A Clinicopathological study of Primary Gastric Lymphoma Associated with interfollicular Proliferation.

The seventy-six cases of primary gastric lymphomas have been studied morpholigically, immunohistochemically and genetically. The lymphomas usually showed B-cell phenotype. According to the update Kiel classification 33 were of low-grade malignancy (all B-cell) and 43 were of high-grade malignancy (41 of B-cells and 2 of T -cell) . Diffuse, follicular and interfollicular types were categorized by the infiltrating patterns. Specific interfollicular pattern was detected in 14 cases and the cases consisted of various histological groups, including lymphocytic type with monoclonal surface immunoglobulin and clear cell variant, and possessed no bcl-2 gene rearrangement. Bcl2 gene rearrangement was detected in three of centroblastic type including one with follicular patterns, and one of centroblastic/centrocytic type. The results indicate the presence of follicular center cell origin of the gastric lymphoma.