Wiadomosci lekarskie最新文献

{"title":"Use of honey in dentistry - literature review.","authors":"Karol Demel, Justyna Talaska, Monika Dziedzic, Jakub Król, Zuzanna Szatkowska, Olga Odrzywolska, Wojciech Niemczyk, Anna Zawilska","doi":"10.36740/WLek/199734","DOIUrl":"10.36740/WLek/199734","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To assess the effects of honey and its derivatives on oral health.</p><p><strong>Patients and methods: </strong>Materials and methods: PubMed, Google Scholar, Scopus, Embase, Cochrane databases were searched using relevant keywords and Boolean operators.</p><p><strong>Conclusion: </strong>Conclusions: Honey is a promising natural alternative for the treatment of various dental diseases due to its antimicrobial, anti-inflammatory and wound-healing properties. Scientific studies show that honey has numerous health properties, including antibacterial, antiviral, anti-inflammatory, wound-healing and anticancer effects. In the context of dentistry, honey shows potential in the treatment of various oral conditions, such as dental caries, gingivitis, halitosis, radiotherapy-induced mucositis, xerostomia or post-extraction stomatitis. Honey's safety and multifunctional benefits make it a valuable potential addition to dental treatments.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"156-161"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Casein phosphopeptide-amorphous- calcium phosphate's effect on enamel microhardness of teeth treated with nano silver in sodium fluoride solution.","authors":"Zinah Shakib Majeed, Mohammed Qays Mahmood Fahmi","doi":"10.36740/WLek/203072","DOIUrl":"https://doi.org/10.36740/WLek/203072","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To detect the effect of an experimental 0.7% nanosilver in sodium fluoride (NSSF) and compare it to that of 5% sodium fluoride (NaF) on demineralized teeth, also observes the impact of applying 10% Casein phosphopeptide-amorphous-calcium phosphate (CPP-ACP) on those groups and compares that to CPP-ACP's lone impact on demineralized teeth.</p><p><strong>Patients and methods: </strong>Materials and Methods: The sample consisted of 60 sound, premolar teeth without hypo-mineralization or cracks. They were divided into three groups following the formation of caries-like lesions using a Feather Stone pH cycle. Group No.1 was treated with NSSF, group No.2 was treated with NaF, and deionized water was used for Group No.3. All groups had two minutes of application time and were then stored for 24 hours in artificial saliva. After that, they were treated with CPP-ACP, for seven days twice a day. Microhardness measurements were carried out four times: before any intervention, after the pH cycle, after 24 hours from the application of NSSF and NaF, and a final one after seven days from the application of CPP-ACP on the previous groups. An XRF, XRD analysis, and particle size analyzer were used to confirm the nanosilver properties of the powder.</p><p><strong>Results: </strong>Results: There was a statistically significant increase in microhardness values (P<0.05) following CPP-ACP's application on teeth previously subjected to NSSF and NaF. The group that was subjected to deionized water before CPP-ACP's application revealed a statistically significant value (P<0.001).</p><p><strong>Conclusion: </strong>Conclusions: CPP-ACP enhances the microhardness and, hence, the mineralization of teeth previously treated with NSSF and NaF solutions.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"885-893"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Certain ethical issues that arise when using 3D bioprinting technology.","authors":"Viktor V Zaborovskyy, Olena V Ustych, Tereziia P Popovych, Vasil V Manzyuk","doi":"10.36740/WLek/203904","DOIUrl":"https://doi.org/10.36740/WLek/203904","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Theoretical and applied study of the ethical issues that arise when using three-dimensional printed bioproducts and their significance for the development of principles for the application of additive manufacturing technologies in medicine.</p><p><strong>Patients and methods: </strong>Materials and Methods: Various methods of scientific knowledge make up the methodological basis of on interdisciplinary approach, which includes a set of methods that allow us to investigate the technological, legal and social aspects of the application of 3D bioprinting, its potential, limitations and ethical challenges.</p><p><strong>Conclusion: </strong>Conclusions: Ethical principles are one of the foundations for ensuring the provision of proper medical care and medical services with the use of threedimensional printed bioproduct technologies at an appropriately high level, and are directly related to strict adherence to the principles and standards of additive manufacturing and bioethics, which are imposed on all participants (be it a doctor a 3D designer, a manufacturer of a 3D bioprinter, etc).</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"915-920"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of clinical flow of traumatic illness on a background chronic stress.","authors":"Stepan S Filip, Rudolf M Slivka, Andrii M Bratasiuk, Yuriy P Skrypynets, Antonina V Varvarynets","doi":"10.36740/WLek/203903","DOIUrl":"https://doi.org/10.36740/WLek/203903","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To focus on the dependence of the severity of the clinical features of traumatic illness on stress components and chronic stress in particular.</p><p><strong>Patients and methods: </strong>Materials and Methods: Analysis of data on the results of existing studies assessing the impact of chronic stress on the course of traumatic illness.