Wiadomosci lekarskie最新文献

{"title":"Morphological condition of the skin following a 4-week opioid exposure in an experimental study.","authors":"Ivan S Diskovskyi, Orysya O Syzon, Lesya R Mateshuk Vatseba, Marta A Kolishetska, Marianna O Dashko, Iryna Ya Vozniak, Iryna O Chaplyk-Chyzho","doi":"10.36740/WLek/201322","DOIUrl":"10.36740/WLek/201322","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The study aimed to determine the peculiarities of the micro- and ultrastructural organization of the skin under conditions of a four-week administration of an opioid to experimental animals.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study material included skin samples of white rats with injected vascular beds, histological preparations, and ultrathin skin sections. The research methods involved injection techniques, histological analysis, electron microscopy, morphometric measurements, and statistical analysis.</p><p><strong>Results: </strong>Results: The results of the study revealed that after four weeks of nalbuphine administration to experimental animals, blood stasis was observed in the lumen of the capillaries and venules, along with perivascular edema and perivascular infiltrates consisting of neutrophils, lymphocytes, macrophages, and tissue basophils. The electron density of the nuclei and cytoplasm of the granular layer keratinocytes was reduced, keratinocytes in the stratum spinosum acquired a rounded shape, with some nuclei appearing shrunken and hyperchromatic, and their cytoplasm exhibiting vacuolization. In the reticular layer, thickened bundles of collagen fibers were observed, with localized swelling and fragmentation of the collagen fibers. Excessive formation of scales was noticed in the stratum corneum. The papillary layer of the dermis contained numerous mast cells and lymphocytes near blood vessels. The shape of sebaceous and sweat gland cells was altered, with swollen cytoplasm, and lymphohistiocytic infiltration was observed around them. A decrease (p<0.05) in the density of capillary loops in the subpapillary vascular plexus of the skin in the gluteal region of white rats after four weeks of nalbuphine administration, along with an increase (p>0.5) in the trophic activity index of the skin, confirms profound destructive changes in the vascular architecture of the skin.</p><p><strong>Conclusion: </strong>Conclusions: Four weeks of nalbuphine administration induces irreversible pathological processes in all skin components.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"347-352"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of maternal ABO blood group and malondialdehyde as diagnostic marker in the development of gestational diabetes mellitus.","authors":"Deema Diyaa Azeez, Sami R AlKatib","doi":"10.36740/WLek/197188","DOIUrl":"10.36740/WLek/197188","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim of research is to assess whether various blood groups can be associated with the occurrence of gestational diabetes mellitus and if malondialdehyde can be used for the diagnosis of GDM.</p><p><strong>Patients and methods: </strong>Materials and Methods: A case control study started from September 2022 to June 2023 enrolled 200 pregnant women aged between 15-45 years, cases included 100 patients selectively collected with a confirmed diagnosis of gestational diabetes mellitus, and 100 were healthy normal in Kerbala obstetrics and gynecology hospital, both patient and controls group categorized according to blood group type.</p><p><strong>Results: </strong>Results: Pregnant women with gestational diabetes mellitus are mostly of blood group AB in comparison with pregnant women without Gestational diabetes mellitus, and both A and B were significantly higher among control pregnant women, additionally, two groups' blood group O levels were almost identical. Malondialdehyde mean was significantly higher in pregnant women with Gestational diabetes mellitus with p-values 0.001. Statistically significant differences could not be detected in the mean levels of MDA across the various blood groups (p= 0.505).</p><p><strong>Conclusion: </strong>Conclusions: This research reveals that mother's ABO blood group has a role in the development of GDM and the blood group AB is more likely to develop GDM, blood group A & B are less likely to develop GDM and may be regarded as a protective factor. MDA can be used for the diagnosis of GDM but further studies are required to support this finding.