Wound management & prevention最新文献

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Antibiotic-loaded bone cement combined with negative pressure wound therapy for treating sacrococcygeal wound following sacral chordoma resection: a case report. 抗生素骨水泥结合负压伤口疗法治疗骶脊索瘤切除术后的骶尾部伤口:病例报告。
IF 1 4区 医学
Wound management & prevention Pub Date : 2023-11-01 DOI: 10.25270/wmp.23008
Yanwei Sun
{"title":"Antibiotic-loaded bone cement combined with negative pressure wound therapy for treating sacrococcygeal wound following sacral chordoma resection: a case report.","authors":"Yanwei Sun","doi":"10.25270/wmp.23008","DOIUrl":"10.25270/wmp.23008","url":null,"abstract":"<p><strong>Background: </strong>Sacral chordoma is a rare, malignant primary bone tumor with subtle clinical manifestations. The extensive cavity and soft tissue defect after radical resection of the tumor can lead to complications such as sacrococcygeal skin necrosis, infection, cerebrospinal fluid (CSF) leakage, and delayed healing or nonhealing.</p><p><strong>Purpose: </strong>To describe the treatment effect of the combination use of antibiotic-loaded bone cement (ALBC), a gluteus maximus muscle flap, and negative pressure wound therapy (NPWT) on the nonhealing sacrococcygeal wound after sacral chordoma resection.</p><p><strong>Case report: </strong>A 67-year-old woman with a sacrococcygeal wound following sacral chordoma resection was admitted to the hospital. In the 2-stage surgery, the internal fixation and synthetic dura substitute were exposed and CSF leakage was found after debridement, a gluteus maximus muscle flap was used to cover the synthetic dura substitute to address the CSF leakage, ALBC was used to cover the internal fixation, and a modified NPWT system was fixed to the wound for improved flushing and drainage.</p><p><strong>Results: </strong>The previously nonhealing wound healed 3 weeks postoperatively, and satisfactory recovery was achieved by 6-month follow-up.</p><p><strong>Conclusion: </strong>This case report suggests that the combination use of ALBC, gluteus maximus muscle flap, and NPWT can effectively promote sacrococcygeal wound healing after chordoma resection.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138831852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acellular flowable dermal matrix for ostomy reconstruction: a safe and effective minimally invasive technique. 用于造口重建的细胞流动真皮基质:一种安全有效的微创技术。
IF 1 4区 医学
Wound management & prevention Pub Date : 2023-11-01 DOI: 10.25270/wmp.22080
Carlos Delgado-Miguel, Miriam Miguel-Ferrero, Mercedes Díaz, Juan Camps, Juan Carlos López-Gutiérrez
{"title":"Acellular flowable dermal matrix for ostomy reconstruction: a safe and effective minimally invasive technique.","authors":"Carlos Delgado-Miguel, Miriam Miguel-Ferrero, Mercedes Díaz, Juan Camps, Juan Carlos López-Gutiérrez","doi":"10.25270/wmp.22080","DOIUrl":"10.25270/wmp.22080","url":null,"abstract":"<p><strong>Background: </strong>Acellular dermal matrices have long been used for complex abdominal wall closure and, more recently, for ostomy reconstruction.</p><p><strong>Purpose: </strong>To describe ostomy reconstruction with acellular flowable dermal matrix (AFDM) in a pediatric patient with a complex abdominal wall defect.</p><p><strong>Case report: </strong>A 14-year-old female who was diagnosed with unspecific hemorrhagic colitis at age 6 months and who underwent several abdominal surgeries (including total colectomy and terminal ileostomy) reported frequent, severe periostomy skin ulcerations secondary to improper fitting and ostomy bag leakage due to multiple periostomy skin retraction as a result of multiple abdominal scars. Under sedation, 2 small (5 mm) peristomal skin incisions were made, through which dissection and release of dermal scar tissue was performed. Afterwards, AFDM 40 mL was injected subcutaneously until a uniform, flat surface around the ostomy was achieved. The patient was discharged a few hours postoperatively, after verification of proper fit of the ostomy bag with no leakage. At 18-month follow-up, the patient was very satisfied with the result, with fewer ostomy bag changes and improved quality of life.</p><p><strong>Conclusion: </strong>This case report indicates that AFDM is a safe and effective minimally invasive technique for ostomy reconstruction, with minimal complications and satisfactory medium-term results.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138831851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal bovine acellular dermal matrix in the management of chronic nonhealing lower extremity wounds. 胎牛非细胞真皮基质在治疗慢性下肢不愈合伤口中的应用。
