than that of non-HCC patients across a wider range of MELD 3.0 scores, compared to MELD, with MELD 3.0 scores of 21-30 and 31-37 (82.0% vs. 72.5% and 72.3% vs. 24.3%, p=0.02 and p<0.001, respectively).Conclusion: MELD 3.0 predicted 90-day survival of the HCC patients more accurately than original MELD score; however, the disparity between HCC and non-HCC patients increased, particularly in patients with MELD scores of 21-30. Therefore, a novel exception score is needed or the current exception score system should be modified.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered Low Frequency Heart Rate Variability Associated with Agoraphobia in Panic Disorder: A Retrospective Study. 惊恐障碍中与广场恐怖症相关的低频心率变异性改变：一项回顾性研究。

IF 2.4 4区医学

Yonsei Medical Journal Pub Date : 2023-11-01 DOI: 10.3349/ymj.2022.0592

Minjung Kim, Jihye Kim, Haein Park, Jin Young Park, Deokjong Lee

{"title":"Altered Low Frequency Heart Rate Variability Associated with Agoraphobia in Panic Disorder: A Retrospective Study.","authors":"Minjung Kim, Jihye Kim, Haein Park, Jin Young Park, Deokjong Lee","doi":"10.3349/ymj.2022.0592","DOIUrl":"10.3349/ymj.2022.0592","url":null,"abstract":"Purpose: This study aimed to compare the clinical features of panic disorder (PD) with comorbid agoraphobia to those of PD alone. We focused on autonomic nervous system (ANS) alterations reflected in heart rate variability (HRV) and executive function deficits reflected in the Stroop test.Materials and methods: We retrospectively compared psychometric features, Stroop test results, and resting-state HRV across three groups: a subclinical group with anxiety attack history, a PD group without agoraphobia, and a PD group with agoraphobia. The subclinical group included 10 male and 34 female, the PD without agoraphobia group included 17 male and 19 female, and the PD with agoraphobia group included 11 male and 18 female.Results: The PD with agoraphobia group had higher Symptom Checklist-95 scores than the other groups. Both PD groups had longer reaction times in the Stroop test than the subclinical group. There were no significant differences in HRV parameters between the PD groups with and without agoraphobia. Compared with the subclinical group, the PD with agoraphobia group showed significantly lower values of the natural logarithm of low-frequency HRV.Conclusion: Our results do not support that executive function deficits and ANS alterations are more pronounced with comorbid agoraphobia among PD groups. However, PD with agoraphobia patients showed more complex and severe clinical symptoms in their self-reports. Compared with the subclinical group, PD patients with agoraphobia showed specific features in the natural logarithm of low-frequency HRV. Our findings suggest that agoraphobia comorbidity should be considered when evaluating or treating patients with PD.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50162997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of Stent Failure for Malignant Ureteral Obstruction in Non-Urological Cancer. 非泌尿系癌症恶性输尿管梗阻支架失效的预测。

IF 2.4 4区医学

Yonsei Medical Journal Pub Date : 2023-11-01 DOI: 10.3349/ymj.2023.0117

Ji Eun Heo, Dae Young Jeon, Jongsoo Lee, Hyun Ho Han, Won Sik Jang

{"title":"Prediction of Stent Failure for Malignant Ureteral Obstruction in Non-Urological Cancer.","authors":"Ji Eun Heo, Dae Young Jeon, Jongsoo Lee, Hyun Ho Han, Won Sik Jang","doi":"10.3349/ymj.2023.0117","DOIUrl":"10.3349/ymj.2023.0117","url":null,"abstract":"Purpose: To analyze prognostic factors associated with ureteral stent failure and to develop a prediction model for malignant ureteral obstruction (MUO) in patients with non-urological cancers.Materials and methods: We retrospectively reviewed patients with non-urological cancers who underwent ureteral stenting or percutaneous nephrostomy (PCN) for MUO between 2006 and 2014. Variables predicting stent failure were identified using Cox regression analysis.Results: Of the 743 patients, 468 (63.0%) underwent ureteral stenting only, and 275 (37.0%) underwent PCN owing to technical (n=215) or functional (n=60) stent failure. The median overall survival was 4 [interquartile range (IQR) 1-11] months, and the median interval duration to stent failure was 2 (IQR 0-7) months. In univariate analysis, lower gastrointestinal cancer, previous radiotherapy to the pelvis, bladder invasion, lower ureteral obstruction, and low previous estimated glomerular filtration rate (eGFR) (<30 mL/min/1.73 m²) were significantly associated with a decreased survival rate. In multivariate analysis, bladder invasion and previous eGFR were significant predictors. With these two predictors, we divided patients into three groups based on their presence: low-risk (neither factor; n=516), intermediate-risk (one factor; n=206), and high-risk (both factors; n=21). The median stent failure-free survival rates of patients in the low-, intermediate-, and high-risk groups were 26 (8-unreached), 1 (0-18), and 0 (0-0) months, respectively (p<0.001).Conclusion: In cases of ureteral obstruction caused by non-urological cancers, patients with bladder invasion and a low eGFR showed poor stent failure-free survival. Therefore, PCN should be considered the primary procedure for these patients.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Necrotizing Myelitis Associated with COVID-19. 与新冠肺炎相关的急性坏死性脊髓炎。

