Wiadomosci lekarskie最新文献

{"title":"Effects of (EGFR-Her1) with continuous illumination on the immunohistochemical and histomorphometric changes of sublingual glands in male mice.","authors":"Noor Kadhiam Jawad, Umalbaneen Hilal Hadi, Zahra Ismail Abdel-Hussein, Haider Abdulrasool Jaafar","doi":"10.36740/WLek/199948","DOIUrl":"10.36740/WLek/199948","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To evaluate the effects of constant light on the histological, histomorphometric and expression of EGFR of sublingual.</p><p><strong>Patients and methods: </strong>Materials and Methods: 20 male mice were applied and classified in to group A was kept in continuous light and control group B was kept in the normal daily variance for 45 days.</p><p><strong>Results: </strong>Results: Group A changes in behavior they become irritable, aggressive, loss of appetite, lethargic& lose weight. Histological examination with H&E showed degeneration of the sublingual tissue, loss architecture and necrosis (acini and ducts), the distraction of cell membrane and vacuolization, loss of nuclei in the necrotic tissue about 60%. Histomorphometric revealed significant differences in acini diameter between groups (p≤0.001). The mean of group A was 116.5960± 3.41668 compared with B group was 340.2720 ± 6.95821. Immunohistochemistry technique by used EGFR antibody in group A revealed expression evaluated as 0.8362±0.00822 increase in values in comparison with group B 0.6988 ± 0.02489.</p><p><strong>Conclusion: </strong>Conclusions: Light has an indirect oxidative stress effects that causes oxidative damage to glands, which affects mucin secretion. Therefore, there was a decrease in diameter of acini sublingual glands of light group than control group, however, there was increase in the expression EGFR of sublingual glands in light group compare with control group as compensatory mechanism for oxidative stress in glands by light.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"53-60"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of serum levels of calprotectin, lactoferrin and zinc in patients with type II diabetes mellitus.","authors":"Hayder Neamah Hassan, Shaymaa Galeel Shamran, Majid A Z Albadry, Ali A Al Fahham","doi":"10.36740/WLek/201198","DOIUrl":"https://doi.org/10.36740/WLek/201198","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The current study aimed to evaluate the role of serum calprotectin, lactoferrin and serum zinc in patients with type II diabetes mellitus.</p><p><strong>Patients and methods: </strong>Materials and Methods: Sixty subjects have been investigated in this study, (40) patients with T2DM and 20 apparently healthy participants (control group) during the period between October 2021 to January 2022. Zinc was measured using a calorimetric method, while calprotectin and lactoferrin were measured by ELISA.</p><p><strong>Results: </strong>Results: The findings also revealed that levels of serum calprotectin and lactoferrin have significantly increased in in patients with T2DM as compared to healthy subjects. The result also showed that serum zin is decreased in patients groups. The correlation matrix exhibited that there was a strong positive correlation between calprotectin and lactoferrin, a significant negative correlation between zinc and calprotectin.</p><p><strong>Conclusion: </strong>Conclusions: It was concluded that high serum calprotectin and lactoferrin indicated a strong inflammatory status in T2DM patients. Zinc is likely to be negative affected by the high inflammatory response indicated by that high serum calprotectin.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"288-294"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of systemic osteoporosis on the bone structure of the alveolar processes.","authors":"Maksym A Datsenko, Yurii L Bandrivsky, Pavlo P Perebyjnis","doi":"10.36740/WLek/196443","DOIUrl":"https://doi.org/10.36740/WLek/196443","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Review and analysis of contemporary professional literature on the impact of systemic osteoporosis on the bone structure of the alveolar processes, with a particular focus on the pathogenetic mechanisms of disorders of bone remodelling processes.</p><p><strong>Patients and methods: </strong>Materials and Methods: The bibliosemantic method was used to clarify the state of the problem, to study the analysis of the results of previous scientific research based on the sources of literature and electronic resources.</p><p><strong>Conclusion: </strong>Conclusions: Thus, the literature shows that the resorptive processes associated with osteoporosis not only alter the bones of the supporting and peripheral skeleton, but also alter the structure of the bone tissue of the jaw. The introduction of a pathogenesis-based approach to treatment will allow significant progress to be made in the dental care of patients with primary osteoporosis. Given the high prevalence of osteoporosis in patients of various profiles, the role of the dentist in the diagnosis and correction of this pathology is becoming increasingly important. It is of particular importance to direct attention to older patients, given the increased risk of developing postmenopausal and senile osteoporosis.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"410-414"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterine Leiomyoma in women of reproductive age: A systematic review.","authors":"Tetiana V Fartushok, Vladyslav Smiianov, Halyna Semenyna, Nadiia Fartushok","doi":"10.36740/WLek/195321","DOIUrl":"https://doi.org/10.36740/WLek/195321","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The objective of this literature review was to determine the current aspects of the clinic, diagnosis and treatment of uterine leiomyoma in women of reproductive age.</p><p><strong>Patients and methods: </strong>Materials and Methods: Pubmed, Google Scholar, Web of Science, and Scopus databases were used to search for materials on current aspects of the clinic, diagnosis, and treatment of uterine leiomyoma in women of reproductive age.