Wound management & prevention最新文献

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Hydrocolloid wound dressing for sealing periwound with poor normal skin: negative pressure wound therapy for deep limb burns with extensive burns. 水胶体伤口敷料用于封闭正常皮肤较差的伤口周围:对大面积烧伤的深肢烧伤进行负压伤口治疗。
IF 1 4区 医学
Wound management & prevention Pub Date : 2023-09-01
Junya Oshima, Taiki Kamma, Yoshiaki Inoue, Yoichiro Shibuya, Kaoru Sasaki, Mitsuru Sekido
{"title":"Hydrocolloid wound dressing for sealing periwound with poor normal skin: negative pressure wound therapy for deep limb burns with extensive burns.","authors":"Junya Oshima, Taiki Kamma, Yoshiaki Inoue, Yoichiro Shibuya, Kaoru Sasaki, Mitsuru Sekido","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Negative pressure wound therapy (NPWT) is effective for wounds with exposed bones and tendons, but when the wound is accompanied by extensive burns, sealing is difficult. We performed sealing with a hydrocolloid wound dressing on limb burns.</p><p><strong>Case report: </strong>A 61-year-old woman was burned in a fire at her home. Split-thickness skin grafting was performed 14 and 35 days post injury, but exposure of the right patella and patellar tendon became apparent. The hydrocolloid wound dressing was wrapped around the proximal and distal aspects of a deep wound. The limb was sandwiched from the front and back surfaces and sealed with 2 film dressings, including the hydrocolloid, according to the sandwich method. Using this method, NPWT could be performed without leakage, the exposed tendons and bones were covered with granulation, and skin grafts were performed on day 88 after injury.</p><p><strong>Conclusion: </strong>Our method allows NPWT to be easily and effectively performed for deep limb burns with poor normal skin periwound area.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Training and practice of wound ostomy continence nurse specialists in China. 中国伤口造口护理专家的培训与实践。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2023-09-01 DOI: 10.25270/wmp.22083
Dandan Yang, Ruihong Zhang, Holly Kirkland-Kyhn
{"title":"Training and practice of wound ostomy continence nurse specialists in China.","authors":"Dandan Yang, Ruihong Zhang, Holly Kirkland-Kyhn","doi":"10.25270/wmp.22083","DOIUrl":"https://doi.org/10.25270/wmp.22083","url":null,"abstract":"BACKGROUND In China, with chronic wound patients increasing by 10% per year and more than 1 million stoma patients, there is an increasing demand for wound ostomy continence care. Accordingly, specialized wound care in China is developing rapidly and the gap with developed countries is narrowing. PURPOSE This paper aims to describe the status of training, practice, and management of wound nurses in China. METHODS Data on the training and practice of wound specialist nurses in the Chinese Mainland were collected through literature review and hospital surveys. RESULTS The training system of Chinese Wound, Ostomy and Continence (WOC) specialist nurses is developing rapidly, but lacks a unified access standard, curriculum, teaching materials, and assessment system. Specialist nurses play an important role in education, clinical practice, and scientific research, but home care and independent nursing practices are still in their infancy. CONCLUSION The developing momentum of wound care in China is encouraging, but it is necessary to unify and standardize WOC nurses' qualification certification, scope of practice, level-to-level administration, and other aspects to cultivate higher-quality specialized wound nurses.","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydrocolloid wound dressing for sealing periwound with poor normal skin: negative pressure wound therapy for deep limb burns with extensive Burns. 水胶体伤口敷料用于封闭正常皮肤较差的伤口周围:对大面积烧伤的深肢烧伤进行负压伤口治疗。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2023-09-01 DOI: 10.25270/wmp.22095
Junya Oshima, Taiki Kamma, Yoshiaki Inoue, Yoichiro Shibuya, Kaoru Sasaki, M. Sekido
