Wiadomosci lekarskie最新文献

{"title":"Epidemiology of endometriosis in female evacuated from the Eastern Ukrainian military conflict regions: results a multicenter study (2022-2024).","authors":"Aidyn G Salmanov, Igor V Maidannyk, Olena O Chorna, Oleksandr V Zabudskyi, Volodymyr V Artyomenko, Pankiv V Mariana, Lidiya V Suslikova, Vitalii S Strakhovetskyi, Victor O Rud, Svitlana M Korniyenko, Serhii Yu Vdovychenko, Andriy I Chubatyy, Serhii V Dudka, Karina Voronina","doi":"10.36740/WLek/203835","DOIUrl":"https://doi.org/10.36740/WLek/203835","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To estimate the prevalence and risk factors associated with endometriosis in female evacuated from the Eastern Ukrainian military conflict regions.</p><p><strong>Patients and methods: </strong>Materials and Methods: A prospective multicenter cohort study was based on surveillance data for endometriosis. 982 women undergoing pelvic surgery were compared to 264 patients unexposed to surgery. The study cohort included women, who underwent a diagnostic and/or therapeutic laparoscopy or laparotomy in 2022-2024. Endometriosis among women was diagnosed visually at laparoscopy/laparotomy or by pelvic magnetic resonance imaging.</p><p><strong>Results: </strong>Results: The prospective multicenter study included 1,246 women. The overall prevalence of endometriosis was 31.5%. Prevalence of the three types of endometrioses included peritoneal/superficial endometriosis, ovarian endometriotic cyst/endometrioma and deep infiltrating endometriosis was 13.8%, 9.8%, and 4.8%, respectively. Three hundred sixty-one women 36,8% in the surgical group and thirty-one women 13.3% in the community treatment group (unexposed to surgery, population cohort) were diagnosed with incident endometriosis. The pelvic pain, infertility and early age at menarche to be a consistent risk factor for endometriosis in both the operative and population cohorts. Data analysis showed that odds were decreased for gravidity, parity, and BMI. Factors that increased the odds of endometriosis diagnosis included dysmenorrhea, older age at first sex, pelvic pain as a surgical indication for laparoscopy, and higher education.</p><p><strong>Conclusion: </strong>Conclusions: Our study findings demonstrate the high prevalence of endometriosis among women in Ukraine. The pelvic pain, infertility and early age at menarche to be a consistent risk factor for endometriosis in both the operative and population cohorts.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"694-701"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of treatment options for impacted mandibular canines in different age groups of patients. A retrospective study.","authors":"Zinaida Y Zhehulovych, Yuriy I Babaskin, Vitalii V Parii, Tetiana A Shumynska, Roman V Popov, Tamara A Melnichuk, Olexandr I Kovalchuk","doi":"10.36740/WLek/203841","DOIUrl":"https://doi.org/10.36740/WLek/203841","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To analyze the effectiveness of traditional treatment options for impacted mandibular canines in adolescents and young people while considering age, the number of impacted teeth, type of treatment, and orthodontic appliances.</p><p><strong>Patients and methods: </strong>Materials and Methods: The retrospective investigation of the data of the case histories of patients with impacted mandibular canines was done: 53 cases in children and adolescents (Q1-Q3 = 13 to 15 years) (Group І) and 19 in young adults (Q1-Q3 = 21.25 to 33.5 years) (Group ІІ). The anamnesis data and clinical examination, x-ray findings, jaw model findings, treatment methods, and results were studied.</p><p><strong>Results: </strong>Results: In Gr. I, unilateral impaction prevailed (71.7%), whereas 20.8% of patients had bilateral impaction of mandibular canines. In Gr. II, 57.9% of patients had unilateral impaction, whereas 26.3% had bilateral impaction of mandibular canines. There is a strong correlation between the treatment outcomes and the patient's age, the number of impacted teeth, and the type of orthodontic appliance.</p><p><strong>Conclusion: </strong>Conclusions: The findings indicate the risk of poor treatment effect increases with the patient's age and the kind of appliances. the number of retained teeth, and their location in the jaw.