Wiadomosci lekarskie最新文献

{"title":"Peculiarities of prevention of chronic pain associated with combat trauma.","authors":"Nadiia Ya Zhylka, Andrii M Strokan","doi":"10.36740/WLek/205402","DOIUrl":"https://doi.org/10.36740/WLek/205402","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To analyze international experience in solving the problems of preventing chronic pain associated with combat trauma.</p><p><strong>Patients and methods: </strong>Materials and Methods: bibliosemantic and analytical methods were used in the study. The materials were international scientific sources that covered the experience of providing medical care in military conflicts for the period 2014-2024.</p><p><strong>Conclusion: </strong>Conclusions: The best practices for preventing chronic pain associated with combat trauma are the effectiveness of pain relief immediately after injury, the timeliness of pain relief at all stages of evacuation, including the hospital and post-hospital period or the so-called stepped care model. In order to overcome the problem of opioid addiction in patients with combat trauma, the use of local and regional pain relief, as well as the use of a complex of non-drug methods, is recommended. The biopsychosocial model of chronic pain prevention (synonymously multidisciplinary, interdisciplinary, multicomponent) has the primary goal of restoring physical, psychological, and social functioning, involving a core team of multidisciplinary health care professionals (physicians, physiotherapists, occupational therapists, psychologists, and nurses) working as an integrated team as a response to the complex suffering of patients with chronic pain worldwide.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 5","pages":"1220-1226"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformation of pharmaceutical care during the matrial state in Ukraine: doctors' perception of interprofessional communication.","authors":"Natalia A Bilousova, Vasyl M Mykhalchuk, Natalia O Tkachenko, Liudmyla I Yakovenko, Maryna M Dolzhenko","doi":"10.36740/WLek/205386","DOIUrl":"https://doi.org/10.36740/WLek/205386","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate the perception of general practitioners of family medicine of the implementation of Good Pharmacy Practice (GPP) standards by pharmacists to determine approaches to interprofessional communication and further integration of pharmacists into primary health care.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study was conducted at the Department of Cardiology of the Shupyk National Healthcare University of Ukraine from March to December 2024 by means of an anonymous online survey using Google Forms. The methods of analysis, deduction, induction, comparison, systematization, generalization, forecasting, statistics and bibliography were used.</p><p><strong>Results: </strong>Results: The functions of pharmacists in integrated care teams were determined: monitoring and compatibility of medicines, monitoring the effectiveness of pharmacotherapy, dispensing prescription medicines \"only on prescription\" (72.5% [CI 95% 72.5 ± 0.02, p<0.0001]); joint training in the process of continuous professional development (4.8% [CI 95% 4.8 ± 0.01, p<0.0001]). It was found that the level of clinical competencies of pharmacists (65.3% [CI 95% 65.3 ± 0.03, p<0.0001]) and safe use of medicines (60.7% [CI 95% 60.7, ± 0.03, p<0.0001]) is mediocre.</p><p><strong>Conclusion: </strong>Conclusions: The high interest of doctors of therapeutic specialties in interprofessional communication with pharmacists as part of integrated care teams was determined (72.5% [CI 95% 72.5 ± 0.02, p<0.0001]). The need for additional training of pharmacists in the process of continuous professional development for work as part of integrated care teams in order to obtain and deepen clinical competencies was substantiated. We see the development of clinical recommendations for community pharmacists in accordance with the ESC/AHA recommendations and taking into account the compatibility of medicines when providing pharmaceutical care to patients with ischemic heart disease with comorbid conditions as a prospect for further research.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 5","pages":"1143-1153"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the relationship between some medical, social, economic factors and manifestations of the COVID-19 pandemic.","authors":"Viktoriia V Korolenko, Hennadii A Mokhort, Tetyana V Petrusevych, Volodymyr V Korolenko","doi":"10.36740/WLek/205371","DOIUrl":"https://doi.org/10.36740/WLek/205371","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate the statistical relationship between the manifestations of the COVID-19 pandemic and individual medical, social, economic indicators in the regions of Ukraine and to improve further research in this direction.