Wound management & prevention最新文献

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Etiology of Chronic Leg Ulcers in a Dermatologic Wound Clinic: A Retrospective Observational Study. 皮肤伤口诊所慢性腿部溃疡的病因学:一项回顾性观察研究。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2022-08-01
Paola Monari, Giulio Gualdi, Sara Rovaris, Anna Venturuzzo, Chiara Rovati, Piergiacomo Calzavara Pinton
{"title":"Etiology of Chronic Leg Ulcers in a Dermatologic Wound Clinic: A Retrospective Observational Study.","authors":"Paola Monari,&nbsp;Giulio Gualdi,&nbsp;Sara Rovaris,&nbsp;Anna Venturuzzo,&nbsp;Chiara Rovati,&nbsp;Piergiacomo Calzavara Pinton","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Chronic leg ulcers affect approximately 1% to 2% of the European population, with an increasing prevalence. The treatment of chronic wounds is a socioeconomical problem worldwide.</p><p><strong>Purpose: </strong>The main purpose of the current investigation was to detect the etiology of leg ulcers treated in a dermatologic wound clinic from January 1, 2010, to December 31, 2019.</p><p><strong>Methods: </strong>This retrospective observational study was performed at the Dermatologic Clinic of Spedali Civili in Brescia, Italy. The authors enrolled 465 patients with chronic leg ulcers.</p><p><strong>Results: </strong>The 3 most represented causes of ulcers were vascular (238 patients, 51.2%), inflammatory (71 patients, 15.3%) and traumatic (43 patients, 9.3%). Altogether, a total of 13 different entities were identified as a cause of leg ulcer.</p><p><strong>Conclusion: </strong>Vascular genesis was the most common etiology of leg ulcers in this population, even though uncommon causes were also represented. These findings are in agreement with other studies reported in the literature.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40692474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and Effectiveness of Moxibustion and Abdominal Massage in Hospitalized Older Patients With Constipation: A Retrospective Study. 艾灸加腹部按摩治疗住院老年便秘患者的安全性和有效性:一项回顾性研究。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2022-08-01
Kexin Li
{"title":"Safety and Effectiveness of Moxibustion and Abdominal Massage in Hospitalized Older Patients With Constipation: A Retrospective Study.","authors":"Kexin Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Evidence about moxibustion and abdominal massage for treating constipation in older hospitalized patients is limited.</p><p><strong>Purpose: </strong>To investigate the safety and effectiveness of moxibustion and abdominal massage in hospitalized older patients with constipation.</p><p><strong>Methods: </strong>Hospitalized older patients (age ≥60 years) with constipation were retrospectively categorized as 2 cohorts according to whether the patients received moxibustion and abdominal massage in addition to routine nursing care. Gastrointestinal symptoms, Constipation Assessment Scale (CAS) scores, and Geriatric Depression Scale (GDS) scores were compared before and after treatment between cohorts.</p><p><strong>Results: </strong>The 2 cohorts (n = 100 for each) had similar baseline characteristics and gastrointestinal symptoms; the control cohort and the additional intervention cohort also had similar CAS scores (7.14 ± 3.67 vs 7.48 ± 2.96, respectively), and GDS scores (>17: 31% vs 29%, respectively). Improvement in the 2 scores from baseline was observed after 2 weeks in both the control cohort and the additional intervention cohort (CAS, 5.37 ± 5.34 and 3.80 ± 4.47, respectively; GDS, >17: 28% and 15%, respectively). The cohort with additional interventions had a lower ineffective rate (defined as persistent symptoms or absence of decrease in CAS, 49% vs 32%; P = .028) but had more diarrhea (9% vs 21%; P = .017).</p><p><strong>Conclusion: </strong>Moxibustion and abdominal massage may help relieve constipation in hospitalized elderly patients, but attention should be paid to the increased occurrence of diarrhea. More study is needed.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40692475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Etiology of Chronic Leg Ulcers in a Dermatologic Wound Clinic: A Retrospective Observational Study. 皮肤科伤口诊所慢性腿部溃疡的病因:一项回顾性观察研究。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2022-08-01 DOI: 10.25270/wmp.2022.8.1215