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"303-310"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foodstuffs for particular nutritional purposes and dietary supplements in the legal-medical context.","authors":"Rafał Patryn, Agnieszka Kowalska-Olczyk, Michał Sekuła, Joanna Niezbecka-Zając, Juliana Woszczyło","doi":"10.36740/WLek/202429","DOIUrl":"https://doi.org/10.36740/WLek/202429","url":null,"abstract":"<p><p>Foodstuffs for special dietary purposes are products that, due to their special method of preparation or composition, differ from common foodstuffs and are intended to meet the nutritional needs of specific groups of consumers, such as oncology patients. The indication for the use of these products is to provide the body with essential nutrients in the right proportions, thereby improving or maintaining the current state of health. Dietary supplements are also food products that contain vitamins and other substances, and their intake is aimed at helping to maintain specific nutrients in the human body at the appropriate level.Dietary supplements should be used under medical supervision and at a dosage determined by the body's needs. Both of the above-mentioned groups of nutritional products are gaining increasing popularity among consumers. Many of them, encouraged by the described health benefits, use and dose these products without consulting a doctor or pharmacist, often exceeding the recommended intake and even replacing a well-balanced diet, which can pose a serious health risk.These products, in combination with certain medications, can also pose a serious risk of adverse effects, especially in the elderly population taking multiple medications.Therefore, their use should be cautious, and in case of any doubts, it should be preceded by consultation with a doctor or pharmacist.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"559-564"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, treatment and diagnosis of Hepatitis C virus infections.","authors":"Nisreen Jawad Kadhim, Laith M Abbas Al-Huseini, Fadhl Alzamili, Ali Mansoor Al Ameri","doi":"10.36740/WLek/202252","DOIUrl":"10.36740/WLek/202252","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Studding several aspects of Hepatitis C virus infection, such as epidemiology, prevalence, diagnosis, and outcome of patients with hepatitis C infection.</p><p><strong>Patients and methods: </strong>Materials and Methods: Systematic review of electronic medical records and epidemiological data and risk factors for Hepatitis C virus infection in patients evaluated in relevant studies.</p><p><strong>Conclusion: </strong>Conclusions: Hepatitis C virus serology and viral genotyping. Hepatitis B may be associated with risk factors such as perinatal infection, kidney disease, dialysis, intravenous or percutaneous drug use, occupational factors, suddenly local population factors of hepatitis transmission and pay children. These young and vulnerable cultures bear the enormous social, economic, and political costs of Hepatitis C virus infection. Therefore, to combat the effects of Hepatitis C at regional and national levels, specific intervention approaches and policies are needed.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"469-473"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Certain ethical issues that arise when using 3D bioprinting technology.","authors":"Viktor V Zaborovskyy, Olena V Ustych, Tereziia P Popovych, Vasil V Manzyuk","doi":"10.36740/WLek/203904","DOIUrl":"10.36740/WLek/203904","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Theoretical and applied study of the ethical issues that arise when using three-dimensional printed bioproducts and their significance for the development of principles for the application of additive manufacturing technologies in medicine.</p><p><strong>Patients and methods: </strong>Materials and Methods: Various methods of scientific knowledge make up the methodological basis of on interdisciplinary approach, which includes a set of methods that allow us to investigate the technological, legal and social aspects of the application of 3D bioprinting, its potential, limitations and ethical challenges.</p><p><strong>Conclusion: </strong>Conclusions: Ethical principles are one of the foundations for ensuring the provision of proper medical care and medical services with the use of threedimensional printed bioproduct technologies at an appropriately high level, and are directly related to strict adherence to the principles and standards of additive manufacturing and bioethics, which are imposed on all participants (be it a doctor a 3D designer, a manufacturer of a 3D bioprinter, etc).</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"915-920"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of clinical flow of traumatic illness on a background chronic stress.","authors":"Stepan S Filip, Rudolf M Slivka, Andrii M Bratasiuk, Yuriy P Skrypynets, Antonina V Varvarynets","doi":"10.36740/WLek/203903","DOIUrl":"10.36740/WLek/203903","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To focus on the dependence of the severity of the clinical features of traumatic illness on stress components and chronic stress in particular.