Wiadomosci lekarskie最新文献_第7页

Ag/Cu₂O nanocomposites as an alternative antimicrobial agent for multidrug-resistant bacterial infections. Ag/Cu₂O纳米复合材料作为耐多药细菌感染的替代抗菌剂。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/217263

Igor Duzhyi, Petro Myronov, Tetiana Ivakhniuk, Roman Pshenychnyi, Oleksandr Pylypenko, Anatolii Opanasyuk, Viktoriia Holubnycha, Vladyslav Smiianov

{"title":"Ag/Cu₂O nanocomposites as an alternative antimicrobial agent for multidrug-resistant bacterial infections.","authors":"Igor Duzhyi, Petro Myronov, Tetiana Ivakhniuk, Roman Pshenychnyi, Oleksandr Pylypenko, Anatolii Opanasyuk, Viktoriia Holubnycha, Vladyslav Smiianov","doi":"10.36740/WLek/217263","DOIUrl":"10.36740/WLek/217263","url":null,"abstract":"Objective: Aim: To investigate the physicochemical properties and antibacterial and antibiofilm activity of nanocomposites Ag/Cu2O synthesized by the polyol method.Patients and methods: Materials and Methods: The nanocomposites Ag/Cu2O were synthesized using the polyol method, followed by a study of their physicochemical properties. The antibacterial and antibiofilm properties of the nanocomposites Ag/Cu2O were investigated against multidrug-resistant clinical strains of bacteria S. aureus, E.coli, and P. aeruginosa.Results: Results: Nanocomposites Ag/Cu2O, were mostly spherical in shape and had an average size of 135.6±65 nm. X-ray diffraction analysis confirmed the presenceof Ag and Ag/Cu2O phases. Energy-dispersive spectroscopy revealed the following elemental composition: 13.05% silver, 31.81% copper, and 55.14% oxygen. Ultraviolet-visible spectroscopy suggested the potential presence of silver oxides in the structure. The minimum inhibitory concentration and minimum bactericidal concentration values were as follows: for S. aureus, the minimum inhibitory concentration was 52.08±18.04 µg/ml, and the minimum bactericidal concentration - 72.92±47.74 µg/ml; for P. aeruginosa - 26.04±9.02 µg/ml, and 41.67±18.04 µg/ml, respectively; and for E. coli - 83.33±36.08 µg/ml, and 208.30±72.17 µg/ml, respectively. The nanocomposites Ag/Cu2O NCs also demonstrated antibiofilm activity, being effective against S. aureus at 3 and 5 times the minimum bactericidal concentration, against E. coli at 1, 3, and 5 times the minimum bactericidal concentration, and against P. aeruginosa at 5 times the minimum bactericidal concentration.Conclusion: Conclusions: The nanocomposites Ag/Cu2O revealed high antibacterial and antibiofilm properties, which support their use as an alternative to conventional antibiotics in nanomedicine for treating multidrug-resistant infections.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 1","pages":"9-14"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of calcitonin gene-related peptide levels with cardiovascular disease in hypertensive male patients. 降钙素基因相关肽水平与高血压男性患者心血管疾病的关系