</p><p><strong>Conclusion: </strong>Conclusions: Women who have a pregnancy in the background of leiomyomas of the uterus, constitute a high-risk group for the occurrence of obstetric and perinatal complications, therefore, in the most dangerous periods of pregnancy, hospitalization in a specialized obstetrical hospital is recommended. It is advisable to exclude the tactics of passive surveillance of women of childbearing age with leiomyoma of the uterus. Women of childbearing age with leiomyoma of the uterus are recommended to carry out organ-preserving operations in the volume of leiomyomectomy in order to preserve the reproductive function of the woman.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"415-424"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of honey in dentistry - literature review.","authors":"Karol Demel, Justyna Talaska, Monika Dziedzic, Jakub Król, Zuzanna Szatkowska, Olga Odrzywolska, Wojciech Niemczyk, Anna Zawilska","doi":"10.36740/WLek/199734","DOIUrl":"10.36740/WLek/199734","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To assess the effects of honey and its derivatives on oral health.</p><p><strong>Patients and methods: </strong>Materials and methods: PubMed, Google Scholar, Scopus, Embase, Cochrane databases were searched using relevant keywords and Boolean operators.</p><p><strong>Conclusion: </strong>Conclusions: Honey is a promising natural alternative for the treatment of various dental diseases due to its antimicrobial, anti-inflammatory and wound-healing properties. Scientific studies show that honey has numerous health properties, including antibacterial, antiviral, anti-inflammatory, wound-healing and anticancer effects. In the context of dentistry, honey shows potential in the treatment of various oral conditions, such as dental caries, gingivitis, halitosis, radiotherapy-induced mucositis, xerostomia or post-extraction stomatitis. Honey's safety and multifunctional benefits make it a valuable potential addition to dental treatments.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"156-161"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, treatment and diagnosis of Hepatitis C virus infections.","authors":"Nisreen Jawad Kadhim, Laith M Abbas Al-Huseini, Fadhl Alzamili, Ali Mansoor Al Ameri","doi":"10.36740/WLek/202252","DOIUrl":"https://doi.org/10.36740/WLek/202252","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Studding several aspects of Hepatitis C virus infection, such as epidemiology, prevalence, diagnosis, and outcome of patients with hepatitis C infection.</p><p><strong>Patients and methods: </strong>Materials and Methods: Systematic review of electronic medical records and epidemiological data and risk factors for Hepatitis C virus infection in patients evaluated in relevant studies.</p><p><strong>Conclusion: </strong>Conclusions: Hepatitis C virus serology and viral genotyping. Hepatitis B may be associated with risk factors such as perinatal infection, kidney disease, dialysis, intravenous or percutaneous drug use, occupational factors, suddenly local population factors of hepatitis transmission and pay children. These young and vulnerable cultures bear the enormous social, economic, and political costs of Hepatitis C virus infection. Therefore, to combat the effects of Hepatitis C at regional and national levels, specific intervention approaches and policies are needed.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"469-473"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological condition of the skin following a 4-week opioid exposure in an experimental study.","authors":"Ivan S Diskovskyi, Orysya O Syzon, Lesya R Mateshuk Vatseba, Marta A Kolishetska, Marianna O Dashko, Iryna Ya Vozniak, Iryna O Chaplyk-Chyzho","doi":"10.36740/WLek/201322","DOIUrl":"https://doi.org/10.36740/WLek/201322","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The study aimed to determine the peculiarities of the micro- and ultrastructural organization of the skin under conditions of a four-week administration of an opioid to experimental animals.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study material included skin samples of white rats with injected vascular beds, histological preparations, and ultrathin skin sections. The research methods involved injection techniques, histological analysis, electron microscopy, morphometric measurements, and statistical analysis.</p><p><strong>Results: </strong>Results: The results of the study revealed that after four weeks of nalbuphine administration to experimental animals, blood stasis was observed in the lumen of the capillaries and venules, along with perivascular edema and perivascular infiltrates consisting of neutrophils, lymphocytes, macrophages, and tissue basophils. The electron density of the nuclei and cytoplasm of the granular layer keratinocytes was reduced, keratinocytes in the stratum spinosum acquired a rounded shape, with some nuclei appearing shrunken and hyperchromatic, and their cytoplasm exhibiting vacuolization. In the reticular layer, thickened bundles of collagen fibers were observed, with localized swelling and fragmentation of the collagen fibers. Excessive formation of scales was noticed in the stratum corneum. The papillary layer of the dermis contained numerous mast cells and lymphocytes near blood vessels. The shape of sebaceous and sweat gland cells was altered, with swollen cytoplasm, and lymphohistiocytic infiltration was observed around them. A decrease (p<0.05) in the density of capillary loops in the subpapillary vascular plexus of the skin in the gluteal region of white rats after four weeks of nalbuphine administration, along with an increase (p>0.5) in the trophic activity index of the skin, confirms profound destructive changes in the vascular architecture of the skin.</p><p><strong>Conclusion: </strong>Conclusions: Four weeks of nalbuphine administration induces irreversible pathological processes in all skin components.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"347-352"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of maternal ABO blood group and malondialdehyde as diagnostic marker in the development of gestational diabetes mellitus.","authors":"Deema Diyaa Azeez, Sami R AlKatib","doi":"10.36740/WLek/197188","DOIUrl":"https://doi.org/10.36740/WLek/197188","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim of research is to assess whether various blood groups can be associated with the occurrence of gestational diabetes mellitus and if malondialdehyde can be used for the diagnosis of GDM.