IF 2.4 4区医学

Yonsei Medical Journal Pub Date : 2023-11-01 DOI: 10.3349/ymj.2023.0202

Ji Eun Yoo, Hui Jin Shin, Hoon-Chul Kang, Joon Soo Lee, Heung Dong Kim, Ha Neul Lee

{"title":"Acute Necrotizing Myelitis Associated with COVID-19.","authors":"Ji Eun Yoo, Hui Jin Shin, Hoon-Chul Kang, Joon Soo Lee, Heung Dong Kim, Ha Neul Lee","doi":"10.3349/ymj.2023.0202","DOIUrl":"10.3349/ymj.2023.0202","url":null,"abstract":"Acute ascending hemorrhagic longitudinally extensive transverse myelitis is a rare inflammatory demyelinating disorder, which invades several vertebral segments and progresses rapidly and manifests severe symptoms. We present a case of acute necrotizing myelitis associated with COVID-19 infection. A 10-year-old female, with no previous medical history and no prior administration of COVID-19 vaccination, contracted COVID-19 in early April 2022. Two weeks later, she suffered from severe posterior neck pain and also presented with motor weakness and numbness in both lower extremities, making it difficult to walk independently and spontaneously void urine. Initial spinal cord MR showed longitudinally segmental extensive T2 hyperintensities. Cerebrospinal fluid (CSF) analysis revealed elevated red blood cell, normal white blood cell, and elevated protein levels and absence of oligoclonal bands. CSF culture and viral polymerase chain reaction were negative. Autoimmune work-up was negative. She was started on intravenous methylprednisolone 1g/day for 5 days and immunoglobulin (Ig) 2 g/kg for 5 days. She was also treated with six courses of therapeutic plasma exchange. Nevertheless, her pain and motor weakness persisted. She eventually developed respiratory failure. Follow-up MR presented a newly noted small hemorrhagic component. She was consequently treated with two additional courses of methylprednisolone and Ig. At 6-months follow-up, neurological examination showed improvement with normal sensory function and motor grade IV function in both upper extremities. We present the case of acute necrotizing myelitis associated with COVID-19 infection. Multiple courses of methylprednisolone and Ig showed mild improvement in motor and sensory function. However, poor prognosis was unavoidable due to rapid progression of the disease.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50162996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in the Impact of Obesity and Metabolic Unhealthiness on the Risk of Gallbladder Polyp. 肥胖和代谢不健康对胆囊息肉风险影响的差异。

IF 2.4 4区医学

Yonsei Medical Journal Pub Date : 2023-11-01 DOI: 10.3349/ymj.2023.0182

Nam Hee Kim, Ji Hun Kang, Hong Joo Kim

{"title":"Differences in the Impact of Obesity and Metabolic Unhealthiness on the Risk of Gallbladder Polyp.","authors":"Nam Hee Kim, Ji Hun Kang, Hong Joo Kim","doi":"10.3349/ymj.2023.0182","DOIUrl":"10.3349/ymj.2023.0182","url":null,"abstract":"Purpose: Differences in the impact of obesity and metabolic health status on the risk of gallbladder polyp (GBP) remain uncertain. Herein, we aimed to compare the risk of GBP ≥5 mm among individuals with different phenotypes based on obesity and metabolic health status.Materials and methods: A cohort of 253485 asymptomatic adults who underwent abdominal ultrasonography screening were categorized into the following four groups according to obesity and metabolic health status: 1) metabolically healthy non-obese (MHNO), 2) metabolically unhealthy and non-obese (MUNO), 3) metabolically healthy but obese (MHO), and 4) metabolically unhealthy obese (MUO).Results: The prevalences of GBP ≥5 mm were 2.4%, 3.1%, 3.7%, and 4.0% in the MHNO, MUNO, MHO, and MUO groups, respectively. The multivariable-adjusted odds ratio (OR) values for prevalence of GBP ≥5 mm by comparing the MUNO, MHO, and MUO with the MHNO group were 1.11 [95% confidence interval (CI), 1.04-1.19], 1.30 (95% CI, 1.15-1.47), and 1.37 (95% CI, 1.28-1.45), respectively. The risk of GBP ≥5 mm in the MHO group was significantly higher than that in the MUNO group, but not significantly different from that in the MUO group.Conclusion: Obesity and metabolic unhealthiness appear to be independent risk factors for the prevalence of GBP, and the impact of obesity is greater than that of metabolic unhealthiness, suggesting that maintaining both normal weight and metabolic health may help reduce the risk of GBP.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Risk Factors to Predict Occurrence and Prognosis of Postsurgical Hypertrophic Scar Development: A Review of 4238 Cases. 预测术后增生性瘢痕发生和预后的危险因素分析：4238例病例回顾。