P. Monari, G. Gualdi, S. Rovaris, A. Venturuzzo, C. Rovati, P. C. Pinton
{"title":"Etiology of Chronic Leg Ulcers in a Dermatologic Wound Clinic: A Retrospective Observational Study.","authors":"P. Monari, G. Gualdi, S. Rovaris, A. Venturuzzo, C. Rovati, P. C. Pinton","doi":"10.25270/wmp.2022.8.1215","DOIUrl":"https://doi.org/10.25270/wmp.2022.8.1215","url":null,"abstract":"BACKGROUND\u0000Chronic leg ulcers affect approximately 1% to 2% of the European population, with an increasing prevalence. The treatment of chronic wounds is a socioeconomical problem worldwide.\u0000\u0000\u0000PURPOSE\u0000The main purpose of the current investigation was to detect the etiology of leg ulcers treated in a dermatologic wound clinic from January 1, 2010, to December 31, 2019.\u0000\u0000\u0000METHODS\u0000This retrospective observational study was performed at the Dermatologic Clinic of Spedali Civili in Brescia, Italy. The authors enrolled 465 patients with chronic leg ulcers.\u0000\u0000\u0000RESULTS\u0000The 3 most represented causes of ulcers were vascular (238 patients, 51.2%), inflammatory (71 patients, 15.3%) and traumatic (43 patients, 9.3%). Altogether, a total of 13 different entities were identified as a cause of leg ulcer.\u0000\u0000\u0000CONCLUSION\u0000Vascular genesis was the most common etiology of leg ulcers in this population, even though uncommon causes were also represented. These findings are in agreement with other studies reported in the literature.","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45951868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Content and Quality of Online Videos About Ostomy Pouch Changes: A Descriptive Study. 关于造口术后眼袋变化的在线视频内容和质量:一项描述性研究。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2022-08-01
Zeynep Temiz, Didem Kandemir
{"title":"Content and Quality of Online Videos About Ostomy Pouch Changes: A Descriptive Study.","authors":"Zeynep Temiz,&nbsp;Didem Kandemir","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Many health-related videos are available online. One type of health-related video is related to stoma pouch change. However, a system to evaluate the quality and content of these videos is lacking.</p><p><strong>Purpose: </strong>To evaluate the content and quality of YouTube videos on colostomy pouch change.</p><p><strong>Methods: </strong>A descriptive study was carried out by searching for videos on March 15, 2021, using the key words \"colostomy care,\" \"colostomy bag/pouch change,\" and \"ostomy bag/pouch change.\" A 5-point Global Quality Scale was used to evaluate the quality of the videos, and a 10-point scale was used to evaluate the content. The videos were classified as \"useful\" or \"useless\" according to their content and quality scores.</p><p><strong>Results: </strong>A total of 128 videos were found; 94 videos met the criteria and were included in the study. The content of the 94 videos was examined by 2 independent researchers. The overall content score of the videos was 8.24 ± 1.56, and the overall quality score was 3.14 ± 0.97. A total of 66 (70.21%) videos were useful, and 28 (29.79%) videos were useless. The mean scores of useful videos for content (9.09 ± 0.83) and the average Global Quality Scale scores (3.53 ± 0.76) were significantly higher than those of useless videos (6.17 ± 0.90 and 2.25 ± 0.75, respectively; (P < .05). The results showed that 57.6% of the useful videos were uploaded by universities, professional organizations, and health care professionals, and 67.9% of the useless videos were uploaded by patients; the difference was statistically significant (P < .05).</p><p><strong>Conclusions: </strong>Results indicated that the majority of online videos evaluated were accurate. Most of these videos were uploaded by universities, professional organizations, health care professionals, or medical advertisers. Although there were many limitations to this study, the authors suggest that health care professionals can direct their patients to these sources after hospital discharge. However, future studies are needed..</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40692476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Content and Quality of Online Videos About Ostomy Pouch Changes: A Descriptive Study. 关于造口术包变化的在线视频的内容和质量:一项描述性研究。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2022-08-01 DOI: 10.25270/wmp.2022.8.2532