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"702-709"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personal data protection in mHealth apps: international experience and prospects for legislative changes in Ukraine.","authors":"Vadym I Pishta, Sandra O Boldizhar, Tereziia P Popovych, Nazar T Holovatskiy, Anatoliy M Potapchuk, Mykhaylo M Hechko","doi":"10.36740/WLek/203908","DOIUrl":"https://doi.org/10.36740/WLek/203908","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study aims to analyze the legal aspects of mHealth apps in Ukraine, focusing on personal data protection and the effectiveness of the current legislation. The paper also zeroes in on examining international personal data protection standards and offers recommendations for improving the respective Ukrainian legislation.</p><p><strong>Patients and methods: </strong>Matherials and Methods: we employed method such as Overview to study Ukrainian and foreign legislation on personal data protection.</p><p><strong>Conclusion: </strong>Conclusions: The study highlights the shortcomings in the legal regulation of mHealth apps in Ukraine, which creates risks to the privacy of users' personal data. To ensure the safe use of mHealth apps, it is necessary to implement international standards for protecting personal data, taking into account the experience of the United States, Canada, and the EU. Improving the legislation will help increase user confidence in mHealth apps and favour the interaction between patients and healthcare providers.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"949-954"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of antibiotic resistance of the main infectious contaminants on the wound surface of wounded men in the Russian-Ukrainian war.","authors":"Oksana Melnyk, Dmytro Vorobets, Viktor Chaplyk, Mykola Vorobets, Roman Fafula, Anna Besedina, Zinoviy Vorobets","doi":"10.36740/WLek/197142","DOIUrl":"10.36740/WLek/197142","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To study the spectrum of antibiotic resistance of causative agents of wound infection in wounded men at the stage of specialized medical care.</p><p><strong>Patients and methods: </strong>Materials and Methods: Retrospective analysis of the results of culture of wound secretions on chromogenic media. The research involved 113 samples of biomaterial from 85 wounded. Sensitivity of antibiotics was studied by the Kirby-Bauer method.</p><p><strong>Results: </strong>Results: Analysis of the microflora of the wound surface made it possible to determine the dominance of gram-negative bacteria, they were isolated in 80% of cases. The microbial spectrum of gram-negative bacteria is represented by Pseudomonas aeruginosa - 31 isolates, Acinetobacter baumannii - 29 isolates, Enterobacter aerogenes - 21 isolates, Proteus vulgaris - 13 isolates, Escherichia coli - 7 isolates, Enterobacter cloacae - 5 isolates, Klebsiella pneumoniae - 7 isolates and gram-positive bacteria Staphylococcus aureus - 5 isolates, Enterococcus fecalis - 32 isolates. Among all tested isolates of gram-negative non-fermenting bacteria and enterobacteria, the highest sensitivity was observed to colomycin and polymyxin B, from 60 to 80%. When analyzing of antibiotic sensitivity of Klebsiella pneumoniae and Acinetobacter baumannii, it was found that these pathogens retain 80-100% of their actual antibiotic sensitivity to polymyxins.</p><p><strong>Conclusion: </strong>Conclusions: Gram-negative strains isolated from wound infection are sensitive to antibiotics: 70% to polymyxins (colistin), 30% to aminoglycosides (amikacin), 24-16% to cephalosporins (cefoperazone-sulbactam/cefoperazone-avibactam).</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"295-302"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute coronary syndrome in post-partum period: challenge for differential diagnosis and proper management.","authors":"Sofiya Lypovetska, Mykola Shved","doi":"10.36740/WLek/197133","DOIUrl":"10.36740/WLek/197133","url":null,"abstract":"<p><p>The patient was presented with chest pain, new ECG changes indicating ischemia, an increase in troponin and NT pro BNP, elevated D-dimer levels, and wall motion abnormalities on an Echo. A chest computed tomography angiography did not show pulmonary embolism but revealed a sac-like aneurysm of the left anterior descending artery (LAD). The coronary angiogram confirmed an aneurysm of the LAD in 6-7 segments, along with an extended 80% stenosis of the a. intermedia. The interventional cardiology team concluded that the patient required coronary artery bypass grafting (CABG) due to extensive vessel damage. She underwent CABG three months after acute coronary syndrome in an experienced center.