Wiadomosci lekarskie最新文献

{"title":"Gender dimorphism of neurodynamic and cognitive functions of sub-elite and elite athletes (on the example of sports acrobatics).","authors":"Nataliia Veronika Bachynska, Dmytro Anisimov, Oleksandr Zhuravel, Dmytro Kaznacheiev, Vadym Fursa, Nataliia Martynova, Liudmyla Lysenko","doi":"10.36740/WLek/197138","DOIUrl":"10.36740/WLek/197138","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To evaluate the impact of a specific acrobatic load on the neurodynamic and cognitive functions of acrobats, as well as to study how these functions change depending on the gender, age and level of sports qualification of athletes (sub-elite and elite athletes).</p><p><strong>Patients and methods: </strong>Materials and Methods: Athletes specializing in pair and group acrobatics, of two age categories: 1. Sub-elite - athletes of puberty age, which included: girls (n=32), average age 13.96±1.02 years; boys (n=36), average age 14.88±2.32 years. 2. Youth acrobats (elite athletes): girls (n=30), average age 19.36±2.86 years; young men (n=34), average age 20.38±2.89. The computer program \"Diagnost-1\" was used in researches.</p><p><strong>Results: </strong>Results: In female acrobats, the latency period of simple visual-motor information, the latent period of the visual-motor reaction to choosing two out of three stimuli are statistically different from those of young acrobats. Boys acrobats are faster in terms of functional mobility of nervous processes than girls in both age categories (at p<0.05). A greater amount of processed information was found in acrobat boys than in adolescent girls. According to the indicators of cognitive characteristics features of sexual dimorphism between acrobats of different age categories were revealed due to different information processing strategies taking into account sexual characteristics.</p><p><strong>Conclusion: </strong>Conclusions: Boys-acrobats of puberty and adolescence showed more effective processing of simple and complex visual-motor information compared to girls-acrobats of the same age categories. The indicators of neurodynamic and cognitive functions of young acrobats are better than those of pubescent athletes and different by gender (p<0.05).</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"61-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential cardioprotective effect of trimetazidine in mice model of endotoxemia: role of AMPK-Nrf2.","authors":"Alaa Kadhum Mosa, Sahar Majeed, Fadhaa Abdulameer Ghafil, Najah Rayish Hadi","doi":"10.36740/WLek/190820","DOIUrl":"10.36740/WLek/190820","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To clarify the potential cardioprotective effect of Trimetazidine against experimentally sepsis-caused endotoxic cardiac injury damage in mice.</p><p><strong>Patients and methods: </strong>Materials and Methods: 24 Mice were divided into four groups (n=6): Sham group, CLP group DMSO group, trimetazidine-treated group 50 mg/kg IP, 1hr before CLP, then the animals were sacrificed 24 hr after CLP and tissue sample was taken for measurement of TNF-α, TNF-αr1, IL-1β, HO-1, MPO, caspase-11, F2-isoprostane and serum troponin by ELISA and gene expression of AMPK-Nrf2 by qpcr and histopathological study.</p><p><strong>Results: </strong>Results: trimetazidine treated group showed significant changes as compared with clp group regarding TNF-α, TNF-αr1, IL-1β, HO-1, MPO, CASPASE-11, F2-ISOPROSTANE as well as affect tissue mRNA expression of AMPK-Nrf2 genes p<0.05.</p><p><strong>Conclusion: </strong>Conclusions: We evaluate that Trimetazidine has cardio protective effects due to its anti-inflammatory and anti-oxidative action. Also, trimetazidine showed a cardio-protective effect as they affect tissue mRNA expression of AMPK-Nrf2 genes.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"35-44"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerobic skin microbiota study in patients with paratraumatic eczema developed as a result of combat injuries.","authors":"Svitlana Dzhoraieva, Yanina Kutasevych, Oksana Sokol, Valentina Honcharenko, Hanna Kondakova, Iryna Oliinyk, Olha Oliinyk","doi":"10.36740/WLek/197131","DOIUrl":"10.36740/WLek/197131","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To establish taxonomic composition, population level and microecological indicators of the \"macroorganism-microbiota\" ecosystem by determining the expression levels of individual pathogenicity factors of microorganisms isolated from the skin areas of patients with paratraumatic eczema developed as a result of combat injuries.