IF 2.4 4区医学

Yonsei Medical Journal Pub Date : 2023-11-01 DOI: 10.3349/ymj.2023.0003

Mi Yeon Cho, Sang Gyun Lee, Jee Eun Kim, Yong Sang Lee, Hang-Seok Chang, Mi Ryung Roh

{"title":"Analysis of Risk Factors to Predict Occurrence and Prognosis of Postsurgical Hypertrophic Scar Development: A Review of 4238 Cases.","authors":"Mi Yeon Cho, Sang Gyun Lee, Jee Eun Kim, Yong Sang Lee, Hang-Seok Chang, Mi Ryung Roh","doi":"10.3349/ymj.2023.0003","DOIUrl":"10.3349/ymj.2023.0003","url":null,"abstract":"Purpose: This study aimed to identify the risk factors associated with the occurrence and prognosis of hypertrophic scarring following thyroidectomy.Materials and methods: A total of 4238 patients who underwent thyroidectomy were included in this study. A multivariable logistic regression model was developed to identify the risk factors for hypertrophic scar development and its prognosis.Results: Our analysis revealed that hypertrophic scar development was associated with younger age [odds ratio (OR)=0.949, p<0.0001], male sex (OR=0.562, p<0.0001), higher body mass index (OR=1.137, p<0.0001), prominent sternocleidomastoid muscles (OR=2.522, p<0.0001), scarring located within 1 cm of the sternal notch (OR=4.345, p<0.0001), and a history of keloid development (OR=2.789, p=0.0031). Additionally, scar location within 1 cm of the sternal notch (beta=4.326, p=0.0429) and a history of keloid development (beta=23.082, p<0.0001) were found to be associated with the prognosis of hypertrophic scarring.Conclusion: The findings of this study provide valuable insights into the risk factors associated with hypertrophic scarring following thyroidectomy. Clinicians can use this information to predict the occurrence of hypertrophic scarring and its prognosis, and take preventative measures accordingly.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50162998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Age Estimation and Prediction of Final Adult Height Using Deep Learning. 使用深度学习的骨龄估计和成人最终身高预测。

IF 2.4 4区医学

Yonsei Medical Journal Pub Date : 2023-11-01 DOI: 10.3349/ymj.2023.0244

Junghwan Suh, Jinkyoung Heo, Su Jin Kim, Soyeong Park, Mo Kyung Jung, Han Saem Choi, Youngha Choi, Jun Suk Oh, Hae In Lee, Myeongseob Lee, Kyungchul Song, Ahreum Kwon, Hyun Wook Chae, Ho-Seong Kim

{"title":"Bone Age Estimation and Prediction of Final Adult Height Using Deep Learning.","authors":"Junghwan Suh, Jinkyoung Heo, Su Jin Kim, Soyeong Park, Mo Kyung Jung, Han Saem Choi, Youngha Choi, Jun Suk Oh, Hae In Lee, Myeongseob Lee, Kyungchul Song, Ahreum Kwon, Hyun Wook Chae, Ho-Seong Kim","doi":"10.3349/ymj.2023.0244","DOIUrl":"10.3349/ymj.2023.0244","url":null,"abstract":"Purpose: The appropriate evaluation of height and accurate estimation of bone age are crucial for proper assessment of the growth status of a child. We developed a bone age estimation program using a deep learning algorithm and established a model to predict the final adult height of Korean children.Materials and methods: A total of 1678 radiographs from 866 children, for which the interpretation results were consistent between two pediatric endocrinologists, were used to train and validate the deep learning model. The bone age estimation algorithm was based on the convolutional neural network of the deep learning system. The test set simulation was performed by a deep learning program and two raters using 150 radiographs and final height data for 100 adults.Results: There was a statistically significant correlation between bone age interpreted by the artificial intelligence (AI) program and the reference bone age in the test set simulation (r=0.99, p<0.001). In the test set simulation, the AI program showed a mean absolute error (MAE) of 0.59 years and a root mean squared error (RMSE) of 0.55 years, compared with reference bone age, and showed similar accuracy to that of an experienced pediatric endocrinologist (rater 1). Prediction of final adult height by the AI program showed an MAE of 4.62 cm, compared with the actual final adult height.Conclusion: We developed a bone age estimation program based on a deep learning algorithm. The AI-derived program demonstrated high accuracy in estimating bone age and predicting the final adult height of Korean children and adolescents.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50162999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0