Zeynep Temiz, Didem Kandemir
{"title":"Content and Quality of Online Videos About Ostomy Pouch Changes: A Descriptive Study.","authors":"Zeynep Temiz, Didem Kandemir","doi":"10.25270/wmp.2022.8.2532","DOIUrl":"https://doi.org/10.25270/wmp.2022.8.2532","url":null,"abstract":"BACKGROUND\u0000Many health-related videos are available online. One type of health-related video is related to stoma pouch change. However, a system to evaluate the quality and content of these videos is lacking.\u0000\u0000\u0000PURPOSE\u0000To evaluate the content and quality of YouTube videos on colostomy pouch change.\u0000\u0000\u0000METHODS\u0000A descriptive study was carried out by searching for videos on March 15, 2021, using the key words \"colostomy care,\" \"colostomy bag/pouch change,\" and \"ostomy bag/pouch change.\" A 5-point Global Quality Scale was used to evaluate the quality of the videos, and a 10-point scale was used to evaluate the content. The videos were classified as \"useful\" or \"useless\" according to their content and quality scores.\u0000\u0000\u0000RESULTS\u0000A total of 128 videos were found; 94 videos met the criteria and were included in the study. The content of the 94 videos was examined by 2 independent researchers. The overall content score of the videos was 8.24 ± 1.56, and the overall quality score was 3.14 ± 0.97. A total of 66 (70.21%) videos were useful, and 28 (29.79%) videos were useless. The mean scores of useful videos for content (9.09 ± 0.83) and the average Global Quality Scale scores (3.53 ± 0.76) were significantly higher than those of useless videos (6.17 ± 0.90 and 2.25 ± 0.75, respectively; (P < .05). The results showed that 57.6% of the useful videos were uploaded by universities, professional organizations, and health care professionals, and 67.9% of the useless videos were uploaded by patients; the difference was statistically significant (P < .05).\u0000\u0000\u0000CONCLUSIONS\u0000Results indicated that the majority of online videos evaluated were accurate. Most of these videos were uploaded by universities, professional organizations, health care professionals, or medical advertisers. Although there were many limitations to this study, the authors suggest that health care professionals can direct their patients to these sources after hospital discharge. However, future studies are needed..","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47104796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and Feasibility of Temporary Ileostomy in Older Patients: A Retrospective Study. 老年患者临时回肠切开术的安全性和可行性:一项回顾性研究。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2022-07-01 DOI: 10.25270/wmp.2022.7.1824
S. Maeda, A. Ouchi, K. Komori, T. Kinoshita, Taihei Oshiro, Yoshihisa Numata, S. Ito, T. Abe, Y. Shimizu
{"title":"Safety and Feasibility of Temporary Ileostomy in Older Patients: A Retrospective Study.","authors":"S. Maeda, A. Ouchi, K. Komori, T. Kinoshita, Taihei Oshiro, Yoshihisa Numata, S. Ito, T. Abe, Y. Shimizu","doi":"10.25270/wmp.2022.7.1824","DOIUrl":"https://doi.org/10.25270/wmp.2022.7.1824","url":null,"abstract":"BACKGROUND\u0000Temporary ileostomy reduces the incidence of severe anastomotic leakage and postoperative mortality. However, little is known about ileostomy-related complications in older adults.\u0000\u0000\u0000PURPOSE\u0000To clarify the safety and feasibility of temporary ileostomy for rectal cancer in older patients.\u0000\u0000\u0000METHODS\u0000Data were collected from a prospectively created database and complemented by secondary chart review for consecutive patients with rectal malignancy who underwent curative proctectomy with diverting loop ileostomy between 2013 and 2018. Ileostomy construction and closure were compared between two groups (defined as elderly and non-elderly patients). Data for 22 patients who were 75 years of age and older (elderly group) and 160 patients who were younger than 75 years (non-elderly group) were analyzed.\u0000\u0000\u0000RESULTS\u0000The median maximum fecal output was significantly higher in the non-elderly group compared with the elderly group. No significant differences were observed between the two groups in postoperative intravenous hydration, creatinine ratio, and ileostomy-related complication rate. Although the elderly group had a higher rate of early stoma closure, the causes were not related to those complications.\u0000\u0000\u0000CONCLUSION\u0000Temporary ileostomy was a safe and feasible procedure in this population of older patients with rectal malignancies.","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44400538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Proposed Algorithm to Diagnose and Treat Lower Extremity Hematomas. 一种诊断和治疗下肢血肿的算法。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2022-07-01