</p><p><strong>Patients and methods: </strong>Materials and Methods: Studied microbiologically eczematous lesions content in 54 military men to determine the qualitative and quantitative composition of microbiocenosis to analyze the taxonomic composition, population-species level, microecological indicators and expression levels of individual pathogenicity factors.</p><p><strong>Results: </strong>Results: The results indicate that most eczematized areas are contaminated with S.aureus (48.1% ) with the highest level of quantitative dominance. The rate of quantitative dominance of other strains is significantly lower: S.epidermidis - 2.56 times, S.haemolyticus - 4.56 times, S.pyogenes - 5.86 times, E.faecalis and K.pneumoniae - 20.56 times. When determining the sensitivity of S. aureus clinical strains to antibacterial drugs, we established high levels of sensitivity to mupirocin, fusidic acid, and oxazolidinones - 95.1%, 90.2%, and 87.8%, respectively. Moreover, S. aureus dominated among the strains with a high ability to form biofilms - 68.2%, with an average ability - S epidermidis, 28.8%.</p><p><strong>Conclusion: </strong>Conclusions: S.aureus is the leading pathogen in the infectious-allergic process with paratraumatic eczema according to the constancy index of each taxon, frequency of manifestation, Margalef's species richness index, Whittaker's species diversity, the value of Simpson's and Berger-Parter's species dominance indices, as well as the population level of each taxon, the coefficient of quantitative dominance and the coefficient of significance. We should consider this fact when prescribing therapy.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The study of the base resin impact on planktonic growth of microorganisms of oral origin.","authors":"Yurij Kushnir, Roman Kutsyk, Mykola Rozhko, Tetyana Dmytryshyn, Roksolana Verbovska, Bohdan Pelekhan, Olena Rozhko","doi":"10.36740/WLek/197145","DOIUrl":"10.36740/WLek/197145","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To study the main differences in the intensity of growth of microbial strains of oral origin when they are cultivated in the presence of base resins that are widely used in the clinic of prosthetic dentistry.</p><p><strong>Patients and methods: </strong>Materials and Methods: 3 types of base resin samples were used to evaluate the impact on the growth of microorganisms. Strains of opportunistic pathogens representing the facultative anaerobic transient microflora of the oral cavity were used for the research. Microbial cultures were isolated from the oral mucosa of the patients with removable dentures. The optical density of the culture was determined using a multi-mode photometer. Control growth of the cultures was evaluated under similar cultivation conditions in test tubes with a nutrient medium without resin samples.</p><p><strong>Results: </strong>Results: All resins reduced the intensity of polyantibiotic-resistant S. aureus MRSA growth compared to control samples. The impact on S. epedermidis growth was different. Thus, Vertex and Вreflex reduced the growth intensity insignificantly, and Villacryl increased it to the level of 1.104 ±0.026 CU in comparison with glass constituting 1.178 ±0.033 CU. All studied resins inhibited the growth of polyantibiotic-resistant S. aureus MRSA. Villacryl resin had the least impact on the growth of S. epedermidis. Villacryl resin inhibited C. albicans growth only by 13.70%, and the other two resins inhibited it by 25% on average.</p><p><strong>Conclusion: </strong>Conclusions: The conducted microbiological studies showed the diverse influence of base materials on such important indicators as the optical density of cultures grown in the presence of base resins and the growth inhibition index of cultures.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"110-115"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of program cell death ligand-1 (rs4143815 G>C) with some clinical symptoms and oral ulcer types in systemic lupus erythematosus.","authors":"Mona Al-Terehi, Mohammed Faris Jabaz, Ola Hatif Hazim, Najah Rayish Hadi","doi":"10.36740/WLek/197185","DOIUrl":"10.36740/WLek/197185","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The study aims to detect Association of Program Cell Death Ligand-1(PD-L1) rs4143815 G>C with some Clinical Symptoms and Oral Ulcer Types in Systemic Lupus Erythematosus (SLE).</p><p><strong>Patients and methods: </strong>Materials and Methods: A case control design was suggested in the study enrolled about 60 SLE patients and 20 healthy individuals as a control group, PD-L1 variation implemented using allele specific PCR.