Wiadomosci lekarskie最新文献

Effects of (EGFR-Her1) with continuous illumination on the immunohistochemical and histomorphometric changes of sublingual glands in male mice.

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/199948

Noor Kadhiam Jawad, Umalbaneen Hilal Hadi, Zahra Ismail Abdel-Hussein, Haider Abdulrasool Jaafar

{"title":"Effects of (EGFR-Her1) with continuous illumination on the immunohistochemical and histomorphometric changes of sublingual glands in male mice.","authors":"Noor Kadhiam Jawad, Umalbaneen Hilal Hadi, Zahra Ismail Abdel-Hussein, Haider Abdulrasool Jaafar","doi":"10.36740/WLek/199948","DOIUrl":"10.36740/WLek/199948","url":null,"abstract":"Objective: Aim: To evaluate the effects of constant light on the histological, histomorphometric and expression of EGFR of sublingual.Patients and methods: Materials and Methods: 20 male mice were applied and classified in to group A was kept in continuous light and control group B was kept in the normal daily variance for 45 days.Results: Results: Group A changes in behavior they become irritable, aggressive, loss of appetite, lethargic& lose weight. Histological examination with H&E showed degeneration of the sublingual tissue, loss architecture and necrosis (acini and ducts), the distraction of cell membrane and vacuolization, loss of nuclei in the necrotic tissue about 60%. Histomorphometric revealed significant differences in acini diameter between groups (p≤0.001). The mean of group A was 116.5960± 3.41668 compared with B group was 340.2720 ± 6.95821. Immunohistochemistry technique by used EGFR antibody in group A revealed expression evaluated as 0.8362±0.00822 increase in values in comparison with group B 0.6988 ± 0.02489.Conclusion: Conclusions: Light has an indirect oxidative stress effects that causes oxidative damage to glands, which affects mucin secretion. Therefore, there was a decrease in diameter of acini sublingual glands of light group than control group, however, there was increase in the expression EGFR of sublingual glands in light group compare with control group as compensatory mechanism for oxidative stress in glands by light.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"53-60"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of honey in dentistry - literature review.

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/199734

Karol Demel, Justyna Talaska, Monika Dziedzic, Jakub Król, Zuzanna Szatkowska, Olga Odrzywolska, Wojciech Niemczyk, Anna Zawilska

引用次数: 0

The right to life. 生命权。

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/197134

Anastasiia Mernyk, Oleh Hyliaka, Viktoriia Sheverdina

{"title":"The right to life.","authors":"Anastasiia Mernyk, Oleh Hyliaka, Viktoriia Sheverdina","doi":"10.36740/WLek/197134","DOIUrl":"10.36740/WLek/197134","url":null,"abstract":"Objective: Aim: The article is devoted to the study of the right to life as a key aspect of legal theory. The purpose of the study is to examine the theoretical aspects of the right to life, to analyze its essence, place and significance in the system of general human rights; to outline the main principles and concepts related to the right to life, to consider their evolution in different legal systems and to discuss important ethical aspects related to this topic.Patients and methods: Materials and Methods: The article examines the right to life, defines its place in the modern world, highlights the issues of correlation between this right and the right to abortion and euthanasia, and assesses the prospects for their realization. The empirical basis of the study is grounded on articles by scholars and assessments by leading experts in the field. The authors used general scientific methods, including system analysis, system modeling, and the dialectical method. To demonstrate the relationship between the right to life of an unborn child and a woman's right to abortion, a social survey was conducted among different population groups.Conclusion: Conclusions: Analyzing the right to life in the context of its interrelationship with other human rights, such as the right to liberty, the right to health and the right to a fair trial, helps to affirm the principles of the rule of law and ensure equality before the law for all. In the modern world, the concept of the right to life has become an important element of international law, which covers not only physical existence, but also the provision of a decent and quality life, health, education and social protection. Cultural and religious aspects play a significant role in shaping the understanding of the right to life. Different religious and cultural traditions have their own interpretations of the beginning and end of life, influencing attitudes to aspects related to medical interventions, abortion, euthanasia and other issues.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"197-209"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of deficiency of natural anticoagulants on clinical heterogeneity of rheumatoid arthritis.

