World journal of microbiology & biotechnology最新文献_第7页

Molecular structural arrangement in quorum sensing and bacterial metabolic production.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-13 DOI: 10.1007/s11274-025-04280-3

Victor U Chigozie, Morteza Saki, Charles O Esimone

{"title":"Molecular structural arrangement in quorum sensing and bacterial metabolic production.","authors":"Victor U Chigozie, Morteza Saki, Charles O Esimone","doi":"10.1007/s11274-025-04280-3","DOIUrl":"10.1007/s11274-025-04280-3","url":null,"abstract":"Quorum sensing (QS) regulates bacterial behaviors such as biofilm formation, virulence, and metabolite production through signaling molecules like acyl-homoserine lactones (AHLs), peptides, and AI-2. These signals are pivotal in bacterial communication, influencing pathogenicity and industrial applications. This review explores the molecular architecture of QS signals and their role in metabolite production, emphasizing structural modifications that disrupt bacterial communication to control virulence and enhance industrial processes. Key findings highlight the development of synthetic QS analogs, engineered inhibitors, and microbial consortia as innovative tools in biotechnology and medicine. The review underscores the potential of molecular engineering in managing microbial behaviors and optimizing applications like biofuel production, bioplastics, and anti-virulence therapies. Additionally, cross-species signaling mechanisms, particularly involving AI-2, reveal new opportunities for regulating interspecies cooperation and competition. This synthesis aims to bridge molecular insights with practical applications, showcasing how QS-based technologies can drive advancements in microbial biotechnology and therapeutic strategies.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"71"},"PeriodicalIF":4.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactobacillomics as a new notion in lactic acid bacteria research through omics integration.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-11 DOI: 10.1007/s11274-025-04285-y

Özge Kahraman Ilıkkan

{"title":"Lactobacillomics as a new notion in lactic acid bacteria research through omics integration.","authors":"Özge Kahraman Ilıkkan","doi":"10.1007/s11274-025-04285-y","DOIUrl":"10.1007/s11274-025-04285-y","url":null,"abstract":"Omics technologies are a set of disciplines that analyze large-scale molecular data to understand biological systems in a holistic way. These technologies aim to reveal the structure, functions and interactions of organisms by studying processes at many levels of biomolecules, from the genome to metabolism. Lactobacillomics is introduced as an interdisciplinary field that integrates multiple \"omics\" technologies-including genomics, transcriptomics, proteomics, metabolomics, and metagenomics- to provide a comprehensive insight into \"lactic acid bacteria\" species. Lactobacillomics aims to elucidate the genetic, metabolic, and functional characteristics of lactic acid bacteria (LAB) species, providing insights into the mechanisms underlying their probiotic effects and contributions to the host microbiome. By analyzing genomes and metabolic pathways, researchers can identify specific genes responsible for health-promoting functions and desirable fermentation characteristics, which can guide the development of targeted probiotic strains with optimized health benefits. The integration of these omics data allows facilitating the discovery of biomarkers for health and disease states, the development of new probiotics tailored to specific populations or health conditions, and the optimization of fermentation processes to enhance the safety, flavor, and nutritional profile of fermented foods. A comprehensive review and bibliometric analysis were conducted to provide an overview of this promising field between 2005 and 2025 by examining Web of Science Core Collection data. Research results reveal trending topics, future perspectives, and key areas of growth within lactic acid bacteria (LAB) studies, particularly as they intersect with omics technologies.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"68"},"PeriodicalIF":4.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategies for cost-optimized biocement production: a comprehensive review.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-08 DOI: 10.1007/s11274-025-04281-2

Zhen Yan, Kazunori Nakashima, Chikara Takano, Satoru Kawasaki

引用次数: 0

Microbial production systems and optimization strategies of antimicrobial peptides: a review.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-08 DOI: 10.1007/s11274-025-04278-x

Mengxue Lou, Shuaiqi Ji, Rina Wu, Yi Zhu, Junrui Wu, Jiachao Zhang

{"title":"Microbial production systems and optimization strategies of antimicrobial peptides: a review.","authors":"Mengxue Lou, Shuaiqi Ji, Rina Wu, Yi Zhu, Junrui Wu, Jiachao Zhang","doi":"10.1007/s11274-025-04278-x","DOIUrl":"10.1007/s11274-025-04278-x","url":null,"abstract":"Antibiotic resistance has become a public safety issue of the twenty-first century, posing a growing threat and drawing increased attention. Compared to traditional antibiotics, antimicrobial peptides (AMPs), as naturally produced small peptides, can target multiple pathways within pathogens and render them less prone to developing resistance. This makes them promising alternatives to antibiotics. However, traditional chemical synthesis methods face challenges, such as high costs, low yields, and poor stability, limiting the large-scale industrial production of AMPs. Despite extensive research to improve AMP production efficiency, issues such as low yields and complex extraction processes continue to pose significant barriers to commercial application. Therefore, there is an urgent need for new biosynthesis strategies and optimization methods to enhance AMP production efficiency and quality. This review summarizes the sources, classification, mechanisms of action and recent advances in the microbial synthesis of AMPs. It also explores innovative production methods, including recombinant microbial expression systems, fusion tags, codon optimization, tandem multimer expression, and hybrid peptide expression. Furthermore, we review the applications of gene editing technologies and artificial intelligence in AMP production, providing new perspectives and strategies for efficient, large-scale AMP production.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"66"},"PeriodicalIF":4.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Production of aromatic amino acids and their derivatives by Escherichia coli and Corynebacterium glutamicum.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-07 DOI: 10.1007/s11274-025-04264-3