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/215250

Nahlah F Makkia, Mustafa M Khalil

{"title":"Association of calcitonin gene-related peptide levels with cardiovascular disease in hypertensive male patients.","authors":"Nahlah F Makkia, Mustafa M Khalil","doi":"10.36740/WLek/215250","DOIUrl":"10.36740/WLek/215250","url":null,"abstract":"Objective: Aim:The current study aimed to investigate the association between CGRP, lipid profile, and atherogenic indices in hypertensive male patients with respect to cardiovascular risk.Patients and methods: Materials and Methods: Fifty-four male HTN patients and 45 healthy controls (ages 51-69) were enrolled. The subjects were divided into two subgroups according to LAP: Group 1 was HTN patients with LAP (≤50), and Group 2 was HTN patients with LAP >50. Serum CGRP (pg/mL) was measured via ELISA; lipid profiles and atherogenic indices were assessed spectrophotometrically.Results: Results: The mean values of WHR, VAI, LAP, SBP, DBP, atherogenic indices, and lipid profile in the HTN patients showed a statistically significant increase compared to the control, except CGRP and HDL-C, which revealed a significant decrease (P < 0.001). Also, the G2 displayed a decrease in CGRP compared to the G1. After adjusting for main hazard factors, the relation between CGRP and CVD remained significant in the multivariate analysis. The curve of ROC based on CGRP levels to indicate the existence of CVD in HTN patients was 0.80. Additionally, the AUC of CGRP was 0.82 in patients with a LAP greater than 50, compared to those with a LAP less than 50.Conclusion: Conclusions: These findings indicate that reduced CGRP levels are significantly associated with higher CVD risk in hypertensive men, suggesting that CGRP may be explored as a potential biomarker for cardiovascular risk assessment in future longitudinal studies.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 1","pages":"148-155"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization and validation of an HPLC method for the quantification of Etodolac in liposomes and assessment of its pharmacokinetic profile. 高效液相色谱法测定脂质体中依托度酸含量及药动学分析的优化与验证。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/216771

Fatimah M H Wais, Sarmad Al-Edresi

{"title":"Optimization and validation of an HPLC method for the quantification of Etodolac in liposomes and assessment of its pharmacokinetic profile.","authors":"Fatimah M H Wais, Sarmad Al-Edresi","doi":"10.36740/WLek/216771","DOIUrl":"10.36740/WLek/216771","url":null,"abstract":"Objective: Aim: To develop and evaluate high performance liquid chromatogram method to simultaneously quantify Etodolac in liposomes.Patients and methods: Materials and Methods: The chromatographic separation was carried out on the C18 column, mobile phase of methanol: acetonitrile: water at a ratio of (30:60:10) and a flow rate of (1ml.min-1), with a detection wavelength of 225 nm. Liposomes were prepared by thin film hydrating method using Distearoylphosphatidylcholine and cholesterol.Results: Results: Linear concentration range of the assay was 2.5-25 µg.ml-1 with a regression coefficient factor R2 ≥ 0.999 with a retention time of Etodolac 4.11 ± 0.081 min. The method was rigorously validated for linearity, accuracy, precision, specificity, and stability, ensuring its reliability. The concentrations of Etodolac 2.5, 5, 7.5, and 10 µg.ml-1 were used, with the intraday n=6 and intraday n=6 precision and accuracy for Etodolac meeting the accepted criteria of the United States Food and Drug Administration guideline. The limited detection and limited quantification values for Etodolac were 0.42 µg.ml-1 and 1.3 µg.ml-1, respectively. Conventional liposomes have characterization (PZ 88 ± 0.02, PDI 0.012 ± 0.01, %EE 89.5 ± 0.004, and Z-potential -10.2mV ± 0.001), while PEGylated liposomes (PZ 92 ± 0.003, PDI 0.01 ± 0.02, %EE 94.3% ± 0.01, and Z-potential -13.6mV ± 0.012).Conclusion: Conclusions: The developed and validated method of HPLC was successfully applied to determine Etodolac in bulk and liposomes for routine quantitative analysis.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 1","pages":"15-27"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of kidney transplantation in lurus nephritis: Literature review. 肾移植治疗肾炎的疗效：文献综述。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/210012

