Evaluation of serum and urine levels of matrix metalloproteinase (MMP-2) in children with nephrotic syndrome.

Objective: Aim: To evaluate the serum and urine levels of MMP-2 in children with nephrotic syndrome.

Patients and methods: Materials and Methods: This study was conducted at Pediatric Nephrology consultation Clinic in Al Imamain Kadhimain Medical City, Ibn Balady Children and Maternity Hospital, Child Central Teaching Hospital, Baghdad, Iraq and Children Welfare Teaching Hospital/Medical City Complex from 1st of November 2021 to 31th of March 2022 and included 60 Patients who are children with NS , and 60 healthy children age and sex matched as a control group Patients with NS were admitted to pediatric ward or attending the pediatric Nephrology clinic.

Results: Results: found there was no significant difference in age and gender between the three groups, healthy controls, SSNS and SRNS However, SRNS had significantly higher mean SBP and DBP (123.0±15.79 mmHg and 79.97±12.44mmHg, respectively) than either SSNS patients (109.58±13.08 mmHg and 73.5±11.31mmHg, respectively) or controls (99.75±9.23 mmHg and 65.58±5.83 mmHg, respectively).

Conclusion: Conclusions: there was no significant difference in age and gender between the three groups, healthy controls, SSNS and SRNS However, SRNS had significantly higher mean SBP and DBP, However , ACE, cyclosporine and MMF were more common among patients with SRNS For MMP-2 the results found serum MMP-2 and urine MMP-2 was significantly higher in SSNS patients SRNS patients.