Wiadomosci lekarskie最新文献_第8页

Igf-1 in acne pathogenesis and inositol as possible adjuvant treatment of acne. Igf-1在痤疮发病机制中的作用和肌醇作为痤疮的可能辅助治疗。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/220839

Iryna Y Smolanka, Roman R Yaremkevych, Pavlo Y Lesyk, Oleksandr P Lozynskyi

引用次数: 0

Patient autonomy and the right to refuse medical intervention: Medical and legal aspects. 病人自主和拒绝医疗干预的权利：医学和法律方面。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/220843

Maryna M Vyshnevska, Oleksandr O Kotukha, Viktoriia Yu Svyshcho, Serhii S Pyroha

{"title":"Patient autonomy and the right to refuse medical intervention: Medical and legal aspects.","authors":"Maryna M Vyshnevska, Oleksandr O Kotukha, Viktoriia Yu Svyshcho, Serhii S Pyroha","doi":"10.36740/WLek/220843","DOIUrl":"https://doi.org/10.36740/WLek/220843","url":null,"abstract":"Objective: Aim: To examine the right to refuse medical treatment and resuscitation as a component of somatic rights, to analyze comparative legal frameworks in the USA, EU member states and Ukraine, and to identify criteria for distinguishing lawful refusal of treatment from violations of medical and legal obligations.Patients and methods: Materials and Methods: The study employs a comparative legal method to analyze legislation across multiple jurisdictions, formal legal analysis of national and international normative acts, and case-law analysis of key ECtHR decisions, including Arskaya v. Ukraine, Pindo Mulla v. Spain, and Lambert v. France. Doctrinal legal sources on patient autonomy, informed consent, and advance directives were also examined.Conclusion: Conclusions: The right to refuse medical treatment constitutes a fundamental somatic right grounded in personal autonomy and human dignity. Ukraine requires systemic legislative reform to introduce legally binding advance directives and DNR orders, accompanied by safeguards including competency verification, centralized registries, and guaranteed access to palliative care.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 5","pages":"1127-1133"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148340544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifestyle interventions for diabetic retinopathy during pregnancy: Current evidence from clinical studies. 妊娠期糖尿病视网膜病变的生活方式干预：来自临床研究的最新证据

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/219973

Tomasz Bartuś, Jerzy Bartuś

{"title":"Lifestyle interventions for diabetic retinopathy during pregnancy: Current evidence from clinical studies.","authors":"Tomasz Bartuś, Jerzy Bartuś","doi":"10.36740/WLek/219973","DOIUrl":"https://doi.org/10.36740/WLek/219973","url":null,"abstract":"Objective: Aim: To summarize current evidence on lifestyle interventions, metabolic stabilization and screening strategies relevant to diabetic retinopathy during pregnancy.Patients and methods: Materials and Methods: A narrative review of clinical studies, systematic reviews, meta-analyses and guideline documents was performed using PubMed/MEDLINE, Scopus and Google Scholar. Baseline retinal status in early pregnancy is the strongest predictor of progression. Additional risk is associated with longer diabetes duration, elevated glycated hemoglobin, glycemic variability, nephropathy and hypertensive disorders, including preeclampsia. Women without retinopathy in early pregnancy generally have a low risk of sight-threatening disease during the same gestation, whereas women with pre-existing retinopathy require close surveillance. Lifestyle interventions do not directly treat retinal lesions, but they improve glycemic control, support appropriate gestational weight gain and reduce vascular burden. Evidence also suggests that continuous glucose monitoring and automated insulin delivery may indirectly support retinal protection by improving metabolic stability.Conclusion: Conclusions: In pregnant women with diabetes, ophthalmic screening remains the main clinical priority. However, lifestyle-based metabolic support is a meaningful complementary strategy and should be integrated into antenatal care alongside risk-stratified retinal follow-up.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 5","pages":"1076-1080"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148340554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing and molecular docking analysis of newly acetazolamide derived compounds integrating 4-oxothiazolidine group as possible carbonic anhydrase deactivators. 整合4-氧噻唑烷基的乙酰唑胺衍生化合物的设计与分子对接分析。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/216769

