World journal of microbiology & biotechnology最新文献_第6页

Transcriptional profiling reveals the effect of arginine on Actinobacillus succinogenes growth and fermentation.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-27 DOI: 10.1007/s11274-025-04290-1

Zuomu Xie, Chunmei Chen, Yuan Tian, Dan Wu, Pengcheng Chen, Pu Zheng

{"title":"Transcriptional profiling reveals the effect of arginine on Actinobacillus succinogenes growth and fermentation.","authors":"Zuomu Xie, Chunmei Chen, Yuan Tian, Dan Wu, Pengcheng Chen, Pu Zheng","doi":"10.1007/s11274-025-04290-1","DOIUrl":"10.1007/s11274-025-04290-1","url":null,"abstract":"Actinobacillus succinogenes is considered one of the most promising strains for succinic acid production due to its ability to utilize various carbon sources for high-concentration fermentation. However, limited understanding of genetic and metabolic changes during its growth and fermentation processes hinders further modification of A. succinogenes for application in SA production. In this study, we analyzed transcriptome profiles during A. succinogenes fermentation using high-throughput RNA sequencing. Compared to cells after 8 h of fermentation, cells at 34 h exhibited significant upregulation of genes related to glycerophospholipid metabolism and arginine biosynthesis pathways. We explored the effects of arginine on cell growth and fermentation by overexpressing or knocking down argH encoding argininosuccinate lyase (ArgH), a key enzyme in arginine biosynthesis. The integrity of the arginine metabolic pathway is essential for normal growth, and both exogenous addition of arginine and increased intracellular arginine metabolic flux improved cell growth and SA yield at low pH (5.0 ≤ pH ≤ 6.0). However, at non-low pH (6.0 ≤ pH ≤ 7.0), arginine had no significant effect on cell growth and SA yield. In a 3 L bioreactor under non-low pH conditions, the overexpression strain (::ArgH) produced 73.9 g/L SA with 1.65 g/L/h productivity, similar to the control strain. This implies that arginine metabolism in A. succinogenes is more associated with resistance to acid stress and less closely related to direct SA production. These findings provide insight into the critical physiological and biochemical processes of this non-model microorganism.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 3","pages":"77"},"PeriodicalIF":4.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The diversity pattern of soil bacteria in the rhizosphere of different plants in mountain ecosystems.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-27 DOI: 10.1007/s11274-025-04299-6

Maryamgul Yasen, Mingyuan Li, Jilian Wang

{"title":"The diversity pattern of soil bacteria in the rhizosphere of different plants in mountain ecosystems.","authors":"Maryamgul Yasen, Mingyuan Li, Jilian Wang","doi":"10.1007/s11274-025-04299-6","DOIUrl":"10.1007/s11274-025-04299-6","url":null,"abstract":"Research on the composition and diversity of rhizosphere microbial communities of different plant species can help to identify important microbial functional groups or functional potentials, which is of great significance for vegetation restoration and ecological reconstruction. To provide scientific basis for the management of mountain ecosystem, the diversity pattern of rhizosphere bacterial community was investigated using 16 S rRNA high-throughput sequencing method among different host plants (Cirsium japonicum, Artemisia annua, Descurainia sophia, Lepidium apetalum, Phlomis umbrosa, and Carum carvi) in Tomur Peak National Nature Reserve, China. The results showed that the richness and diversity of rhizosphere bacteria were highest in Descurainia sophia, and lowest in Lepidium apetalum. Pseudomonadota, Acidobacteriota, and Actinomycetota were the common dominant phyla, and Sphingomonas was the predominant genus. Furthermore, there were some specific genera in different plants. The relative abundance of non-dominant genera varied among the plant species. Canonical correspondence analysis indicated that available potassium (AK), total phosphorus (TP), total potassium (TK), and soil organic matter (SOM) were the main drivers of bacterial community structure. Based on PICRUSt functional prediction, the bacterial communities in all samples encompass six primary metabolic pathways and 47 secondary metabolic pathways. The major secondary metabolic pathways (with a relative abundance of functional gene sequences > 3%) include 15 categories. Co-occurrence network analysis revealed differences in bacterial composition and interactions among different modules, with rhizosphere microorganisms of different plants exhibiting distinct functional advantages. This study elucidates the distribution patterns of rhizosphere microbial community diversity in mountain ecosystems, which provides theoretical guidance for the ecological protection of mountain soil based on the microbiome.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 3","pages":"88"},"PeriodicalIF":4.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic anti-biofilm strategy based on essential oils and its application in the food industry.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-27 DOI: 10.1007/s11274-025-04289-8