</p><p><strong>Patients and methods: </strong>Materials and Methods: Analysis of data on the results of existing studies assessing the impact of chronic stress on the course of traumatic illness.</p><p><strong>Conclusion: </strong>Conclusions: The introduction of a therapeutic complex of immunotherapy and sedatives for traumatic illness with a pronounced stress component, with the possible development of severe complications, will make it possible to improve the results of treatment and rehabilitation of patients with traumatic illness.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"908-914"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective strategies for the treatment of eyelid diseases in modern ophthalmology.","authors":"Rimma L Skrypnyk, Nataliia A Tykhonchuk, Inna D Skrypnychenko, Alla I Zadorozhna, Nataliia W Zhaboedova, Oksana I Parfonova","doi":"10.36740/WLek/205359","DOIUrl":"https://doi.org/10.36740/WLek/205359","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Investigate the effectiveness of micellar foam containing tea tree oil and Roman chamomile oil in preoperative eyelid sanitation in patients with blepharitis.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study involved 37 patients with blepharitis, aged 28-62. Patients were split into two groups: 22 who used micellar foam preoperatively and 15 who did not. Diagnoses included chronic, seborrheic, and demodicosis blepharitis. Symptoms and signs were monitored over a ten-day treatment period, showing varied responses to micellar foam.</p><p><strong>Results: </strong>Results: The study showed a significant improvement in blepharitis symptoms with the use of foam containing tea tree and Roman chamomile oils. Patients reported reduced dryness, scaling, hyperemia, and itching. Microscopic examination showed disappearance of scales and couplings, and reduced hyperemia. Bacterial contamination decreased significantly, with good tolerance to the treatment.</p><p><strong>Conclusion: </strong>Conclusions: Recent literature and our study indicate that women predominantly suffer from blepharitis, possibly due to their higher medical service utilization. Most cases were mild to moderate, with multifactorial causes and bacterial influence. Eight patients (36.4%) had non-bacterial blepharitis. Understanding blepharitis epidemiology helps in pathogenetically targeted treatment. The innovative micellar foam with tea tree oil and chamomile shows positive results and reduces antibiotic resistance risks.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 5","pages":"1006-1012"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a new diagnostic tool for identifying burnout syndrome.","authors":"Oleg S Chaban, Olena O Khaustova, Vitaliy Yu Omelyanovich","doi":"10.36740/WLek/205365","DOIUrl":"https://doi.org/10.36740/WLek/205365","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To creation the first Ukrainian burnout syndrome diagnostic scale and confirm the quality of its psychometric characteristics.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study was conducted using a newly developed questionnaire administered to 1,405 academic staff members of higher educational institutions in Ukraine. Test validation was carried out using exploratory factor analysis, Spearman's rank correlation coefficient, Ferguson's δ coefficient, Cronbach's α coefficient, Guttman's split-half coefficient, and the Spearman-Brown equivalent forms coefficient.</p><p><strong>Results: </strong>Results: The criterion validity was assessed through factor analysis, yielding 10 factors. Consequently, the initial version of the questionnaire was reduced by 10 items with the lowest factor loadings. The final version consists of 50 items with a dichotomous response scale. The discriminatory power of the questionnaire, evaluated using Ferguson's δ coefficient, was found to be extremely high (δ-Ferguson = 0.988). Consistency indices also demonstrated high reliability: α-Cronbach = 0.877; Guttman split-half = 0.848; Equal-length Spearman-Brown = 0.857. The concurrent reliability of the questionnaire was assessed using Spearman's correlation analysis, showing statistically significant positive correlations of most questionnaire items with the overall test score (≥ 0.419; p ≤ 3.29E-15).</p><p><strong>Conclusion: </strong>Conclusions: The obtained results confirm the feasibility of using the first Ukrainian \"Questionnaire for Identifying Burnout Syndrome\" (© Chaban O.S., 2025) in practical psychology, medicine, and burnout research.