IF 1 4区 医学
Wound management & prevention Pub Date : 2023-11-01 DOI: 10.25270/wmp.23031
Susan Benitez-Sanchez, Amit Rao, Alisha Oropallo
{"title":"Fetal bovine acellular dermal matrix in the management of chronic nonhealing lower extremity wounds.","authors":"Susan Benitez-Sanchez, Amit Rao, Alisha Oropallo","doi":"10.25270/wmp.23031","DOIUrl":"10.25270/wmp.23031","url":null,"abstract":"<p><strong>Background: </strong>The management of chronic nonhealing lower extremity wounds remains a problem that substantially affects patients and significantly burdens the health care system. Nonhealing wounds lead to increased hospitalization, decreased quality of life, minor and major amputations, and increased risk of mortality. Dermal matrices have advanced the science of wound healing.</p><p><strong>Purpose: </strong>To evaluate fetal bovine acellular dermal matrix (FBADM), an acellular dermal collagen repair scaffold derived from fetal bovine dermis, in the management of chronic nonhealing lower extremity wounds.</p><p><strong>Methods: </strong>A single-center retrospective chart review was conducted to collect data on patients with chronic nonhealing lower extremity wounds treated with FBADM from January 2013 through December 2019.</p><p><strong>Results: </strong>A total of 43 patients were enrolled, with a mean age of 68.5 years and a mean wound area of 27 cm2. Complete closure of the wound occurred in 53% of patients overall, with 28% of patients achieving healing within 12 weeks.</p><p><strong>Conclusion: </strong>Application of FBADM in the management of chronic nonhealing lower extremity wounds is safe, effective, and efficient.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138831853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A non-inferiority study to compare the effect of silica gel fiber dressing with alginate dressing on healing of venous leg ulcers. 比较硅凝胶纤维敷料和藻酸盐敷料对腿部静脉溃疡愈合效果的非劣效性研究。
IF 1 4区 医学
Wound management & prevention Pub Date : 2023-11-01 DOI: 10.25270/wmp.22091
Long Zhang, Jin Yang, Haofu Wang, Yunmin Cai, Wenjun Zhao, Ruiping Dong, Dongyang Liu, Xingwu Lu
{"title":"A non-inferiority study to compare the effect of silica gel fiber dressing with alginate dressing on healing of venous leg ulcers.","authors":"Long Zhang, Jin Yang, Haofu Wang, Yunmin Cai, Wenjun Zhao, Ruiping Dong, Dongyang Liu, Xingwu Lu","doi":"10.25270/wmp.22091","DOIUrl":"10.25270/wmp.22091","url":null,"abstract":"<p><strong>Background: </strong>Silica gel fiber (SGF) dressing is a novel patch for wound healing.</p><p><strong>Objective: </strong>To compare the efficacy and safety of SGF dressing with alginate dressing in local treatment of venous leg ulcers.</p><p><strong>Methods: </strong>Patients with venous leg ulcers who had undergone effective treatment of venous hypertension and debridement were randomized to receive wound care with either SGF dressing or alginate dressing for 4 weeks. Wounds were assessed weekly during the first 4 weeks and then every 2 weeks until the 8th week. The primary endpoint was the efficacy rate. Secondary endpoints included ulcer area reduction rate, healing rate, frequency of dressing changes, pain score, patient satisfaction, and treatment-related adverse events.</p><p><strong>Results: </strong>A total of 130 patients were enrolled, 67 treated with SGF and 63 with alginate dressing, and the efficacy rates were 89.6% (SGF group) and 84.1% (alginate group). SGF induced a higher \"no pain\" rate than alginate at week 2 (61.4% vs 43.5%) and week 3 (67.6% vs 53.1%), and a higher \"highly satisfied\" rate at week 4 (83.3% vs 78.8%) and week 8 (75% vs 59.1%). Markedly fewer dressing changes were required in the SGF group.</p><p><strong>Conclusions: </strong>SGF dressing is non-inferior to alginate dressing in treating venous leg ulcers. It even substantially decreased the frequency of dressing changes when compared with alginate dressing.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138831850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sepsis episodes caused by pressure injuries in critical illness: a retrospective observational cohort study. 危重病人压伤导致的败血症发作:一项回顾性观察队列研究。