Pei Yang, Yuxiao Huo, Qingli Yang, Fangyuan Zhao, Changjian Li, Jian Ju

{"title":"Synergistic anti-biofilm strategy based on essential oils and its application in the food industry.","authors":"Pei Yang, Yuxiao Huo, Qingli Yang, Fangyuan Zhao, Changjian Li, Jian Ju","doi":"10.1007/s11274-025-04289-8","DOIUrl":"10.1007/s11274-025-04289-8","url":null,"abstract":"The microbial biofilm can induce a variety of food safety problems, and cause huge economic losses. Essential oils (EOs) not only have broad-spectrum antibacterial activity but also have a good ability to inhibit biofilm. However, the addition dose of EOs in practical application usually exceeds their flavor threshold, resulting in the appearance of undesired flavor. Therefore, synergistic antimicrobial may be a potential strategy to improve the antibacterial activity of EOs and to reduce their dosage. This paper focuses on the analysis of the synergistic anti-biofilm strategies based on EOs. Based on these, the action mechanism of EOs against biofilm and other commonly used anti-biofilm strategies in the food industry are summarized. The anti-biofilm mechanism of EOs is mainly related to inhibiting the synthesis of extracellular polysaccharides and proteins, destroying biofilm structure, inhibiting the metabolic activity of biofilm, inhibiting quorum sensing (QS) and regulating the formation of biofilm and the expression of toxicity-related genes. At present, the commonly used anti-biofilm strategies in the food industry mainly include physical strategies, chemical strategies and biological strategies, among which the combined application of different strategies is the future development trend. In particular, the synergistic anti-biofilm strategy based on EOs has shown great application value in the food industry. To sum up, some new information in this paper will give guidance and provide more reference for the development of efficient biofilm regulation strategies in future.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 3","pages":"81"},"PeriodicalIF":4.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in root-associated bacterial communities across growth stages of salt-tolerant and salt-sensitive rice grown in coastal saline-alkali soils.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-27 DOI: 10.1007/s11274-025-04284-z

Qing Li, Jihui Jiang, Haoyang Cheng, Bin Zhang, Yang Zhang, Jian Hu

{"title":"Changes in root-associated bacterial communities across growth stages of salt-tolerant and salt-sensitive rice grown in coastal saline-alkali soils.","authors":"Qing Li, Jihui Jiang, Haoyang Cheng, Bin Zhang, Yang Zhang, Jian Hu","doi":"10.1007/s11274-025-04284-z","DOIUrl":"10.1007/s11274-025-04284-z","url":null,"abstract":"In this study, the root-associated bacterial communities of salt-tolerant and salt-sensitive rice grown in coastal saline-alkali soils were characterized at three major growth stages (jointing, heading and maturity) using Illumina MiSeq sequencing. The results showed that the growth stage had a stronger influence on endophytic bacterial diversity than the genotype, with diversity decreasing as growth progressed. However, the rhizospheric bacterial diversity was minimally affected by both growth stage and genotype. The variation in both rhizospheric and endophytic bacterial communities was primarily driven by the growth stages, but was also influenced by the genotype. Interestingly, there were distinct differences in changes in taxon abundance between the rhizospheric and endophytic bacterial communities, suggesting that the assembly mechanisms of these communities may differ, particularly in salt-sensitive rice. Additionally, certain genera were found to be enriched in the rhizosphere and endosphere compared to the bulk soil, and this enrichment varied depending on the growth stage and genotype. Notably, the dominant bacterium Clostridium was consistently enriched in the endosphere of salt-tolerant rice throughout all growth stages. This genus was also found to be more abundant overall in the rhizosphere and endosphere of salt-tolerant rice compared to salt-sensitive rice. These findings provide a deeper understanding of the co-evolution between rice and its associated microbes, and offer valuable insights for the isolation and application of beneficial root-associated bacteria in coastal saline-alkali soils.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 3","pages":"76"},"PeriodicalIF":4.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and biodegradation characterization of high-density polyethylene using marine bacteria isolated from the coastal region of the Arabian Sea, at Gujarat, India.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-27 DOI: 10.1007/s11274-025-04283-0