Jaroslav Tolstyak

{"title":"Effectiveness of kidney transplantation in lurus nephritis: Literature review.","authors":"Jaroslav Tolstyak","doi":"10.36740/WLek/210012","DOIUrl":"10.36740/WLek/210012","url":null,"abstract":"Objective: Aim: Conducting a scientific analysis of domestic and foreign sources of information regarding modern conceptual views diagnostic and effectiveness of kidney transplantation in Lupus Nephritis.Patients and methods: Materials and Methods: Used methods of historical-bibliographic and systematic approach. The search for literary sources was carried out in four main scientific databases: Google Scholar, PubMed, The review included original articles, research, and official recommendations from medical associations. The search query used in both platforms was: («lupus nephritis» AND «kidney transplantation»). In Google Scholar, the results were limited to publications from 2017 to 2024. As a result of the search, Google Scholar provided 25 relevant articles, while PubMed yielded 57.Conclusion: Conclusions: Scientific analysis confirmed better survival rates and a lower complication rate compared to hemodialysis and peritoneal dialysis. Survival rates for kidney transplantation over 5 to 10 years are comparable to those for patients with other diseases. Identifying new serological and immunological markers is crucial for the early diagnosis and prevention of acute kidney damage and subsequent graft loss.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 2","pages":"384-389"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiological follow-up after endovascular aortic repair - review of surveillance modalities. 血管内主动脉修复后的影像学随访——监测方式的回顾。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218764

Krzysztof Jakimow, Jakub Ciesielka, Katarzyna Sznajder

{"title":"Radiological follow-up after endovascular aortic repair - review of surveillance modalities.","authors":"Krzysztof Jakimow, Jakub Ciesielka, Katarzyna Sznajder","doi":"10.36740/WLek/218764","DOIUrl":"10.36740/WLek/218764","url":null,"abstract":"Objective: Aim: This review aims to present diagnostic modalities suitable for monitoring patients after endovascular aortic repair.Patients and methods: Materials and Methods: A literature search was conducted across electronic databases from January 2024 to May 2025 using a combination of keywords and Boolean operators.Conclusion: Conclusions: While computed tomography angiography remains the reference standard for monitoring after endovascular aortic repair, with 92% sensitivity for endoleak detection, magnetic resonance imaging and ultrasonography offer viable alternatives that eliminate radiation exposure and may reduce contrast agent requirements. Magnetic resonance imaging detects twice as many endoleaks as computed tomography angiography, whereas contrast-enhanced duplex ultrasonography achieves 98% sensitivity and 88% specificity. Treatment of abdominal aorta aneurysm with endovascular aortic repair offers a significant opportunity for a carefully selected patient population. The selection of surveillance modalities should be tailored to individual patient characteristics.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 4","pages":"855-862"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147948470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complications of immediate-loading dental implants: Current insights into etiology and pathogenesis. 即刻加载牙种植体的并发症：病因和发病机制的最新见解。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/219915

Sviatoslav A Ohiienko, Davyd S Avetikov, Tetiana Yu Ohiienko, Oksana H Popadynets, Yaroslav V Pyuryk, Larysa Ya Fedoniuk

{"title":"Complications of immediate-loading dental implants: Current insights into etiology and pathogenesis.","authors":"Sviatoslav A Ohiienko, Davyd S Avetikov, Tetiana Yu Ohiienko, Oksana H Popadynets, Yaroslav V Pyuryk, Larysa Ya Fedoniuk","doi":"10.36740/WLek/219915","DOIUrl":"10.36740/WLek/219915","url":null,"abstract":"Objective: Aim: To analyze the scientific literature on the etiology and pathogenic mechanisms underlying complications arising from dental implantation under immediate loading protocols and to outline promising approaches to their prevention and management.Patients and methods: Materials and Methods: A review of the scientific literature addressing the complex mechanisms underlying potential complications of dental implantation under immediate loading protocols was conducted.Conclusion: Conclusions: The literature suggests that the primary causes of early dental implant failure include compromised mechanical stability during the critical phase of bone remodeling, inadequate seal control, and violation of the biological width. Soft tissue thickness deficiency (thin biotype) or the absence of keratinized mucosa triggers pathological bone destruction, which, in turn, facilitates infection and inflammation, further exacerbating destructive changes. These mechanisms are interrelated and mutually reinforce one another. The findings underscore the need to develop protocols for guided implant therapy in high-risk patients, to implement clear algorithms for objective monitoring of implant stability at all stages of treatment, and to identify the optimal sealing material. These measures have the potential to improve approaches to the fixation of prosthetic restorations.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 4","pages":"877-883"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical pathology: Diagnosis, treatment and management of patients with Human Papillomavirus. 宫颈病理学：人乳头瘤病毒患者的诊断、治疗和管理。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/216928