Takashi Hirasawa, Yasuharu Satoh, Daisuke Koma

引用次数: 0

Association between intraspecific variability and penicillin production in industrial strain, Penicillium chrysogenum revealed by RAPD and SRAP markers.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-06 DOI: 10.1007/s11274-025-04277-y

Yu Jong Ri, Chang Ho Ri, Un Hyang Ho, Sam Rang Song, Il Sim Pak, Tae Ryong Ri, Yong Jo Kim, Jun Song Ri

{"title":"Association between intraspecific variability and penicillin production in industrial strain, Penicillium chrysogenum revealed by RAPD and SRAP markers.","authors":"Yu Jong Ri, Chang Ho Ri, Un Hyang Ho, Sam Rang Song, Il Sim Pak, Tae Ryong Ri, Yong Jo Kim, Jun Song Ri","doi":"10.1007/s11274-025-04277-y","DOIUrl":"10.1007/s11274-025-04277-y","url":null,"abstract":"Penicillin represents antibiotic discovered for the first time that prevents bacterial infections. Production of penicillin using penicillin-producing fungi (Penicillium chrysogenum) mainly depends on activity of industrial strain, optimization of culture condition and purification efficiency. To contribute to management of penicillin-producing strains, we conducted phylogenetic study on 27 P. chrysogenum variants originated from industrial strain and selected on media supplemented with penicillin or phenylacetic acid (PAA) using 4 Random Amplified Polymorphic DNA (RAPD) primers and 2 Sequence-Related Amplified Polymorphic (SRAP) primer pairs. The UPGMA dendrogram distinguished 27 variants into 2 clusters at the genetic distance of 0.3, consistent with classification by penicillin titers of variants and supported by principal component analysis (PCA) and STRUCTURE analysis. These results suggest effectiveness of RAPD and SRAP markers in management of P. chrysogenum variants exhibiting different penicillin titers and may contribute to increase in penicillin production by enabling inoculation of confirmed industrial strain exhibiting high penicillin productivity at the beginning of culture.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"64"},"PeriodicalIF":4.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovations and challenges in collagen and gelatin production through precision fermentation.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-06 DOI: 10.1007/s11274-025-04276-z

Sofia de Moura Campos, Gabriela Dos Santos Costa, Susan Grace Karp, Vanete Thomaz-Soccol, Carlos Ricardo Soccol

{"title":"Innovations and challenges in collagen and gelatin production through precision fermentation.","authors":"Sofia de Moura Campos, Gabriela Dos Santos Costa, Susan Grace Karp, Vanete Thomaz-Soccol, Carlos Ricardo Soccol","doi":"10.1007/s11274-025-04276-z","DOIUrl":"10.1007/s11274-025-04276-z","url":null,"abstract":"Collagen and gelatin are essential biomaterials widely used in industries such as food, cosmetics, healthcare, and pharmaceuticals. Traditionally derived from animal tissues, these proteins are facing growing demand for more sustainable and ethical production methods. Precision fermentation (PF) offers a promising alternative by using genetically engineered microorganisms to produce recombinant collagen and gelatin. This technology not only reduces environmental impact but also ensures consistent quality and higher yields. In this review, we provide a comprehensive overview of collagen and gelatin production through PF destined for the food sector, exploring key advances in recombinant technologies, synthetic biology, and bioprocess optimization. Challenges such as scaling production, cost-efficiency, and market integration are addressed, alongside emerging solutions for enhancing industrial competitiveness. We also highlight leading companies leveraging PF to drive innovation in the food industry. As PF continues to evolve, future developments are expected to improve efficiency, reduce costs, and expand the applications of recombinant collagen and gelatin, particularly in the food and supplement sectors.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"63"},"PeriodicalIF":4.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of Paraburkholderia species to enhance crop growth.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-05 DOI: 10.1007/s11274-025-04256-3

Fernando Uriel Rojas-Rojas, Ingrid Melissa Gómez-Vázquez, Paulina Estrada-de Los Santos, Harumi Shimada-Beltrán, Julio C Vega-Arreguín

