Wiadomosci lekarskie最新文献

{"title":"Endometrial hyperplasia as a consequence of mixed urogenital infections.","authors":"Nataliya Yu Bysaha, Oxana O Korchynska, Shtefanija Andrashchikova, Silvija Zhultakova, Alena Shlosserova","doi":"10.36740/WLek/195137","DOIUrl":"https://doi.org/10.36740/WLek/195137","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Investigation of hyperproliferative diseases of the female genital organs as a consequence of mixed urogenital infections.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study included 56 women of reproductive age who experienced discomfort in the external genital area in the form of excessive vaginal discharge and/or unpleasant odour of the discharge, itching in the external genital area (main group). The control group consisted of 30 somatically and gynaecologically healthy patients.</p><p><strong>Results: </strong>Results: The following complaints were noted in mixed infections: increased amount of vaginal discharge (28 women / 50% of the main group), unpleasant odour of discharge (19 women / 34%), less frequently - itching (10 women / 18%), burning (11 women / 20%), pain during intercourse (8 women / 14%), digestive tract disorders - bloating and irregular bowel movements (13 women / 23%). Two or more complaints were noted in 29 patients (52% of the main group). The microscopy revealed a small number or complete absence of lactobacilli, abundant polymorphic gram-negative and gram-positive bacillus and coccusmicroflora, and the presence of 'key cells'.</p><p><strong>Conclusion: </strong>Conclusions: Taking into account the information described above, it can be noted that mixed urogenital infections affect the pathogenesis of endometrial hyperplastic processes.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 10","pages":"1888-1891"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of postoperative acute pancreatitis of non-resection genesis in abdominal surgery.","authors":"Tetiana V Formanchuk, Maxym A Hudz, Оleg V Honcharenko, Hryhoriy V Lapshyn","doi":"10.36740/WLek/197078","DOIUrl":"https://doi.org/10.36740/WLek/197078","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To analyse in detail the incidence of POAP after urgent abdominal and endoscopic transpapillary surgical interventions.</p><p><strong>Patients and methods: </strong>Materials and Methods: A retrospective analysis of 52 clinical cases of POAP was done, among which 27 patients developed POAP after urgent abdominal interventions and 25 patients - after endoscopic transpapillary interventions.</p><p><strong>Results: </strong>Results: The incidence of POAP after urgent surgical interventions consisted 0,3%, after endoscopic transpapillary interventions - 18,25%. In the structure of urgent surgical interventions complicated by POAP, gastric and duodenal surgery - 25% (13) and splenectomy - 9,6% (5) were dominating. There was a significant predominance of men in the group of patients with POAP after abdominal interventions and a significant predominance of women in the group with endoscopic retrograde cholangiopancreatography induced POAP (ERCP-induced POAP). POAP can develop at any age; up to 70 years of age, there was an increase in the incidence of POAP with the age of patients, and after 70 years of age the incidence rate was decreasing. The dominant morphological form of POAP was edematous - 67,3% (35).</p><p><strong>Conclusion: </strong>Conclusions: The issue of a unified definition of POAP after operations on internal organs of nonresectional genesis is not resolved. The incidence rate of POAP after surgeries on internal organs, which have direct anatomical and functional relationship with the pancreas dominate.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 11","pages":"2119-2126"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary study of the influence of maternal and neonatal NOS3 (rs1799983), IL1B (rs1143634) genes variants and their intergenic interaction on the development of hypoxic-ischemic encephalopathy in newborns in the context of treatment planning.","authors":"Yuliia Cherniavska, Alina Davydenko, Valerii Pokhylko, Liliia Fishchuk, Zoia Rossokha","doi":"10.36740/WLek/197108","DOIUrl":"https://doi.org/10.36740/WLek/197108","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To determine the influence of maternal and neonatal variants of the eNOS (G894T, rs1799983) and IL1B (C3953T, rs1143634) genes and their intergenic interactions on the development of HIE in newborns.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study included a cohort of 105 newborns and their 99 mothers. Determination of variants of the genes eNOS (G894T, rs1799983) and IL1B (C3953T, rs1143634) was carried out for the patients of study groups.</p><p><strong>Results: </strong>Results: The frequency of detection of the 894TT genotype by the eNOS gene was increased in newborns with severe asphyxia (p=0.018) and in their mothers (p=0,0057). Further analysis of intergenic interactions, performed in mother-child pairs, revealed an increased frequency of the neonatal 894GG (eNOS)/maternal 3953С (IL-1B) genotype combination in the comparison group versus the group of newborns with HIE (p=0.007).</p><p><strong>Conclusion: </strong>Conclusions: The significance of the intergenic maternal combination of 894GG/3953CT genotypes for the eNOS and IL1B genes and the intergenic combination of neonatal 894GG (eNOS)/maternal 3953CT (IL-1B) genotypes in the development of HIE in newborns has been proven. Associations of maternal and neonatal 894TT genotypes for the eNOS gene with the development of severe asphyxia, bradycardia, and respiratory failure were found in newborns with HIE.