IF 1 4区 医学
Wound management & prevention Pub Date : 2023-11-01
Pınar Küçükdemirci Kaya, Murad Kaya, Nermin Kelebek Girgin, Ferda Ş Kahveci, Emin Halis Akalın, Remzi İşçimen
{"title":"Sepsis episodes caused by pressure injuries in critical illness: a retrospective observational cohort study.","authors":"Pınar Küçükdemirci Kaya, Murad Kaya, Nermin Kelebek Girgin, Ferda Ş Kahveci, Emin Halis Akalın, Remzi İşçimen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Critically-ill patients (CIPs) with pressure injuries (PIs) may develop bloodstream infections (BSIs).</p><p><strong>Purpose: </strong>To identify predisposing factors and discuss diagnosis and management of sepsis-related PIs in CIPs.</p><p><strong>Methods: </strong>The records of CIPs in the intensive care unit (ICU) between January 1, 2014, and January 1, 2020, with PI with sepsis-diagnoses and with different site cultures that were positive concurrent with bloodstream-cultures were retrospectively reviewed.</p><p><strong>Results: </strong>Ninety-one sepsis episodes were included in the study. Low albumin level (U = 382.00, P = .006), renal failure (odds ratio [OR], 0.108 [95% CI, 0.015-0.783]; P = .025), and length of ICU stay (U = 130.00, P < .001) were identified as risk factors of BSIs due to PIs. The probability of BSI during a sepsis episode was lower in CIPs with PIs with higher C-reactive protein levels (U = 233.00, P < .001) and whose injury resulted from trauma or surgery (OR, 0.101 [95% CI, 0.016-0.626]; P = .014). The mortality was higher in CIPs with PI-induced BSIs (OR, 0.051 [95% CI, 0.008-0.309]; P = .001).</p><p><strong>Conclusions: </strong>Pressure injury-induced sepsis was associated with a high risk of 28-day mortality. The findings suggest that CIPs with PI are at increased risk of BSIs if they have low albumin levels, renal-failure, and prolonged ICU stay during sepsis episodes.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevention of hospital-acquired transnasal tube-related pressure injuries: a quality improvement project. 预防医院获得性经鼻导管相关压伤:质量改进项目。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2023-09-01 DOI: 10.25270/wmp.22059
Xianrong Wu, Liangzhi Qiu, Min Cai, Yuehua Huang, Yucui Wang, Yihong Qiu
{"title":"Prevention of hospital-acquired transnasal tube-related pressure injuries: a quality improvement project.","authors":"Xianrong Wu, Liangzhi Qiu, Min Cai, Yuehua Huang, Yucui Wang, Yihong Qiu","doi":"10.25270/wmp.22059","DOIUrl":"https://doi.org/10.25270/wmp.22059","url":null,"abstract":"BACKGROUND Nurses certified in wound, ostomy, and continence (WOC) monitored an increasing incidence of hospital-acquired transnasal tube-related pressure injuries (TTPIs) in a tertiary hospital. Hospital-acquired pressure injuries are one of the most common preventable complications of hospitalization; however, the significance of TTPI prevention must be considered alongside the safety of tube fixation to prevent unplanned extubations (UEs), which are serious adverse events. Thus, exploring a quality improvement (QI) project to effectively reduce the risk of TTPIs while safeguarding tube safety is urgently needed. PURPOSE To decrease the incidence of TTPIs. METHODS Inpatients from 2017 to 2018 were set as the control group, using routine precautions. Inpatients from 2019 to 2020 were set as the experimental group, and a bundle of training and clinical practice interventions was implemented to compare the incidence of TTPIs and UEs between the 2 groups. RESULTS After improvement, the incidence of TTPIs reduced from 1.20% to 0.69%, the incidence of UEs reduced from 2.40% to 1.63%, and the differences were both statistically significant (P < .05). CONCLUSION The QI project reduced the incidence of TTPIs and UEs, thereby protecting the nasal skin/mucosal surfaces, safeguarding tube fixation, and ultimately improving the quality of clinical care.","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139345767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A study on prevalence, profile, and risk factors of developing fungal infection in patients with diabetic foot ulcer. 关于糖尿病足溃疡患者真菌感染的发病率、概况和风险因素的研究。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2023-09-01 DOI: 10.25270/wmp.22076