</p><p><strong>Results: </strong>Results: The findings showed significant changes in age (<0.011), sex (p<0.000), and non-sig in BMI (p<0.654). in SLE group about 23.3% of patients have a family history, 93.7% suffered from fever, 51.66% have a Butterfly-shaped rash, 73.3% suffered from oral ulcer, single oral ulcer was observed 65.90% and multiple ulcer observed 34.09%. Oral mouth was more frequent (55%) while pharynx ulcer was low frequent (3.3%). The rs4143815 G>C showed three genotypes (GC, CC and GG), Significant association of CC with SLE patients (OR 67.8874, p <0.003), A non-sig association was observed in GG with SLE (OR 5.8571, p <0.395), significant association of C allele with SLE group (OR 1.3529, p< 0.0008). The PD-L1 rs4143815 (G>C) genotyping distribution according to some clinical symptoms showed a non-significant association with all symptoms. The PD-L1 rs4143815 (G>C) genotyping distribution according to oral ulcer sites showed a non-significant association also.</p><p><strong>Conclusion: </strong>Conclusions: The present results concluded closed correlation between rs4143815 G>C and SLE patients, but no association was observed with some clinical symptoms and oral ulcer types.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"136-142"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious exanthemas in clinical practice.","authors":"Vadym A Bodnar, Nataliia O Pryimenko, Olena H Marchenko, Olena M Izyumska","doi":"10.36740/WLek/197135","DOIUrl":"10.36740/WLek/197135","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Analyze the causes and mechanisms of development of exanthems, provide a classification of the morphological elements and characterize clinical manifestations of rash in patients with infectious diseases based on a review of available literature data.</p><p><strong>Patients and methods: </strong>Materials and Methods: The authors analyzed the current literature sources, including a description of exanthema syndrome and a discussion of the features of rashes in various infectious diseases.</p><p><strong>Conclusion: </strong>Conclusions: As a result of the analysis of existing literature data, it was established that exanthema syndrome is associated with various diseases, disorders and pathological conditions, characterized by a variety of clinical manifestations, which requires clinical differential diagnosis and subsequent laboratory confirmation. Comprehensive knowledge of the causes, mechanisms of development, as well as the clinical manifestations of skin rash will contribute to the development of an improved algorithm for diagnosis and treatment of the diseases accompanied by exanthema syndrome, as well as optimization of therapeutic tactics.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"168-176"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and evaluation of Sulfonamide-Thiazolidinone conjugates as promising anticancer agents via carbonic anhydrase inhibition.","authors":"Zahraa Falah Naji, Noor H Naser","doi":"10.36740/WLek/197183","DOIUrl":"10.36740/WLek/197183","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study focuses on developing and evaluating five newly created compounds targeting carbonic anhydrase isoforms found in solid tumors. Our primary goal is to create exceptionally potent anti-cancer drugs.</p><p><strong>Patients and methods: </strong>Materials and Methods: Sulfanilamide, chloroacetyl chloride, Gamma-aminobutyric acid, thionyl chloride, methanol, hydrazine hydrate, aromatic aldehyde derivatives, glacial acetic acid, and thioglycolic acid were used in the chemical synthesis. We performed docking studies using the Molecular Operating Environment software program version 2015.10, and used MTT assay to predict cytotoxic activity.</p><p><strong>Results: </strong>Results: The compounds we developed demonstrated impressive antineoplastic action in both in silico experiments as well as cell line experiments. Their toxicity to normal cells varied significantly, but their efficacy against cancer cells differed significantly from cisplatin. When compared to acetazolamide, each of the produced compounds exhibited significant differences in their effects on MCF7 cells. Based on these findings, synthetic compounds may serve as antineoplastic medications. Including the thiazolidinone ring in these compounds enhanced their affinity for the receptor by binding to multiple crucial amino acids that play a significant role in our target's enzymatic activity and substrate binding.</p><p><strong>Conclusion: </strong>Conclusions: Our synthetic compounds revealed cytotoxicity and inhibitory potencies against carbonic anhydrase. Moreover, they exhibited cytotoxicity.