Shaymaa Abdul Zahra Ayoub, Noor H Naser Aldabagh, Rana Neama Atiya

{"title":"Designing and molecular docking analysis of newly acetazolamide derived compounds integrating 4-oxothiazolidine group as possible carbonic anhydrase deactivators.","authors":"Shaymaa Abdul Zahra Ayoub, Noor H Naser Aldabagh, Rana Neama Atiya","doi":"10.36740/WLek/216769","DOIUrl":"10.36740/WLek/216769","url":null,"abstract":"Objective: Aim: The study aims to create new acetazolamide products that have a thiazolidin-4-one moiety and test how well they stop the carbonic anhydrase XII enzyme (protein data bank code: (4KP5)) and defeat cancer in silico.Patients and methods: Materials and Methods: We will make four acetazolamide derivatives that have a thiazolidin-4-one group. Acetazolamide will be the starting material. We used the Molecular Operating Environment program 2015.10 to figure out the molecular docking studies. Root Mean Square Deviation (RMSD) and Standard Score (S. score) were used to describe docking how well docked ligands stuck to the target protein carbonic anhydrase XII.Results: Results: The process of docking showed that the four test ligands (IIIa, IIIb, IIIc, and IIId) bound to the target protein carbonic anhydrase XII more strongly than the reference ligand, which is an acetazolamide.Conclusion: Conclusions: Of the four chemicals, IIIa had the maximum affinity for binding and a S. score of -7.39. The results propose that the acetazolamide compounds that were designed, especially IIIa, could be carbonic anhydrase inhibitors and anti-cancer drugs that work on the carbonic anhydrase XII enzyme.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 1","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and structure of periodontal diseases in the Ukrainian population based on the AAP/EFP 2017 classification. 基于AAP/EFP 2017分类的乌克兰人口牙周病患病率和结构

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218749

Oleksandr O Pompii

{"title":"Prevalence and structure of periodontal diseases in the Ukrainian population based on the AAP/EFP 2017 classification.","authors":"Oleksandr O Pompii","doi":"10.36740/WLek/218749","DOIUrl":"https://doi.org/10.36740/WLek/218749","url":null,"abstract":"Objective: Aim: To determine the prevalence and structure of periodontal diseases among the population of Ukraine using the AAP/EFP 2017 Classification.Patients and methods: Materials and Methods: A retrospective analysis of electronic outpatient medical charts of dental patients aged 25 to 75 years was conducted; the patients were divided into 3 groups depending on age. According to the data contained in the charts, each patient was diagnosed according to the AAP/EFP 2017 Classification. Statistical methods were used to determine the associations between age, gender and periodontal tissue condition, prevalence of inflammation, stage and grade of periodontitis.Results: Results: There were 12.8% of patients with intact periodontal tissues, 54.4% of patients were diagnosed with gingivitis, and 32.8% of patients were diagnosed with periodontitis. The most common diagnosis among patients with periodontitis was generalized periodontitis of stage II, grade B (25.9%). Statistically significant relationships were found between age and the presence of periodontal pathology, its prevalence, stage and grade of periodontitis. In addition, associations between gender and the condition of periodontal tissues and the stage of periodontitis were found.Conclusion: Conclusions: In patients of different age groups and genders, gingivitis was the most common diagnosis, and generalized moderate form prevailed in the structure of periodontitis. Age and gender affect the risk of occurrence and clinical course of periodontal diseases. The use of AAP/EFP 2017 Classification in clinical practice provides an individualized approach to treatment planning for patients with various periodontal tissue lesions.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 6","pages":"1203-1208"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular docking analysis of the interaction between metformin/glimepiride combination and organic cation transporter in diabetic patients. 二甲双胍/格列美脲联合用药与糖尿病患者有机阳离子转运体相互作用的分子对接分析。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/219793