Windy Cole, Stacey Coe, Sarah Messina, Valeria Marmolejo
{"title":"A Proposed Algorithm to Diagnose and Treat Lower Extremity Hematomas.","authors":"Windy Cole,&nbsp;Stacey Coe,&nbsp;Sarah Messina,&nbsp;Valeria Marmolejo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Pretibial injury is common. Although the mechanism of injury may be minor, in a specific patient population, misdiagnosis and delay in appropriate treatment can lead to dire consequences. The ability to identify and properly treat these patients early has the potential to reduce the need for surgical intervention, hospitalization, and prolonged care.</p><p><strong>Methods: </strong>A literature review was performed to develop the Lower Extremity Hematoma Algorithm (LEHA) to aid in identifying and managing these injuries in the patient population at greatest risk.</p><p><strong>Results: </strong>A case example is provided to demonstrate how implementation of the LEHA may have led to early diagnosis and treatment, avoiding expensive advanced and prolonged care.</p><p><strong>Conclusion: </strong>Implementation of the LEHA may expedite the identification of patients at risk for deep dissecting hematomas, enabling faster implementation of appropriate treatment and thereby helping to contain health care costs through avoiding surgical intervention.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40550426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Proposed Algorithm to Diagnose and Treat Lower Extremity Hematomas. 一种诊断和治疗下肢血肿的算法。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2022-07-01 DOI: 10.25270/wmp.2022.7.1117
Windy E. Cole, Stacey Coe, Sarah Messina, Valeria Marmolejo
{"title":"A Proposed Algorithm to Diagnose and Treat Lower Extremity Hematomas.","authors":"Windy E. Cole, Stacey Coe, Sarah Messina, Valeria Marmolejo","doi":"10.25270/wmp.2022.7.1117","DOIUrl":"https://doi.org/10.25270/wmp.2022.7.1117","url":null,"abstract":"BACKGROUND\u0000Pretibial injury is common. Although the mechanism of injury may be minor, in a specific patient population, misdiagnosis and delay in appropriate treatment can lead to dire consequences. The ability to identify and properly treat these patients early has the potential to reduce the need for surgical intervention, hospitalization, and prolonged care.\u0000\u0000\u0000METHODS\u0000A literature review was performed to develop the Lower Extremity Hematoma Algorithm (LEHA) to aid in identifying and managing these injuries in the patient population at greatest risk.\u0000\u0000\u0000RESULTS\u0000A case example is provided to demonstrate how implementation of the LEHA may have led to early diagnosis and treatment, avoiding expensive advanced and prolonged care.\u0000\u0000\u0000CONCLUSION\u0000Implementation of the LEHA may expedite the identification of patients at risk for deep dissecting hematomas, enabling faster implementation of appropriate treatment and thereby helping to contain health care costs through avoiding surgical intervention.","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44587220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and Feasibility of Temporary Ileostomy in Older Patients: A Retrospective Study. 老年患者临时回肠造口术的安全性和可行性:一项回顾性研究。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2022-07-01
Shingo Maeda, Akira Ouchi, Koji Komori, Takashi Kinoshita, Taihei Oshiro, Yoshihisa Numata, Seiji Ito, Tetsuya Abe, Yasuhiro Shimizu