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"116-129"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurses' attitudes towards mental illness and home health care quality as a means of managing psychiatric patients' relapses and re-admissions: a quasi -experimental study.","authors":"Amal Ibrahim Khalil, Manni Alharbi, Reem Alsulami, Manar Alotaibi","doi":"10.36740/WLek/199813","DOIUrl":"10.36740/WLek/199813","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study aims to assess the impact of an educational intervention on nurses' knowledge and attitudes regarding home health care, relapse management, and psychiatric hospital admissions.</p><p><strong>Patients and methods: </strong>Materials and Methods: A quasi-experimental study was conducted with 106 nurses at Erada for Mental Health and Addiction. Standardized assessment tools, including a knowledge scale for home health care quality and a mental illness devaluation scale, were used.</p><p><strong>Results: </strong>Results: Most participants were female 78.4% with a bachelor's degree 77%, and the average age was 2.06±.954. The analysis revealed a significant improvement in knowledge levels post-intervention P<0.000, however, there was a slight non-significant increase in devaluation scale scores after the intervention (pre-24.55±2.96, post-25.18±3.45).</p><p><strong>Conclusion: </strong>Conclusions: Targeted interventions to enhance nurses' knowledge of home health care quality and promote positive attitudes toward mental illnesses can lead to improved patient care, potentially reducing relapses and readmissions among psychiatric patients. Future research should explore the long-term impact and sustainability of such interventions in mental health care settings.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"16-27"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of INSR (rs2229429) G>A genetic polymorphism on response to exogenous insulin in type 1 diabetic Iraqi patients.","authors":"Farah Ali ALQuraishi, Mohammed Ibrahim Rasool","doi":"10.36740/WLek/199949","DOIUrl":"10.36740/WLek/199949","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To examine prevalence of genotypic distribution, particularly assessing how genetic polymorphisms in Insulin Receptor gene influence effectiveness of insulin therapy in a sample of Iraqi population.</p><p><strong>Patients and methods: </strong>Materials and Methods: Effect of Single Nucleotide Polymorphisms rs2229429 G>A have been investigated in 99 T1DM individuals, with a mean age of 12.3 years. These patients were managed with exogenous insulin through a basal-bolus monotherapy regimen. Genotyping was performed using an allele-specific polymerase chain reaction technique, and the data were statistically analyzed.</p><p><strong>Results: </strong>Results: The prevalence of the minor allele frequency is 12% in a sample of Iraqi population. Homozygous mutant carriers of rs2229429 G>A were 10.479 times at higher risk for developing poor glycemic control (HbA1c >86 mmol/mol) compared to wild genotype in type 1 diabetes mellitus, p=0.008. Ultimately poor responders to exogenous insulin, demonstrating significantly higher plasma insulin receptors levels p<0.001.</p><p><strong>Conclusion: </strong>Conclusions: The investigated Single Nucleotide Polymorphisms is significantly associated with hyperglycemia in type 1 diabetes mellitus and contributes to the development of double diabetes.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"71-81"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhinocerebral form of mucormycosis in a patient with post-COVID-19 syndrome and type 1 diabetes mellitus: clinical and morphological analysis of the case from practice.","authors":"Mykhailo S Myroshnychenko, Igor S Brodetskyi, Yevgen V Tytov, Alla M Bilovol, Olena O Pavlova, Yevheniia A Hromko, Liudmyla O Brodetska, Yuliia Ya Fedulenkova, Viktoriia O Bibichenko","doi":"10.36740/WLek/200319","DOIUrl":"10.36740/WLek/200319","url":null,"abstract":"<p><p>Mucormycosis is a serious life-threatening opportunistic infection which is characterized by various clinical and morphological manifestations, rapid progression, unpredictable course and high mortality. The development of mycormycosis depends on the metabolic and immune status of the human body. The authors conducted a clinical and morphological analysis of the case of rhinocerebral mucormycosis in a patient who was diagnosed lifetime, but despite a set of therapeutic and surgical measures led to death, which was due to the severity of the pathology, late hospitalization of the patient and the presence of comorbidities (type 1 diabetes mellitus and post-COVID-19 syndrome). The clinical case presented by the authors raises the issue of the need to increase physicians' awareness about the rhinocerebral form of mucormycosis, improve early diagnostic methods and find effective approaches to therapeutic and surgical treatment of this pathology.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"216-222"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}