World journal of microbiology & biotechnology最新文献_第6页

Role of glycosylation in bacterial resistance to carbapenems.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-01-30 DOI: 10.1007/s11274-025-04272-3

Jing Dang, Xinlu Yu, Mengyuan Zhang, Liuyi Dang, Zheng Li, Jian Shu

{"title":"Role of glycosylation in bacterial resistance to carbapenems.","authors":"Jing Dang, Xinlu Yu, Mengyuan Zhang, Liuyi Dang, Zheng Li, Jian Shu","doi":"10.1007/s11274-025-04272-3","DOIUrl":"10.1007/s11274-025-04272-3","url":null,"abstract":"Carbapenems are a class of β-lactam antibacterial drugs with a broad antibacterial spectrum and strong activity, commonly used to treat serious bacterial infections. However, improper or excessive use of carbapenems can lead to increased bacterial resistance, which is a significant concern as they are often used as last resort for treating multidrug-resistant (MDR) gram-negative bacteria. Confronted with this challenge, it is crucial to comprehensively understand the mechanism of carbapenem resistance to develop effective therapeutic strategies and innovative drugs. In recent years, emerging research on the glycosylation of bacterial proteins has highlighted the crucial role of glycans in various bacterial processes, including carbapenem resistance. Given the limited understanding of bacterial glycosylation, its role in in carbapenem resistance may be more pivotal than currently acknowledged. In this review, we summarize the direct and multifunctional role of glycosylation in bacterial resistance as well as the classical and recently reported mechanisms of bacterial carbapenem resistance, focusing on illuminating the potential role of glycosylation in carbapenem resistance. We also discuss the potential of leveraging this knowledge to develop more effective strategies for combating clinically resistant bacteria.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"55"},"PeriodicalIF":4.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cloning and functional characterization of sesquiterpene synthase genes from Inonotus obliquus using a Saccharomyces cerevisiae expression system.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-01-30 DOI: 10.1007/s11274-025-04274-1

Qiao Liu, Junzhi Peng, Ziling Tao, Jiluan Zhang, Weifan Wu, Zhiwu Tan, Tao Zhou, Xiaoying Cao, Jihong Jiang

{"title":"Cloning and functional characterization of sesquiterpene synthase genes from Inonotus obliquus using a Saccharomyces cerevisiae expression system.","authors":"Qiao Liu, Junzhi Peng, Ziling Tao, Jiluan Zhang, Weifan Wu, Zhiwu Tan, Tao Zhou, Xiaoying Cao, Jihong Jiang","doi":"10.1007/s11274-025-04274-1","DOIUrl":"10.1007/s11274-025-04274-1","url":null,"abstract":"Inonotus obliquus (Chaga mushroom) is a large medicinal and edible fungus that contains a wealth of bioactive terpenoids. However, the detection of certain low-abundance sesquiterpenoids remains a challenge due to limitations in extraction and analytical techniques. Furthermore, the synthase genes responsible for the biosynthesis of the identified terpenoids have not yet been clearly elucidated. To address this, our study combined transcriptome mining with yeast heterologous expression to investigate the synthase genes involved in sesquiterpenoid production in I. obliquus. We successfully identified eight sesquiterpene synthase genes and one farnesyltransferase. Among these, only cis-β-farnesene, synthesized by IoTPS2, had been previously detected before in the sclerotium of I. obliquus, while the other nine sesquiterpenoids-including neoisolongifolene-8-ol, β-longipinene, vetiselinenol, isolongifolene, 7,8-dehydro-8a-hydroxy-, 4a,8b,10b,11a-tetramethylbicyclo[6.3.0]undec-1-en-5-one, 6,11-oxido-acor-4-ene, β-maaliene, neointermedeol, and longifolenaldehyde-were discovered for the first time. This research provides a critical scientific foundation for expanding the known repertoire of sesquiterpenoids and their corresponding synthase genes in I. obliquus.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"56"},"PeriodicalIF":4.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current insights into molecular mechanisms of environmental stress tolerance in Cyanobacteria.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-01-29 DOI: 10.1007/s11274-025-04260-7

Preeti Rai, Ruchi Pathania, Namrata Bhagat, Riya Bongirwar, Pratyoosh Shukla, Shireesh Srivastava

