Vision ResearchPub Date : 2025-04-09DOI: 10.1016/j.visres.2025.108596
María Arcas-Carbonell , Elvira Orduna-Hospital , Sara Oliete-Lorente , María Mechó-García , Guisela Fernández-Espinosa , Ana Sanchez-Cano
{"title":"Structural and functional analysis of the eye according to the accommodation-age relationship","authors":"María Arcas-Carbonell , Elvira Orduna-Hospital , Sara Oliete-Lorente , María Mechó-García , Guisela Fernández-Espinosa , Ana Sanchez-Cano","doi":"10.1016/j.visres.2025.108596","DOIUrl":"10.1016/j.visres.2025.108596","url":null,"abstract":"<div><div>This study investigates how accommodative demand affects ocular function by examining variations in the anterior chamber depth (ACD), as well as the retinal and anterior surface curvatures of the crystalline lens across different age groups.</div><div>The study included 96 right eyes from healthy individuals aged 18 to 66 years. Accommodation was assessed using an aberrometer under demands up to 5 diopters (D). Images of the anterior segment and retina were recorded and analyzed with custom software to adjust these surfaces to conic curves, providing data on changes in ACD, anterior surface curvature of the crystalline lens, and retinal shape during accommodation.</div><div>The average age of participants was 35.42 ± 13.55 years. Accommodation matched the demand at low levels (up to 1D) but under-accommodated at higher demands. No significant differences were found in the anterior surface curvature of the crystalline lens with increased accommodation, though a weak trend was observed in younger individuals. ACD significantly decreased with accommodation due to the anterior displacement of the lens. Retinal curvature showed significant changes, including flattening, with increased accommodative demand. There were correlations between the anterior surface eccentricity of the crystalline lens and both ACD changes and retinal eccentricity.</div><div>In conclusion, accommodation effectively responds to demands up to 1D across all ages. Our findings suggest a tendency for retinal curvature to flatten to higher demands, requiring further validation. While the central curvature of the anterior surface of the crystalline lens does not change significantly, ACD decreases with accommodation, indicating how age and presbyopia influence accommodative capacity and structural changes in the eye.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"230 ","pages":"Article 108596"},"PeriodicalIF":1.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vision ResearchPub Date : 2025-04-03DOI: 10.1016/j.visres.2025.108594
Mackenzie V. Wise, Gideon P. Caplovitz, Gabriel Foster, Michael A. Crognale
{"title":"Comparison of tripolar and traditional EEG recording of the visual evoked potential","authors":"Mackenzie V. Wise, Gideon P. Caplovitz, Gabriel Foster, Michael A. Crognale","doi":"10.1016/j.visres.2025.108594","DOIUrl":"10.1016/j.visres.2025.108594","url":null,"abstract":"<div><div>Scalp-recorded electroencephalography (EEG) is an effective method to quantify brain activity because it is noninvasive and has high temporal resolution. Even so, EEG is highly susceptible to physiological and non-physiological noise. Tripolar concentric ring electrodes (TCREs) provide an EEG measure (tEEG) designed to be robust to extraneous sources of noise. Previous studies have demonstrated this benefit in settings of high physiological noise such as muscle-related potentials and seizure detection. However, less has been done to study the efficacy of this technology in visual neuroscience. This study compares the noise profiles of traditional EEG and tEEG as well as the morphology of the pattern-reversal visual evoked potential recorded simultaneously using tEEG and emulated traditional EEG techniques. Our results indicate the two approaches have qualitatively similar noise profiles with the tEEG being significantly more robust to line noise (i.e. 60 Hz and its harmonics). In addition, while the overall morphology of the evoked potentials are similar, systematic differences in the latencies of the primary peaks of the waveforms indicate the two approaches do not detect exactly the same signal. Arising from the distinct electrode configuration of the TCRE, we hypothesize that the observed differences reflect the spatiotemporal geometry of the underlying neural responses to the pattern-reversing stimulus. Taken together, the results of this study suggest that tEEG is well suited to the study of human visual processing and offers both increased robustness to non-physiological sources of noise and a new opportunity to study the spatiotemporal dynamics of visual processing in the human brain.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"230 ","pages":"Article 108594"},"PeriodicalIF":1.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vision ResearchPub Date : 2025-03-28DOI: 10.1016/j.visres.2025.108592
Suharsha Paidimarri, Baskar Arumugam, Li-Fang Hung, Earl L. Smith III, Alan R. Burns, Lisa A. Ostrin