Raj Kumar Sardar

{"title":"Identification and biodegradation characterization of high-density polyethylene using marine bacteria isolated from the coastal region of the Arabian Sea, at Gujarat, India.","authors":"Raj Kumar Sardar","doi":"10.1007/s11274-025-04283-0","DOIUrl":"10.1007/s11274-025-04283-0","url":null,"abstract":"High-Density Polyethylene (HDPE) PE is one of the primary contributors of long-lasting and prolonged pollution in the environment. In this study, more than three hundred marine isolates collected off the Gujarat Sea coast were tested for HDPE plastic utilizing ability. Among fifty-one positive noted isolates, RS124 as a potential strain was identified as Micrococcus flavus (accession is PP858228) based on 16 S rRNA gene sequencing and total cellular fatty acid profiling. Initial bacterial adherence on the film surface was shown in a scanning electron microscopy (SEM) image as a key step to biodegradation. Moreover, atomic force microscopy (AFM) shows that the film surface became more fragile, damaged, and rougher than untreated films. Shifts and alterations in peak transmittance with emergence of two new shouldered peak in degraded HDPE observed by fourier transform infrared spectroscopy (FTIR) was associated to chemical and mechanical alteration. Thermogravimetric analysis (TGA) analysis designated larger difference in percent weight loss provisions thermal instability. In the enzymatic study, the highest activity of peroxidase and dehydrogenase was recorded on the 3rd and 4th weeks of treatment with strain, respectively, during co-incubation. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis disclosed the presence of a distinct 19 kDa size protein, uncovering its role in the colonization of bacteria on the hydrophilic HDPE surfaces. About 1.8% weight reduction in HDPE was recorded as a result after 30 days of bio-treatment with M. flavus. Hence, the entire observed results reveal that the M. flavus RS124 could be effectively applied for the degradation of HDPE. This is the first report on M. flavus that it exhibits plastic degrading characteristic ever, which may allow for green scavenging of plastic waste.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 3","pages":"74"},"PeriodicalIF":4.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro validation concept for lyophilized fecal microbiota products with a focus on bacterial viability.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-27 DOI: 10.1007/s11274-025-04291-0

Sara A Sedeek, Fedja Farowski, Stella Youssafi, Anastasia Tsakmaklis, Susanne Brodesser, Madiha M El-Attar, Mohamed Omar Abdelmalek, Maria J G T Vehreschild

{"title":"In vitro validation concept for lyophilized fecal microbiota products with a focus on bacterial viability.","authors":"Sara A Sedeek, Fedja Farowski, Stella Youssafi, Anastasia Tsakmaklis, Susanne Brodesser, Madiha M El-Attar, Mohamed Omar Abdelmalek, Maria J G T Vehreschild","doi":"10.1007/s11274-025-04291-0","DOIUrl":"10.1007/s11274-025-04291-0","url":null,"abstract":"Fecal microbiota transplantation (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), typically administered as a fresh or frozen stool suspension through colonoscopy, nasojejunal tube, or oral capsules. Lyophilized fecal microbiota (LFM) are an alternative to frozen FM products. We aimed to assess whether lyophilization affects bacterial viability and metabolite levels and to develop LFM capsules for clinical use in Germany. Fecal donations from pre-screened volunteers were aliquoted and analyzed through microbial cell counting, bacterial culture, 16S rRNA gene amplicon sequencing, and bile acid assays. Results showed higher counts of viable bacterial cells and cultured anaerobes in unprocessed stool compared to freshly processed stool (p = 0.012 and p < 0.001, respectively). No significant difference in viable bacterial counts was found between freshly processed (day 0), lyophilized (day 3) and frozen FM (day 3) (p = 0.15), nor between freshly processed (day 0), lyophilized (days 30 and 90) and frozen FM (day 30) (p = 0.07). lyophilization did not significantly impact bile acid and 16S rRNA profiling. Encapsulation of lyophilized powder required fewer capsules (10-14) than frozen capsules (30). LFM products are a practical, viable alternative to frozen and fresh FM products, potentially improving storage and patient acceptance.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 3","pages":"83"},"PeriodicalIF":4.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Boosting triterpene production in cell suspension culrures of Betula pendula Roth: the role of endophytic and basidiomycete fungi isolated from birch trees.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-27 DOI: 10.1007/s11274-025-04293-y