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/200316

Olena V Solyeyko, Mariia O Chernykh, Olena Y Galiutina, Inna P Kuvikova, Iryna B Romash, Oleg V Fedorchenko, Larysa P Soleiko

{"title":"Effect of deficiency of natural anticoagulants on clinical heterogeneity of rheumatoid arthritis.","authors":"Olena V Solyeyko, Mariia O Chernykh, Olena Y Galiutina, Inna P Kuvikova, Iryna B Romash, Oleg V Fedorchenko, Larysa P Soleiko","doi":"10.36740/WLek/200316","DOIUrl":"10.36740/WLek/200316","url":null,"abstract":"Objective: Aim: To investigate the concentration of natural anticoagulants protein C (PC) and tissue plasminogen activator (t-PA) in patients with rheumatoid arthritis (RA) and to evaluate the effect of their concentration on the course of the disease.Patients and methods: Materials and Methods: We examined 74 patients with RA. There were 15 men and 59 women and control group consisted of 27 subjects. The average age of the patients was 47.3±1.12 years. Laboratory (PC, t-PA, C-reactive protein, TNF-alpha, von Willebrand factor, and lipid profile) and instrumental (ultrasonography and Doppler) examinations were performed.Results: Results: PC deficiency was significantly more common among men with RA (26.6%), but did not depend on the age and the duration of the disease (p<0.05). PC deficiency correlates with the degree of activity of the inflammatory process (r = -0.27) and TNF-alpha (r = -0.37). The levels of PC and t-PA were associated with the level of cholesterol (r = -0.25), LDL-C (r = -0.31), and HDL-C (r = 0.31). In patients with PC and t-PA deficiency, significantly higher (by 19% and 12%, respectively) serum levels of Von Willebrand factor were recorded than in patients with normal levels (p<0.05).Conclusion: Conclusions: The study of PС and t-PA revealed a deficiency of important natural anticoagulants, that helps us to expand the understanding of the mutually aggravating effect of the deficiency of these compounds and changes in known biologically active substances on the course of RA, and to supplement the pathogenetic picture of RA with certain links.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients 'satisfaction and views about pharmacists in community pharmacies as healthcare providers in Iraq: Najaf province.

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/199947

Helen F Marzooq, Yahiya Ibrahim Yahiya, Ali M Jaafar Abdulsahib

{"title":"Patients 'satisfaction and views about pharmacists in community pharmacies as healthcare providers in Iraq: Najaf province.","authors":"Helen F Marzooq, Yahiya Ibrahim Yahiya, Ali M Jaafar Abdulsahib","doi":"10.36740/WLek/199947","DOIUrl":"10.36740/WLek/199947","url":null,"abstract":"Objective: Aim: To assess the level of patient satisfaction and their opinions about the services provided by community pharmacists and their changes depending on the socio-demographic characteristics that influence the level of satisfaction and expectations of patients served in the city of Al-Najaf Al-Ashraf city of Iraq.Patients and methods: Materials and Methods: A structured questionnaire was allocated among patients who were staying pharmacies regarding aspects like accessibility, communication, and quality of services. A descriptive cross-sectional survey was executed utilizing a questionnaire that encompassed various dimensions of pharmaceutical services. The sample population comprised 449 patients who frequented a range of pharmacies with varying regularity within the province.Results: Results: A significant majority of individuals exhibit a favorable perception regarding community pharmacists in Al-Najaf Al-Ashraf, with patients articulating substantial satisfaction, recognition, and esteem for the contributions that pharmacists make within the healthcare team.Conclusion: Conclusions: Pharmacists play a vital role in providing pharmaceutical care, and patients generally express satisfaction with their services. However, there is a significant need for additional initiatives to enhance the clinical skills of community pharmacists, identify factors affecting patient satisfaction, and conduct comparative research on pharmacy services in different regions of Iraq.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"100-109"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the psychological well-being among adolescent and children.