Haneen A Mohammed, Ekhlass M Taha, Amaal S Sadiq

{"title":"Molecular docking analysis of the interaction between metformin/glimepiride combination and organic cation transporter in diabetic patients.","authors":"Haneen A Mohammed, Ekhlass M Taha, Amaal S Sadiq","doi":"10.36740/WLek/219793","DOIUrl":"https://doi.org/10.36740/WLek/219793","url":null,"abstract":"Objective: Aim: This study aimed to evaluate the interaction of glimepiride/metformin with organic cation transporter protein-1 (OCT-1) using molecular docking technology, as well as to determine the drug's effect on serum OCT-1 levels in patients compared to healthy individuals. This may contribute to understanding the efficacy of this treatment in controlling blood glucose levels.Patients and methods: Materials and Methods: Molecular docking technology was used to determine the interaction of the glimepiride/metformin combination with organic cation transporter 1 (OCT-1). The study included 50 women: 26 with type 2 diabetes and 24 healthy women as a control group. ELISA was used to determine the levels of organic cations in the participants' serum.Results: Results: The results showed a high binding energy of -10.2 kcal/mol between the glimepiride/metformin combination and the OCT-1 protein, indicating the drug's efficacy in treating diabetes. These results confirm the findings of the clinical trial on OCT-1, which showed that the protein level in patients was (511.6 ± 120.3), similar to the concentration in the control group (558.8 ± 39.2), indicating that most of the drug had entered the cells.Conclusion: Conclusions: The results suggest that the glimepiride/metformin combination is a recommended treatment option for lowering blood glucose levels and treating type 2 diabetes.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 6","pages":"1223-1230"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of tongue pressure force: Experimental research. 舌压力测定：实验研究。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/222569

Igor A Lazarev, Alona O Melnyk, Jan Zentgraf, Franz Suess, Oleksandr A Kaniura, Andrii V Kopchak, Valerii V Filonenko

{"title":"Determination of tongue pressure force: Experimental research.","authors":"Igor A Lazarev, Alona O Melnyk, Jan Zentgraf, Franz Suess, Oleksandr A Kaniura, Andrii V Kopchak, Valerii V Filonenko","doi":"10.36740/WLek/222569","DOIUrl":"https://doi.org/10.36740/WLek/222569","url":null,"abstract":"Objective: Aim: To identify the zones of maximum contact force (F, N) of the tongue at 100% and 125% tongue volume on areas of the oral cavity in an experimental study, and to conduct a comparative analysis of the contact force indicators.Patients and methods: Materials and Methods: 3D prototypes of the patient's upper and lower jaws were created. Measurements were carried out using a FlexiForce film force sensor and an Arduino Nano microcontroller module. This allowed recording of the contact force applied by the tongue.Results: Results: The maximum values of contact force were recorded in the following areas: the marginal gingiva on the lingual surface of the lower central incisors, the marginal gingiva on the palatal surface of the upper central incisors, the middle third on the lingual surface of the lower central incisors, and the middle third on the palatal surface of the upper central incisors. An increase in values was noted in all studied zones when the tongue volume increased to 125%.Conclusion: Conclusions: A comparative analysis of tongue contact force indicators obtained during the experimental study demonstrated an increase in values when the tongue volume was enlarged to 125% in the areas of the oral cavity of the upper and lower jaws, compared with the actual tongue volume.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 6","pages":"1273-1279"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous coronary artery dissection following induced vaginal delivery. 阴道引产后自发性冠状动脉剥离。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/217689

Agata Stawska, Szymon Kaczyński, Małgorzata Głogiewicz, Rafał Adamczak

{"title":"Spontaneous coronary artery dissection following induced vaginal delivery.","authors":"Agata Stawska, Szymon Kaczyński, Małgorzata Głogiewicz, Rafał Adamczak","doi":"10.36740/WLek/217689","DOIUrl":"10.36740/WLek/217689","url":null,"abstract":"Cardiovascular diseases represent a significant threat to the health and life of women during pregnancy and the postpartum period, accounting for 13% of all maternal deaths and constituting the third most common cause of perinatal mortality. A particular cause of myocardial infarction in young women, including pregnant patients, is spontaneous coronary artery dissection (SCAD).The occurrence of spontaneous coronary artery dissection may be preceded by triggering factors such as intense physical exertion, intense Valsalva manoeuvres, emotional or physical stress, labour, as well as exposure to exogenous hormones and β hCG. Despite the increasing number of reported cases, the true incidence of pregnancy related SCAD remains unknown. The presented clinical case describes an acute coronary syndrome in a 32-year-old woman in the early postpartum period, secondary to spontaneous coronary artery dissection. The patient was qualified for urgent coronary angiography, which revealed critical, ninety-percent stenosis of the left anterior descending coronary artery (LAD). Following percutaneous transluminal coronary angioplasty, effective myocardial reperfusion was achieved. Young women with low cardiovascular risk and without clinically significant risk factors may develop acute myocardial ischaemia.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 2","pages":"448-453"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconstruction of the hip stump. 髋关节残端重建。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/214418