Vladyslav V Smiianov, Tetiana V Fartushok, Halyna B Semenyna, Nadiia V Fartushok

{"title":"Cervical pathology: Diagnosis, treatment and management of patients with Human Papillomavirus.","authors":"Vladyslav V Smiianov, Tetiana V Fartushok, Halyna B Semenyna, Nadiia V Fartushok","doi":"10.36740/WLek/216928","DOIUrl":"10.36740/WLek/216928","url":null,"abstract":"Objective: Aim: The objective of this literature review was to identify current aspects of the diagnosis, treatment, and management of patients with human papillomavirus.Patients and methods: Materials and Methods: 15 articles published from 2018 to 2024 were analyzed using the keywords: cervix, Papillomavirus, precancerous cervical pathology, cervical cancer, cervical screening, cytological method, colposcopy, cervical biopsy, for which a review of the available literature was conducted. Pubmed, Google Scholar, Web of Science, and Scopus databases were used to search for materials on current aspects of the diagnosis, treatment and management of patients with Human Papillomavirus. Inclusion criteria were cervical pathology caused by human papillomavirus.Conclusion: Conclusions: The goal of the screening program is to detect and treat high-grade precancer and prevent the development of cancer. Detection of LSIL (CIN1) is carried out by HPV testing and cervical screening, and the diagnosis is verified by histology. Most guidelines talk about surveillance from 18 years of age for 2 years for CIN 1. Diagnosis of persistent infection with HPV 16, 18, 31, 33 and others, and not the presence of CIN1, determines the risk of developing CIN 3.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 4","pages":"863-876"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural characteristics of the kidney in conditions of experimental hypothermia. 实验性低温条件下肾脏的结构特征。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/225986

Vasyl M Pertsovych, Oksana H Popadynets, Vasyl M Ivanochko, Halyna Yu Yurakh, Romaniia R Barchuk, Ivan O Mykhailiuk

{"title":"Structural characteristics of the kidney in conditions of experimental hypothermia.","authors":"Vasyl M Pertsovych, Oksana H Popadynets, Vasyl M Ivanochko, Halyna Yu Yurakh, Romaniia R Barchuk, Ivan O Mykhailiuk","doi":"10.36740/WLek/225986","DOIUrl":"https://doi.org/10.36740/WLek/225986","url":null,"abstract":"Objective: Aim: To investigate histological, ultrastructural, and morphometric changes in the wall of arterial vessels, glomerular and peritubular capillaries, and convoluted tubules of the kidney under the influence of a cold factor in an experiment.Patients and methods: Materials and Methods: The experiment was conducted on 80 mature white Wistar male rats, 10 of which served as controls. Animals were divided into 7 groups of 10 animals each according to experimental time points: at the peak of cooling and at 1, 3, 7, 14, 21, and 30 days of the recovery period. All procedures with animals were performed according to bioethical standards. Experimental-morphological analysis was conducted using histological, electron microscopic, and morphometric research methods.Results: Results: It was established that hypothermia causes vasoconstriction of the kidney's arterial vessels. From day 1 of the post-hypothermic period, edematous changes develop, which increase maximally by day 3 and persist through day 7 of the experiment. Starting from day 14, edematous changes decrease and structural organization of kidney parenchyma is restored. Reparative processes are completed by day 30.Conclusion: Conclusion: Profound renal hypothermia causes a complex process: early vascular spasm leading to ischemia, subsequent inflammatory enhancement of damage with maximum effect at days 3-7, followed predominantly by reversible recovery with isolated foci of irreversible remodeling.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 7","pages":"1625-1632"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of a group-based intervention programme on selfefficacy in type 2 diabetes mellitus patients. 群体干预方案对2型糖尿病患者自我效能感的影响。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/225979

Eirini Vafopoulou, Evangelos C Fradelos, Anna Mavroforou, Ioannis Moisoglou, Areti Tsaloglidou, Ourania Kotsiou, Theodosios Paralikas, Ioanna V Papathanasiou

