Wiadomosci lekarskie最新文献_第3页

Diagnosis and surgical treatment of tracheal cicatricial stenoses: literature review. 气管瘢痕狭窄的诊断与手术治疗：文献回顾。

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/197144

Valeriy Boyko, Vasyl Kritsak, Anastasiia Sochnieva, Volodymir Tkachenko

{"title":"Diagnosis and surgical treatment of tracheal cicatricial stenoses: literature review.","authors":"Valeriy Boyko, Vasyl Kritsak, Anastasiia Sochnieva, Volodymir Tkachenko","doi":"10.36740/WLek/197144","DOIUrl":"10.36740/WLek/197144","url":null,"abstract":"Objective: Aim: To study of the data about the results of tracheal cicatricial stenoses treatment with the goal of further improvement of its results on the basis of diagnosis enhancing, identification of factors of prognosis of the disease and by conducting a differential analysis of tactics of surgical treatment with the use of minimally invasive interventions.Patients and methods: Materials and Methods: We have identified contemporary literature sources on the topic of modern directions of treatment of tracheal cicatricial stenoses and their complications. The studied material has been summarized and represented in the form of literature review in this article.Conclusion: Conclusions: To increase the quality of treatment of patients with tracheal cicatricial stenoses and their surgical complications an important role is played by objective formation of groups at risk of complications development and prognosis of the disease dynamics. Successful solution of the problem is related mostly to the highly informative diagnostics, reliable determination of severity of disease, as well creation of multidirectional classification of tracheal cicatricial stenoses. These issues may not be considered completely solved, they require further study. All of the above dictates search of new effective methods of treatment of the indicated pathology and proves relevance of the topic. The stated information emphasizes necessity of improvement of surgical tactics of patients with tracheal cicatricial stenoses.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"177-186"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of deficiency of natural anticoagulants on clinical heterogeneity of rheumatoid arthritis. 天然抗凝剂缺乏对类风湿关节炎临床异质性的影响。

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/200316

Olena V Solyeyko, Mariia O Chernykh, Olena Y Galiutina, Inna P Kuvikova, Iryna B Romash, Oleg V Fedorchenko, Larysa P Soleiko

{"title":"Effect of deficiency of natural anticoagulants on clinical heterogeneity of rheumatoid arthritis.","authors":"Olena V Solyeyko, Mariia O Chernykh, Olena Y Galiutina, Inna P Kuvikova, Iryna B Romash, Oleg V Fedorchenko, Larysa P Soleiko","doi":"10.36740/WLek/200316","DOIUrl":"10.36740/WLek/200316","url":null,"abstract":"Objective: Aim: To investigate the concentration of natural anticoagulants protein C (PC) and tissue plasminogen activator (t-PA) in patients with rheumatoid arthritis (RA) and to evaluate the effect of their concentration on the course of the disease.Patients and methods: Materials and Methods: We examined 74 patients with RA. There were 15 men and 59 women and control group consisted of 27 subjects. The average age of the patients was 47.3±1.12 years. Laboratory (PC, t-PA, C-reactive protein, TNF-alpha, von Willebrand factor, and lipid profile) and instrumental (ultrasonography and Doppler) examinations were performed.Results: Results: PC deficiency was significantly more common among men with RA (26.6%), but did not depend on the age and the duration of the disease (p<0.05). PC deficiency correlates with the degree of activity of the inflammatory process (r = -0.27) and TNF-alpha (r = -0.37). The levels of PC and t-PA were associated with the level of cholesterol (r = -0.25), LDL-C (r = -0.31), and HDL-C (r = 0.31). In patients with PC and t-PA deficiency, significantly higher (by 19% and 12%, respectively) serum levels of Von Willebrand factor were recorded than in patients with normal levels (p<0.05).Conclusion: Conclusions: The study of PС and t-PA revealed a deficiency of important natural anticoagulants, that helps us to expand the understanding of the mutually aggravating effect of the deficiency of these compounds and changes in known biologically active substances on the course of RA, and to supplement the pathogenetic picture of RA with certain links.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients 'satisfaction and views about pharmacists in community pharmacies as healthcare providers in Iraq: Najaf province. 伊拉克纳杰夫省社区药房药剂师作为医疗保健提供者的满意度和看法。

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/199947

Helen F Marzooq, Yahiya Ibrahim Yahiya, Ali M Jaafar Abdulsahib

{"title":"Patients 'satisfaction and views about pharmacists in community pharmacies as healthcare providers in Iraq: Najaf province.","authors":"Helen F Marzooq, Yahiya Ibrahim Yahiya, Ali M Jaafar Abdulsahib","doi":"10.36740/WLek/199947","DOIUrl":"10.36740/WLek/199947","url":null,"abstract":"Objective: Aim: To assess the level of patient satisfaction and their opinions about the services provided by community pharmacists and their changes depending on the socio-demographic characteristics that influence the level of satisfaction and expectations of patients served in the city of Al-Najaf Al-Ashraf city of Iraq.Patients and methods: Materials and Methods: A structured questionnaire was allocated among patients who were staying pharmacies regarding aspects like accessibility, communication, and quality of services. A descriptive cross-sectional survey was executed utilizing a questionnaire that encompassed various dimensions of pharmaceutical services. The sample population comprised 449 patients who frequented a range of pharmacies with varying regularity within the province.Results: Results: A significant majority of individuals exhibit a favorable perception regarding community pharmacists in Al-Najaf Al-Ashraf, with patients articulating substantial satisfaction, recognition, and esteem for the contributions that pharmacists make within the healthcare team.Conclusion: Conclusions: Pharmacists play a vital role in providing pharmaceutical care, and patients generally express satisfaction with their services. However, there is a significant need for additional initiatives to enhance the clinical skills of community pharmacists, identify factors affecting patient satisfaction, and conduct comparative research on pharmacy services in different regions of Iraq.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"100-109"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Socio-psychological causes and consequences of combat stress in armed conflict participants. 武装冲突参与者战斗压力的社会心理原因和后果。

