Wiadomosci lekarskie最新文献

{"title":"The regional burden of acute pancreatitis in Ukraine: current trends in incidence, etiology, morbidity, gender distribution and mortality.","authors":"Tetiana Formanchuk, Ulrich Friedrich Wellner, Andrii Formanchuk, Hryhoriy Lapshyn","doi":"10.36740/WLek/200414","DOIUrl":"10.36740/WLek/200414","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim of the study was to analyze trends in incidence, etiology, gender distribution, morbidity and mortality for acute pancreatitis and to determine whether they correspond to the world trends and to identify changes in trends under the influence of the circumstances of recent years, in particular the COVID-19 pandemic and the full-scale war unleashed by Russia on the territory of Ukraine.</p><p><strong>Patients and methods: </strong>Materials and Methods: The retrospective study of the prospectively maintained data base of the incidence rate dynamics, mortality, age and gender distribution of AP at the regional level in the period from 2011 to 2022 was done. The data were obtained from the statistics services of the regional healthcare department and two clinical hospitals, Vinnytsia, Ukraine.</p><p><strong>Results: </strong>Results: Over the past 12 years, 18715 patients with AP have been treated at the regional level. Annually, 1559±259 people require inpatient treatment for this pathology, with an average annual length of hospital stay of 10850±856 days. The incidence rate of AP in 2022 consisted 134,4 cases/100000 population. During the studied period, the population of the region decreased by 8,02%. On the other hand, there is an increase in cases of AP, namely, in 2022, the number of patients with acute pancreatitis reached 177,83% from the level of 2011. There was also an increase in overall mortality from AP from 1,7% to 2,2%.</p><p><strong>Conclusion: </strong>Conclusions: During the 12-year period under study, against the background of a decrease in the average population at the regional level, there was a tendency for the incidence and mortality of AP to increase.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"353-366"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Сonnection and assessment of the psychological status of orthodontic patients with various types of malocclusion.","authors":"Oleksiy A Stasyuk, Vira Kuroiedova, Kira Sedykh, Yuliya Sokolohorska-Nykina, Yevhenii Vyzhenko, Liudmila Halych, Pavlo Korobov","doi":"10.36740/WLek/197129","DOIUrl":"10.36740/WLek/197129","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Assessment of relationship between the psychological status of orthodontic patients and the type of malocclusion using the Eysenck Personality Questionnaire.</p><p><strong>Patients and methods: </strong>Materials and Methods: Interviews were conducted using the Eysenck test. After the survey, the results of the questionnaire were analyzed according to the openness scale and 206 people aged 12 to 38 years were included in the further study. All patients were divided into groups according to the classification of malocclusion according to Angle - I, II and III class.</p><p><strong>Results: </strong>Results: During the verification of the first hypothesis regarding the relationship between patients with malocclusion and the level of neuroticism, a relationship was established in patients with II class (χ2=8.87, p=0.064). When establishing a relationship between patients with different classes of malocclusion and personality traits, no correlations were found (χ2=1.72, p=0.787). According to the results of the Pearson's Chi-square analysis, a relationship was established between patients with different classes of malocclusion and types of temperament (χ2=32.0 p=0.004).</p><p><strong>Conclusion: </strong>Conclusions: According to the results of our research, patients with pathology of III class according to Angle most often have the temperament type of sanguine and melancholic with introverted personality traits, with II class - melancholic and choleric, with I class according to Angle - sanguine and choleric, who are characterized by extraversion traits. According to the psychosocial status, patients with pathology of I and II class correspond to a high level of neuroticism, with III class - to an average level of neuroticism.