{"title":"Effect of a group-based intervention programme on selfefficacy in type 2 diabetes mellitus patients.","authors":"Eirini Vafopoulou, Evangelos C Fradelos, Anna Mavroforou, Ioannis Moisoglou, Areti Tsaloglidou, Ourania Kotsiou, Theodosios Paralikas, Ioanna V Papathanasiou","doi":"10.36740/WLek/225979","DOIUrl":"https://doi.org/10.36740/WLek/225979","url":null,"abstract":"Objective: Aim: The aim of this study is to investigate the effectiveness of a group-based intervention of patients with T2DM on self-efficacy. The main objective of the study was to explore the appropriateness and feasibility of diabetes intervention as a motivational strategy to enhance self-care of patients with T2DM and its possible integration in primary care from health professionals.Patients and methods: Materials and Methods: A quasi -experimental study was conducted with a pre- and post-test design in an experimental group and a control group, in Larissa Greece, at the patients with T2DM during their regular visits in Primary Care Units.Results: Results: The study samples were comprised 2 groups from forty one patients each. None of the patients in either group had received intervention programme previously. The study was conducted throughout in 4 sessions during the period of 3 months. Self-efficacy scores in intervention group differed statistically significantly in all items before and after the experimental procedure, (p<0.05). Intervention group achieved significantly higher scores compared with the control group in certain items (Diet, Medical therapy, Medication-feet check, and Physical activity p=0.001, p=0.001, p=0.001 and p=0.007, respectively).Conclusion: Conclusions: Our study confirms the positive effect of a group-based intervention programme of patients with T2DM on self-efficacy. Future research should assess the viability of group-based intervention to be extended to more adults with T2DM in the community.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 7","pages":"1467-1474"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Condition of periodontal tissues in experimental animals under the model of periodontitis combined with intestinal dysbiosis. 牙周炎合并肠道生态失调模型下实验动物牙周组织状况。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/220834

Valentina N Kulygina, Olha V Polishchuk, Elvira M Danko, Halyna M Poberezhna, Yuliia O Slynko, Roman S Arshynnikov, Larysa F Kurdysh

{"title":"Condition of periodontal tissues in experimental animals under the model of periodontitis combined with intestinal dysbiosis.","authors":"Valentina N Kulygina, Olha V Polishchuk, Elvira M Danko, Halyna M Poberezhna, Yuliia O Slynko, Roman S Arshynnikov, Larysa F Kurdysh","doi":"10.36740/WLek/220834","DOIUrl":"https://doi.org/10.36740/WLek/220834","url":null,"abstract":"Objective: Aim: To study the nature of clinical and morphological changes in periodontal tissues under combined modeling of periodontitis and intestinal dysbiosis in an animal experiment.Patients and methods: Materials and Methods: The study involved 30 rats (1 control and 2 experimental groups of 10 animals each). Histological changes in the gingiva were examined during periodontitis modeling in 10 animals over 30 days and its combination with intestinal dysbiosis in the remaining 10 animals over 30-35 days. The degree of alveolar bone ridge atrophy was assessed, and the composition of the intestinal microflora was analyzed to confirm intestinal dysbiosis.Results: Results: It was established that the reproduction of experimental periodontitis in animals and its subsequent combination with intestinal dysbiosis contributed to the development of a pathological process in the periodontal tissues in 100% of rats, resembling an exacerbated course of human periodontitis, with increased severity and progression. In rats with simultaneous modeling of periodontitis and intestinal dysbiosis, more pronounced pathological changes were observed-compared to those without dysbiotic lesions-in the gingival epithelium, the connective tissue of the mucous membrane, and especially in the blood vessels of the microcirculatory bed and perivascular areas.Conclusion: Conclusions: Morphological studies confirmed that disturbances in the intestinal microecological system, accompanied by suppression of its saprophytic flora, aggravate the course of periodontitis, promote its generalization, and contribute to the development of abscess-forming inflammation.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 5","pages":"918-928"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148340403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0