Journal of the Japan Society of the Reticuloendothelial System最新文献

{"title":"Immunohistological Study of Lymphoblastic Lymphoma","authors":"H. Segami, Nobutaka Ono, N. Nakamura, M. Abe, H. Wakasa","doi":"10.3960/jslrt1961.27.285","DOIUrl":"https://doi.org/10.3960/jslrt1961.27.285","url":null,"abstract":"Immunological characteristics of eight cases of lymphoblastic lymphoma (LBL) were studied. When LBLs were divided into T-cell and B-cell type according to marker expression of neoplastic cells, six of eight cases displayed T-cell markers and other cases expressed B-cell markers. Based on nuclear shape, the cases were morphologically divided into convoluted (two cases) and non-convoluted type (six cases).Expression of B-cell markers in one of two cases with convoluted nucleus suggested that convoluted nucleus was not limited to T-cell type. In T-LBL, some cases expressed CALLA (J5) or HLA-DR (Ia-like antigen). In five of six cases of T-LBL, Leu-8 positive neoplastic cells were observed. In non-neoplastic thymus, Leu-8 positive cells were found in medulla and subcapsular region. Leu-8 antigen may give a clue to clarify the origin of T-LBL.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131902172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The usefulness and limitation of molecular genetical analysis in diagnosing malignant lymphoma.","authors":"H. Miwa, N. Matsuoka, T. Nosaka, K. Kita, S. Shirakawa","doi":"10.3960/JSLRT1961.29.127","DOIUrl":"https://doi.org/10.3960/JSLRT1961.29.127","url":null,"abstract":"We analyzed 176 cases of lymphoproliferative disorders by molecular genetical approach in conjunction with phenotypical examinations.Tγ/LGL proliferative disorder has been revealed to consist of at least two groups; one is CD3(+), TcR gene rearranged group which is considered as T-cell lineage, the other is CD3(-), TcR gene germ line one which is cosidered as “NK cell” origin.Many AILD cases with some atypic cells (AILD-T) have rearranged TcR genes and are supposed to be related to T-cell lymphoma. Though we examined the gene expression of IL-4, 5 to clarify the clinical features of AILD, we failed to observe distinct participation of IL-4, 5.We frequently observed dual genotype (simultaneous rearralgements of Ig and TcR genes) cases in CD20(+) c-ALL and stage II T-ALL/LBL. It has been supposed that common recombinase and accessibility for it are activated at such specific stages of lymphocyte maturation.In addition, we analyzed precise biallelic IgH gene structure by examining 5'D region of IgH, and observed difference of rearrangement patterns which are specific for diseases or maturational stage.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"519 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134110959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the immuno-adjuvant to plasma fibronectins of mouse.","authors":"T. Kikuchi","doi":"10.3960/JSLRT1961.24.171","DOIUrl":"https://doi.org/10.3960/JSLRT1961.24.171","url":null,"abstract":"","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132078705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse B cell lymphoma without lymphadenopathy accompanied by reactive histiocytosis simulating malignant histiocytosis: A report of three autopsy cases.","authors":"C. Sakai, T. Takagi, M. Oguro, S. Wakatsuki, T. Aoi, Kohshi Maruyama","doi":"10.3960/JSLRT1961.31.27","DOIUrl":"https://doi.org/10.3960/JSLRT1961.31.27","url":null,"abstract":"The clinical and autopsy findings of three cases of B cell lymphoma simulating malignant histiocytosis are reported. Case 1 was 60y.o. female, case 2 was 75y.o. male and case 3 was 61y.o. female. The presenting symptoms were pyrexia in three cases, dyspnea in case 1 and jaundice in case 2. There was no peripheral lymphadenopathy in these cases. A hyperplasia of monocytes and hemophagocytic histiocytes was seen in their bone marrow and many abnormal lymphoid cells were seen in the marrow of case 3. The lung biopsy revealed infiltration of abnormal cells in case 1. Case 1 and 2 were diagnosed as malignant histiocytosis and case 3 was diagnosed as malignant lymphoma with reactive histiocytosis. After chemotherapy using adriamycin or THP-adriamycin case 1 and 3 improved, however case 2 did not respond. The overall survivals of three cases were 26 months in case 1, 3.5 months in case 2 and 12 months in case 3.The postmortem examination showed that abnormal cells infiltrated diffusely into many organs such as lungs, liver, spleen and kidneys. Neither lymphadenopathy nor tumor-formation was seen. Infiltrating abnormal cells were positive for pan B cell antibody (L26) but negative for pan T cell antibody, lysozyme and S-100 protein.These cases indicate that a part of B cell lymphoma is accompanied by reactive histiocytosis simulating malignant histiocytosis.