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Effect of Sitagliptin on Micro150-5p in patients with T2DM with left ventricular diastolic dysfunction. 西格列汀对T2DM左室舒张功能不全患者微150-5p的影响。
Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/202972
Aswer J Abdulkadhium, Bassim I Mohammad
{"title":"Effect of Sitagliptin on Micro150-5p in patients with T2DM with left ventricular diastolic dysfunction.","authors":"Aswer J Abdulkadhium, Bassim I Mohammad","doi":"10.36740/WLek/202972","DOIUrl":"10.36740/WLek/202972","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To clarify Sitagliptin effect on left ventricular diastolic dysfunction in T2DM, to investigate the potential effect of Sitagliptin on epigenetic modulation (Micro RNA150-5P) and inflammatory process.</p><p><strong>Patients and methods: </strong>Materials and Methods: This study was carried out at a single center and is cross-sectional, descriptive, and observational. A specialist cardiologist selected a cohort of sixty individuals who had both left ventricular diastolic failure and type 2 diabetes mellitus (T2DM). The study was carried out at AL-Diwaniyah teaching hospital and the department of pharmacology and therapeutics, school of medicine, university of Al-Qadisiyah, Iraq. Total RNA was isolated using Trizol reagent (Genaid, Korea) and the concentration of RNA was determined. The primer amplification was performed according to the instructions published by AddBio (Korea) for the AddScript RT-qPCR Syber master kit. Transthoracic echocardiography measuring were patients at rest utilizing a commercially accessible ultrasound machine (Vinno E20; Echo Ultrasound AS, china). Ultrasound imaging acquisitions were automatically saved from at least three following cardiac contractions for subsequent processing. Standard parameters (LVED, LVES, and LVEF) were acquired as previously explained.</p><p><strong>Results: </strong>Results: Our results indicate a significant down regulation of miR-150-5p in the Sitagliptin treated group (P<0.0001) in comparison with metformin treatment. This was analyzed by Graph pad prizim software (version 8.4.3).</p><p><strong>Conclusion: </strong>Conclusions: The results of our study indicate that the expression of miR-150-5p is dramatically reduced in the cardiac tissue of individuals with diabetes. Furthermore, reducing the levels of miR-150-5p is linked to an enhancement in the functioning of the left ventricle, partially via reducing the occurrence of programmed cell death in heart muscle cells. Hence, suppressing the activity of miR-150-5p could be a new and effective approach for treating cardiac dysfunction associated with diabetes.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 5","pages":"1167-1175"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nurses' attitudes towards mental illness and home health care quality as a means of managing psychiatric patients' relapses and re-admissions: a quasi -experimental study. 护士对精神疾病的态度和家庭保健质量作为管理精神病人复发和再入院的手段:一项准实验研究。
Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/199813
Amal Ibrahim Khalil, Manni Alharbi, Reem Alsulami, Manar Alotaibi
{"title":"Nurses' attitudes towards mental illness and home health care quality as a means of managing psychiatric patients' relapses and re-admissions: a quasi -experimental study.","authors":"Amal Ibrahim Khalil, Manni Alharbi, Reem Alsulami, Manar Alotaibi","doi":"10.36740/WLek/199813","DOIUrl":"10.36740/WLek/199813","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study aims to assess the impact of an educational intervention on nurses' knowledge and attitudes regarding home health care, relapse management, and psychiatric hospital admissions.</p><p><strong>Patients and methods: </strong>Materials and Methods: A quasi-experimental study was conducted with 106 nurses at Erada for Mental Health and Addiction. Standardized assessment tools, including a knowledge scale for home health care quality and a mental illness devaluation scale, were used.</p><p><strong>Results: </strong>Results: Most participants were female 78.4% with a bachelor's degree 77%, and the average age was 2.06±.954. The analysis revealed a significant improvement in knowledge levels post-intervention P<0.000, however, there was a slight non-significant increase in devaluation scale scores after the intervention (pre-24.55±2.96, post-25.18±3.45).</p><p><strong>Conclusion: </strong>Conclusions: Targeted interventions to enhance nurses' knowledge of home health care quality and promote positive attitudes toward mental illnesses can lead to improved patient care, potentially reducing relapses and readmissions among psychiatric patients. Future research should explore the long-term impact and sustainability of such interventions in mental health care settings.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"16-27"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hormonal influence on osteoporosis. 激素对骨质疏松症的影响。
Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/202332
Zuzanna Rupeć, Mateusz Trubalski, Zeeshan Zulfiquar, Aleksandra Bełżek, Marta Żerebiec, Natalia Saj, Paweł Kamiński, Mateusz Kaczmarski, Firoz Rizvi, Wojciech Kłapeć
{"title":"Hormonal influence on osteoporosis.","authors":"Zuzanna Rupeć, Mateusz Trubalski, Zeeshan Zulfiquar, Aleksandra Bełżek, Marta Żerebiec, Natalia Saj, Paweł Kamiński, Mateusz Kaczmarski, Firoz Rizvi, Wojciech Kłapeć","doi":"10.36740/WLek/202332","DOIUrl":"https://doi.org/10.36740/WLek/202332","url":null,"abstract":"<p><p>Osteoporosis is a global health issue that weakens bones and increases the risk of fractures, particularly in postmenopausal women and older adults. This review explores the influence of hormones on osteoporosis, with a focus on estrogen, glucocorticoids, vitamin D, parathyroid hormone, and thyroid hormones. Scientific evidence is analyzed to highlight hormonal mechanisms, therapeutic interventions, and their effects on bone health. The review examines hormonal therapies, including selective estrogen receptor modulators, and discusses the impact of glucocorticoids, essential for managing inflammation but known to significantly increase bone porosity. It underscores the importance of minimizing glucocorticoid use and implementing preventive measures such as calcium and vitamin D supplementation. Additionally, the review addresses the consequences of vitamin D deficiency, which disrupts calcium and phosphate metabolism, contributing to bone fragility. It also explores the regulatory roles of parathyroid and thyroid hormones in bone remodeling and calcium balance, with a Focus on their therapeutic applications in osteoporosis management. This review emphasizes the complex interplay between hormonal, genetic, and environmental factors, advocating for holistic and personalized treatment approaches. Future research should aim to bridge existing knowledge gaps regarding hormone-environment interactions and assess the long-term efficacy of therapies to optimize osteoporosis prevention and treatment strategies.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"531-538"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The science of posture: how the spine shapes health and mobility. 姿势的科学:脊椎如何塑造健康和活动。
Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/202582
Wojciech Kłapeć, Adrian Możdżeń, Julia Jaśkowska, Paweł Szymonek
{"title":"The science of posture: how the spine shapes health and mobility.","authors":"Wojciech Kłapeć, Adrian Możdżeń, Julia Jaśkowska, Paweł Szymonek","doi":"10.36740/WLek/202582","DOIUrl":"https://doi.org/10.36740/WLek/202582","url":null,"abstract":"<p><p>The spine is a key component of the skeletal system, with a complex anatomical structure that varies along its length. Its specific structure allows it to fulfill multiple functions, including maintaining proper upright posture. Human posture reflects the coordinated interaction between the kinesthetic sense, muscular system, and nervous system. Various factors influence posture formation, including environmental conditions, lifestyle, physical activity, nutrition, and genetics. Data from Poland indicate that postural defects affect 30% to 60% of children and adolescents, with variations due to assessment methods. According to the Center for Health Information Systems, incorrect posture was diagnosed in 17.14% of children and adolescents aged 0-18 years, with 9.7% of spinal deformities identified in children aged 2-9 years. This study explores the etiological factors of spinal deformities, particularly scoliosis, including genetic predisposition, environmental influences, and hormonal factors such as vitamin D. This study is based on a literature review and analysis of research on postural defects, particularly scoliosis, focusing on prevalence, etiology, and risk factors. The methodology involves a systematic search of peer-reviewed articles, clinical studies, and epidemiological reports from databases such as PubMed, Google Scholar, Scopus, and Web of Science. Research suggests a possible correlation between scoliosis severity and vitamin D levels. Vitamin D is essential for bone mineralization and neuromuscular function, and deficiencies may contribute to reduced postural stability and increased spinal curvature. Some studies indicate a negative correlation between vitamin D levels and Cobb angle severity, though further research is needed.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"609-614"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The significant impact of T-cell immunoglobulin and mucin domain 3(Tim-3) gene polymorphism on HCV infection and viral load. t细胞免疫球蛋白和粘蛋白结构域3(Tim-3)基因多态性对HCV感染和病毒载量的显著影响
Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/202971
Hiba Hadi Rashid, Raghad Emad Salman, Alyaa Younis Ali, Maysaa Ali Abdul Khaleq