Jamile Nazari, Vahide Payamnoor, Mohammad Reza Kavosi, Jahanbakhsh Asadi

{"title":"Boosting triterpene production in cell suspension culrures of Betula pendula Roth: the role of endophytic and basidiomycete fungi isolated from birch trees.","authors":"Jamile Nazari, Vahide Payamnoor, Mohammad Reza Kavosi, Jahanbakhsh Asadi","doi":"10.1007/s11274-025-04293-y","DOIUrl":"10.1007/s11274-025-04293-y","url":null,"abstract":"This research aims to improve the synthesis of triterpenoids in cell suspension cultures of Betula pendula Roth stem cells using biological elicitors, including basidiomycete fungi (Arthrinium arundinis, Hyphodontia paradoxa, and Stereum hirsutum) and endophytes (Fusarium fuckelii, Alternaria alternata, and Penicillium citrinum). Five of the mentioned fungi were isolated from the bark, while A. arundinis was isolated from lichen of birch trees. Their extracellular extracts were used as elicitors. In most cases, these factors were significantly higher than the control. The growth index of Birch stem cells under the influence of different elicitors mostly yielded positive results. The highest percentage of cell viability was observed after a 24-hour treatment with 300 mg/L of F. fuckelii extract. Elicitation for 24 h with P. citrinum at concentrations of 150 and 450 mg/L, respectively, caused the greatest increase in betulin (8.8 times) and its terpenoid derivatives (2 times) compared to the control. A 36-hour elicitation with H. paradoxa at 450 mg/L resulted in a fourfold increase in betulinic acid compared to the control. The highest function of betulin and betulinic acid was achieved with A. alternata at concentrations of 300 mg/L and 150 mg/L respectively, within 36 h of exposure time. The highest function of terpenoid derivatives was achieved after 12 h of elicitation with 450 mg/L P. citrinum (5 times). This report presents, the positive effect of fungal elicitors extracted from birch trees on induced betulin, betulinic acid, and their triterpenoid derivatives production in cell suspension cultures of Betula pendula, for the first time.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 3","pages":"86"},"PeriodicalIF":4.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A psychrotolerant extracellular phosphatase from Krossfjorden sediment bacterium Bacillus cereus KR_O9: purification and functional characterization.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-14 DOI: 10.1007/s11274-025-04252-7

E S Lisintta, Annie George, Sona Gafoor, S Vishnupriya, Jesmi Yousuf, Bhavya Kachiprath, A K Valsa, Ally C Antony, P A Aneesa, A A Mohamed Hatha