{"title":"Current insights into molecular mechanisms of environmental stress tolerance in Cyanobacteria.","authors":"Preeti Rai, Ruchi Pathania, Namrata Bhagat, Riya Bongirwar, Pratyoosh Shukla, Shireesh Srivastava","doi":"10.1007/s11274-025-04260-7","DOIUrl":"10.1007/s11274-025-04260-7","url":null,"abstract":"The photoautotrophic nature of cyanobacteria, coupled with their fast growth and relative ease of genetic manipulation, makes these microorganisms very promising factories for the sustainable production of bio-products from atmospheric carbon dioxide. However, both in nature and in cultivation, cyanobacteria go through different abiotic stresses such as high light (HL) stress, heavy metal stress, nutrient limitation, heat stress, salt stress, oxidative stress, and alcohol stress. In recent years, significant improvement has been made in identifying the stress-responsive genes and the linked pathways in cyanobacteria and developing genome editing tools for their manipulation. Metabolic pathways play an important role in stress tolerance; their modification is also a very promising approach to adapting to stress conditions. Several synthetic as well as systems biology approaches have been developed to identify and manipulate genes regulating cellular responses under different stresses. In this review, we summarize the impact of different stresses on metabolic processes, the small RNAs, genes and heat shock proteins (HSPs) involved, changes in the metabolome and their adaptive mechanisms. The developing knowledge of the adaptive behaviour of cyanobacteria may also be utilised to develop better stress-responsive strains for various applications.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"53"},"PeriodicalIF":4.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and structure determination of a new antibacterial lanthipeptide derived from the marine derived bacterium Lysinibacillus sp.CTST325.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-01-29 DOI: 10.1007/s11274-024-04212-7

Chanaphat Thetsana, Ryota Moriuchi, Shinya Kodani

引用次数: 0

The legacy of endophytes for the formation of bioactive agents, pigments, biofertilizers, nanoparticles and bioremediation of environment.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-01-28 DOI: 10.1007/s11274-025-04265-2

Anjali Panwar, Suvendu Manna, Gayatri Sahini, Vivek Kaushik, Manoj Kumar, Muthusamy Govarthanan

{"title":"The legacy of endophytes for the formation of bioactive agents, pigments, biofertilizers, nanoparticles and bioremediation of environment.","authors":"Anjali Panwar, Suvendu Manna, Gayatri Sahini, Vivek Kaushik, Manoj Kumar, Muthusamy Govarthanan","doi":"10.1007/s11274-025-04265-2","DOIUrl":"10.1007/s11274-025-04265-2","url":null,"abstract":"Endophytes have significant prospects for applications beyond their existing utilization in agriculture and the natural sciences. They form an endosymbiotic relationship with plants by colonizing the root tissues without detrimental effects. These endophytes comprise several microorganisms, including bacteria and fungi. They act as repositories of compounds of medicinal importance. They are considered sources of pigments besides synthetic dyes and assist with soil fertility and plant growth as bio-fertilizers. They also have immense potential for advanced technology using endophyte-synthesized nanoparticles. In assisting bioremediation, they facilitate detoxification of pollutants in all spheres of the environment. Studies on the potential of endophytic microbes in drug discovery and biotic stress management are underway. In this review, published databases on endophytes and their diverse roles and applications in various fields, such as bio-fertilizers and nanoparticles, as well as bioremediation, are critically discussed while exploring unanswered questions. In addition, future perspectives on endosymbiotic microorganisms and their prospective use in plants, environmental management, and medicine are discussed in this review.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"52"},"PeriodicalIF":4.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungal lignocellulolytic enzymes: an in silico and full factorial design approach.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-01-27 DOI: 10.1007/s11274-024-04241-2

Esteffany de Souza Candeo, Fabiano Bisinella Scheufele, Aline de Cassia Campos Pena, Gabriel Dequigiovanni, Giani Andrea Linde, Gerardo Mata, Nelson Barros Colauto, Patricia Dayane Carvalho Schaker

{"title":"Fungal lignocellulolytic enzymes: an in silico and full factorial design approach.","authors":"Esteffany de Souza Candeo, Fabiano Bisinella Scheufele, Aline de Cassia Campos Pena, Gabriel Dequigiovanni, Giani Andrea Linde, Gerardo Mata, Nelson Barros Colauto, Patricia Dayane Carvalho Schaker","doi":"10.1007/s11274-024-04241-2","DOIUrl":"10.1007/s11274-024-04241-2","url":null,"abstract":"Efficient degradation of lignocellulosic biomass is key for the production of value-added products, contributing to sustainable and renewable solutions. This study employs a two-step approach to evaluate lignocellulolytic enzymes of Ceratocystis paradoxa, Colletotrichum falcatum, and Sporisorium scitamineum. First, an in silico genomic analysis was conducted to predict the potential enzyme groups produced by these fungi. Second, a 2³ full factorial design of solid-state cultivation was employed to investigate the cultivation conditions that optimize enzyme activity. In silico analysis of phytopathogen genomes identified proteins with the potential for biomass degradation. Cellulase and phenoloxidase activities were assessed in culture medium and solid-state cultivation. A 2³ full factorial design was employed for solid-state cultivation to evaluate the cellulose, endoglucanase, and laccase activities. In silico analysis shows that C. falcatum has the most diverse enzyme set for lignocellulosic biomass degradation. In vitro assays corroborate this, demonstrating that C. falcatum produces the highest enzyme quantities, except for cellulase, where C. paradoxa outperforms it. Both C. paradoxa and C. falcatum exhibit cellulase and phenoloxidase activities, but only C. falcatum shows laccase activity. Most favorable enzyme production in solid-state cultivation occurred with 85-95 g 100 g- 1 bagasse moisture and 5 g 100 g- 1 yeast extract, with four-day cultivation period needed for cellulase and endoglucanase in C. paradoxa and 12 days for endoglucanase and laccase in C. falcatum. The in silico and in vitro assays demonstrated that C. falcatum can produce a diverse enzyme set, including laccase, cellulase, and endoglucanase, making it a promising candidate for enzymatic industrial applications.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"50"},"PeriodicalIF":4.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fitness and adaptive evolution of a Rhodococcus sp. harboring dioxin-catabolic plasmids.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-01-27 DOI: 10.1007/s11274-025-04270-5

