Journal of the Japan Society of the Reticuloendothelial System最新文献

{"title":"An Autopsy Case of Smoldeing Adult Tcell Leukemia/Lymphoma with Intestinal Perforation and Hemophagocytic Histiocytosis","authors":"T. Kasajima, A. Masuda, N. Yamasita, Y. Nakagami","doi":"10.3960/JSLRT1961.27.403","DOIUrl":"https://doi.org/10.3960/JSLRT1961.27.403","url":null,"abstract":"An autopsy case with atypical adult T cell leukemia lymphoma (ATL) was reported. A 24-year-old male who had skin lesions and respiratory distress as premonitory symptoms from his childhood. Skin lesions appeared in the form of vasculitis. Infiltration of ATL cells were not recognizable in the skin and peripheral blood. On his admission, before four months of his death, ATLA (antibody to ATL virus associated antigen) was detected to be positive in his serum and simultenously also in the serum of his mother whose native place south-west region of Japan (Kagawa prefecture). After admission, acute abdominal symptoms occurred and roentgenography revealed multiple intestinal ulcers. He was treated with surgical operations three times, however, massive alimentary bleeding has continued and died on July, 1, 1987.The infiltration of atypical lymphoid cell of T cell character (Leu 1 positive) was observed in the ulcerated walls of intestine surgically resected. Autopsy revealed systemic swelling of lymph nodes of their cell components being in agreement with picture of pleomorphic type of ATL Invasion of ATL cells were found in various organs, i.e. liver, kidneys, spleen, gastrointestinal tract, adrenals and bone marrow. Moreover, remarkable haemophagocytic cells appeared in the lymph nodes, spleen and liver. Lymphoid cells had pleomorphic contour and large, irregular shaped, convoluted nuclei. Immunocytochemically, these cells were positive for Leu 1 and faintly positive for OKIa. On the other hand, reaction for MT-1, MB-1, immunoglobulins and histiocytic markers were negative. Phagocytic histiocytes positively reacted for lysozyme, α1-antitrypsin, and CEA, but negatively for S100 protein. No pulmonary infection was recognized. From clinical and anatomical evidences the patient developed typical ATL having duration of more than ten years with insidious course but without leukemic manifestation. This picture corresponded to smoldering ATL proposed by Takatsuki and Yamaguchi.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129431681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemophagocytic syndrome associated with nasal T-cell lymphoma: Report of an autopsy case.","authors":"K. Takai, M. Sanada, K. Honma, E. Okazaki","doi":"10.3960/JSLRT1961.28.195","DOIUrl":"https://doi.org/10.3960/JSLRT1961.28.195","url":null,"abstract":"A 59-year-old man was admitted because of fever and nasal obstruction. On admission, bilateral nasal cavities and the palate were replaced by necrotic tissue. Physical examination revealed cervical lymphadenopathy, hepatosplenomegaly and edema but no icterus. Nasal mucosa and cervical lymph node were biopsied and they showed diffuse proliferation of large tumor cells with convoluted nuclei admixing with macrophages. Tumor cells, studied immunohistochemically, were positive for Leu4, MT1, but negative for SmIg, B1, B2, MB1, OKM1, and the tumor was diagnosed as T-cell lymphoma.During the course, pancytopenia rapidly progressed and the bone marrow aspiration showed hypoplastic marrow with increased large histiocytic cells but no apparent tumor cells. Clinical and laboratory features revealed disseminated intravascular coagulation (DIC). Chemotherapy with the CHOP regimen was initiated but he died of extensive hemorrhagic pneumonia and bronchopneumonia. Autopsy showed lymphoma cell infiltration in pharynx, tonsils, liver, spleen and lymph nodes of neck and carina. Activation of mature histiocytes with marked erythrophagocytosis was characteristic and seen throughout the mononuclear phagocytic system, i.e. splenic red pulp, hepatic sinusoids, lymph node sinuses and bone marrow.This case would be clinically classified in so-called lethal midline granuloma, but histologically diagnosed as nasal T-cell lymphoma complicated by hemophagocytic syndrome and DIC. Erythrophagocytic histiocytosis was considered to be the reactive process to the opportunistic infection associated with the T-cell malignancy.