Risk Factors for Heterotopic Ossification in Traumatic Brain Injury: An Analysis of the Korean National Health Insurance Service Data.

IF 2.8 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Seo Yeon Yoon, Hyunsun Lim, Jun Min Cha, Sang Chul Lee, Jang Woo Lee
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Abstract

Purpose: This study investigated the risk factors for heterotopic ossification (HO) in patients with traumatic brain injury (TBI).

Materials and methods: This was a retrospective study using the Korean National Health Insurance Service (KNHIS) database and included as many relevant factors as possible. Data were collected from the KNHIS cohort, a nationwide cohort covering the entire Korean population. Patients diagnosed with TBI from 2004 to 2018 were included. TBI was defined as individuals who 1) had been hospitalized, 2) were diagnosed with TBI under ICD-10 code S06, and 3) underwent brain imaging within 1 week before or after diagnosis. Among 637315 adult patients, 1909 (0.30%) developed HO. This study aimed to clarify the relationship between HO and various factors, including demographic and medical history, medication history, complications, and accompanying injuries in TBI patients.

Results: Among TBI patients, HO was more common in female and peaked in patients in their 50s, with a lower incidence in their 70s. Preobesity and obesity were significant risk factors, while smokers had a reduced risk. HO was more common in patients with rheumatic diseases and medical comorbidities, and those who had undergone tracheostomies. The use of antiseptics was associated with an increased risk, whereas anticonvulsants, antithrombotics, steroids, and non-steroidal anti-inflammatory drugs were associated with lower risks. HO was more common in registered patients with disability due to brain lesion.

Conclusion: In conclusion, middle-age range, female sex, obesity, comorbidities, injury severity, systemic inflammation, and bony metabolism-affecting medications appear to increase the risk of HO in patients with TBI.

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外伤性脑损伤异位骨化的危险因素:韩国国民健康保险服务数据分析。
目的:探讨外伤性脑损伤(TBI)患者异位骨化(HO)的危险因素。材料和方法:这是一项回顾性研究,使用韩国国民健康保险服务(KNHIS)数据库,并包括尽可能多的相关因素。数据是从KNHIS队列中收集的,这是一个覆盖整个韩国人口的全国性队列。纳入了2004年至2018年诊断为TBI的患者。TBI定义为:1)住院治疗,2)根据ICD-10代码S06诊断为TBI, 3)在诊断前后1周内进行脑成像。637315例成人患者中,1909例(0.30%)发展为HO。本研究旨在阐明TBI患者HO与人口统计学、病史、用药史、并发症、伴发损伤等因素的关系。结果:在TBI患者中,HO以女性多见,50多岁为高峰,70多岁发生率较低。肥胖前期和肥胖是重要的风险因素,而吸烟者的风险较低。HO更常见于风湿病和内科合并症患者,以及气管切开术患者。使用防腐剂与风险增加相关,而抗惊厥药、抗血栓药、类固醇和非甾体抗炎药的风险较低。HO在因脑损伤而致残的登记患者中更为常见。结论:总之,年龄、女性、肥胖、合并症、损伤严重程度、全身性炎症和影响骨代谢的药物可能会增加TBI患者发生HO的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Yonsei Medical Journal
Yonsei Medical Journal 医学-医学:内科
CiteScore
4.50
自引率
0.00%
发文量
167
审稿时长
3 months
期刊介绍: The goal of the Yonsei Medical Journal (YMJ) is to publish high quality manuscripts dedicated to clinical or basic research. Any authors affiliated with an accredited biomedical institution may submit manuscripts of original articles, review articles, case reports, brief communications, and letters to the Editor.
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