Xu Wang, Changai Fu, Meng Chen, Yanan Wu, Yu Chen, Yan Chen, Li Li

{"title":"Fitness and adaptive evolution of a Rhodococcus sp. harboring dioxin-catabolic plasmids.","authors":"Xu Wang, Changai Fu, Meng Chen, Yanan Wu, Yu Chen, Yan Chen, Li Li","doi":"10.1007/s11274-025-04270-5","DOIUrl":"10.1007/s11274-025-04270-5","url":null,"abstract":"Catabolic plasmids are critical factors in the degradation of recalcitrant xenobiotics, such as dioxins. Understanding the persistence and evolution of native catabolic plasmids is pivotal for controlling their function in microbial remediation. Here, we track the fitness and evolution of Rhodococcus sp. strain p52 harboring dioxin-catabolic plasmids under nonselective conditions without contaminant. Growth curve analysis and competition experiments demonstrated that pDF01 imposed fitness costs, whereas pDF02 conferred fitness benefits. During stability tests, pDF01 tended to be lost from the population, while pDF02 maintained at least one copy in the cell until proliferation of the 400th generation. Genome-wide gene expression profiling combined with codon usage bias analysis revealed that the high expression of pDF01 genes involved in dibenzofuran catabolism and regulation caused metabolic burdens. In contrast, potential cooperation between the pDF02-encoded short-chain dehydrogenase/reductase family oxidoreductase and the redox cofactor mycofactocin, which synthetic genes are located on the chromosome, may explain the benefit of pDF02. The fitness cost imposed by pDF01 was alleviated during adaptive evolution and was associated with the transcriptional downregulation of the dibenzofuran degradation genes on pDF01, and the global regulation of genome-wide gene expression involving basic metabolism, transport, and signal transduction. This study broadens our understandings on the persistence and evolution of dioxin-catabolic mega-plasmids, thus paving the way for the bioremediation of recalcitrant xenobiotic pollution in the environment.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"51"},"PeriodicalIF":4.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the potential of Loigolactobacillus coryniformis BCH-4 to ameliorate drought stress in Zea mays L.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-01-24 DOI: 10.1007/s11274-025-04267-0

Anam Tariq, Mahwish Salman, Muhammad Arslan Ashraf, Muhammad Rizwan Javed, Abdul Tawab

{"title":"Unveiling the potential of Loigolactobacillus coryniformis BCH-4 to ameliorate drought stress in Zea mays L.","authors":"Anam Tariq, Mahwish Salman, Muhammad Arslan Ashraf, Muhammad Rizwan Javed, Abdul Tawab","doi":"10.1007/s11274-025-04267-0","DOIUrl":"10.1007/s11274-025-04267-0","url":null,"abstract":"The lactic acid bacterial (LAB) species have proven multifaceted roles in sustainable agriculture due to their biologically safe nature, making them eco-friendly. However, their plant growth-improving mechanisms in stressed and non-stressed conditions are still under consideration. Thus, the current work has been planned to evaluate the drought tolerance potential and plant growth-promoting (PGP) traits of Loigolactobacillus coryniformis BCH-4 in Zea mays L. This bacterium was tolerant in the presence of 30% PEG. It also exhibited auxin synthesis, ammonia production, and phosphate solubilization potential. Based on these findings, a pot experiment was conducted with selected drought-tolerant maize seeds (Sawari Kashmir) and drought-sensitive seeds (Malka-2016), bioprimed with L. coryniformis under 2 water regimes; 100% field capacity (optimal watering condition) and 50% field capacity (a drought stress condition). Our results manifested an upsurge in maize growth, photosynthetic pigments, and nutrient uptake in bioprimed seeds under stressed conditions. Besides, biopriming considerably improved nitrate reductase levels alongside higher nitric oxide and hydrogen sulphide activity. This treatment also improved drought-induced oxidative stress tolerance in maize plants by promoting osmolytes and antioxidant activities. Further, the GC-MS analysis revealed various drought-tolerant metabolites, known to have plant growth-promoting potential i.e., 1-hexadecene, tetradecane, hexadecanoic acid, 15-methyl-, methyl ester, and hexadecane, produced by L. coryniformis. Remarkably, these metabolites synergistically improve maize growth and tolerate the drought. This study publicized an extensive variety of metabolites, produced by L. coryniformis liable for plant growth promotion and drought tolerance.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"49"},"PeriodicalIF":4.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative microbial activators for enhanced bioremediation of oil-contaminated soils: mechanistic insights.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-01-24 DOI: 10.1007/s11274-025-04258-1