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"336-341"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case of early uncomplicated multivascular nonobstructive coronary atherosclerosis in young male: novel aspects of noninvasive diagnostic.","authors":"Yuliya Tyravska, Oleksandr Savchenko, Iryna Melnychuk, Viktor Lizogub","doi":"10.36740/WLek/197140","DOIUrl":"10.36740/WLek/197140","url":null,"abstract":"<p><p>This clinical report demonstrates the case of nonobstructive coronary artery disease in a 38-year-old male with the only complaint of an episodical increase in blood pressure. A combination of risk factors raised the suspicion of nonobstructive coronary artery disease. It was substantiated by the modified stress test which consists of electrocardiography, echocardiography, laser Doppler flowmetry, pulse oxymetry, capnometry, lactate measurement, and blood pressure monitoring while cycling. Only afterward, the patient passed over coronary computed tomography angiography, which confirmed the suspected diagnosis precisely. Based on the current case, we aimed to increase the awareness of physicians about nonobstructive coronary artery disease and propose an algorithm for nonobstructive coronary atherosclerosis screening.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"487-495"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical confidentiality as an element of privacy vs. public interest in crime disclosure: striving for balance.","authors":"Dariia Abbasova, Olga Tyshchenko, Ivan Titko","doi":"10.36740/WLek/197335","DOIUrl":"10.36740/WLek/197335","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This article aims to raise awareness and stimulate scientific discussion on the issue of protecting medical confidentiality during criminal proceedings, with the goal of further improving legal tools to ensure compliance with the standards of the European Court of Human Rights (hereinafter referred to as the ECHR) in this field.</p><p><strong>Patients and methods: </strong>Materials and Methods: In preparing the article, the following issues were addressed: the provisions of international legal acts; the legal positions of the ECHR related to the protection of medical confidentiality in criminal proceedings; and scientific research in this field. The methodological basis of the research includes the method of generalization, methods of analysis and synthesis.</p><p><strong>Conclusion: </strong>Conclusions: The right to confidentiality regarding health status may be restricted during criminal procedural activities in forms prescribed by law. Such a restriction will be considered lawful and justified in a democratic society, provided that the interference meets the set of criteria established by the practice of the ECHR. The storage of biological material outside the scope of criminal proceedings is, in some cases, justified to safeguard public interests in a democratic society; however, under certain conditions, it may conflict with the principles of the presumption of innocence and the right to privacy.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"448-455"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between chronic diseases and lifestyle: A comparative study between two groups.","authors":"Ahmed D Salman, Zahid J Mohammed","doi":"10.36740/WLek/201199","DOIUrl":"10.36740/WLek/201199","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To identify lifestyle factors associated with chronic diseases and explore the biological mechanisms linking these behaviors to disease development.</p><p><strong>Patients and methods: </strong>Materials and Methods: A quasi-experimental design was used to compare a study group receiving the program to a control group. Data was collected through questionnaires and analyzed statistically.</p><p><strong>Results: </strong>Results: Participants in the study group showed significant improvements in healthy lifestyle behaviors compared to the control group. The study found that the program significantly improved health behaviors (p < 0.01, r > 0.6), highlighting the importance of targeted interventions for chronic disease prevention.</p><p><strong>Conclusion: </strong>Conclusions: The study highlights the effectiveness of lifestyle interventions in promoting healthier behaviors among chronic disease patients. Future research can explore the impact of socioeconomic factors on health behaviors to develop targeted interventions.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"367-375"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of INSR (rs2229429) G>A genetic polymorphism on response to exogenous insulin in type 1 diabetic Iraqi patients.","authors":"Farah Ali ALQuraishi, Mohammed Ibrahim Rasool","doi":"10.36740/WLek/199949","DOIUrl":"10.36740/WLek/199949","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To examine prevalence of genotypic distribution, particularly assessing how genetic polymorphisms in Insulin Receptor gene influence effectiveness of insulin therapy in a sample of Iraqi population.</p><p><strong>Patients and methods: </strong>Materials and Methods: Effect of Single Nucleotide Polymorphisms rs2229429 G>A have been investigated in 99 T1DM individuals, with a mean age of 12.3 years. These patients were managed with exogenous insulin through a basal-bolus monotherapy regimen. Genotyping was performed using an allele-specific polymerase chain reaction technique, and the data were statistically analyzed.