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 12","pages":"2373-2380"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radial shock wave therapy with \"Intelect PRW Lite\" for calcifying tendinopathy of the shoulder, comparative effectiveness with conventional physical therapy and follow up data.","authors":"Radostina Hristova Simeonova, Ignat Ignatov, Zlatin Ivanov, Georgi Nanov","doi":"10.36740/WLek/195550","DOIUrl":"https://doi.org/10.36740/WLek/195550","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To reveal the criteria for effective treatment of this pathology and to compare it with the conventional physical factors.</p><p><strong>Patients and methods: </strong>Materials and Methods: The research has been taken on 60 people, A control group (CG), including 30 people, treated with basic therapy and experimental group (EG). including 30 people, treated with the same basic therapy and RSWT once per week for seven consecutive weeks. The effect of the treatment was shown by: sonographic examination before and after treatment, physical tests for motor skills in shoulder region, scale of pain and the range of motion (ROM).</p><p><strong>Results: </strong>Results: The results have high statistical significance (p<0,001) for both groups. The comparision between EG and CG (p<0,001) proves that usage of RSWT reduces the pain quicker and restores mobility in the shoulder region in a shorter period than conventional physical therapy and only in the EG there is reduction in the parameters of the calcifications and total disappearance in the follow up.</p><p><strong>Conclusion: </strong>Conclusions: The results have high statistical significance (p<0,001) for both groups. The statistical difference between EG and CG (p<0,001) proves that usage of RSWT reduces the pain quicker and restores mobility in the shoulder region in a shorter period than conventional physical therapy and only the patients in the EG have reduction in the parameters of the calcifications and total disappearance in the follow up.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 12","pages":"2451-2456"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy outcomes after assisted reproductive technology among women with endometriosis in Ukraine: results a multicenter study.","authors":"Aidyn G Salmanov, Volodymyr V Artyomenko, Victor O Rud, Olena A Dyndar, Oleksandra Z Dymarska, Svitlana M Korniyenko, Orusia A Kovalyshyn, Anastasia S Padchenko, Vitalii S Strakhovetskyi","doi":"10.36740/WLek202407101","DOIUrl":"10.36740/WLek202407101","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To evaluate the association between adverse pregnancy outcome, assisted reproductive technology (ART) and a previous diagnosis of endometriosis in Ukraine.</p><p><strong>Patients and methods: </strong>Materials and Methods: We conducted a multicentre retrospective cohort study was based on infertility surveillance data among women reproductive age from January 1st, 2017 to December 31st, 2021 in Ukraine. The patients from 10 Ukrainian regions who achieved singleton pregnancy by ART were included in this study. Linked hospital, pregnancy/birth and mortality data were used. Logistic regression analysis was performed to calculate odds ratios (OR) and 95 % confidence interval (CI) for the rates of adverse pregnancy outcomes.</p><p><strong>Results: </strong>Results: During study period within the cohort of 11,271 singleton births, 94 women with endometriosis diagnosed before birth delivered 102 infants. Compared with women without endometriosis, women with endometriosis had higher risks of preterm birth [adjusted odds ratio 1.33, 95% confidence interval (CI), 1.23-1.44]. Women with endometriosis had higher risks of antepartal bleeding/placental complications, pre-eclampsia and Caesarean section. There was no association between endometriosis and risk of SGA-birth or stillbirth.</p><p><strong>Conclusion: </strong>Conclusions: Endometriosis and ART use are both independently associated with increased risk of preterm birth, antepartum haemorrhage, placenta praevia and planned birth. These findings are clinically relevant to obstetricians for distinguishing high- and low-risk pregnancies. Pregnant women with endometriosis require increased antenatal surveillance.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 7","pages":"1303-1310"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D receptor gene rs2228570 (FOKI) polymorphism associated with essential hypertension in Iraqi patients.","authors":"Aseel R Jabir, Hussein A Saheb, Bassim I Mohammad, Ahmed M Sultan, Sinaa Abdul Amir Kadhim, Asma A Swadi","doi":"10.36740/WLek202407112","DOIUrl":"10.36740/WLek202407112","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To understand how vitamin D receptor gene polymorphism (VDR rs2228570) affects blood pressure in Iraqi patients with essential hypertension in Al Diwaniya province.</p><p><strong>Patients and methods: </strong>Materials and Methods: This is a single-center observational cross-sectional descriptive study of 90 patients with essential hypertension. Using the PCRTETRA ARM technique, blood samples were genotyped and examined for the polymorphisms of FOKI (rs2228570) gene.