Yating Deng, Wujuan Sun, Yongbin Li, Jun Wei, Ruirui Rao, Qiongyu Cao, Sichang Wang, Qunzheng Zhang, Congyu Ke

{"title":"Innovative microbial activators for enhanced bioremediation of oil-contaminated soils: mechanistic insights.","authors":"Yating Deng, Wujuan Sun, Yongbin Li, Jun Wei, Ruirui Rao, Qiongyu Cao, Sichang Wang, Qunzheng Zhang, Congyu Ke","doi":"10.1007/s11274-025-04258-1","DOIUrl":"10.1007/s11274-025-04258-1","url":null,"abstract":"This paper developed an efficient microbial activator formula and conducted an in-depth study on its efficacy and mechanism in promoting the degradation of petroleum hydrocarbons in oil-contaminated soil. A 60-day microbial remediation experiment conducted on oily soil revealed that the microbial activators significantly boosted the activities of dehydrogenase and catalase, subsequently speeding up the degradation of petroleum hydrocarbons in the soil. The overall degradation rate reached as high as 71.23%, with the most significant degradation effect observed in asphaltenes, achieving a degradation rate of 93.98%. This was followed by aromatic hydrocarbons (90.45%), saturated hydrocarbons (84.39%), and asphaltenes (65%). Compared to traditional microbial stimulation methods, this activator demonstrated significant superiority. Microbial diversity analysis reveals that microbial activators can effectively activate microbial activity in soil targeting refractory petroleum hydrocarbon components. By comparing the changes in microbial community structure before and after the addition of microbial activators, we found that the activators promoted an increase in the abundance of microorganisms belonging to the Bacillota, Pseudomonadota, and Bacteroidetes, which have petroleum hydrocarbon degradation functions, and facilitated the evolution of microbial community structure towards a direction more conducive to petroleum hydrocarbon degradation. KEGG metabolic pathway analysis revealed that the degradation pathways for alkanes, aromatic hydrocarbons, and PAHs are primarily present in these bacterial phylum. This research not only clarifies the degradation mechanism but also supports future bioremediation efforts.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"47"},"PeriodicalIF":4.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in engineering non-native microorganisms for poly(3-hydroxybutyrate) production.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-01-24 DOI: 10.1007/s11274-025-04261-6

Said Nawab, Muhammad Wajid Ullah, Syed Bilal Shah, Ya-Fei Zhang, Hareef Ahmed Keerio, Yang-Chun Yong

{"title":"Recent advances in engineering non-native microorganisms for poly(3-hydroxybutyrate) production.","authors":"Said Nawab, Muhammad Wajid Ullah, Syed Bilal Shah, Ya-Fei Zhang, Hareef Ahmed Keerio, Yang-Chun Yong","doi":"10.1007/s11274-025-04261-6","DOIUrl":"10.1007/s11274-025-04261-6","url":null,"abstract":"Poly(3-hydroxybutyrate) (PHB) is a biodegradable polymer that belongs to a group of polymers called polyhydroxyalkanoates (PHAs). PHB can be synthesized from renewable resources, making it a promising alternative to petroleum-derived plastics. It is also considered non-toxic, biodegradable, and biocompatible, which makes it suitable for various applications in the medicine and biomedicine. Many microorganisms biosynthesize and accumulate PHB naturally. However, recent advancements in metabolic engineering and synthetic biology have allowed scientists to engineer non-native microorganisms to produce PHB. This review comprehensively summarizes all non-native microbial hosts used for PHB biosynthesis and discusses different metabolic engineering approaches used to enhance PHB production. These strategies include optimizing the biosynthesis pathway through cofactor engineering, metabolic pathway reconstruction, and cell morphology engineering. Moreover, the CRISPR/Cas9 approach is also used for manipulating the genome of non-host microorganisms to enable them produce PHB. Among non-native microbial hosts, Escherichia coli has been successfully used for industrial-scale PHB production. However, further genetic engineering approaches are needed to make non-native microbial hosts more suitable for large-scale PHB production.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"48"},"PeriodicalIF":4.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0