Azharuddin Sk, C. Vijayakumar, Thirugnanasambandam Nelson, G. Balasubramanian, Nagarajan Raj Kumar, Rakesh Singh
{"title":"A study on prevalence, profile, and risk factors of developing fungal infection in patients with diabetic foot ulcer.","authors":"Azharuddin Sk, C. Vijayakumar, Thirugnanasambandam Nelson, G. Balasubramanian, Nagarajan Raj Kumar, Rakesh Singh","doi":"10.25270/wmp.22076","DOIUrl":"https://doi.org/10.25270/wmp.22076","url":null,"abstract":"BACKGROUND Many chronic nonhealing diabetic foot ulcers (DFUs) with increased rates of amputation are frequently associated with fungal infections. PURPOSE To evaluate the prevalence, profile, and risk factors of developing a fungal infection in patients with DFU. METHODS This prospective observational study was carried out from October 2018 to July 2020. All adult patients with DFUs admitted to the surgery ward were recruited. Patients on antifungal therapy or who received such therapy within 6 weeks prior to admission were excluded. Three deep tissue samples were sent for bacterial culture, fungal culture, and histopathological examination of fungal elements. RESULTS A total of 251 patients were enrolled in the study. Of the 23.3% of patients with positive fungal growth (n = 47/202), 2% (n = 4/202) had pure fungal growth and 21.3% (n = 43/202) had mixed growth with bacteria in their ulcers (ie, non-contaminated samples). A significant association was found between wound grade (P = .027), ulcer duration (P = .028), and positive fungal growth in DFUs. CONCLUSIONS In this study, the prevalence of fungal infection in DFUs was 23.3%; Candida tropicalis (27.08%) was the most common isolate, followed by C. albicans (20.83%). The rate of fungal infections was high in patients with mild diabetic foot infection or DFU of 7 to 14 days' duration.","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevention of hospital-acquired transnasal tube-related pressure injuries: a quality improvement project. 预防医院获得性经鼻导管相关压伤:质量改进项目。
IF 1 4区 医学
Wound management & prevention Pub Date : 2023-09-01
Xianrong Wu, Liangzhi Qiu, Min Cai, Yuehua Huang, Yucui Wang, Yihong Qiu
{"title":"Prevention of hospital-acquired transnasal tube-related pressure injuries: a quality improvement project.","authors":"Xianrong Wu, Liangzhi Qiu, Min Cai, Yuehua Huang, Yucui Wang, Yihong Qiu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Nurses certified in wound, ostomy, and continence (WOC) monitored an increasing incidence of hospital-acquired transnasal tube-related pressure injuries (TTPIs) in a tertiary hospital. Hospital-acquired pressure injuries are one of the most common preventable complications of hospitalization; however, the significance of TTPI prevention must be considered alongside the safety of tube fixation to prevent unplanned extubations (UEs), which are serious adverse events. Thus, exploring a quality improvement (QI) project to effectively reduce the risk of TTPIs while safeguarding tube safety is urgently needed.</p><p><strong>Purpose: </strong>To decrease the incidence of TTPIs.</p><p><strong>Methods: </strong>Inpatients from 2017 to 2018 were set as the control group, using routine precautions. Inpatients from 2019 to 2020 were set as the experimental group, and a bundle of training and clinical practice interventions was implemented to compare the incidence of TTPIs and UEs between the 2 groups.</p><p><strong>Results: </strong>After improvement, the incidence of TTPIs reduced from 1.20% to 0.69%, the incidence of UEs reduced from 2.40% to 1.63%, and the differences were both statistically significant (P < .05).</p><p><strong>Conclusion: </strong>The QI project reduced the incidence of TTPIs and UEs, thereby protecting the nasal skin/mucosal surfaces, safeguarding tube fixation, and ultimately improving the quality of clinical care.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Training and practice of wound ostomy continence nurse specialists in China. 中国伤口造口护理专家的培训与实践。