Yurii O Bezsmertnyi, Viktor I Shevchuk, Dmytro V Bondarenko, Olexandr Y Branitsky

{"title":"Reconstruction of the hip stump.","authors":"Yurii O Bezsmertnyi, Viktor I Shevchuk, Dmytro V Bondarenko, Olexandr Y Branitsky","doi":"10.36740/WLek/214418","DOIUrl":"10.36740/WLek/214418","url":null,"abstract":"The formation of a functional limb stump after combat injuries with extensive soft tissue damage is challenging. After amputations or revision surgeries, long femoral stumps may remain. Although functionally inferior to tibial stumps, they can still provide satisfactory movement and performance. However, prolonged prosthesis use or poor-quality muscle grafting can lead to complications, such as skin breakdown, trophic issues, and inability to continue prosthetic use. These problems are partly due to the mismatch between the area of the bone stump end and the applied body weight. Ilizarov compression-distraction osteosynthesis, radiographic assessment, and gait analysis before and after treatment using the GaitRite system. We describe a case of femoral stump reconstruction following a mine-blast injury. Prosthetic fitting was complicated by massive scars covering the bone fragments. A method was developed to expand the distal end of the femoral stump via distraction osteogenesis using the Ilizarov apparatus. This approach created a stable platform with a significantly larger bearing surface. For the first time, the bearing surface area was increased twofold, reducing soft tissue trauma and enhancing the load-bearing capacity of the prosthesis. The proposed reconstruction method significantly enlarges the distal femoral stump area, creates a mushroom-shaped end, decreases load per unit area, ensures even pressure distribution within the prosthetic socket, and improves the patient's functional outcome.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 2","pages":"454-462"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative rehabilitation of a patient with resected aggressive parasagittal meningioma infiltrating the superior sagittal sinus and presenting with paraplegia. 一例切除侵袭性矢状旁脑膜瘤浸润上矢状窦并表现为截瘫的患者的术后康复。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218285

Valentyna Hombolevska, Nataliia Fedorenko, Mateusz Kaczmarski, Zeeshan Zulfiqar

{"title":"Postoperative rehabilitation of a patient with resected aggressive parasagittal meningioma infiltrating the superior sagittal sinus and presenting with paraplegia.","authors":"Valentyna Hombolevska, Nataliia Fedorenko, Mateusz Kaczmarski, Zeeshan Zulfiqar","doi":"10.36740/WLek/218285","DOIUrl":"10.36740/WLek/218285","url":null,"abstract":"The aim of this case report is to describes the postoperative neurological complications and importance of early rehabilitation course of a patient with an aggressive parasagittal meningioma. The particular emphasis on the role of intensive, multidisciplinary rehabilitation in the setting of postoperative spastic paraplegia. The program included physiotherapy, assisted verticalization, gait and locomotion training, proprioceptive neuromuscular facilitation techniques, and psychological support. Clinical status, imaging findings, and functional recovery were evaluated during rehabilitation. A 47-year-old woman with frontoparietal parasagittal tumor infiltrating the superior sagittal sinus underwent preoperative embolization followed by microsurgical resection. Postoperatively, patient developed bilateral spastic paralysis of the lower limbs, complicated by cerebrospinal fluid leakage and surgical-site infection. After neurosurgical treatment of parasagittal meningiomas involving the superior sagittal sinus severe neurological deficits may occur. This case shows the importance of early, structured and multidisciplinary rehabilitation as an essential component of postoperative care. Early rehabilitation may contribute to functional improvement and preservation of quality of life even in patients with severe motor deficits.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 3","pages":"661-665"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0