</p><p><strong>Patients and methods: </strong>Materials and Methods: Research methods include epidemiological, medical-statistical, bibliographic. Statistical analysis of data from the Center for Public Health of the Ministry of Health of Ukraine and the State Statistics Service of Ukraine was carried out.</p><p><strong>Results: </strong>Results: Correlation analysis showed the presence of an average strength of direct correlation (p<0.05) between the incidence of COVID-19 and the number of retired persons; the number of doctors; the prevalence of malignant neoplasms; also, between mortality from COVID-19 and the number of retired persons; the number of doctors; the number of households; the prevalence of malignant neoplasms; gross regional product per capita; the average age of the population. The analysis also showed the presence of an average strength of inverse correlation (p<0.05) between the incidence of COVID-19 and the average age of the population; the unemployment rate; also, between COVID-19 mortality and unemployment rate; case fatality rate and the number of doctors.</p><p><strong>Conclusion: </strong>Conclusions: Correlation analysis revealed moderate direct correlations between medical, social, economic parameters. These findings are crucial for developing strategies to predict, prepare for, and mitigate pandemics.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 5","pages":"1065-1070"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of endometriosis in female evacuated from the Eastern Ukrainian military conflict regions: results a multicenter study (2022-2024).","authors":"Aidyn G Salmanov, Igor V Maidannyk, Olena O Chorna, Oleksandr V Zabudskyi, Volodymyr V Artyomenko, Pankiv V Mariana, Lidiya V Suslikova, Vitalii S Strakhovetskyi, Victor O Rud, Svitlana M Korniyenko, Serhii Yu Vdovychenko, Andriy I Chubatyy, Serhii V Dudka, Karina Voronina","doi":"10.36740/WLek/203835","DOIUrl":"10.36740/WLek/203835","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To estimate the prevalence and risk factors associated with endometriosis in female evacuated from the Eastern Ukrainian military conflict regions.</p><p><strong>Patients and methods: </strong>Materials and Methods: A prospective multicenter cohort study was based on surveillance data for endometriosis. 982 women undergoing pelvic surgery were compared to 264 patients unexposed to surgery. The study cohort included women, who underwent a diagnostic and/or therapeutic laparoscopy or laparotomy in 2022-2024. Endometriosis among women was diagnosed visually at laparoscopy/laparotomy or by pelvic magnetic resonance imaging.</p><p><strong>Results: </strong>Results: The prospective multicenter study included 1,246 women. The overall prevalence of endometriosis was 31.5%. Prevalence of the three types of endometrioses included peritoneal/superficial endometriosis, ovarian endometriotic cyst/endometrioma and deep infiltrating endometriosis was 13.8%, 9.8%, and 4.8%, respectively. Three hundred sixty-one women 36,8% in the surgical group and thirty-one women 13.3% in the community treatment group (unexposed to surgery, population cohort) were diagnosed with incident endometriosis. The pelvic pain, infertility and early age at menarche to be a consistent risk factor for endometriosis in both the operative and population cohorts. Data analysis showed that odds were decreased for gravidity, parity, and BMI. Factors that increased the odds of endometriosis diagnosis included dysmenorrhea, older age at first sex, pelvic pain as a surgical indication for laparoscopy, and higher education.</p><p><strong>Conclusion: </strong>Conclusions: Our study findings demonstrate the high prevalence of endometriosis among women in Ukraine. The pelvic pain, infertility and early age at menarche to be a consistent risk factor for endometriosis in both the operative and population cohorts.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"694-701"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious exanthemas in clinical practice.","authors":"Vadym A Bodnar, Nataliia O Pryimenko, Olena H Marchenko, Olena M Izyumska","doi":"10.36740/WLek/197135","DOIUrl":"10.36740/WLek/197135","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Analyze the causes and mechanisms of development of exanthems, provide a classification of the morphological elements and characterize clinical manifestations of rash in patients with infectious diseases based on a review of available literature data.</p><p><strong>Patients and methods: </strong>Materials and Methods: The authors analyzed the current literature sources, including a description of exanthema syndrome and a discussion of the features of rashes in various infectious diseases.