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131355726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of macrophages in atherosclerotic vascular lesions and xanthomas.","authors":"Akira Yamoto, H. Hara, S. Takaichi","doi":"10.3960/JSLRT1961.28.169","DOIUrl":"https://doi.org/10.3960/JSLRT1961.28.169","url":null,"abstract":"Intracellular accumulation of lipids occurs in macrophages and smooth muscle cells in atherosclotic vascular lesions and xanthomas associated with hypercholesterolemia. Blood monocytes are originally provided with receptors for native LDL, while macrophages are provided with another kind of receptors for denatured LDL named scavenger receptors. By treating the cells of a monocytic leukemia cell line, THP-1, by a phorbol ester, we could observe a rapid induction of the scavenger receptor with a decrease in LDL-receptor in a very short period of time (80% in 24hr). When we incubated the cells with acetylated LDL, the accumulation of cholesterol and other lipids took place and the cells were changed into foam cell. The cells can also synthesize and secrete apolipoprotein E. When we incubated the cells in the medium containing HDL or artificial lipid paricles containing apolipoprotein E, free cholesterol was released from the cell surface into the medium. The series of experiments provided us a convenient model for the study of development and regression of atherosclerosis. Probucol, a kind of antilipidemic drug provided with an activity as an antioxidant, prevented the lipid storage in macrophages. It inhibited the uptake of acetylated LDL and stimulated the release of cholesterol into the medium. Such in vitro observation explains why probucol is very effective in causing the regression of xanthomas and also in the prevention of atherosclerotic coronary heart diseases.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"387 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116484833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIC and reticuloendothelial system.","authors":"Tohru Hayashi, K. Marutsuka, J. Suzumiya, A. Sumiyoshi","doi":"10.3960/JSLRT1961.28.43","DOIUrl":"https://doi.org/10.3960/JSLRT1961.28.43","url":null,"abstract":"The relationship between disseminated intravascular coagulation (DIC) and reticuloendothelial system (RES) was investigated clinicopathologically using autopsy cases and experimentally in rabbits treated with two injections of endotoxin at an interval of 24 hours. Fibrin thrombi were observed in the liver in 42% of the 14 DIC cases and in the spleen in 35%. There was a tendency of thrombus formation in an earlier phase in the liver and spleen than in other organs. This result was compatible with the experimental one. Kupffer cells and macrophages in DIC cases increased in number and showed an increased phagocytic activity than in the control ones.In the experimental model, first intravenous injection of endotoxin made RES a more active form with many phagosomes and tiny fibrin threads around them. After the second injection of endotoxin, a great number of fibrin thrombi were observed in the spleen, liver, kidney and lung. The cells of RES showed intimate relationship to fibrin thrombi with the intricate invagination of cytoplasmic membrane engulfing fibrin thrombi. However, no definite evidence of phagocytosis, such as phagolysosomal disposition of fibrin, was observed.In rabbits in a state of DIC induced by one intravenous injection of endotoxin with pretreatment of intravenous latex injection, features of active fibrin disposition were observed even in swollen macrophages phagocytizing many latex particles. The particles of colloidal iron injected intravenously in the rabbits three hours after the second injection of endotoxin were phagocytized by splenic phagocytes, and its number was greater than that in control rabbits.These results suggest that the RES activation or hyperfunction rather than its blockade may be more important in the pathogenesis of DIC.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125713266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative process of marrow in the medullary cavities of femurs after subcutaneous implantation. Immunohistochemical and biochemical analysis of the extracellular matrix components.","authors":"T. Nagasaka, N. Nakashima, Miya Kobayashi, T. Hotta, J. Takeuchi","doi":"10.3960/JSLRT1961.32.283","DOIUrl":"https://doi.org/10.3960/JSLRT1961.32.283","url":null,"abstract":"When mouse femoral bone was subcutaneously implanted after the cutting of both ends into the abdominal wall of syngeneic mouse, bone marrow tissue regenerated in the medullary cavity of the bone. We removed the implanted bones at 1-week intervals and evaluated the regenerative process. The medullary cavity underwent necrosis after 1 week. Regeneration of the stromal components appeared in the epiphyses after 2 weeks and progressed with resorption of the necrotic tissue. After 3-4 weeks, myxomatous stroma rich in matrix components formed resulting in enlodgement and proliferation of hematopoietic cells. Marrow graftment was nearly completed after 6 weeks. Immunohistochemical examination showed a large amount of chondroitin sulfate proteoglycan (PG) and large PG in the myxomatous stroma that formed after 3-4 weeks. Biochemical analysis of the glycosaminoglycan chain primarily revealed low-sulfated chondroitin sulfate. Formation of myxomatous stroma rich in chondroitin sulfate PG and large PG seemes to play an important role in the regeneration of hematopoietic tissue.