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 5","pages":"1037-1044"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interconnections of different types of fertiliser consumption on disability-adjusted life years of digestive system diseases in European countries.","authors":"Vladyslav Smiianov, Maksim Husenko, Olena Vishnikina, Olena Churikanova, Tetiana Vasylieva","doi":"10.36740/WLek/205403","DOIUrl":"https://doi.org/10.36740/WLek/205403","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study examines the impact of different fertiliser types - phosphate, nitrogen, and potash -and pesticide use on disability-adjusted life years (DALYs) associated with digestive system diseases in European countries. It focuses on pancreatitis, upper digestive system disorders, and non-alcoholic fatty liver disease (NAFLD), including cirrhosis.</p><p><strong>Patients and methods: </strong>Materials and Methods: Using a balanced panel dataset covering 39 European countries from 2006 to 2021, the study incorporates data from the Global Burden of Disease database (DALYs), the Food and Agriculture Organization (fertiliser and pesticide use), and the World Bank (trade indicators). A fixed-effects regression model was applied to assess the influence of agricultural chemical use and trade dynamics on DALYs.</p><p><strong>Results: </strong>Results: Pesticide use per hectare was significantly associated with higher DALYs for NAFLD, indicating substantial health risks. Nitrogen fertiliser use showed a protective effect against DALYs for upper digestive diseases and pancreatitis. In contrast, excessive potash application was linked to increased DALYs for pancreatitis. The effects of phosphate use varied by disease type. Trade-related interaction terms demonstrated complex and sometimes amplifying effects on health outcomes.</p><p><strong>Conclusion: </strong>Conclusions: Agricultural inputs have both beneficial and adverse health implications. While essential for productivity, their misuse can contribute to chronic disease burdens. The findings highlight the importance of sustainable farming practices and regulatory oversight. Integrating health metrics such as DALYs into agricultural and environmental policy could improve public health outcomes across Europe.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 5","pages":"1176-1183"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problems of antimicrobial resistance in the primary health care system (results of the sociological study).","authors":"Valery M Lekhan, Nadiia V Puchkova, Mykola I Zaiarskyi","doi":"10.36740/WLek/205352","DOIUrl":"https://doi.org/10.36740/WLek/205352","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To assess the level of awareness of primary health care physicians regarding the problem of antimicrobial resistance and identify the main obstacles to the rational use of antibiotics in practice.</p><p><strong>Patients and methods: </strong>Materials and Methods: A sociological survey was conducted among primary health care physicians using a specially designed questionnaire containing questions on knowledge, antibiotic prescribing practices, and ways to address the problem of antimicrobial resistance. The survey was conducted in January 2025. Descriptive and analytical statistics were used to analyze the results obtained from 221 respondents.</p><p><strong>Results: </strong>Results: Most respondents (about 90%) encountered cases of antimicrobial resistance in their work. The respondents named the following as the main reasons: the use of antibiotics without a prescription (87.8% of respondents), their excessive use (80.1%), and non-compliance by patients with the course of treatment (77.8%). Analysis of the responses shows that respondents sometimes prescribe antibiotics from the watch and reserve groups (53.4% and 29%, respectively), regularly prescribe antibiotics without a prescription (14%), use injectable antibiotics (21% of respondents); 54.3% note that patients often take antibiotics on their own.</p><p><strong>Conclusion: </strong>Conclusions: The survey results show that antimicrobial resistance is a serious problem in the primary healthcare system. Primary care physicians often do not follow recommendations for selecting and prescribing antibiotics. Effectively solving the problem requires a comprehensive approach, which should include improving antibiotic stewardship, increasing the level of knowledge of medical professionals, and widely informing the population about their proper use.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 5","pages":"981-987"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}