{"title":"The significant impact of T-cell immunoglobulin and mucin domain 3(Tim-3) gene polymorphism on HCV infection and viral load.","authors":"Hiba Hadi Rashid, Raghad Emad Salman, Alyaa Younis Ali, Maysaa Ali Abdul Khaleq","doi":"10.36740/WLek/202971","DOIUrl":"https://doi.org/10.36740/WLek/202971","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To evaluate the role of -574 locus gene polymorphism in promotor region of TIM-3 gene in HCV infection and viral load.</p><p><strong>Patients and methods: </strong>Materials and Methods: The current study executed on 100 subjects (50 patients with HCV and 50 obviously healthy objects as control). Blood sample compiled from all participants. All samples underwent to diagnosis for HCV confirm by viral load measurement by real time-polymerase chain reaction (RTPCR). Extraction the Genomic DNA performed from blood. The gene fragment corresponding the-574 locus (rs10515746) in TIM-3 gene was amplified and genotyping by allele specific - polymerase chain reaction (AS-PCR).</p><p><strong>Results: </strong>Results: In recessive model, in patients the frequency of GT-TT genotype was significantly higher than controls (86% vs. 62%) with a highly important variation (OR=3.76, 95% CI=1.41-10.05, p=0.008 at allelic level, T allele was more continual in patients than controls (60% contra 42%) with a considerable variation (OR=2.07, 95%CI=1.18-3.64, p= 0.015). About 42% of patients carrying TT genotype had viral load ≥200000 IU/ml compared with 15.38% GT carriers and 0% GG carries with such a viral load with a significant difference. At allelic level, T allele was more continual in patients than controls (60% contra 42%) with a significant variation (OR=2.07, 95%CI=1.18-3.64, p= 0.015.</p><p><strong>Conclusion: </strong>Conclusions: T allele of rs10515746 considered a risk factor for HCV infection as well as for higher hepatitis C viral load in those patients, and it could predict treatment failure. However, with more aggressive antiviral therapies, viral cure could be achieved.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"845-852"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of olfactory and gustatory dysfunction in post-COVID dentists by a modified CCCRC. 改进的CCCRC评估新冠肺炎后牙医嗅觉和味觉功能障碍。
Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/202969
Ferial Mahmood Abdulrida, Ameena Ryhan Diajil, Taghreed Fahdil Zaidan
{"title":"Assessment of olfactory and gustatory dysfunction in post-COVID dentists by a modified CCCRC.","authors":"Ferial Mahmood Abdulrida, Ameena Ryhan Diajil, Taghreed Fahdil Zaidan","doi":"10.36740/WLek/202969","DOIUrl":"https://doi.org/10.36740/WLek/202969","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study aimed to evaluate the prevalence of sense loss and their deterioration within and post infection with COVID-19.</p><p><strong>Patients and methods: </strong>Materials and Methods: A systematic informative questionnaire was filled out for each participant. Chemosensitive symptoms were recorded by using n-butyl alcohol and environmentally realistic odorants and calculated in a modified way for the detection of olfactory function. The gustatory test scoring was done using the four standard primary tastes.</p><p><strong>Results: </strong>Results: Out of 133 participants, dentists were more commonly females (81, 61%) with the majority below 35 years of age (97, 72%). Half of the participants experienced smell and/or taste loss during the COVID-19 pandemic; whereas almost all reported having had olfactory dysfunction (132, 99.2%) and (105, 78.2%) gustatory dysfunction. Males reported a higher significant rate of taste loss (P=0.009) and females showed a higher recovery rate within the first two weeks after the onset than males. The Pfizer vaccine showed a significantly more frequent smell loss than other vaccinations (P=0.038).</p><p><strong>Conclusion: </strong>Conclusions: Gender variation was noticed with taste and smell loss. Females recovered faster from dysfunction. Pfizer fully vaccinated participants were more prone to lose smell compared to others.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"768-776"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond traditional lipid markers: why lipoprotein(a) screening matters. 超越传统的脂质标志物:为什么脂蛋白(a)筛查很重要。
Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/203847
Vitalina V Ivachevska, Daria A Korchagina, Olesya A Kozel, Liliia V Tsyhanyk, Mykhaylo M Hechko, Mykhailo M Ivachevskyi