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/197184

Adil Ali Hussein, Amer Abdullah Sachit, Hajer S Essa

{"title":"Assessing the psychological well-being among adolescent and children.","authors":"Adil Ali Hussein, Amer Abdullah Sachit, Hajer S Essa","doi":"10.36740/WLek/197184","DOIUrl":"10.36740/WLek/197184","url":null,"abstract":"Objective: Aim: To assess the psychological well-being of children and adolescents, socio demographic distribution data of parents and children and to find out the relationship between psychological well-being of children and adolescents and their socio demographic characteristics.Patients and methods: Materials and Methods: A descriptive cross- sectional study to assess the psychological well-being of children and adolescents in AI-Nasiriyah schools. The study period was extended (from December 1, 2023 to April 1, 2024). A non- probability (purposive sample) consist of (200) children and adolescents.Results: Results: Results revealed That children and adolescent in current study have moderate levels of Psychological Well-Being, our study revealed that is significant correlation (between participants' age and Psychological Well-being, difference in psychological wellbeing between history of school fail, difference in psychological Well-being among between mother educational groups and difference in Psychological well-being among father job groups) and no statistically Significant ( between difference psychological well-being and school history, difference in psychological well- being Among socioeconomic status groups, difference in psychological well-being among father level of education Groups and difference in psychological wellbeing among father job groups).Conclusion: Conclusions: Study provides valuable insights into factors influencing the psychological well- being of children and adolescents, highlighting the complex interaction between age, social status, parental education, and parental occupation. Academic performance and school experiences play a significant role in psychological well-being, especially in cases of academic failure.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"130-135"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and surgical treatment of tracheal cicatricial stenoses: literature review.

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/197144

Valeriy Boyko, Vasyl Kritsak, Anastasiia Sochnieva, Volodymir Tkachenko

{"title":"Diagnosis and surgical treatment of tracheal cicatricial stenoses: literature review.","authors":"Valeriy Boyko, Vasyl Kritsak, Anastasiia Sochnieva, Volodymir Tkachenko","doi":"10.36740/WLek/197144","DOIUrl":"10.36740/WLek/197144","url":null,"abstract":"Objective: Aim: To study of the data about the results of tracheal cicatricial stenoses treatment with the goal of further improvement of its results on the basis of diagnosis enhancing, identification of factors of prognosis of the disease and by conducting a differential analysis of tactics of surgical treatment with the use of minimally invasive interventions.Patients and methods: Materials and Methods: We have identified contemporary literature sources on the topic of modern directions of treatment of tracheal cicatricial stenoses and their complications. The studied material has been summarized and represented in the form of literature review in this article.Conclusion: Conclusions: To increase the quality of treatment of patients with tracheal cicatricial stenoses and their surgical complications an important role is played by objective formation of groups at risk of complications development and prognosis of the disease dynamics. Successful solution of the problem is related mostly to the highly informative diagnostics, reliable determination of severity of disease, as well creation of multidirectional classification of tracheal cicatricial stenoses. These issues may not be considered completely solved, they require further study. All of the above dictates search of new effective methods of treatment of the indicated pathology and proves relevance of the topic. The stated information emphasizes necessity of improvement of surgical tactics of patients with tracheal cicatricial stenoses.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"177-186"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Socio-psychological causes and consequences of combat stress in armed conflict participants.

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/197120

Andrii O Fedyk, Olha A Valchuk, Ivan M Okhrimenko, Tetiana V Danylchenko, Iryna O Bets, Lesia O Balahur, Artem G Brykovskyi