{"title":"The potential of Paraburkholderia species to enhance crop growth.","authors":"Fernando Uriel Rojas-Rojas, Ingrid Melissa Gómez-Vázquez, Paulina Estrada-de Los Santos, Harumi Shimada-Beltrán, Julio C Vega-Arreguín","doi":"10.1007/s11274-025-04256-3","DOIUrl":"10.1007/s11274-025-04256-3","url":null,"abstract":"Agrochemicals are the primary alternative for maintaining the high yields necessary to produce sufficient plant-based foods to supply the world population. In recent decades, one of the most extensively explored alternatives to replace agrochemicals and reduce their environmental impact has been the use of microorganism-based products to boost crop yields with less environmental impact. This review focuses on the results of studies that have demonstrated the potential of the genus Paraburkholderia to increase crop yields and be utilized in biofertilizers and biocontrol products. A literature search was performed electronically considering articles and books published until August 19, 2024. We identified 24 species of Paraburkholderia with the ability to improve crop yields after their inoculation by different methods on seeds, seedlings, plantlets, adult crops, or fruits. The effects of these bacteria have been tested under laboratory, greenhouse, or field conditions. These Paraburkholderia species mediate their positive impact on crop growth by direct and indirect plant growth-promoting mechanisms, which include improving nutrient uptake, stimulating growth by phytohormone production, regulation and stimulation of metabolic pathways, induction of abiotic stress tolerance, and disease control by direct pathogen inhibition or induction of systemic resistance in plants. The literature reviewed here supports the use of Paraburkholderia in bio-inputs under the actual panorama of climate change and the necessity to increase sustainable agriculture worldwide.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"62"},"PeriodicalIF":4.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic insights into habitat adaptation of Lactobacillus species.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-04 DOI: 10.1007/s11274-025-04275-0

Alejandra Mejía-Caballero, Rafael López-Sánchez, Blanca Ramos-Cerrillo, Alejandro Garciarrubio, Lorenzo Segovia

{"title":"Genomic insights into habitat adaptation of Lactobacillus species.","authors":"Alejandra Mejía-Caballero, Rafael López-Sánchez, Blanca Ramos-Cerrillo, Alejandro Garciarrubio, Lorenzo Segovia","doi":"10.1007/s11274-025-04275-0","DOIUrl":"10.1007/s11274-025-04275-0","url":null,"abstract":"Lactobacillus is one of the most important genera within the lactic acid bacteria group, due to its importance in the food industry and the health field. This diversity can be explained either by their radiation in different environments or by the domestication process in artificial habitats, such as fermented foods. In this study, we performed a comparative genomic analysis of 1020 Lactobacillus genomes, categorizing them into five broad habitats: insects, vertebrates (including humans and animals), vegetables, free-living environments, and dairy products. Utilizing phylogenetic relationships, genomic distances, and gene presence/absence profiles, we identified distinct clustering patterns associated with specific environmental adaptations. Notably, species within the Lactobacillus delbrueckii clade exhibited GC content variations fivefold greater than those observed in other bacterial genera, indicating significant genomic divergence. Insect-associated species showed a strong correlation between genes for carbohydrate utilization and those for amino acid biosynthesis across all habitats. However, individual gene analyses revealed no consistent correlation between habitat adaptation and phylogenetic proximity, suggesting that Lactobacillus employs strain-specific adaptive mechanisms rather than universal genetic markers. Notably, around 50% of the genes associated with specific habitats are hypothetical. Our findings highlight the genomic complexity of Lactobacillus, driven by diverse adaptive strategies, and underscore the need for more comprehensive sampling to fully elucidate the evolutionary dynamics within this important genus.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"61"},"PeriodicalIF":4.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biotechnological uses of purified and characterized alkaline cellulase from extremophilic Bacillus pumilus VLC7 from Lake Van.

IF 4 3区生物学

World journal of microbiology & biotechnology Pub Date : 2025-02-04 DOI: 10.1007/s11274-025-04271-4

Aysun Ayse Yilmaz, Sumeyra Gurkok

{"title":"Biotechnological uses of purified and characterized alkaline cellulase from extremophilic Bacillus pumilus VLC7 from Lake Van.","authors":"Aysun Ayse Yilmaz, Sumeyra Gurkok","doi":"10.1007/s11274-025-04271-4","DOIUrl":"10.1007/s11274-025-04271-4","url":null,"abstract":"The present study focuses on the isolation and characterization of a bacterium from Lake Van adapted to an alkaline pH environment with significant cellulase production potential. The identified isolate, Bacillus pumilus VLC7 (GenBank Acc No: OR415888.1), exhibited the highest cellulase activity among other alkaliphilic isolates. The purification employing protein precipitation by ammonium sulfate, ultrafiltration, and ion exchange chromatography resulted in 20-fold purification with a specific activity of 16 U/mg protein. Cellulase had a molecular weight of 76 kDa, 3.13 mM Km and 0.160 U/mg Vmax values. The enzyme displayed maximum activity at pH 9.0 and 40 °C and retained at least 80% of its activity at temperatures of 25-60 °C for 90 min and pH 4-12 for one hour. Stability tests also revealed the enzyme's resilience to various reagents, metal ions, organic solvents, and detergents. Furthermore, the biotechnological applications of cellulase were explored, demonstrating its effectiveness in fabric biopolishing (removing pilling), as well as in the removal of fabric dyes. The research findings underscore the potential of B. pumilus VLC7 as a valuable source for eco-friendly industrial biotechnology applications.","PeriodicalId":23703,"journal":{"name":"World journal of microbiology & biotechnology","volume":"41 2","pages":"60"},"PeriodicalIF":4.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0