{"title":"Hydrocolloid wound dressing for sealing periwound with poor normal skin: negative pressure wound therapy for deep limb burns with extensive Burns.","authors":"Junya Oshima, Taiki Kamma, Yoshiaki Inoue, Yoichiro Shibuya, Kaoru Sasaki, M. Sekido","doi":"10.25270/wmp.22095","DOIUrl":"https://doi.org/10.25270/wmp.22095","url":null,"abstract":"BACKGROUND Negative pressure wound therapy (NPWT) is effective for wounds with exposed bones and tendons, but when the wound is accompanied by extensive burns, sealing is difficult. We performed sealing with a hydrocolloid wound dressing on limb burns. CASE REPORT A 61-year-old woman was burned in a fire at her home. Split-thickness skin grafting was performed 14 and 35 days post injury, but exposure of the right patella and patellar tendon became apparent. The hydrocolloid wound dressing was wrapped around the proximal and distal aspects of a deep wound. The limb was sandwiched from the front and back surfaces and sealed with 2 film dressings, including the hydrocolloid, according to the sandwich method. Using this method, NPWT could be performed without leakage, the exposed tendons and bones were covered with granulation, and skin grafts were performed on day 88 after injury. CONCLUSION Our method allows NPWT to be easily and effectively performed for deep limb burns with poor normal skin periwound area.","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of PechaKucha presentation about prevention of pressure injury on knowledge of elderly care department students: a randomized controlled study. 一项随机对照研究:PechaKucha关于预防压伤的演讲对老年护理系学生知识的影响。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2023-05-01 DOI: 10.25270/wmp.2023.2.22097
H. T. Damar, Sueda Gür
{"title":"Effects of PechaKucha presentation about prevention of pressure injury on knowledge of elderly care department students: a randomized controlled study.","authors":"H. T. Damar, Sueda Gür","doi":"10.25270/wmp.2023.2.22097","DOIUrl":"https://doi.org/10.25270/wmp.2023.2.22097","url":null,"abstract":"BACKGROUND\u0000PechaKucha (PK) is a presentation technique that uses visual and narrative presentations consisting of 20 slides, each shown for 20 seconds.\u0000\u0000\u0000PURPOSE\u0000The aim of this study was to evaluate the effects of the PK presentation on elderly care department students' knowledge about pressure injury prevention.\u0000\u0000\u0000METHODS\u0000This study used a single-blinded randomized control trial. Elderly care department students were randomized to the PK presentation technique (intervention group) and traditional PowerPoint presentations only (control group). The sample of the study consisted of 54 (intervention group = 28, control group = 26) elderly care department students. Data was collected using the Sociodemographic Form and the Pressure Ulcer Prevention Knowledge Assessment Instrument (PUPKAI). PUPKAI was administered before the presentations (pre-test), after the presentations (post-test 1), and 4 weeks after the presentations (post-test 2).\u0000\u0000\u0000RESULTS\u0000Following the presentations, the intervention group's PUPKAI mean score (47.23 ± 11.62) was significantly higher than the control group's mean score (36.64 ± 12.41) (P < .05). Four weeks after completing the education, the intervention group's mean PUPKAI score (43.11 ± 13.72) was significantly higher than the control group's mean score (36.46 ± 12.76) (P < .05).\u0000\u0000\u0000CONCLUSION\u0000The knowledge level of the elderly care department students was found to be below the satisfactory level. It was determined that the PK presentation increased the knowledge level of the students regarding pressure injury prevention.","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45733001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A single-center pilot study investigating the effects of a native cross-linked extracellular matrix with polyhexamethylene biguanide to manage chronic lower extremity wounds exhibiting bacterial contamination. 一项单中心试点研究调查了天然交联细胞外基质与聚六亚甲基双胍治疗慢性下肢伤口细菌污染的效果。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2023-05-01 DOI: 10.25270/wmp.2023.2.22077
Windy E. Cole, Janina A. Krumbeck, Christopher Schattinger