IF 1 4区 医学
Wound management & prevention Pub Date : 2023-09-01
Dandan Yang, Ruihong Zhang, Holly Kirkland-Kyhn
{"title":"Training and practice of wound ostomy continence nurse specialists in China.","authors":"Dandan Yang, Ruihong Zhang, Holly Kirkland-Kyhn","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>In China, with chronic wound patients increasing by 10% per year and more than 1 million stoma patients, there is an increasing demand for wound ostomy continence care. Accordingly, specialized wound care in China is developing rapidly and the gap with developed countries is narrowing.</p><p><strong>Purpose: </strong>This paper aims to describe the status of training, practice, and management of wound nurses in China.</p><p><strong>Methods: </strong>Data on the training and practice of wound specialist nurses in the Chinese Mainland were collected through literature review and hospital surveys.</p><p><strong>Results: </strong>The training system of Chinese Wound, Ostomy and Continence (WOC) specialist nurses is developing rapidly, but lacks a unified access standard, curriculum, teaching materials, and assessment system. Specialist nurses play an important role in education, clinical practice, and scientific research, but home care and independent nursing practices are still in their infancy.</p><p><strong>Conclusion: </strong>The developing momentum of wound care in China is encouraging, but it is necessary to unify and standardize WOC nurses' qualification certification, scope of practice, level-to-level administration, and other aspects to cultivate higher-quality specialized wound nurses.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A study on prevalence, profile, and risk factors of developing fungal infection in patients with diabetic foot ulcer. 糖尿病足溃疡患者真菌感染的流行、概况及危险因素研究。
IF 1 4区 医学
Wound management & prevention Pub Date : 2023-09-01
Azharuddin Sk, Chellappa Vijayakumar, Thirugnanasambandam Nelson, Gopal Balasubramanian, Nagarajan Raj Kumar, Rakesh Singh
{"title":"A study on prevalence, profile, and risk factors of developing fungal infection in patients with diabetic foot ulcer.","authors":"Azharuddin Sk, Chellappa Vijayakumar, Thirugnanasambandam Nelson, Gopal Balasubramanian, Nagarajan Raj Kumar, Rakesh Singh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Many chronic nonhealing diabetic foot ulcers (DFUs) with increased rates of amputation are frequently associated with fungal infections.</p><p><strong>Purpose: </strong>To evaluate the prevalence, profile, and risk factors of developing a fungal infection in patients with DFU.</p><p><strong>Methods: </strong>This prospective observational study was carried out from October 2018 to July 2020. All adult patients with DFUs admitted to the surgery ward were recruited. Patients on antifungal therapy or who received such therapy within 6 weeks prior to admission were excluded. Three deep tissue samples were sent for bacterial culture, fungal culture, and histopathological examination of fungal elements.</p><p><strong>Results: </strong>A total of 251 patients were enrolled in the study. Of the 23.3% of patients with positive fungal growth (n = 47/202), 2% (n = 4/202) had pure fungal growth and 21.3% (n = 43/202) had mixed growth with bacteria in their ulcers (ie, non-contaminated samples). A significant association was found between wound grade (P = .027), ulcer duration (P = .028), and positive fungal growth in DFUs.</p><p><strong>Conclusions: </strong>In this study, the prevalence of fungal infection in DFUs was 23.3%; Candida tropicalis (27.08%) was the most common isolate, followed by C. albicans (20.83%). The rate of fungal infections was high in patients with mild diabetic foot infection or DFU of 7 to 14 days' duration.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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