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122716240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary B cell malignancy of the bone marrow with marked IgA.KAPPA. paraproteinemia.","authors":"S. Kuwabara, Hitoshi Houjou, Y. Kimura, M. Nakano, K. Toyama, H. Serizawa, Y. Enomoto, Yonosuke Watanabe","doi":"10.3960/JSLRT1961.29.229","DOIUrl":"https://doi.org/10.3960/JSLRT1961.29.229","url":null,"abstract":"","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123990839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extranodal lymphoma of low grade malignancy-including lymphoma of mucosa-associated lymphoid tissue(MALT).","authors":"M. Ohsawa, K. Aozasa","doi":"10.3960/JSLRT1961.32.397","DOIUrl":"https://doi.org/10.3960/JSLRT1961.32.397","url":null,"abstract":"Malignant lymphoma (ML) of low grade malignancy includes small lymphocytic lymphoma and follicular lymphoma other than large cell type. Recent study revealed intermediate lymphocytic lymphoma (ILL) and monocytoid B-cell lymphoma (MBCL) to be new types of ML of low grade malignancy. These two types of ML are fundamental elements of ML developing in so-called mucosa associated lymphoid tissue (MALT). In this report, results of our study on ILL and MBCL of extranodal organs were described.ILL is composed of small lymphoid cells with morphologic features between those of well-differentiated lymphocytic lymphoma and poorly differentiated lymphocytic lymphoma of follicular center cell origin. The frequency of ILL in nodal and extranodal non-Hodgkin's lymphoma was almost same. The frequency was high in salivary gland and thyroid lymphoma. Histologic features of chronic lymphocytic thyroiditis (CLTH) are constantly observed in cases with thyroid lymphoma. Histologic findings suggestive of Sjogren's syndrome such as formation of lymphoid follicles and myoepithelial islands were observed in one third of cases with salivary lymphoma. These findings suggested that autoimmune diseases such as CLTH and Sjogren's syndrome played an important role in the etiology of thyroid and salivary lymphoma.MBCL shows the proliferation of the atypical lymphoid cells with abundant and pale cytoplasm and reniform nucleus. The high incidence of Sjogren's syndrome in cases with MBCL was evident suggesting the etiologic role of Sjogern's syndrome for development of MBCL. Six cases of MBCL developing in extranodal sites such as thyroid, stomach, and rectum were described below. Two of three patients with thyroid lymphoma presented with positive serum antithyroid antibodies, and one had CLTH. In all three patients with gastric or rectal lymphoma, reactive lymphoid hyperplasia was present near the tumors. These findings suggested the important role of long-standing inflammation for development of MBCL as well as ILL.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127751005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vasculatures in the extranodal B cell lymphoma.","authors":"Yuichiro Saito, K. Morise","doi":"10.3960/JSLRT1961.30.379","DOIUrl":"https://doi.org/10.3960/JSLRT1961.30.379","url":null,"abstract":"11 cases received operation for primary B cell lymphoma of the gastrointestinal tract were studied immunohistochemically to clarify vascular endothelial cell (EnC) function in extranodal lymphoma tissues. Microvasculature in primary B cell lymphoma of the gastrointestinal tract, based on the morphological characteristics, were devided into high endothelial cell vessels (HEV) and flat endothelial cell vessels (FEV). HEV were characterized as HLA-DR- OKM1- OKM5- F VIII RAg+ IL-1-, accompanied by the cluster of non-neoplastic T lymphocytes, and FEV were HLA-DR- OKM1- OKM5+ F VIII RAg+ IL-1- not by T lymphocyte infiltration. In contrast, microvascular EnC in the surrounding non-lymphoma tissue, normal gastric and ileal tissues showed HLA-DR+ IL-1+. Our results suggest that microvascular EnC in primary B cell lymphoma of the gastrointestinal tract lack a fuction as antigen presentation, and that HEV regulate non-neoplastic T cell migration.