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"474-478"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious exanthemas in clinical practice.","authors":"Vadym A Bodnar, Nataliia O Pryimenko, Olena H Marchenko, Olena M Izyumska","doi":"10.36740/WLek/197135","DOIUrl":"10.36740/WLek/197135","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Analyze the causes and mechanisms of development of exanthems, provide a classification of the morphological elements and characterize clinical manifestations of rash in patients with infectious diseases based on a review of available literature data.</p><p><strong>Patients and methods: </strong>Materials and Methods: The authors analyzed the current literature sources, including a description of exanthema syndrome and a discussion of the features of rashes in various infectious diseases.</p><p><strong>Conclusion: </strong>Conclusions: As a result of the analysis of existing literature data, it was established that exanthema syndrome is associated with various diseases, disorders and pathological conditions, characterized by a variety of clinical manifestations, which requires clinical differential diagnosis and subsequent laboratory confirmation. Comprehensive knowledge of the causes, mechanisms of development, as well as the clinical manifestations of skin rash will contribute to the development of an improved algorithm for diagnosis and treatment of the diseases accompanied by exanthema syndrome, as well as optimization of therapeutic tactics.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"168-176"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of program cell death ligand-1 (rs4143815 G>C) with some clinical symptoms and oral ulcer types in systemic lupus erythematosus.","authors":"Mona Al-Terehi, Mohammed Faris Jabaz, Ola Hatif Hazim, Najah Rayish Hadi","doi":"10.36740/WLek/197185","DOIUrl":"10.36740/WLek/197185","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The study aims to detect Association of Program Cell Death Ligand-1(PD-L1) rs4143815 G>C with some Clinical Symptoms and Oral Ulcer Types in Systemic Lupus Erythematosus (SLE).</p><p><strong>Patients and methods: </strong>Materials and Methods: A case control design was suggested in the study enrolled about 60 SLE patients and 20 healthy individuals as a control group, PD-L1 variation implemented using allele specific PCR.</p><p><strong>Results: </strong>Results: The findings showed significant changes in age (<0.011), sex (p<0.000), and non-sig in BMI (p<0.654). in SLE group about 23.3% of patients have a family history, 93.7% suffered from fever, 51.66% have a Butterfly-shaped rash, 73.3% suffered from oral ulcer, single oral ulcer was observed 65.90% and multiple ulcer observed 34.09%. Oral mouth was more frequent (55%) while pharynx ulcer was low frequent (3.3%). The rs4143815 G>C showed three genotypes (GC, CC and GG), Significant association of CC with SLE patients (OR 67.8874, p <0.003), A non-sig association was observed in GG with SLE (OR 5.8571, p <0.395), significant association of C allele with SLE group (OR 1.3529, p< 0.0008). The PD-L1 rs4143815 (G>C) genotyping distribution according to some clinical symptoms showed a non-significant association with all symptoms. The PD-L1 rs4143815 (G>C) genotyping distribution according to oral ulcer sites showed a non-significant association also.</p><p><strong>Conclusion: </strong>Conclusions: The present results concluded closed correlation between rs4143815 G>C and SLE patients, but no association was observed with some clinical symptoms and oral ulcer types.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"136-142"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and evaluation of Sulfonamide-Thiazolidinone conjugates as promising anticancer agents via carbonic anhydrase inhibition.","authors":"Zahraa Falah Naji, Noor H Naser","doi":"10.36740/WLek/197183","DOIUrl":"10.36740/WLek/197183","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study focuses on developing and evaluating five newly created compounds targeting carbonic anhydrase isoforms found in solid tumors. Our primary goal is to create exceptionally potent anti-cancer drugs.</p><p><strong>Patients and methods: </strong>Materials and Methods: Sulfanilamide, chloroacetyl chloride, Gamma-aminobutyric acid, thionyl chloride, methanol, hydrazine hydrate, aromatic aldehyde derivatives, glacial acetic acid, and thioglycolic acid were used in the chemical synthesis. We performed docking studies using the Molecular Operating Environment software program version 2015.10, and used MTT assay to predict cytotoxic activity.