</p><p><strong>Patients and methods: </strong>Materials and Methods: A case control study started from September 2022 to June 2023 enrolled 200 pregnant women aged between 15-45 years, cases included 100 patients selectively collected with a confirmed diagnosis of gestational diabetes mellitus, and 100 were healthy normal in Kerbala obstetrics and gynecology hospital, both patient and controls group categorized according to blood group type.</p><p><strong>Results: </strong>Results: Pregnant women with gestational diabetes mellitus are mostly of blood group AB in comparison with pregnant women without Gestational diabetes mellitus, and both A and B were significantly higher among control pregnant women, additionally, two groups' blood group O levels were almost identical. Malondialdehyde mean was significantly higher in pregnant women with Gestational diabetes mellitus with p-values 0.001. Statistically significant differences could not be detected in the mean levels of MDA across the various blood groups (p= 0.505).</p><p><strong>Conclusion: </strong>Conclusions: This research reveals that mother's ABO blood group has a role in the development of GDM and the blood group AB is more likely to develop GDM, blood group A & B are less likely to develop GDM and may be regarded as a protective factor. MDA can be used for the diagnosis of GDM but further studies are required to support this finding.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"303-310"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The right to life.","authors":"Anastasiia Mernyk, Oleh Hyliaka, Viktoriia Sheverdina","doi":"10.36740/WLek/197134","DOIUrl":"10.36740/WLek/197134","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The article is devoted to the study of the right to life as a key aspect of legal theory. The purpose of the study is to examine the theoretical aspects of the right to life, to analyze its essence, place and significance in the system of general human rights; to outline the main principles and concepts related to the right to life, to consider their evolution in different legal systems and to discuss important ethical aspects related to this topic.</p><p><strong>Patients and methods: </strong>Materials and Methods: The article examines the right to life, defines its place in the modern world, highlights the issues of correlation between this right and the right to abortion and euthanasia, and assesses the prospects for their realization. The empirical basis of the study is grounded on articles by scholars and assessments by leading experts in the field. The authors used general scientific methods, including system analysis, system modeling, and the dialectical method. To demonstrate the relationship between the right to life of an unborn child and a woman's right to abortion, a social survey was conducted among different population groups.</p><p><strong>Conclusion: </strong>Conclusions: Analyzing the right to life in the context of its interrelationship with other human rights, such as the right to liberty, the right to health and the right to a fair trial, helps to affirm the principles of the rule of law and ensure equality before the law for all. In the modern world, the concept of the right to life has become an important element of international law, which covers not only physical existence, but also the provision of a decent and quality life, health, education and social protection. Cultural and religious aspects play a significant role in shaping the understanding of the right to life. Different religious and cultural traditions have their own interpretations of the beginning and end of life, influencing attitudes to aspects related to medical interventions, abortion, euthanasia and other issues.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"197-209"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of deficiency of natural anticoagulants on clinical heterogeneity of rheumatoid arthritis.","authors":"Olena V Solyeyko, Mariia O Chernykh, Olena Y Galiutina, Inna P Kuvikova, Iryna B Romash, Oleg V Fedorchenko, Larysa P Soleiko","doi":"10.36740/WLek/200316","DOIUrl":"10.36740/WLek/200316","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate the concentration of natural anticoagulants protein C (PC) and tissue plasminogen activator (t-PA) in patients with rheumatoid arthritis (RA) and to evaluate the effect of their concentration on the course of the disease.</p><p><strong>Patients and methods: </strong>Materials and Methods: We examined 74 patients with RA. There were 15 men and 59 women and control group consisted of 27 subjects. The average age of the patients was 47.3±1.12 years. Laboratory (PC, t-PA, C-reactive protein, TNF-alpha, von Willebrand factor, and lipid profile) and instrumental (ultrasonography and Doppler) examinations were performed.</p><p><strong>Results: </strong>Results: PC deficiency was significantly more common among men with RA (26.6%), but did not depend on the age and the duration of the disease (p<0.05). PC deficiency correlates with the degree of activity of the inflammatory process (r = -0.27) and TNF-alpha (r = -0.37). The levels of PC and t-PA were associated with the level of cholesterol (r = -0.25), LDL-C (r = -0.31), and HDL-C (r = 0.31). In patients with PC and t-PA deficiency, significantly higher (by 19% and 12%, respectively) serum levels of Von Willebrand factor were recorded than in patients with normal levels (p<0.05).</p><p><strong>Conclusion: </strong>Conclusions: The study of PС and t-PA revealed a deficiency of important natural anticoagulants, that helps us to expand the understanding of the mutually aggravating effect of the deficiency of these compounds and changes in known biologically active substances on the course of RA, and to supplement the pathogenetic picture of RA with certain links.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}