{"title":"Safety and Feasibility of Temporary Ileostomy in Older Patients: A Retrospective Study.","authors":"Shingo Maeda,&nbsp;Akira Ouchi,&nbsp;Koji Komori,&nbsp;Takashi Kinoshita,&nbsp;Taihei Oshiro,&nbsp;Yoshihisa Numata,&nbsp;Seiji Ito,&nbsp;Tetsuya Abe,&nbsp;Yasuhiro Shimizu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Temporary ileostomy reduces the incidence of severe anastomotic leakage and postoperative mortality. However, little is known about ileostomy-related complications in older adults.</p><p><strong>Purpose: </strong>To clarify the safety and feasibility of temporary ileostomy for rectal cancer in older patients.</p><p><strong>Methods: </strong>Data were collected from a prospectively created database and complemented by secondary chart review for consecutive patients with rectal malignancy who underwent curative proctectomy with diverting loop ileostomy between 2013 and 2018. Ileostomy construction and closure were compared between two groups (defined as elderly and non-elderly patients). Data for 22 patients who were 75 years of age and older (elderly group) and 160 patients who were younger than 75 years (non-elderly group) were analyzed.</p><p><strong>Results: </strong>The median maximum fecal output was significantly higher in the non-elderly group compared with the elderly group. No significant differences were observed between the two groups in postoperative intravenous hydration, creatinine ratio, and ileostomy-related complication rate. Although the elderly group had a higher rate of early stoma closure, the causes were not related to those complications.</p><p><strong>Conclusion: </strong>Temporary ileostomy was a safe and feasible procedure in this population of older patients with rectal malignancies.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40550427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Topical Application and/or Systemic Use of Red Ginseng Extract on Wound Healing in Rats With Experimentally Induced Diabetes. 红参提取物的局部应用和/或全身应用对实验性糖尿病大鼠伤口愈合的影响。
IF 1.2 4区 医学
Wound management & prevention Pub Date : 2022-06-01 DOI: 10.25270/wmp.2022.6.2837
X. Xxxxxxx, M. Duymus, H. A. Aydin, Abdullah Bulğurcu, Z. Bayramoğlu, A. Durhan, Salih M Salih, M. R. Pekcici, K. Kısmet
{"title":"Effect of Topical Application and/or Systemic Use of Red Ginseng Extract on Wound Healing in Rats With Experimentally Induced Diabetes.","authors":"X. Xxxxxxx, M. Duymus, H. A. Aydin, Abdullah Bulğurcu, Z. Bayramoğlu, A. Durhan, Salih M Salih, M. R. Pekcici, K. Kısmet","doi":"10.25270/wmp.2022.6.2837","DOIUrl":"https://doi.org/10.25270/wmp.2022.6.2837","url":null,"abstract":"BACKGROUND\u0000Red ginseng (Rg) is an herbal product that has been used in traditional medicine in Asian and European countries for many years.\u0000\u0000\u0000PURPOSE\u0000To study the effects of Rg extract on wound healing when used systemically, locally, or in combination in rats with experimentally induced diabetes.\u0000\u0000\u0000METHODS\u0000A total of 60 rats were randomly divided into 4 groups: saline (control), local Rg (LRg), systemic Rg (SRg), and local + systemic = combined Rg (CRg). A full-thickness wound (2 cm × 1 cm) was created on the back of the rats, and treatment protocols were carried out for 14 days. Wound areas of all rats were measured on days 0 and 14. Tissue samples were taken from the wound areas for histopathologic evaluation of inflammation, epithelialization, and fibrosis. Vascular endothelial growth factor (VEGF), CD4+, and CD8+ expressions were examined by immunohistochemistry.\u0000\u0000\u0000RESULTS\u0000Wound contraction measurements were 63.8%, 80.5%, 88.5%, and 86.6% in the control, LRg, SRg and CRg groups, respectively. Although significant differences were observed for all treated groups (LRg, SRg, and CRg) compared with the control group in terms of wound contraction, there was no difference among the treatment groups. VEGF-positive vessel/mm2 was observed 4.00 ± 0.75, 5.93 ± 0.70, 5.93 ± 1.93, and 7.93 ± 0.70 in the control, LRg, SRg and CRg groups, respectively. There was no difference between LRg and SRg in terms of VEGF expression, but there was significant difference for all other groups compared with each other.\u0000\u0000\u0000CONCLUSION\u0000All usage methods of Rg extract increased wound contraction, and differences were observed compared with the control group. However, the authors believe that the combined usage was more effective due to higher VEGF expression levels and lower CD4+:CD8+ ratio.","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46083136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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