</p><p><strong>Results: </strong>Results: The compounds we developed demonstrated impressive antineoplastic action in both in silico experiments as well as cell line experiments. Their toxicity to normal cells varied significantly, but their efficacy against cancer cells differed significantly from cisplatin. When compared to acetazolamide, each of the produced compounds exhibited significant differences in their effects on MCF7 cells. Based on these findings, synthetic compounds may serve as antineoplastic medications. Including the thiazolidinone ring in these compounds enhanced their affinity for the receptor by binding to multiple crucial amino acids that play a significant role in our target's enzymatic activity and substrate binding.</p><p><strong>Conclusion: </strong>Conclusions: Our synthetic compounds revealed cytotoxicity and inhibitory potencies against carbonic anhydrase. Moreover, they exhibited cytotoxicity.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"116-129"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation of a patient after total endoprosthesis of the hip joint removal so-called \"hanging hip\". Case report.","authors":"Izabela Dąbkowska, Magdalena Sobiech, Karolina Turżańska","doi":"10.36740/WLek/202446","DOIUrl":"https://doi.org/10.36740/WLek/202446","url":null,"abstract":"<p><p>The aim of our study is to present the problem of rehabilitation of a patient after endoprosthesis surgery and an attempt to revise the endoprosthesis and then leave the hip hanging. This case study describes an 80-year-old woman who underwent left hip replacement due to primary severe arthrosis. The patient had undergone an unsuccessful attempt at endoprosthesis revision after multiple dislocation of the prosthesis, which ended in an infection of the surgical wound. The operating team decided to remove the revision endoprosthesis, leaving the hip hanging. The challenge for the treatment team was to rehabilitate the patient, aiming to adapt her to her new situation and make her as independent as possible. The final treatment outcome according to the treatment team was satisfactory. The patient achieved relative independence of movement. At discharge home, she had no symptoms of infection of the infected hip and did not report pain related to the operated hip joint. Radical hip replacement surgery is a method that provides the patient with a pain-free life and a relative return to independence and function in daily life.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"657-663"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects, possibilities and determinants of rehabilitation in nursing.","authors":"Joanna Niezbecka-Zając, Zuzanna Łuba, Anna Mazurek, Anna Pacian","doi":"10.36740/WLek/202524","DOIUrl":"https://doi.org/10.36740/WLek/202524","url":null,"abstract":"<p><p>Contemporary nursing models address complex human needs, emphasizing prevention, education, and rehabilitation. Nursing and rehabilitation are closely linked, aiming to restore full or partial functionality and support patients in returning to social, family, and professional life. The aim of this study was to analyze the role of nurses in rehabilitation and assess the potential for developing rehabilitation nursing in Poland, considering current trends and the growing demand for qualified staff. A comprehensive literature analysis was conducted, with a particular focus on the Canadian model and its scope in rehabilitation. The results indicate that rehabilitation nursing should expand in response to the needs of an aging society. The introduction of specialized training and the incorporation of rehabilitation nursing courses into higher education programs could significantly contribute to this field's development. The Canadian model demonstrates that proper education and certification in rehabilitation nursing enhance patient care and recovery. Implementing similar solutions in Poland could improve rehabilitation outcomes and overall patient well-being. However, adapting modern nursing models requires systemic changes and a shift in professional perception. Nursing should evolve from a primarily supportive role focused on basic care to an active, leadership-oriented function within the rehabilitation team. A well-trained rehabilitation nurse can significantly improve the effectiveness of rehabilitation, ensuring a more holistic and patient-centered approach.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"591-594"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}