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"153 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129152686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"二次性骨髄線維症,血球貪食症候群およびstage I,非Hodgkinリンパ腫を合併した肝のInflammatory Pseudotumor (IPT)の一例","authors":"理夫 熊谷, 功 壺井, 幸治 森本, 良政 蔵, 海彦 沢田, 孝至 堀江","doi":"10.3960/JSLRT1961.35.17","DOIUrl":"https://doi.org/10.3960/JSLRT1961.35.17","url":null,"abstract":"A 73-year-old male was admitted to our hospital with pyrexia, weight loss, anorexia and liver tumor found by ultrasonography on April 6, 1992. Physical examination revealed hepatomegaly 5cm below the costal margin. Laboratory findings on admission were as follows: a hemoglobin of 7.3g/dl, a platelet count of 2.8×104/μl, elevated levels of lactic dehydrogenase and alkaline phosphatase as well as leucine aminopeptidase and γ-glutamyltranspeptidase. Bone marrow examinations revealed hemophagocytosis and myelofibrosis. Antibiotics therapy was then initiated, and symptoms and abnormal laboratory findings including hemophagocytosis improved. He had hepatectomy of the left lobe with the diagnosis of malignant hepatic tumor by imagings. Inflammatory pseudotumor (IPT) without evidence of malignancy was diagnosed microscopically. Biopsy of a enlarged paraesophageal lymph node in operation showed stage I, non-Hodgkin's lymphoma (NHL). The postoperative course was excellent, and the disappearance of myelofibrosis was found by the second bone marrow biopsy after lobectomy for the IPT. Clinical course with those analytical results suggest that myelofibrosis and hemophagocytosis are closely associated with IPT. And an etiologically important role of chronic inflammatory stimulation of IPT for developing of NHL is suggested.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133604402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxicity of dust particles on colony-forming capacity of pulmonary alveolar macrophages.","authors":"Y. Oghiso, Huijuan Xiao, Yutaka Yamada","doi":"10.3960/JSLRT1961.33.179","DOIUrl":"https://doi.org/10.3960/JSLRT1961.33.179","url":null,"abstract":"Cytotoxic effects of fibrogenic dust particles on the colony-forming capacity of murine pulmonary alveolar macrophages (PAM) were tested to define the possibility that the proliferation and the maintenance of PAM population could be affected by inhaled substances. Intratracheal instillation of crocidolite asbestos or Min-u-sil silica particles into mice induced significant and persistent reduction of alveolar macrophage colony -forming cells detected in vitro during the period of 1 to 6 months after treatments as compared to untreated control or groups of mice administered with non-fibrogenic TiO2 particles. Total numbers of PAM recovered by bronchoalveolar lavage, however, were not significantly different from the controls after asbestos- or silica-instillation. Instead, inflammatory exudation of polymorphonuclear leukocytes, Iymphocytes and monocytes significantly increased in the groups of asbestos- or silica-instilled animals, but not in TiO2-instilled mice. These data suggest that instilled fibrogenic particles have a cytotoxicity on the proliferation and differentiation of PAM, while total PAM population could be maintained by recruitments of monocytes following inflammation or chemotactic events.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122227000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinicopathological study of Primary Gastric Lymphoma Associated with interfollicular Proliferation.","authors":"Y. Masuda, K. Ohshima, M. Takeshita, M. Kikuchi","doi":"10.3960/jslrt1961.32.93","DOIUrl":"https://doi.org/10.3960/jslrt1961.32.93","url":null,"abstract":"The seventy-six cases of primary gastric lymphomas have been studied morpholigically, immunohistochemically and genetically. The lymphomas usually showed B-cell phenotype. According to the update Kiel classification 33 were of low-grade malignancy (all B-cell) and 43 were of high-grade malignancy (41 of B-cells and 2 of T -cell) . Diffuse, follicular and interfollicular types were categorized by the infiltrating patterns. Specific interfollicular pattern was detected in 14 cases and the cases consisted of various histological groups, including lymphocytic type with monoclonal surface immunoglobulin and clear cell variant, and possessed no bcl-2 gene rearrangement. Bcl2 gene rearrangement was detected in three of centroblastic type including one with follicular patterns, and one of centroblastic/centrocytic type. The results indicate the presence of follicular center cell origin of the gastric lymphoma.