</p><p><strong>Conclusion: </strong>Conclusions: As a result of the analysis of existing literature data, it was established that exanthema syndrome is associated with various diseases, disorders and pathological conditions, characterized by a variety of clinical manifestations, which requires clinical differential diagnosis and subsequent laboratory confirmation. Comprehensive knowledge of the causes, mechanisms of development, as well as the clinical manifestations of skin rash will contribute to the development of an improved algorithm for diagnosis and treatment of the diseases accompanied by exanthema syndrome, as well as optimization of therapeutic tactics.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"168-176"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of program cell death ligand-1 (rs4143815 G>C) with some clinical symptoms and oral ulcer types in systemic lupus erythematosus.","authors":"Mona Al-Terehi, Mohammed Faris Jabaz, Ola Hatif Hazim, Najah Rayish Hadi","doi":"10.36740/WLek/197185","DOIUrl":"10.36740/WLek/197185","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The study aims to detect Association of Program Cell Death Ligand-1(PD-L1) rs4143815 G>C with some Clinical Symptoms and Oral Ulcer Types in Systemic Lupus Erythematosus (SLE).</p><p><strong>Patients and methods: </strong>Materials and Methods: A case control design was suggested in the study enrolled about 60 SLE patients and 20 healthy individuals as a control group, PD-L1 variation implemented using allele specific PCR.</p><p><strong>Results: </strong>Results: The findings showed significant changes in age (<0.011), sex (p<0.000), and non-sig in BMI (p<0.654). in SLE group about 23.3% of patients have a family history, 93.7% suffered from fever, 51.66% have a Butterfly-shaped rash, 73.3% suffered from oral ulcer, single oral ulcer was observed 65.90% and multiple ulcer observed 34.09%. Oral mouth was more frequent (55%) while pharynx ulcer was low frequent (3.3%). The rs4143815 G>C showed three genotypes (GC, CC and GG), Significant association of CC with SLE patients (OR 67.8874, p <0.003), A non-sig association was observed in GG with SLE (OR 5.8571, p <0.395), significant association of C allele with SLE group (OR 1.3529, p< 0.0008). The PD-L1 rs4143815 (G>C) genotyping distribution according to some clinical symptoms showed a non-significant association with all symptoms. The PD-L1 rs4143815 (G>C) genotyping distribution according to oral ulcer sites showed a non-significant association also.</p><p><strong>Conclusion: </strong>Conclusions: The present results concluded closed correlation between rs4143815 G>C and SLE patients, but no association was observed with some clinical symptoms and oral ulcer types.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"136-142"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and evaluation of Sulfonamide-Thiazolidinone conjugates as promising anticancer agents via carbonic anhydrase inhibition.","authors":"Zahraa Falah Naji, Noor H Naser","doi":"10.36740/WLek/197183","DOIUrl":"10.36740/WLek/197183","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study focuses on developing and evaluating five newly created compounds targeting carbonic anhydrase isoforms found in solid tumors. Our primary goal is to create exceptionally potent anti-cancer drugs.</p><p><strong>Patients and methods: </strong>Materials and Methods: Sulfanilamide, chloroacetyl chloride, Gamma-aminobutyric acid, thionyl chloride, methanol, hydrazine hydrate, aromatic aldehyde derivatives, glacial acetic acid, and thioglycolic acid were used in the chemical synthesis. We performed docking studies using the Molecular Operating Environment software program version 2015.10, and used MTT assay to predict cytotoxic activity.</p><p><strong>Results: </strong>Results: The compounds we developed demonstrated impressive antineoplastic action in both in silico experiments as well as cell line experiments. Their toxicity to normal cells varied significantly, but their efficacy against cancer cells differed significantly from cisplatin. When compared to acetazolamide, each of the produced compounds exhibited significant differences in their effects on MCF7 cells. Based on these findings, synthetic compounds may serve as antineoplastic medications. Including the thiazolidinone ring in these compounds enhanced their affinity for the receptor by binding to multiple crucial amino acids that play a significant role in our target's enzymatic activity and substrate binding.</p><p><strong>Conclusion: </strong>Conclusions: Our synthetic compounds revealed cytotoxicity and inhibitory potencies against carbonic anhydrase. Moreover, they exhibited cytotoxicity.