{"title":"Socio-psychological causes and consequences of combat stress in armed conflict participants.","authors":"Andrii O Fedyk, Olha A Valchuk, Ivan M Okhrimenko, Tetiana V Danylchenko, Iryna O Bets, Lesia O Balahur, Artem G Brykovskyi","doi":"10.36740/WLek/197120","DOIUrl":"10.36740/WLek/197120","url":null,"abstract":"Objective: Aim: The aim is to determine the causes and consequences of combat stress in armed conflict participants.Patients and methods: Materials and Methods: The research involved 109 service members (under 30) who participated in the russian-Ukrainian war in 2022-2024 on a rotational basis for different durations (from 4 to 18 months). Research methods included theoretical analysis and generalization of literary sources, interviews, questionnaires, and statistical methods.Results: Results: The causes of combat stress in service members participating in military operations have been identified. It has been established that during the first rotation, service members most often suffer from being in conditions of constant threats (71.6 %), experience fear of death and injury (70.6 %), fear of killing a person (67.9 %), loud sounds (63.3 %) and lack of sleep (52.3 %). With the acquisition of combat experience, the frequency of these factors decreases. The research revealed the consequences of combat stress, which worsen depending on the duration of stay in a combat situation: increased aggressiveness (71.1 %), anxiety, fear (68.4 %), sleep problems (31.6 %), cognitive impairment (28.9 %), and psychosomatic disorders (26.3 %).Conclusion: Conclusions: Ensuring military personnel's access to qualified psychological assistance, creating a support and rehabilitation program, and raising public awareness of the problems faced by service members participating in combat operations will reduce the negative effects of combat stress and help improve the quality of life of military personnel and their families.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"82-89"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extrinsic black staining of teeth: a review.

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/197130

Inessa I Yakubova, Volodymyr Ostrianko, Yurii Skrypnyk, Roman Volovodovskiy

{"title":"Extrinsic black staining of teeth: a review.","authors":"Inessa I Yakubova, Volodymyr Ostrianko, Yurii Skrypnyk, Roman Volovodovskiy","doi":"10.36740/WLek/197130","DOIUrl":"10.36740/WLek/197130","url":null,"abstract":"Objective: Aim: Discovering of the prevalence, causes and consequences of the Extrinsic black staining(EBS) of teeth in pediatric population.Patients and methods: Materials and Methods: Upon completion of the scientific search, the review included 47 scientific articles from the electronic databases, reference lists of articles, and selected textbooks in the time interval from 1976 to 2023.Conclusion: Conclusions: The results show that EBS is a possible protective factor against early childhood caries. Dental plaque and gut microbiome may be related to EBS in the temporary dentition. The literature suggests a decreased caries prevalence in the presence of EBS which associated with low incidence of caries in children. The nature of the black pigmentation is suggested to be a form of bacterial plaque with an insoluble ferric salt. Tabaco smoke, food and antibiotics that can be also a risk factors for EBS. There are some clinical and localization features that dentist have to pay attention for. Many diseases of various systems and organs are directly related to black plaque. With this review, we wanted to encourage dentists to identify the problem in childhood and collaborate in a multidisciplinary team to improve treatment efficiency and speed up the selection of the right tactics for the most person-centered approach to avoid worsening the problem in adulthood.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"210-215"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From efficacy to adversity: understanding the side effects of antidepressants - systematic review.

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/197143

Vasyl Hrabar, Taras Studeniak, Mariana Pryima, Vitalii Kondratskyi

{"title":"From efficacy to adversity: understanding the side effects of antidepressants - systematic review.","authors":"Vasyl Hrabar, Taras Studeniak, Mariana Pryima, Vitalii Kondratskyi","doi":"10.36740/WLek/197143","DOIUrl":"10.36740/WLek/197143","url":null,"abstract":"Objective: Aim: To investigate how and why antidepressant side effects occur, in order to use them effectively in clinical practice.Patients and methods: Materials and Methods: We have studied modern literary sources on the topic of side effects of antidepressant and presented in the form of a literature review in this article. Electronic Scopus and Pubmed databases were searched for articles on the studied topic. The review included original articles, research, and official recommendations from medical associations.Conclusion: Conclusions: Side effects of antidepressants can reduce treatment adherence and delay recovery. Therefore, it is extremely important to consider possible side effects when choosing a therapy. While there is no perfect antidepressant that works quickly and is completely free of side effects, newer antidepressants are safer, better tolerated, and associated with lower rates of treatment failure. Most side effects occur as a consequence of the basic mechanism of action of the drugs. Therefore, it is important to understand the neurobiology of side effects, their frequency and risks, ways to prevent them or use them to your advantage resources.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"187-196"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0