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121046485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induction of macrophage growth by phagocytic stimuli via scavenger receptor.","authors":"Toshinori Sasaki, S. Yui, M. Yamazaki","doi":"10.3960/JSLRT1961.35.9","DOIUrl":"https://doi.org/10.3960/JSLRT1961.35.9","url":null,"abstract":"Scavenger receptors on macrophages were recently discovered and molecularly identified. Although the roles of the scavenger receptors in phagocytic function of macrophage were well-characterized, it might affect on many macrophage functions other than phagocytosis. Macrophage growth is known to be induced by protein factors, namely, macrophage colony-stimulating factor (CSF) and granulocyte/macrophage CSF. On the other hand, we previously reported that phagocytic stimuli of dead cells or cell membrane component induce the growth of macrophages. Therefore, the possibility was raised that macrophage growth could also be induced by ligands for scavenger receptors such as chemically modified lipoproteins or advanced glycation end products (AGE) of proteins. Actually, when murine peritoneal exudate macrophages were cultured with acetylated LDL, oxidized LDL, or AGE-BSA, significant growth was induced. These in vitro data revealed a new function of ligands of scavenger receptors as effective inducers of macrophage growth. Capacity of AGE-BSA to induce macrophage growth was blocked when the cells were cultured with antibody to GM-CSF. Moreover, it was confirmed that AGE actually induced production of GM-CSF in macrophages. Therefore, it is suggested that endogenous production of GM-CSF is implicated in the growth-stimulating activity of the ligands of scavenger receptors.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129018182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between cytokine receptors and lymphocyte activation.","authors":"J. Yodoi, S. Iwata, K. Nakamura","doi":"10.3960/jslrt1961.31.1","DOIUrl":"https://doi.org/10.3960/jslrt1961.31.1","url":null,"abstract":"In the immunological field, many substances that have biological activities on lymphocytes or hematopoietic cells have been purified and cloned. These substances are called “lymphokines” or “cytokines”, and have important roles on cell activation and differentiation. Cytokines have been proved to affect the wide variety of target cell through their receptors in “autocrine” or “paracrine” manner. They are also produced by the many kind of cells other than lymphocytes or hematopoietic cells, and sometimes have multifunctions in the same molecules.ADF (ATL-derived factor), which we have purified and cloned as an IL2R/p55 (Tac) inducing factor from the HTLV-I infected T-cell line, has high homologus DNA sequence to E. coli thioredoxin. As is the case with the E. coli thioredoxin, ADF has active disulfide bond and potent reducing activity and radical scavenging activity. ADF is also homologous to PDI (Protein Disulfide Isomerase) and has similar isomerase activity. Whereas ADF doesn't have the signal peptide, ADF is released to culture supernatant and has synergistic or additive effects with cytokines including IL-1 and IL-2 on the mitogenic response of some lymphoid cell lines. ADF is highly expressed in many virus-transformed cell lines such as HTLV-I, EBV, HPV and induced in the PHA-stimulated blast of normal PBL. These finding suggest the multifunctional property of ADF/Thioredoxin and the association with the cell activation or blastic transformation.Majority of EBV-transformed B cell lines express the low affinity Fc receptor for IgE (FceRII) which is an animal lectin-like protein and is identical to an activation antigen on B cells (CD23). FceRII/CD23 is expressed on the wide variety of hematopoietic cell lines including EBV (+) B and some HTLV-I (+) T cell lines. These cell lines released the soluble form of FceRII to the culture supernatant by proteolysis. Soluble FceRII has been called as IgE binding factor, which has affinity to IgE and other biological activities including growth promoting activity on lymphocytes. Membrane associated FceRII/CD23 has been proved to be associated with some tyrosine kinase, indicating that IgE or some other ligand may induce activation signal through the FceRII/CD23.The possible role of ADF in the induction of IL-2R/p55 (Tac) as well as FceRII/CD23 is discussed in relation to the normal and abnormal trasformation of lymphocytes.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115991417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical investigation of 184 cases of extranodal non-Hodgkin's lymphoma: Determination of prognostic factors by univariate and multi-variate analysis.","authors":"Nozomi Niisu, M. Umeda","doi":"10.3960/JSLRT1961.35.271","DOIUrl":"https://doi.org/10.3960/JSLRT1961.35.271","url":null,"abstract":"","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116860476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}