</p><p><strong>Results: </strong>Results: The prevalence of the minor allele frequency is 12% in a sample of Iraqi population. Homozygous mutant carriers of rs2229429 G>A were 10.479 times at higher risk for developing poor glycemic control (HbA1c >86 mmol/mol) compared to wild genotype in type 1 diabetes mellitus, p=0.008. Ultimately poor responders to exogenous insulin, demonstrating significantly higher plasma insulin receptors levels p<0.001.</p><p><strong>Conclusion: </strong>Conclusions: The investigated Single Nucleotide Polymorphisms is significantly associated with hyperglycemia in type 1 diabetes mellitus and contributes to the development of double diabetes.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"71-81"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomorphological characteristics of the nasopharyngeal mucosa in children with acute respiratory infections.","authors":"Olesya M Horlenko, Iryna Yu Pikina, Olga A Pushkarenko, Oksana O Korchynska, Iryna M Boysak, Ivan I Pushkash, Halyna M Beley","doi":"10.36740/WLek/203896","DOIUrl":"https://doi.org/10.36740/WLek/203896","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study aims to investigate the relationships between cytomorphological markers of pathological processes and the development of acute respiratory infections in children.</p><p><strong>Patients and methods: </strong>Materials and Methods: A microbiological study was conducted to identify pathogens based on their morphological, cultural, and biochemical properties using nasopharyngeal swabs. Pure culture isolation and subsequent colonization were performed on standard nutrient media. Cytological studies were carried out using electron microscopy.</p><p><strong>Results: </strong>Results: A total of 114 strains of conditionally pathogenic microorganisms were identified, including 33 strains (29.0%) of Gram-positive bacteria (Streptococcus pyogenes, Staphylococcus aureus, Enterococcus faecalis) and 81 strains (71.0%) of Gram-negative bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli). Escherichia coli (37.0%) and Staphylococcus aureus (21.0%) were the predominant pathogens. The study identified key metabolic markers, including sucrose (n=69), maltase (n=87), and lactoperoxidase (n=89), with lactoperoxidase showing the highest levels. Aminoacids and alcohols were analyzed to assess their role in the inflammatory response. Electron microscopy confirmed bacterial localization within epithelial cells and extracellular areas, with morphological signs of epithelial cell destruction, including nuclear degradation and increased vascularization.</p><p><strong>Conclusion: </strong>Conclusions: The findings highlight the significant role of nasopharyngeal microbiota in respiratory infections and their correlation with inflammation markers. The high prevalence of Gram-negative bacteria, particularly Escherichia coli and Staphylococcus aureus, underscores the need for targeted prevention and treatment strategies. Understanding the cytomorphological and biochemical changes in the nasopharyngeal mucosa contributes to a better comprehension of pathogen-host interactions in respiratory infections.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"853-859"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of the clinical application of modern adhesive protocols for ceramic restorations (literature review).","authors":"Anatoliy Potapchuk, Vasyl Almashi, Viktoria Demidowa, Nazar Basarab","doi":"10.36740/WLek/203905","DOIUrl":"https://doi.org/10.36740/WLek/203905","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To analyze the well-known physicomechanical and clinical properties of modern adhesive systems, explore the latest trends and approaches to their improvement, and assess the prospects for the further development of restorative dentistry.</p><p><strong>Patients and methods: </strong>Materials and Methods: A comprehensive search for relevant publications related to the topic was conducted using scientific databases such as Scopus, PubMed, BVS, and Scielo.</p><p><strong>Conclusion: </strong>Conclusions: The standardization of knowledge regarding tooth tissue preparation, adhesive application techniques, as well as potential errors and complications, will contribute to enhancing the quality of dental care and elevating it to a new level.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"921-929"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the influence of medication properties and lifestyle of patients with coronary heart disease on adherence to treatment.","authors":"Maryna M Dolzhenko, Natalia A Bilousova, Vasyl M Mykhalchuk, Natalia O Tkachenko, Yuliya O Luchinskaya","doi":"10.36740/WLek/203897","DOIUrl":"https://doi.org/10.36740/WLek/203897","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate how lifestyle factors of patients with CHD and comorbid conditions, along with medicines properties, influence treatment adherence.