{"title":"A single-center pilot study investigating the effects of a native cross-linked extracellular matrix with polyhexamethylene biguanide to manage chronic lower extremity wounds exhibiting bacterial contamination.","authors":"Windy E. Cole, Janina A. Krumbeck, Christopher Schattinger","doi":"10.25270/wmp.2023.2.22077","DOIUrl":"https://doi.org/10.25270/wmp.2023.2.22077","url":null,"abstract":"BACKGROUND\u0000Elevated bacterial bioburden and biofilm formation are common causes for delayed wound healing. Biofilm is an assemblage of surface-associated microbes enclosed in a self-produced matrix. Identifying and managing biofilm is a crucial component of successful wound care protocols.\u0000\u0000\u0000PURPOSE\u0000To determine the effects of a native cross-linked extra cellular matrix with polyhexamethylene biguanide (PHMP; PHMP antimicrobial [PCMP]), in conjunction with next-generation DNA sequencing (NGS) and targeted debridement by fluorescence imaging, on managing bacterial bioburden to support wound healing.\u0000\u0000\u0000METHODS\u0000Over 6 weeks, fluorescence images were captured to assess bacterial contamination as were standard images with measurements. Tissue swabs were obtained and analyzed using NGS to quantify bacterial bioburden. PCMP was applied at each treatment visit.\u0000\u0000\u0000RESULTS\u0000Baseline wound duration was 23.0 ± 6.7 weeks, and baseline size was 7.9 ± 7.1 cm2. Two out of 5 wounds healed by week 4. The mean percentage area reduction of all wounds was 59.7% by week 4 and 78.1% by week 6. All wounds were fluorescence positive on week 1 and fluorescence negative by Week 4.\u0000\u0000\u0000CONCLUSION\u0000PCMP, as an antimicrobial barrier, combined with use of a real-time method of bacterial detection, may be beneficial in managing the wound healing environment.","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45314153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The nursing care for the medical device related pressure injury patient with a mucosal pressure injury due to an endotracheal tube: a case report. 医疗器械相关压力损伤患者气管插管致粘膜压力损伤1例的护理
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2023-05-01 DOI: 10.25270/wmp.2023.2.22051
Arzu Bahar, Demet Bal
{"title":"The nursing care for the medical device related pressure injury patient with a mucosal pressure injury due to an endotracheal tube: a case report.","authors":"Arzu Bahar, Demet Bal","doi":"10.25270/wmp.2023.2.22051","DOIUrl":"https://doi.org/10.25270/wmp.2023.2.22051","url":null,"abstract":"BACKGROUND\u0000Pressure injury (PI) due to medical devices is one of the most common PIs, especially in patients treated in intensive care. Medical device-related pressure injuries (MDRPIs), as part of their treatment, require extra care and prevention interventions than injuries caused by immobilization. Standardized nursing models are needed to care for PIs caused by medical devices on mucous membranes.\u0000\u0000\u0000PURPOSE\u0000To provide information about the evaluation and care of the MDRPIs in the mucosal membrane due to the endotracheal tube (ET).\u0000\u0000\u0000CASE REPORT\u0000A 35-year-old male with chronic obstructive pulmonary disease (COPD) and coronavirus disease has MDRPIs on the lower lip edge due to the ET on the fifteenth day after intubation. North American Nursing Diagnosis Association (NANDA) diagnoses were determined by systematically analyzing the data using the Gordon's Functional Health Patterns (GFHP) model in the patient. Nursing care was planned and applied in line with the determined NANDA diagnoses, Nursing Outcomes Classification (NOC) interventions, and using the recommendations of current PI guides for treatment of MDRPIs.\u0000\u0000\u0000CONCLUSION\u0000This case report illustrates MDRPIs resulting from ET and provides information about the formation of MDRPIs and appropriate maintenance therapy. Future research is recommended to examine and evaluate the nursing care and outcome of MDRPIs in different mucosal membranes.","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48168876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Use of disposable negative pressure wound therapy in 16 podiatry clinic patients with chronic wounds. 一次性负压创伤治疗在16例足科门诊慢性创伤患者中的应用。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2023-05-01 DOI: 10.25270/wmp.2023.2.22087