{"title":"Beyond traditional lipid markers: why lipoprotein(a) screening matters.","authors":"Vitalina V Ivachevska, Daria A Korchagina, Olesya A Kozel, Liliia V Tsyhanyk, Mykhaylo M Hechko, Mykhailo M Ivachevskyi","doi":"10.36740/WLek/203847","DOIUrl":"https://doi.org/10.36740/WLek/203847","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To assess the correlation between lipoprotein(a) levels and traditional lipid profile markers in statin-naive men and women without established atherosclerotic cardiovascular disease.</p><p><strong>Patients and methods: </strong>Materials and Methods: Sixty-seven statin-naive adult patients without a prior history of established atherosclerotic cardiovascular disease were included in the study. Lipoprotein(a) levels were determined using nephelometry in all patients.</p><p><strong>Results: </strong>Results: According to the results of the correlation analysis, it was found that there is no statistically significant correlation between lipoprotein(a) level and traditional parametres of lipid profile in both groups (p>0.05). Reliable direct correlation of moderate strength was observed between lipoprotein(a) and age in the group A (R=0.46, p=0.04).</p><p><strong>Conclusion: </strong>Conclusions: Elevated lipoprotein(a) levels, independent of other lipid profile parameters, can significantly contribute to cardiovascular risk, emphasizing the importance of routine lipoprotein(a) screening in clinical practice. It is particularly noteworthy that lipoprotein(a) concentrations tend to increase after menopause, potentially placing postmenopausal women at an elevated risk for cardiovascular events. Consequently, it is imperative to monitor lipoprotein(a) levels in females, especially during the peri-menopausal and postmenopausal stages, to more accurately assess and manage cardiovascular risk in this population.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"735-739"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between MRNA IL1Β and type, duration of infertility in women with endometriosis on the stage preparing to assisted reproductive technologies using probiotics. MRNA IL1Β与子宫内膜异位症妇女在准备使用益生菌辅助生殖技术阶段的不孕症类型和持续时间的相关性
Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/203893
Oksana V Bakun, Kristina V Dyak, Oksana V Kolesnik, Tetiana Protsak, Yevheniia A Dudka
{"title":"Correlation between MRNA IL1Β and type, duration of infertility in women with endometriosis on the stage preparing to assisted reproductive technologies using probiotics.","authors":"Oksana V Bakun, Kristina V Dyak, Oksana V Kolesnik, Tetiana Protsak, Yevheniia A Dudka","doi":"10.36740/WLek/203893","DOIUrl":"https://doi.org/10.36740/WLek/203893","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate the correlations between the level of IL1β mRNA gene expression and the type and duration of infertility and to study the levels of IL1β mRNA gene expression in women with endometriosis associated with infertility.</p><p><strong>Patients and methods: </strong>Materials and Methods: For mRNA gene expression analysis IL1β and determination of relative normalized mRNA expression IL1β used the real-time reverse transcription polymerase chain reaction method (RT-PCR).. Examined group consists of 30 infertile women undergoing assisted reproductive technologies. The main group consisted of 20 women diagnosed with endometriosis undergoing assisted reproductive technologies. The control group consisted of 10 healthy women.</p><p><strong>Results: </strong>Results: In the main group, the level of IL1β mRNA gene expression before preparing was 26.7877±0.01, which was significantly higher than the level after preparing (0.1610±0.01* ). Analized results, it's found out that Mean level of mRNA IL1β in women with endometriosis associated infertility 1-st degree is 8.53 c.u., at the same time Mean level of mRNA IL1β in women with endometriosis associated infertility 2-nd degree is 1.0 c.u.</p><p><strong>Conclusion: </strong>Conclusions: The inclusion of probiotics in a comprehensive regimen of preparation for assisted reproductive technologies leads to a noticeable improvement in the patient's well-being.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"828-837"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histological manifestations in the structures of the anterior abdominal wall after implantation of the acellular dermal matrix using the sublay method. 皮下法植入脱细胞真皮基质后前腹壁结构的组织学表现。
Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/203892
Andriy V Makhnitskyy, Igor M Deykalo, Larysa Ya Fedoniuk, Tamara V Datsko, Nadiia I Grynkiv, Nazar M Ostrovskyy