{"title":"A psychrotolerant extracellular phosphatase from Krossfjorden sediment bacterium Bacillus cereus KR_O9: purification and functional characterization.","authors":"E S Lisintta, Annie George, Sona Gafoor, S Vishnupriya, Jesmi Yousuf, Bhavya Kachiprath, A K Valsa, Ally C Antony, P A Aneesa, A A Mohamed Hatha","doi":"10.1007/s11274-025-04252-7","DOIUrl":"10.1007/s11274-025-04252-7","url":null,"abstract":"This study reports the identification of a phosphatase-producing psychrotolerant bacterium, Bacillus cereus KR_O9, isolated from Arctic Krossfjorden sediments. The extracellular KR_O9 phosphatase was purified to homogeneity through acetone precipitation and ion exchange chromatography, achieving a specific activity of 12.51 U mg⁻1 min⁻1, a 17.3-fold purification, and a 64.94% yield. The molecular mass of the enzyme was estimated as 37 kDa by SDS-PAGE. Km, and Vmax for KR_O9 phosphatase towards substrate p-NPP were determined as 0.033 M L-1, 1.67 mg-1 min-1. The enzyme exhibited optimal activity at 40 °C and pH 6.0, with stability up to ≤ 40 °C and at pH levels ≤ 7.0, highlighting its thermolability and sensitivity to alkaline pH. At 10 mM level, Cu2+, Hg2+, Co2+, Pb2+, urea, EDTA, and GSH significantly stimulated the enzyme, and Ca2+, Zn2+, Mn2+, SDS, and CTAB were, strong inhibitors. The kinetic efficiency, resilience to low to neutral pH, and tolerance to various metal ions, including heavy metals, underscore the potential of B. cereus KR_O9 phosphatase for bioremediation and biofertilizer applications, paving the way for industrial exploration.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"72"},"PeriodicalIF":4.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene knockout studies of Dps protein reveals a novel role for DNA-binding protein in maintaining outer membrane permeability.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-13 DOI: 10.1007/s11274-025-04269-y

Indu Pant, Akhilesh A Potnis, Ravindranath Shashidhar

{"title":"Gene knockout studies of Dps protein reveals a novel role for DNA-binding protein in maintaining outer membrane permeability.","authors":"Indu Pant, Akhilesh A Potnis, Ravindranath Shashidhar","doi":"10.1007/s11274-025-04269-y","DOIUrl":"10.1007/s11274-025-04269-y","url":null,"abstract":"DNA-binding proteins like Dps are crucial for bacterial stress physiology. This study investigated the unexpected role of Dps protein in maintaining outer membrane integrity of Salmonella Typhimurium. We observed that a Δdps mutant displayed increased sensitivity to glycopeptide antibiotics (vancomycin, nisin), which are ineffective against Gram-negative bacteria due to their thick outer membrane (OM). Furthermore, the Δdps mutant exhibited susceptibility to membrane-disrupting agents like detergents (deoxycholate, SDS) and phages. The perforation was observed in OM after the treatment of vancomycin using atomic force microscopy. Notably, this sensitivity was rescued by supplementing the media with calcium and magnesium cations. These findings suggest a novel function for Dps in maintaining outer membrane permeability. We propose two potential mechanisms: 1) Dps might directly localize to the outer membrane 2) Dps might regulate genes responsible for lipopolysaccharide synthesis or outer membrane proteins, key components of outer membrane. This study highlights a previously unknown role for Dps beyond DNA binding and warrants further investigation into the precise mechanism by which it influences outer membrane integrity in Salmonella.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"70"},"PeriodicalIF":4.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Xenosiderophores: bridging the gap in microbial iron acquisition strategies.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-13 DOI: 10.1007/s11274-025-04287-w

Ravinsh Kumar, Ashutosh Singh, Amrita Srivastava

{"title":"Xenosiderophores: bridging the gap in microbial iron acquisition strategies.","authors":"Ravinsh Kumar, Ashutosh Singh, Amrita Srivastava","doi":"10.1007/s11274-025-04287-w","DOIUrl":"10.1007/s11274-025-04287-w","url":null,"abstract":"Microorganisms acquire iron from surrounding environment through specific iron chelators known as siderophores that can be of self-origin or synthesized by neighboring microbes. The latter are termed as xenosiderophores. The acquired iron supports their growth, survival, and pathogenesis. Various microorganisms possess the ability to utilize xenosiderophores, a mechanism popularly termed as 'siderophore piracy' besides synthesizing their own siderophores. This adaptability allows microorganisms to conserve energy by reducing the load of siderogenesis. Owing to the presence of xenosiderophore transport machinery, these microbial systems can be used for targeting antibiotics-siderophore conjugates to control pathogenesis and combat antimicrobial resistance. This review outlines the significance of xenosiderophore utilization for growth, stress management and virulence. Siderogenesis and the molecular mechanism of its uptake by related organisms have been discussed vividly. It focuses on potential applications like disease diagnostics, drug delivery, and combating antibiotic resistance. In brief, this review highlights the importance of xenosiderophores projecting them beyond their role as mere iron chelators.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"69"},"PeriodicalIF":4.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0