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"161 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116637328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The administration of small-dose etoposide for a long period as a maintenance therapy in the patients with non-Hodgikin's lynphoma.","authors":"T. Okamoto, A. Kanamaru, E. Kakisita, N. Yamaguchi, S. Nakayama, Takayuki Takahashi, R. Ogawa, K. Saigou, M. Nishikiori, H. Yamano, M. Okada, H. Tago","doi":"10.3960/JSLRT1961.35.291","DOIUrl":"https://doi.org/10.3960/JSLRT1961.35.291","url":null,"abstract":"We investigated whether the administration of small-dose etoposide for a long period of time as a post intensive therapy is effective on remission duration and survival of patients with non-Hodgkin's lymphoma. After complete remission following CHOP or VEPA therapy, 33 patients were registered and administered etoposide at a daily oral dose of 25mg/body for a long time (median days; 211). Twenty-seven patients who were treated without the maintenance therapy, were used as a historical control.The long-term complete remission ratio at 3 years was 54% for the etoposide group compared with 36% for the control group. Especially in patients over 65 years of age, the remission ratio was 61% for the etoposide group compared with 25% for the control group.The long-term survival ratio at 5 years was 67% for the etoposide group compared with 59% for the control group. The small-dose etoposide as a post intensive therapy seemingly showed a beneficial effect but not statistically significant on the remission duration (P=0.08, Generalized Wilcoxon test) and the survival length (P=0.96, Generalized Wilcoxon test).Side effects and abnormal laboratory findings were minimal in the etoposide group except one patient with leukopenia (grade 4).These preliminary data suggested the usefulness of the small-dose etoposide as a post intensive therapy for treatment of non-Hodgkin's lymphoma.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117221990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An electronmicroscopic cytomorphometric analysis of 55 cases of T-cell lymphomas.","authors":"K. Hasui, E. Sato, K. Warin, S. Kitajima, M. Goto, M. Tokunaga","doi":"10.3960/JSLRT1961.29.367","DOIUrl":"https://doi.org/10.3960/JSLRT1961.29.367","url":null,"abstract":"Lymphoma cells in 55 cases of T-cell lymphomas (T-ML) were analyzed by cytomorphometry on electronmicrographs in order to evaluate the criteria of peripheral T-cell malignant lymphomas (PTML) proposed by Lennert and Suchi et al. and to see the cytomorphological features of adult T-cell leukemia/lymphomas (ATLL). Nuclear area, nuclear contour index (NCI), nucleocytoplasmic ratio (N/C) and the relationship between the thickness of perinuclear heterochromatin (PNHC) and nuclear area were employed as factors of this cytomorphometry. The relationship between PNHC and nuclear area was evaluated as continuous or dispersed by means of statistical comparison of nuclear area among 4 kinds of lymphoma cells showing the PNHC's thickness graded in 4. When T-MLs were categorized in 3 groups by cell size, the factors characterized subtypes according to the criteria of PTML and showed peculiar features of ATLL even in pleomorphic lymphoma (PLEO). In the small or medium-sized cell T-MLs, T-cell lymphoblastic type (1 case) and T-zone lymphoma (I case) were differentiated by N/C, PLEO medium-sized cell type (PLED-M) of ATLL (12 cases) indicated larger nuclear area and higher NCI and showed the continuous relationship of PNHC, PLEO-M of european case (EPTL, 4 cases) and angioimmunoblastic lymphoadenopathy with dysproteinemia (AILD)-type PTML (2 cases) indicated similar cytomorphometric features, and T-cell chronic lymphocytic leukemia (1 case) revealed low value of NCI. In the medium-sized and large cell T-MLs, the contrareiety in the relationship of PNHC differentiated ATLL (continuous, 14 cases) from that of EPTL (dispersed, 2 cases). In the large cell T-MLs, PLEO large cell type (PLED-L) of EPTL (2 cases) indicated smaller nuclear area and PLEO-L of ATLL (3 cases) revealed larger nuclear area than T-cell immunoblastic type (2 cases). Mycosis fungoides (MF) in the lymph node (2 cases) revealed higher values of NCI and N/C. Furthermore, the cytomorphometric factors differentiated ATLL (4 cases) and MF (5 cases) in the skin, indicating much higher values of NCI in MF than ATLL in the skin.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131580648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}