</p><p><strong>Patients and methods: </strong>Materials and Methods: include the results of a survey conducted among patients with CHD and comorbid conditions at the Department of Cardiology of the P.L. Shupyk National Healthcare University of Ukraine from June to September 2024 (n = 101). The study employed methods of analysis, synthesis, deduction, induction, comparison, statistical and bibliographic research.</p><p><strong>Results: </strong>Results: The study revealed a significantly low adherence rate of 13.9% [CI 95% 13.9 ± 0.002; p<0.0001] to risk factor modification and prescribed pharmacotherapy in secondary prevention of CHD. It confirmed a statistically significant influence of patient preferences with CHD and comorbid conditions on effective pharmacotherapy (χ2 = 3.350,232, p = 0.067). Patients receiving consultations from both doctors and pharmacists were 22 times more likely (OR = 22.67) to adhere to pharmacotherapy compared to those consulting only doctors. The study found that only 7.8% [CI 95% 7.8 ± 0.05; p<0.0001] of surveyed patients with CHD and comorbid conditions such as hypertension, diabetes mellitus and chronic kidney disease utilized the \"Affordable Medicines\" program.</p><p><strong>Conclusion: </strong>Conclusions: The decline in the socioeconomic status of the population during the war in Ukraine negatively affects adherence to clinical guidelines for risk factor modification and secondary prevention of CHD, as evidenced by observational studies EUROASPIRE IV and V. The study identified that 42.8% of respondents prefer original medicines when selecting medications, but financial constraints prevent prolonged use as part of prescribed pharmacotherapy, adversely affecting treatment adherence. The effectiveness of a multidisciplinary approach in enhancing treatment adherence among patients with CHD and comorbid conditions was confirmed, demonstrating a 22-fold higher adherence rate compared to consultations with doctors alone.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"860-875"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological studies of changes in dental hard tissues following different methods of dental deposit removal.","authors":"Valentyna M Kulygina, Roman S Arshynnikov, Myroslava S Drohomyretska, Olha Yu Pylypiuk, Nataliia G Gadzhula, Halyna M Poberezhna, Natalya Polyanyk","doi":"10.36740/WLek/203844","DOIUrl":"https://doi.org/10.36740/WLek/203844","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To study structural changes in hard tooth tissues after manual, ultrasonic, and sonic methods of removing dental deposits and identifying the most rational method for various supragingival deposits.</p><p><strong>Patients and methods: </strong>Materials and Methods: Eight patients with supragingival deposits were examined, and eight teeth planned for extraction due to orthodontic or surgical indications: three teeth with dental plaque, three with mineralized deposits, and two with smoker's plaque. Of the three patients with dental plaque, one underwent manual scaling, another ultrasonic scaling, and the third sonic scaling. Similarly, among the three patients with dental calculus, manual, ultrasonic, and sonic scaling were performed. In the two patients with smoker's plaque, ultrasonic and sonic scaling were applied. After tooth extraction, morphological studies were conducted.</p><p><strong>Results: </strong>Results: Manual scaling of dental plaque left residual deposits and damaged enamel surfaces. For dental calculus, minimal residual deposits and relatively intact enamel were observed. Ultrasonic scaling caused microscopic changes: destruction of enamel prisms, partial fragmentation of the reticular layer in teeth with plaque, partial destruction of superficial enamel layers, thickening of the reticular layer with PAS-positive vegetations in teeth with calculus. In teeth with smoker's plaque, enamel prism destruction, hyperplasia, and reticular layer fragmentation were observed. Sonic scaling caused more pronounced destructive changes.</p><p><strong>Conclusion: </strong>Conclusions: Manual scaling is the most rational method for supragingival mineralized deposits, while the air-abrasive method is preferred for non-mineralized deposits and smoker's plaque. The destructive changes caused by ultrasonic scaling limit its clinical applicability. Sonic scaling is unsuitable for removing dental debris due to its aggressiveness.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"717-725"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}