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"116-129"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation of a patient after total endoprosthesis of the hip joint removal so-called \"hanging hip\". Case report.","authors":"Izabela Dąbkowska, Magdalena Sobiech, Karolina Turżańska","doi":"10.36740/WLek/202446","DOIUrl":"https://doi.org/10.36740/WLek/202446","url":null,"abstract":"<p><p>The aim of our study is to present the problem of rehabilitation of a patient after endoprosthesis surgery and an attempt to revise the endoprosthesis and then leave the hip hanging. This case study describes an 80-year-old woman who underwent left hip replacement due to primary severe arthrosis. The patient had undergone an unsuccessful attempt at endoprosthesis revision after multiple dislocation of the prosthesis, which ended in an infection of the surgical wound. The operating team decided to remove the revision endoprosthesis, leaving the hip hanging. The challenge for the treatment team was to rehabilitate the patient, aiming to adapt her to her new situation and make her as independent as possible. The final treatment outcome according to the treatment team was satisfactory. The patient achieved relative independence of movement. At discharge home, she had no symptoms of infection of the infected hip and did not report pain related to the operated hip joint. Radical hip replacement surgery is a method that provides the patient with a pain-free life and a relative return to independence and function in daily life.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"657-663"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects, possibilities and determinants of rehabilitation in nursing.","authors":"Joanna Niezbecka-Zając, Zuzanna Łuba, Anna Mazurek, Anna Pacian","doi":"10.36740/WLek/202524","DOIUrl":"https://doi.org/10.36740/WLek/202524","url":null,"abstract":"<p><p>Contemporary nursing models address complex human needs, emphasizing prevention, education, and rehabilitation. Nursing and rehabilitation are closely linked, aiming to restore full or partial functionality and support patients in returning to social, family, and professional life. The aim of this study was to analyze the role of nurses in rehabilitation and assess the potential for developing rehabilitation nursing in Poland, considering current trends and the growing demand for qualified staff. A comprehensive literature analysis was conducted, with a particular focus on the Canadian model and its scope in rehabilitation. The results indicate that rehabilitation nursing should expand in response to the needs of an aging society. The introduction of specialized training and the incorporation of rehabilitation nursing courses into higher education programs could significantly contribute to this field's development. The Canadian model demonstrates that proper education and certification in rehabilitation nursing enhance patient care and recovery. Implementing similar solutions in Poland could improve rehabilitation outcomes and overall patient well-being. However, adapting modern nursing models requires systemic changes and a shift in professional perception. Nursing should evolve from a primarily supportive role focused on basic care to an active, leadership-oriented function within the rehabilitation team. A well-trained rehabilitation nurse can significantly improve the effectiveness of rehabilitation, ensuring a more holistic and patient-centered approach.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"591-594"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actual scientific data in comorbid periodontal diseases and heart-vessel pathology.","authors":"Zynoviya O Bumbar, Khrystyna A Sichkoriz, Taras I Vykhtiuk, Taras I Pupin","doi":"10.36740/WLek/201340","DOIUrl":"10.36740/WLek/201340","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim of this study is to review and analyze contemporary scientific and professional literature to investigate the role of periodontal diseases in the development and progression of cardiovascular diseases. Specifically, this study aims to deepen our understanding of the pathogenetic mechanisms underlying periodontitis in this category of patients and the reciprocal aggravating influence of these pathologies on each other.</p><p><strong>Patients and methods: </strong>Materials and Methods: bibliometric and analytical methods applied to data from international scientific sources investigating the role of periodontal diseases in the pathogenesis of cardiovascular diseases.</p><p><strong>Conclusion: </strong>Conclusions: The growing body of evidence indicates a significant comorbidity between periodontal diseases and cardiovascular diseases. Given the systemic impact of periodontitis on cardiovascular health, there is a pressing need for enhanced periodontal care and further research to better understand this complex relationship.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"463-468"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}