{"title":"Scleral ultrastructure in young rhesus monkeys: A stereological approach","authors":"Suharsha Paidimarri, Baskar Arumugam, Li-Fang Hung, Earl L. Smith III, Alan R. Burns, Lisa A. Ostrin","doi":"10.1016/j.visres.2025.108592","DOIUrl":"10.1016/j.visres.2025.108592","url":null,"abstract":"<div><div>The sclera provides mechanical support to the globe and plays a key role in maintenance of ocular structural integrity. Evidence shows that scleral remodeling contributes to biomechanical weakening, increasing the risk of pathologies, such as glaucoma and posterior staphyloma in high myopia. A precise characterization of normal regional ultrastructure is needed for a better understanding of scleral remodeling. The purpose of this study was to develop and implement a stereological analysis method to characterize scleral ultrastructure in healthy young rhesus monkey eyes. Monkeys (N = 4 eyes) first underwent normal emmetropization in a primate nursery. At 150 days of age, scleral tissue was collected in 1 mm<sup>2</sup> sections from three regions, equatorial nasal, posterior, and equatorial temporal, and processed for transmission electron microscopy (TEM). Images were captured at three depths: outer, middle, and inner, for all regions. Scleral thickness, fibroblast volume fraction, volume fraction of fibrillin microfibrils, and collagen fibril diameters were quantified using stereology and manual segmentation. The sclera was thickest in the posterior region with a mean thickness of 217.1 ± 10.1 μm. A total of 103 micrographs were analyzed to compute the volume fraction of fibroblasts and fibrillin microfibrils. Median fibroblast volume fraction was 7.4 %, and fibrillin microfibril volume fraction was 1.8 %. A total of 3564 collagen fibrils, encompassing 99 fibrils per region and depth per eye, were analyzed. Median collagen fibril diameter was 79.8 nm and ranged from 23 nm to 205 nm. This stereological approach provides a foundation for future studies investigating myopic scleral remodeling, where axial elongation and scleral thinning are known to show regional differences.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"230 ","pages":"Article 108592"},"PeriodicalIF":1.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vision ResearchPub Date : 2025-03-27DOI: 10.1016/j.visres.2025.108590
Gunnar Wendt, Franz Faul
{"title":"The effect of stimulus size on binocular luster and its implications for the interocular conflict model","authors":"Gunnar Wendt, Franz Faul","doi":"10.1016/j.visres.2025.108590","DOIUrl":"10.1016/j.visres.2025.108590","url":null,"abstract":"<div><div>Using a series of dichoptic center-ring-surround stimuli in a psychophysical experiment, we examined how the phenomenon of binocular luster is affected by the size of the central target area. Generally, we found that the lustrous sensation continuously decreases with increasing patch size. However, this effect also depends on further stimulus features such as the interocular contrast polarity pairings and the width of the ring element. To account for these complex influences on the magnitude of the lustrous response, significant extensions had to be made to our interocular conflict model. We present two improved versions of our model, a summation and an averaging model, which differ in the way the local conflict values are spatially integrated. Both versions have a very high predictive power. At least for the summation model, we show that the modifications are in good agreement with physiological processes. In particular, we provide evidence that the influence of stimulus size on the lustrous effect can be explained by the combination of two mechanisms: An increasing receptive field size of contrast detector cells and at the same time a decrease of the local density of these cells with increasing retinal eccentricity.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"230 ","pages":"Article 108590"},"PeriodicalIF":1.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vision ResearchPub Date : 2025-03-26DOI: 10.1016/j.visres.2025.108591
Markus Conci, Feifei Zhao
{"title":"Attentional misguidance from contextual learning after target location changes in natural scenes","authors":"Markus Conci, Feifei Zhao","doi":"10.1016/j.visres.2025.108591","DOIUrl":"10.1016/j.visres.2025.108591","url":null,"abstract":"<div><div>Attentional orienting in complex visual environments is supported by statistical learning of regularities. For instance, visual search for a target is faster when a distractor layout is repeatedly encountered, illustrating that learned contextual invariances improve attentional guidance (contextual cueing). Although contextual learning is usually relatively efficient, relocating the target (within an otherwise unchanged layout) typically abolishes contextual cueing, while revealing only a slow recovery of learning. However, such a “lack-of-adaptation” was usually only shown with artificial displays with target/distractor letters. The current study in turn used more realistic natural scene images to determine whether a comparable cost would also be evident in real-life contexts. Two experiments compared initial contextual cueing and the subsequent updating after a change in displays that either presented artificial letters, or natural scenes as contexts. With letter displays, an initial cueing effect was found that was associated with non-explicit, incidental learning, which vanished after the change. Natural scene displays either revealed a rather large cueing effect that was related to explicit memory (Experiment 1), or cueing was less strong and based on incidental learning (Experiment 2), with the size of cueing and the explicitness of the memory representation depending on the variability of the presented scene images. However, these variable initial benefits in scene displays always led to a substantial reduction after the change, comparable to the pattern in letter displays. Together, these findings show that the “richness” of natural scene contexts does not facilitate flexible contextual updating.