{"title":"Histological manifestations in the structures of the anterior abdominal wall after implantation of the acellular dermal matrix using the sublay method.","authors":"Andriy V Makhnitskyy, Igor M Deykalo, Larysa Ya Fedoniuk, Tamara V Datsko, Nadiia I Grynkiv, Nazar M Ostrovskyy","doi":"10.36740/WLek/203892","DOIUrl":"https://doi.org/10.36740/WLek/203892","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The objective of this study was to assess the level of vascularization, integration of the acellular dermal matrix, as well as the development of granulation tissue and collagen fibers following implantation on the anterior abdominal wall (\"sub lay\") in pigs over the course of 7, 14, and 21 days.</p><p><strong>Patients and methods: </strong>Materials and Methods: The experiment was conducted on six pigs of the Ukrainian White steppe. Under general anesthesia, an acellular perforated dermal matrix from pigs, produced by the ≪Institute of Biomedical Technologies≫, was implanted into the anterior abdominal wall, between the aponeurosis and muscles. The quality of engraftment, degree of angiogenesis, condition of granulation tissue, and graft structure were assessed. The postoperative period was uncomplicated, with each pig receiving one intramuscular dose of ceftriaxone (1.0). Material was collected from two pigs on the 7th day, two more on the 14th day, and the final two on the 21st day after implantation. Pathomorphological analysis was carried out in the laboratory of I. Horbachevsky Ternopil National Medical University. Sections of the implanted material, stained with hematoxylin-eosin, were evaluated for local inflammation reactivity, vascularization levels, and granulation tissue replacement.</p><p><strong>Results: </strong>Results: The research findings revealed that, after 7 days of implantation, the acellular skin matrix \"sub lay\" led to infiltration caused by acute inflammation, accompanied by the formation of granulation tissue, numerous microcirculatory vessels, and collagen fibers. By day 14, the signs of inflammation had reduced, and there was an increase in fibroblasts and blood vessels. On day 21, the implantation process intensified, marked by a rise in collagen fibers and vascularization, along with a decrease in macrophages and lymphocytes. No signs of infection were observed.</p><p><strong>Conclusion: </strong>Conclusions: Acellular dermal matrix after ≪sub lay≫ implantation causes acute inflammation with slow vascularization in the early period with a moderate increase up to 14 and 21 days. The implant acts as a base to support the migration of natural cells and subsequent replacement by granulation tissue, as a result of strengthening this area. No signs of infection were detected, which gives hope for the use of implants in previously infected environments after complications due to the implantation of meshes made of artificial materials before.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"821-827"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathomorphological characteristics of the supravaginal part of the cervix depending on the echogenicity ratios of the cervix to the uterine body. 宫颈阴道上部分的病理形态学特征,取决于宫颈与子宫体的回声比。
Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/203848
Volodymyr V Maliar, Vitali V Maliar, Vasyl A Maliar
{"title":"Pathomorphological characteristics of the supravaginal part of the cervix depending on the echogenicity ratios of the cervix to the uterine body.","authors":"Volodymyr V Maliar, Vitali V Maliar, Vasyl A Maliar","doi":"10.36740/WLek/203848","DOIUrl":"https://doi.org/10.36740/WLek/203848","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To analyze the morphological features of the supravaginal part of the cervix depending on the echogenicity ratios of the cervix to the body of the uterus.</p><p><strong>Patients and methods: </strong>Materials and Methods: In 87 reproductive-age patients (30-40 years) with uterine leiomyoma (>14 weeks gestation), morphological features of the supravaginal cervix were analyzed in 23 hysterectomy specimens based on echogenicity ratios: Group I (n = 10): Cervical echogenicity > uterine body. Group II (n = 8): Cervical echogenicity = uterine body. Group III (n = 5): Cervical echogenicity < uterine body.</p><p><strong>Results: </strong>Results: Histological analysis revealed that increased cervical echogenicity corresponded to a predominance of collagen fibers over smooth muscle bundles. Conversely, when cervical echogenicity was equal to or lower than the uterine body, smooth muscle bundles dominated. These specimens also exhibited destructive changes, connective tissue disorganization, and dystrophic alterations, which are pathognomonic signs of potential lower uterine segment failure during pregnancy.</p><p><strong>Conclusion: </strong>Conclusions: 1. Comparative studies show that in cases of excess echogenicity of the cervix over the body of the uterus, pathomorphological changes in the supravaginal part of the cervix were not detected. 2. Equal or reduced cervical echogenicity was associated with connective tissue disorganization and dystrophic changes in smooth muscle, indicating structural inferiority. 3. A change in the ratio of echogenicity of the cervix to the body, which is closely related to the morphological structure of the isthmus of the uterus, can serve as one of the criteria for predicting the failure of the lower segment of the uterus in women.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"740-745"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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