</p><p><strong>Results: </strong>Results: The most frequent allele was A (121, 67%) while the most frequent genotype was AG (55, 61%). There was no statistical difference between the actual and expected frequency distribution, according to Hardy-Weinberg equilibrium. The effect of VDR polymorphism rs 2228570 on blood pressure indicates (the mean systolic blood pressure in AA, AG, and GG carrier patients was 149, 150 and 166 respectively, P=0.29. On the other hand, the mean diastolic blood pressure in AA, AG, and GG carrier patients was 89, 89, and 94 respectively P=0.6) there was no statistically significant effect on systolic and diastolic blood pressure.</p><p><strong>Conclusion: </strong>Conclusions: there is no statistically significant effect of VDR rs2228570 on SBP and DBP (p = 0.6), vitamin D receptor gene polymorphism rs2228570 was related to vitamin D level.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 7","pages":"1387-1393"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of changes in proteins of the acute phase of inflammation in the postoperative period in patients with disseminated peritonitis.","authors":"Olga Bilyayeva, Ivan Karol, Vadim Kryzhevsky, Oksana Osadchay","doi":"10.36740/WLek202407115","DOIUrl":"https://doi.org/10.36740/WLek202407115","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To determine the effect of the developed complex treatment of patients with peritonitis on the dynamics of humoral factors of nonspecific reactivity in the course of the disease.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study included 124 patients with toxic and terminal stages of peritonitis, who were divided into 3 groups. Group I (main) included 39 patients whose complex treatment included cytochrome C. Group II (main) included 41 patients whose complex treatment included cytochrome C and a solution containing levocarnitine and arginine hydrochloride. The comparison group comprised 44 patients who did not receive the specified drugs. The patients underwent determination of the levels of fibronectin, ceruloplasmin, and procalcitonin in the serum during the course of the disease.</p><p><strong>Results: </strong>Results: In patients of the I and II main groups, the use of the proposed treatment contributed to the optimization of the production of acute phase proteins: a decrease in procalcitonin production during the study, optimization of ceruloplasmin and fibronectin production, especially in the II main group. In patients of the comparison group, decompensation in the production of humoral inflammatory factors was determined, associated with a significant increase in fibronectin production, a decrease in ceruloplasmin content, and an increase in procalcitonin throughout the entire period.</p><p><strong>Conclusion: </strong>Conclusions: The use of cytochrome C and a solution containing levocarnitine and arginine hydrochloride in the complex treatment of patients with disseminated peritonitis helps to optimize the production of acute phase proteins, which leads to a decrease in inflammation and the preservation of factors of nonspecific humoral activity at a subcompensated level.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 7","pages":"1409-1414"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and functional features of the colonic mucus barrier in patients with symptomatic uncomplicated diverticular disease and acute uncomplicated diverticulitis.","authors":"Hanna A Dorohavtseva, Andrey E Dorofieiev, Olena O Dyadyk, Mykhailo S Myroshnychenko","doi":"10.36740/WLek202407105","DOIUrl":"https://doi.org/10.36740/WLek202407105","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The purpose was to identify the morphological and functional features of the colonic mucus barrier in patients with symptomatic uncomplicated diverticular disease and acute uncomplicated diverticulitis.</p><p><strong>Patients and methods: </strong>Materials and Methods: In the research, three groups were formed. Group 1 included fragments of the mucous membrane of the large intestine, which were collected from 12 people during autopsies. The results of autopsies and histological examination of the material did not reveal any gastrointestinal pathology. Group 2 included biopsies of the mucous membrane of the large intestine from the area of the diverticulum of 34 patients with symptomatic uncomplicated diverticular disease. Group 3 included biopsies of the mucous membrane of the large intestine of 26 patients with acute uncomplicated diverticulitis. Histological (hematoxylin and eosin staining), histochemical (PAS reaction) and immunohistochemical (mouse monoclonal antibodies to Mucin 2 (MUC2) and Mucin 4 (MUC4)) staining methods were used. A morphometric study was also carried out.</p><p><strong>Results: </strong>Results: In patients with diverticular disease, the authors identified disturbances in the morphofunctional state of the mucus barrier of the colon, the structure and function of goblet cells contained in its mucous membrane, characterized by a decrease in the thickness of the mucus layer covering the surface of the mucous membrane; a decrease in the size and number of goblet cells with a decrease in their mucus-producing ability; a change in the mucin profile, characterized by a violation of the content of MUC2 and MUC4. These changes were greatest in patients with acute uncomplicated diverticulitis compared with patients with symptomatic uncomplicated diverticular disease.