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"230 ","pages":"Article 108591"},"PeriodicalIF":1.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vision ResearchPub Date : 2025-03-26DOI: 10.1016/j.visres.2025.108588
Dennis M. Levi, Susana T.L. Chung
{"title":"The impact of eye movements on amblyopic vision: A mini-review","authors":"Dennis M. Levi, Susana T.L. Chung","doi":"10.1016/j.visres.2025.108588","DOIUrl":"10.1016/j.visres.2025.108588","url":null,"abstract":"<div><div>Our eyes move constantly to search for and inspect objects of interest, to track moving objects, to read along a line of text and to prevent image fading. However, persons with amblyopia (PWA), in addition to a broad array of visual deficits, have abnormal eye movements. This review briefly describes the types of eye movements deficits in persons with amblyopia and how they are measured. We then go on to discuss what is known about how abnormal eye movements in persons with amblyopia affect their vision. Finally, we ask whether the abnormal eye movements are amenable to amblyopia treatment and whether they can be used to diagnose/classify amblyopia.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"230 ","pages":"Article 108588"},"PeriodicalIF":1.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vision ResearchPub Date : 2025-03-18DOI: 10.1016/j.visres.2025.108589
Jeroen B.J. Smeets, Eli Brenner
{"title":"The global effect may not be as adaptive as it seems","authors":"Jeroen B.J. Smeets, Eli Brenner","doi":"10.1016/j.visres.2025.108589","DOIUrl":"10.1016/j.visres.2025.108589","url":null,"abstract":"","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"230 ","pages":"Article 108589"},"PeriodicalIF":1.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143641755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vision ResearchPub Date : 2025-03-15DOI: 10.1016/j.visres.2025.108587
Kaida Xiao, Yoko Mizokami
{"title":"Facial skin tone and texture: Measurement, perception, and computation","authors":"Kaida Xiao, Yoko Mizokami","doi":"10.1016/j.visres.2025.108587","DOIUrl":"10.1016/j.visres.2025.108587","url":null,"abstract":"","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"231 ","pages":"Article 108587"},"PeriodicalIF":1.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vision ResearchPub Date : 2025-03-10DOI: 10.1016/j.visres.2025.108583
Kevin R. Duffy
{"title":"Astrocyte activation in the cat dLGN following monocular retinal inactivation","authors":"Kevin R. Duffy","doi":"10.1016/j.visres.2025.108583","DOIUrl":"10.1016/j.visres.2025.108583","url":null,"abstract":"<div><div>Monocular deprivation obstructs the development of visual neural circuits and can impair vision for a lifetime. Effective treatment of this visual disorder, amblyopia, with patching therapy is limited by a short and early critical period, as well as by poor compliance with prescribed treatment. Temporary pharmacological inactivation of the dominant eye has emerged as a means to rapidly correct the effects of monocular deprivation in animal models. Recovery occurs at older ages, and inactivation causes no apparent damage to neural connections within the primary visual pathway. It is unclear what mechanisms protect synaptic connections serving the inactivated eye. Astrocytes are important for the development and maintenance of synapses throughout the nervous system, and can compensate for a prolonged decrease in neural activity. The aim of the current study was to investigate a possible role for astrocytes in mediating the protection of neural connections following monocular inactivation. A significant increase in immunolabeling for glial fibrillary acidic protein (GFAP), a marker for astrocyte activation, was measured within inactivated-eye layers of the dorsal lateral geniculate nucleus from otherwise normal animals. Elevated levels of GFAP persisted even after the period of inactivation wore off, and GFAP was not significantly elevated following monocular deprivation by lid closure. These results implicate astrocyte activation as a possible mechanism that mediates the safeguarding of neural connections during monocular retinal inactivation. The viability of retinal inactivation as a safe and effective treatment for human amblyopia is facilitated by advancing the understanding of its effects within the visual system.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"230 ","pages":"Article 108583"},"PeriodicalIF":1.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}