R. Klein, Rhea Matthew, Daniel J Spangler, Hadley Hudson, Laura Soloway, C. Bongards
{"title":"Use of disposable negative pressure wound therapy in 16 podiatry clinic patients with chronic wounds.","authors":"R. Klein, Rhea Matthew, Daniel J Spangler, Hadley Hudson, Laura Soloway, C. Bongards","doi":"10.25270/wmp.2023.2.22087","DOIUrl":"https://doi.org/10.25270/wmp.2023.2.22087","url":null,"abstract":"BACKGROUND\u0000Disposable mechanical negative pressure wound therapy (dNPWT) can help manage lower extremity wounds in the outpatient clinic.\u0000\u0000\u0000PURPOSE\u0000We assessed dNPWT use in 16 patients at a podiatry clinic.\u0000\u0000\u0000METHODS\u0000Patients were treated between October 31, 2019 and December 16, 2021. All patients received dNPWT with dressing changes every 2 to 3 days. Demographics, baseline wound and subsequent wound visit data, and treatments were recorded. Wound healing outcomes were assessed.\u0000\u0000\u0000RESULTS\u0000Average patient age was 59.6 ± 8.9 years old. Patient comorbidities included poor nutritional status, diabetes, and hypertension. Wound types consisted of 6 diabetic foot ulcers, 9 surgical wounds, and 1 pressure injury. At baseline, the average wound age was 15.6 weeks, average area was 5.5 cm2, and average volume was 3.3 cm3. The average time from presentation to end of dNPWT was 45.5 days. In this timeframe, wounds improved in granulation tissue amount (81%), reduced in area (63%), and reduced in volume (69%). By the end of treatment, a majority of patients (88%) displayed 76% to 100% wound bed coverage with healthy granulation tissue. The remaining 12% showed <76% coverage with granulation tissue.\u0000\u0000\u0000CONCLUSIONS\u0000In this retrospective study, 14 of 16 patients displayed improvement in wound area, volume, and granulation tissue amount during dNPWT treatment.","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49564056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of disposable negative pressure wound therapy in 16 podiatry clinic patients with chronic wounds. 一次性负压创面治疗慢性足病16例临床分析。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2023-05-01
Robert Klein, Rhea Matthew, Daniel J Spangler, Hadley Hudson, Laura Soloway, Christine Bongards
{"title":"Use of disposable negative pressure wound therapy in 16 podiatry clinic patients with chronic wounds.","authors":"Robert Klein,&nbsp;Rhea Matthew,&nbsp;Daniel J Spangler,&nbsp;Hadley Hudson,&nbsp;Laura Soloway,&nbsp;Christine Bongards","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Disposable mechanical negative pressure wound therapy (dNPWT) can help manage lower extremity wounds in the outpatient clinic.</p><p><strong>Purpose: </strong>We assessed dNPWT use in 16 patients at a podiatry clinic.</p><p><strong>Methods: </strong>Patients were treated between October 31, 2019 and December 16, 2021. All patients received dNPWT with dressing changes every 2 to 3 days. Demographics, baseline wound and subsequent wound visit data, and treatments were recorded. Wound healing outcomes were assessed.</p><p><strong>Results: </strong>Average patient age was 59.6 ± 8.9 years old. Patient comorbidities included poor nutritional status, diabetes, and hypertension. Wound types consisted of 6 diabetic foot ulcers, 9 surgical wounds, and 1 pressure injury. At baseline, the average wound age was 15.6 weeks, average area was 5.5 cm2, and average volume was 3.3 cm3. The average time from presentation to end of dNPWT was 45.5 days. In this timeframe, wounds improved in granulation tissue amount (81%), reduced in area (63%), and reduced in volume (69%). By the end of treatment, a majority of patients (88%) displayed 76% to 100% wound bed coverage with healthy granulation tissue. The remaining 12% showed <76% coverage with granulation tissue.</p><p><strong>Conclusions: </strong>In this retrospective study, 14 of 16 patients displayed improvement in wound area, volume, and granulation tissue amount during dNPWT treatment.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9591151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A single-center pilot study investigating the effects of a native cross-linked extracellular matrix with polyhexamethylene biguanide to manage chronic lower extremity wounds exhibiting bacterial contamination. 一项单中心试点研究调查了天然交联细胞外基质与聚六亚甲基双胍治疗慢性下肢伤口细菌污染的效果。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2023-05-01
