Sepsis episodes caused by pressure injuries in critical illness: a retrospective observational cohort study.

IF 0.8 4区 医学 Q4 DERMATOLOGY
Wound management & prevention Pub Date : 2023-11-01
Pınar Küçükdemirci Kaya, Murad Kaya, Nermin Kelebek Girgin, Ferda Ş Kahveci, Emin Halis Akalın, Remzi İşçimen
{"title":"Sepsis episodes caused by pressure injuries in critical illness: a retrospective observational cohort study.","authors":"Pınar Küçükdemirci Kaya, Murad Kaya, Nermin Kelebek Girgin, Ferda Ş Kahveci, Emin Halis Akalın, Remzi İşçimen","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Critically-ill patients (CIPs) with pressure injuries (PIs) may develop bloodstream infections (BSIs).</p><p><strong>Purpose: </strong>To identify predisposing factors and discuss diagnosis and management of sepsis-related PIs in CIPs.</p><p><strong>Methods: </strong>The records of CIPs in the intensive care unit (ICU) between January 1, 2014, and January 1, 2020, with PI with sepsis-diagnoses and with different site cultures that were positive concurrent with bloodstream-cultures were retrospectively reviewed.</p><p><strong>Results: </strong>Ninety-one sepsis episodes were included in the study. Low albumin level (U = 382.00, P = .006), renal failure (odds ratio [OR], 0.108 [95% CI, 0.015-0.783]; P = .025), and length of ICU stay (U = 130.00, P < .001) were identified as risk factors of BSIs due to PIs. The probability of BSI during a sepsis episode was lower in CIPs with PIs with higher C-reactive protein levels (U = 233.00, P < .001) and whose injury resulted from trauma or surgery (OR, 0.101 [95% CI, 0.016-0.626]; P = .014). The mortality was higher in CIPs with PI-induced BSIs (OR, 0.051 [95% CI, 0.008-0.309]; P = .001).</p><p><strong>Conclusions: </strong>Pressure injury-induced sepsis was associated with a high risk of 28-day mortality. The findings suggest that CIPs with PI are at increased risk of BSIs if they have low albumin levels, renal-failure, and prolonged ICU stay during sepsis episodes.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":"69 4","pages":"4-9"},"PeriodicalIF":0.8000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Wound management & prevention","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Critically-ill patients (CIPs) with pressure injuries (PIs) may develop bloodstream infections (BSIs).

Purpose: To identify predisposing factors and discuss diagnosis and management of sepsis-related PIs in CIPs.

Methods: The records of CIPs in the intensive care unit (ICU) between January 1, 2014, and January 1, 2020, with PI with sepsis-diagnoses and with different site cultures that were positive concurrent with bloodstream-cultures were retrospectively reviewed.

Results: Ninety-one sepsis episodes were included in the study. Low albumin level (U = 382.00, P = .006), renal failure (odds ratio [OR], 0.108 [95% CI, 0.015-0.783]; P = .025), and length of ICU stay (U = 130.00, P < .001) were identified as risk factors of BSIs due to PIs. The probability of BSI during a sepsis episode was lower in CIPs with PIs with higher C-reactive protein levels (U = 233.00, P < .001) and whose injury resulted from trauma or surgery (OR, 0.101 [95% CI, 0.016-0.626]; P = .014). The mortality was higher in CIPs with PI-induced BSIs (OR, 0.051 [95% CI, 0.008-0.309]; P = .001).

Conclusions: Pressure injury-induced sepsis was associated with a high risk of 28-day mortality. The findings suggest that CIPs with PI are at increased risk of BSIs if they have low albumin levels, renal-failure, and prolonged ICU stay during sepsis episodes.

危重病人压伤导致的败血症发作:一项回顾性观察队列研究。
背景:目的:确定危重病人(CIPs)压伤(PIs)的诱发因素,并讨论CIPs中脓毒症相关PIs的诊断和管理:方法:回顾性分析重症监护病房(ICU)2014年1月1日至2020年1月1日期间的CIP病例,这些病例的PI均被诊断为败血症,且不同部位的培养结果均为阳性,同时血流培养结果也为阳性:研究共纳入 91 例败血症病例。低白蛋白水平(U = 382.00,P = .006)、肾功能衰竭(比值比 [OR],0.108 [95% CI,0.015-0.783];P = .025)和重症监护室住院时间(U = 130.00,P < .001)被确定为 PIs 引起 BSI 的风险因素。C反应蛋白水平较高(U = 233.00,P < .001)、外伤或手术导致损伤的CIP患者在脓毒症发作期间发生BSI的概率较低(OR,0.101 [95% CI,0.016-0.626];P = .014)。PI诱发BSI的CIP患者死亡率更高(OR,0.051 [95% CI,0.008-0.309];P = .001):结论:压伤引发的败血症与 28 天内的高死亡率相关。研究结果表明,如果白蛋白水平低、肾功能衰竭以及脓毒症发作期间在重症监护室住院时间过长,那么患有 PI 的 CIP 患者发生 BSI 的风险就会增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Wound management & prevention
Wound management & prevention Nursing-Medical and Surgical Nursing
CiteScore
1.70
自引率
8.30%
发文量
41
期刊介绍: Information not localized
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信