</p><p><strong>Conclusion: </strong>Conclusions: The introduction of a therapeutic complex of immunotherapy and sedatives for traumatic illness with a pronounced stress component, with the possible development of severe complications, will make it possible to improve the results of treatment and rehabilitation of patients with traumatic illness.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"908-914"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological condition of the skin following a 4-week opioid exposure in an experimental study.","authors":"Ivan S Diskovskyi, Orysya O Syzon, Lesya R Mateshuk Vatseba, Marta A Kolishetska, Marianna O Dashko, Iryna Ya Vozniak, Iryna O Chaplyk-Chyzho","doi":"10.36740/WLek/201322","DOIUrl":"10.36740/WLek/201322","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The study aimed to determine the peculiarities of the micro- and ultrastructural organization of the skin under conditions of a four-week administration of an opioid to experimental animals.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study material included skin samples of white rats with injected vascular beds, histological preparations, and ultrathin skin sections. The research methods involved injection techniques, histological analysis, electron microscopy, morphometric measurements, and statistical analysis.</p><p><strong>Results: </strong>Results: The results of the study revealed that after four weeks of nalbuphine administration to experimental animals, blood stasis was observed in the lumen of the capillaries and venules, along with perivascular edema and perivascular infiltrates consisting of neutrophils, lymphocytes, macrophages, and tissue basophils. The electron density of the nuclei and cytoplasm of the granular layer keratinocytes was reduced, keratinocytes in the stratum spinosum acquired a rounded shape, with some nuclei appearing shrunken and hyperchromatic, and their cytoplasm exhibiting vacuolization. In the reticular layer, thickened bundles of collagen fibers were observed, with localized swelling and fragmentation of the collagen fibers. Excessive formation of scales was noticed in the stratum corneum. The papillary layer of the dermis contained numerous mast cells and lymphocytes near blood vessels. The shape of sebaceous and sweat gland cells was altered, with swollen cytoplasm, and lymphohistiocytic infiltration was observed around them. A decrease (p<0.05) in the density of capillary loops in the subpapillary vascular plexus of the skin in the gluteal region of white rats after four weeks of nalbuphine administration, along with an increase (p>0.5) in the trophic activity index of the skin, confirms profound destructive changes in the vascular architecture of the skin.</p><p><strong>Conclusion: </strong>Conclusions: Four weeks of nalbuphine administration induces irreversible pathological processes in all skin components.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"347-352"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of maternal ABO blood group and malondialdehyde as diagnostic marker in the development of gestational diabetes mellitus.","authors":"Deema Diyaa Azeez, Sami R AlKatib","doi":"10.36740/WLek/197188","DOIUrl":"10.36740/WLek/197188","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim of research is to assess whether various blood groups can be associated with the occurrence of gestational diabetes mellitus and if malondialdehyde can be used for the diagnosis of GDM.</p><p><strong>Patients and methods: </strong>Materials and Methods: A case control study started from September 2022 to June 2023 enrolled 200 pregnant women aged between 15-45 years, cases included 100 patients selectively collected with a confirmed diagnosis of gestational diabetes mellitus, and 100 were healthy normal in Kerbala obstetrics and gynecology hospital, both patient and controls group categorized according to blood group type.</p><p><strong>Results: </strong>Results: Pregnant women with gestational diabetes mellitus are mostly of blood group AB in comparison with pregnant women without Gestational diabetes mellitus, and both A and B were significantly higher among control pregnant women, additionally, two groups' blood group O levels were almost identical. Malondialdehyde mean was significantly higher in pregnant women with Gestational diabetes mellitus with p-values 0.001. Statistically significant differences could not be detected in the mean levels of MDA across the various blood groups (p= 0.505).</p><p><strong>Conclusion: </strong>Conclusions: This research reveals that mother's ABO blood group has a role in the development of GDM and the blood group AB is more likely to develop GDM, blood group A & B are less likely to develop GDM and may be regarded as a protective factor. MDA can be used for the diagnosis of GDM but further studies are required to support this finding.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"303-310"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, treatment and diagnosis of Hepatitis C virus infections.","authors":"Nisreen Jawad Kadhim, Laith M Abbas Al-Huseini, Fadhl Alzamili, Ali Mansoor Al Ameri","doi":"10.36740/WLek/202252","DOIUrl":"10.36740/WLek/202252","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Studding several aspects of Hepatitis C virus infection, such as epidemiology, prevalence, diagnosis, and outcome of patients with hepatitis C infection.</p><p><strong>Patients and methods: </strong>Materials and Methods: Systematic review of electronic medical records and epidemiological data and risk factors for Hepatitis C virus infection in patients evaluated in relevant studies.</p><p><strong>Conclusion: </strong>Conclusions: Hepatitis C virus serology and viral genotyping. Hepatitis B may be associated with risk factors such as perinatal infection, kidney disease, dialysis, intravenous or percutaneous drug use, occupational factors, suddenly local population factors of hepatitis transmission and pay children. These young and vulnerable cultures bear the enormous social, economic, and political costs of Hepatitis C virus infection. Therefore, to combat the effects of Hepatitis C at regional and national levels, specific intervention approaches and policies are needed.