Windy Cole, Janina Krumbeck, Christopher Schattinger
{"title":"A single-center pilot study investigating the effects of a native cross-linked extracellular matrix with polyhexamethylene biguanide to manage chronic lower extremity wounds exhibiting bacterial contamination.","authors":"Windy Cole,&nbsp;Janina Krumbeck,&nbsp;Christopher Schattinger","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Elevated bacterial bioburden and biofilm formation are common causes for delayed wound healing. Biofilm is an assemblage of surface-associated microbes enclosed in a self-produced matrix. Identifying and managing biofilm is a crucial component of successful wound care protocols.</p><p><strong>Purpose: </strong>To determine the effects of a native cross-linked extra cellular matrix with polyhexamethylene biguanide (PHMP; PHMP antimicrobial [PCMP]), in conjunction with next-generation DNA sequencing (NGS) and targeted debridement by fluorescence imaging, on managing bacterial bioburden to support wound healing.</p><p><strong>Methods: </strong>Over 6 weeks, fluorescence images were captured to assess bacterial contamination as were standard images with measurements. Tissue swabs were obtained and analyzed using NGS to quantify bacterial bioburden. PCMP was applied at each treatment visit.</p><p><strong>Results: </strong>Baseline wound duration was 23.0 ± 6.7 weeks, and baseline size was 7.9 ± 7.1 cm2. Two out of 5 wounds healed by week 4. The mean percentage area reduction of all wounds was 59.7% by week 4 and 78.1% by week 6. All wounds were fluorescence positive on week 1 and fluorescence negative by Week 4.</p><p><strong>Conclusion: </strong>PCMP, as an antimicrobial barrier, combined with use of a real-time method of bacterial detection, may be beneficial in managing the wound healing environment.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9644059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic modalities of human β defensin-2 with prospective significance in diabetic wound treatment. 人β防御素-2治疗方式在糖尿病创面治疗中的前瞻性意义。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2023-05-01
Vidyasrilekha Yele, Bharat Kr Sanapalli
{"title":"Therapeutic modalities of human β defensin-2 with prospective significance in diabetic wound treatment.","authors":"Vidyasrilekha Yele,&nbsp;Bharat Kr Sanapalli","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Diabetic Wounds (DW) are a debilitating complication of diabetes. Although various therapeutic strategies are available for DW management, none of them meet all the fundamentals due to the multifaceted pathophysiology of DW. Given the ever-present threat of DW, novel improved therapeutic strategies and the fortification of DW research deserve better prioritization.</p><p><strong>Purpose: </strong>The current review aims to provide the detailed role of human β defensin-2 (HBD-2) in skin wounds with a prospective significance in DW treatment.</p><p><strong>Methods: </strong>This review was conducted through searches of relevant abstracts, research and review articles, and patents, in Scopus, Web of Science, PubMed, Google Scholar, and Clinical Trials databases of English language articles.</p><p><strong>Results: </strong>HBD-2 is a critical innate immune-response protein that defends the human body from infections. Recent reports also support the role of HBD-2 in suppressing inflammation and promoting proliferation and angiogenesis. Based on the literature, its therapeutic administration has been proposed to maintain the equilibrium of systemic homeostasis in DW.</p><p><strong>Conclusion: </strong>It has been hypothesized that HBD-2 could be a crucial modulator for controlling chronic inflammation and size by promoting proliferation and angiogenesis, opening up new therapy options in DW.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9591153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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