</p><p><strong>Conclusion: </strong>Conclusions: The identified disturbances in the morphofunctional state of the mucus barrier of the colon, structural and functional changes in goblet cells may be one of the mechanisms for the development of acute uncomplicated diverticulitis and symptomatic uncomplicated diverticular disease.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 7","pages":"1331-1337"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of the hormonal background in women with abnormal uterine bleeding and extragenital disorders.","authors":"Liudmyla A Vygivska, Roman Y Blahoveshchenskyi, Yevgenii V Blahoveshchenskyi, Yevgeniia B Radzischevska, Iryna A Guz, Olena V Buhaiova, Olesia O Pliekhova","doi":"10.36740/WLek202407107","DOIUrl":"https://doi.org/10.36740/WLek202407107","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To establish the peculiarities of the hormonal background in women with abnormal uterine bleeding and extragenital disorders.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study involved examination of 100 women of reproductive age with concomitant ED and AUB (MG). CG included 50 healthy women. MG women were additionally divided into subgroups depending on the detected pathological changes in the uterine cavity. When examining the hormonal status, concentrations of FSH, LH, estradiol, progesterone, and leptin in BS were determined. Additionally, the level of 25-hydroxyvitamin D ((25-OH) D) was determined.</p><p><strong>Results: </strong>Results: The decrease in FSH level in subgroups of GP, PSL, EH, EHL was 1.8-2.4 times (KWT, p<0.01). LH in BS of MG patients was statistically lower than that of CG patients (MWT, p=0.0083). The lowest level of LH was registered in patients with EHL, which was 2 times lower than this indicator in CG. A statistically significant increase in the level of estradiol was registered in 73% of MG patients (MWT, p=0.044). The lowest level of progesterone was registered in patients with EHL - 8.40, which is 4.7 times lower than in CG (MWT, p=0.0021). A statistically significant increase in the level of leptin in BS was observed in MG patients (KWT, p=0.0021). The highest level of leptin was found in women with AFP, 2.3 times higher than CG indicators. A statistically significant correlation between the level of leptin and BMI (r=0.86, p=0.011) and a statistically significant (p=0.023) correlation between the level of leptin and estradiol in BS of patients of the examined groups (r=0.42) were revealed. In 87% of MG women, vitamin D deficiency was observed in BS (KWT, p=0.03). A statistically significant (p=0.01) negative correlation between the level of estradiol and vitamin D in the BS of female patients was revealed (r=-0.61, p=0.01).</p><p><strong>Conclusion: </strong>Conclusions: Women of reproductive age with AUB and ED were found to have disorders in the hypothalamic-pituitary-ovarian system. Most patients are characterized by an elevated level of leptin, the concentration of which is closely correlated with BMI, and an elevated level of estradiol is correlated with the level of vitamin D.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 7","pages":"1346-1353"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indicators of biochemical control of diabetes mellitus during limited availability of health service in the context of hypoglycemic therapy.","authors":"Marcin Kleibert, Beata Mrozikiewicz-Rakowska, Klaudia Korycka, Iga Płachta, Patrycja Małgorzata Bąk, Daniel Bałut, Jakub Zieliński, Wojciech Zgliczyński","doi":"10.36740/WLek202407103","DOIUrl":"https://doi.org/10.36740/WLek202407103","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Type 2 diabetes mellitus (T2DM) is a widespread disease that leads to many complications if not adequately controlled. The pandemic and its limitations on healthcare access impaired the management of chronic conditions. The aim of our study was to examine its effects in context of different antidiabetic therapies on key health related factors in patients with T2DM.</p><p><strong>Patients and methods: </strong>Materials and Methods: To the study we enrolled 598 adult patients with diagnosed T2DM treated in diabetology outpatient department of the University Clinical Centre (UCC) of the Medical University of Warsaw. Data on body weight, glycated hemoglobin (HbA1c), and creatinine concentration were collected throughout the first COVID-19 pandemic wave and compared to the results obtained before the 4th of March, 2020 (1st confirmed COVID-19 case in Poland).</p><p><strong>Results: </strong>Results: The HbA1c mean baseline level was 7.15% (±1.39) and increased significantly (7.34% (±1.37), p=0.02) during observation. Importantly, the attendance of patients for HbA1c testing decreased by 57.82% in comparison to the pre-pandemic period. Similarly, creatinine concentrations increased (from 1.27 mg/dl (±0.76) to 1.34 mg/dl (±1.02), (p=0.004)). The increase in creatinine concentration was significantly lower in the group treated with regimens including metformin compared to other regimens. Somewhat surprisingly, the mean body mass remained unchanged.</p><p><strong>Conclusion: </strong>Conclusions: The pandemic period had a significant impact on the tested biochemical parameters. The lesser changes of renal parameters in the group of patients treated with metformin confirms its nephroprotective effect and its value as a first-line treatment in T2DM.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 7","pages":"1318-1324"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}