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"469-473"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone mineral density and pandemic.","authors":"Paweł I Kamińsk, Firoz Rizvi, Mateusz Trubalski, Mateusz Kaczmarski, Aleksandra Bełżek, Marta Żerebiec, Zuzanna Rupeć, Natalia Saj, Zeeshan Zulfiqar, Joanna Niezbecka-Zając","doi":"10.36740/WLek/202327","DOIUrl":"https://doi.org/10.36740/WLek/202327","url":null,"abstract":"<p><p>The COVID-19 pandemic has significantly impacted physical health, including bone mineral density (BMD). This review aims to explore the effects of various pandemic-related factors such as reduced physical activity, stress, depression, dietary changes, and SARS-CoV-2 infection on BMD. Methods involved analyzing studies that investigate the impact of these factors on bone health, including observational studies, systematic reviews, and meta-analyses. Results show that decreased physical activity, depression, and changes in diet lead to a reduction in BMD, particularly in the lumbar spine and femoral neck. SARS-CoV-2 infection and the use of corticosteroids are also associated with an increased risk of osteoporosis. Additionally, cytokine storms induced by the virus further exacerbate bone resorption. The review also highlights the complex interaction between obesity, sedentary behavior, and BMD, which may contribute to either increased BMD in certain areas or lead to a higher risk of fractures. The study suggests that the pandemic may have long-term effects on bone health, emphasizing the need for preventive strategies, including promoting physical activity, managing stress, and cautious use of medications like corticosteroids. Further research is needed to understand the long-term consequences and to develop therapeutic interventions aimed at mitigating the adverse skeletal effects of COVID-19 and its treatments. Understanding the lasting impact on bone health requires a comprehensive approach considering the multifactorial aspects of the pandemic's effect on human physiology.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"571-577"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytoestrogens in osteoporosis.","authors":"Mateusz Kaczmarski, Mateusz Trubalski, Paweł Kamiński, Marta Żerebiec, Aleksandra Bełżek, Natalia Saj, Zuzanna Rupeć, Joanna Niezbecka-Zając, Nataliia Fedorenko, Wojciech Kłapeć","doi":"10.36740/WLek/202326","DOIUrl":"https://doi.org/10.36740/WLek/202326","url":null,"abstract":"<p><p>This article explores the role of phytoestrogens in the prevention and treatment of osteoporosis, focusing on soy isoflavones, red clover, and other plants such as Epimedium, hops, fennel, and prunes. It reviews clinical trials examining the effects of these phytoestrogens on bone mineral density (BMD), bone turnover markers, and osteoporotic fracture risk. Various studies demonstrate that phytoestrogens, particularly those derived from soy and red clover, may help improve bone health, alleviate menopausal symptoms, and reduce the risk of fractures. However, results regarding their impact on BMD are inconsistent, with some trials showing positive effects and others showing no significant difference compared to placebo. The article emphasizes the need for further, more comprehensive research to assess the long-term efficacy, safety, and mechanisms of action of phytoestrogens, considering individual patient characteristics such as genetics, metabolism, and lifestyle factors. While phytoestrogens hold promise as a potential complement or alternative to conventional osteoporosis therapies, personalized approaches to supplementation, as well as more rigorous studies, are necessary to establish their clinical benefits and minimize risks.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"602-608"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foodstuffs for particular nutritional purposes and dietary supplements in the legal-medical context.","authors":"Rafał Patryn, Agnieszka Kowalska-Olczyk, Michał Sekuła, Joanna Niezbecka-Zając, Juliana Woszczyło","doi":"10.36740/WLek/202429","DOIUrl":"https://doi.org/10.36740/WLek/202429","url":null,"abstract":"<p><p>Foodstuffs for special dietary purposes are products that, due to their special method of preparation or composition, differ from common foodstuffs and are intended to meet the nutritional needs of specific groups of consumers, such as oncology patients. The indication for the use of these products is to provide the body with essential nutrients in the right proportions, thereby improving or maintaining the current state of health. Dietary supplements are also food products that contain vitamins and other substances, and their intake is aimed at helping to maintain specific nutrients in the human body at the appropriate level.Dietary supplements should be used under medical supervision and at a dosage determined by the body's needs. Both of the above-mentioned groups of nutritional products are gaining increasing popularity among consumers. Many of them, encouraged by the described health benefits, use and dose these products without consulting a doctor or pharmacist, often exceeding the recommended intake and even replacing a well-balanced diet, which can pose a serious health risk.These products, in combination with certain medications, can also pose a serious risk of adverse effects, especially in the elderly population taking multiple medications.Therefore, their use should be cautious, and in case of any doubts, it should be preceded by consultation with a doctor or pharmacist.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"559-564"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}