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/197120

Andrii O Fedyk, Olha A Valchuk, Ivan M Okhrimenko, Tetiana V Danylchenko, Iryna O Bets, Lesia O Balahur, Artem G Brykovskyi

{"title":"Socio-psychological causes and consequences of combat stress in armed conflict participants.","authors":"Andrii O Fedyk, Olha A Valchuk, Ivan M Okhrimenko, Tetiana V Danylchenko, Iryna O Bets, Lesia O Balahur, Artem G Brykovskyi","doi":"10.36740/WLek/197120","DOIUrl":"10.36740/WLek/197120","url":null,"abstract":"Objective: Aim: The aim is to determine the causes and consequences of combat stress in armed conflict participants.Patients and methods: Materials and Methods: The research involved 109 service members (under 30) who participated in the russian-Ukrainian war in 2022-2024 on a rotational basis for different durations (from 4 to 18 months). Research methods included theoretical analysis and generalization of literary sources, interviews, questionnaires, and statistical methods.Results: Results: The causes of combat stress in service members participating in military operations have been identified. It has been established that during the first rotation, service members most often suffer from being in conditions of constant threats (71.6 %), experience fear of death and injury (70.6 %), fear of killing a person (67.9 %), loud sounds (63.3 %) and lack of sleep (52.3 %). With the acquisition of combat experience, the frequency of these factors decreases. The research revealed the consequences of combat stress, which worsen depending on the duration of stay in a combat situation: increased aggressiveness (71.1 %), anxiety, fear (68.4 %), sleep problems (31.6 %), cognitive impairment (28.9 %), and psychosomatic disorders (26.3 %).Conclusion: Conclusions: Ensuring military personnel's access to qualified psychological assistance, creating a support and rehabilitation program, and raising public awareness of the problems faced by service members participating in combat operations will reduce the negative effects of combat stress and help improve the quality of life of military personnel and their families.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"82-89"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The right to life. 生命权。

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/197134

Anastasiia Mernyk, Oleh Hyliaka, Viktoriia Sheverdina

{"title":"The right to life.","authors":"Anastasiia Mernyk, Oleh Hyliaka, Viktoriia Sheverdina","doi":"10.36740/WLek/197134","DOIUrl":"10.36740/WLek/197134","url":null,"abstract":"Objective: Aim: The article is devoted to the study of the right to life as a key aspect of legal theory. The purpose of the study is to examine the theoretical aspects of the right to life, to analyze its essence, place and significance in the system of general human rights; to outline the main principles and concepts related to the right to life, to consider their evolution in different legal systems and to discuss important ethical aspects related to this topic.Patients and methods: Materials and Methods: The article examines the right to life, defines its place in the modern world, highlights the issues of correlation between this right and the right to abortion and euthanasia, and assesses the prospects for their realization. The empirical basis of the study is grounded on articles by scholars and assessments by leading experts in the field. The authors used general scientific methods, including system analysis, system modeling, and the dialectical method. To demonstrate the relationship between the right to life of an unborn child and a woman's right to abortion, a social survey was conducted among different population groups.Conclusion: Conclusions: Analyzing the right to life in the context of its interrelationship with other human rights, such as the right to liberty, the right to health and the right to a fair trial, helps to affirm the principles of the rule of law and ensure equality before the law for all. In the modern world, the concept of the right to life has become an important element of international law, which covers not only physical existence, but also the provision of a decent and quality life, health, education and social protection. Cultural and religious aspects play a significant role in shaping the understanding of the right to life. Different religious and cultural traditions have their own interpretations of the beginning and end of life, influencing attitudes to aspects related to medical interventions, abortion, euthanasia and other issues.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"197-209"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the relationship between the level of proinflammatory cytokines and β2-microglobulin with indicators of changes in the functional status of the kidneys in diabetic nepropathy to determine the degrees of chronic renal failure. 研究促炎细胞因子和β2微球蛋白水平与糖尿病肾病肾脏功能状态变化指标的关系，判断慢性肾功能衰竭程度。

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/197132

Roman Alekseienko, Volodymyr Markovskiy, Liubov Rysovana, Anton Shapkin, Mykola Lytvynenko, Olha Zaliubovska, Yuliia Avidzba

{"title":"Study of the relationship between the level of proinflammatory cytokines and β2-microglobulin with indicators of changes in the functional status of the kidneys in diabetic nepropathy to determine the degrees of chronic renal failure.","authors":"Roman Alekseienko, Volodymyr Markovskiy, Liubov Rysovana, Anton Shapkin, Mykola Lytvynenko, Olha Zaliubovska, Yuliia Avidzba","doi":"10.36740/WLek/197132","DOIUrl":"10.36740/WLek/197132","url":null,"abstract":"Objective: Aim: The purpose of this study is to analyze the correlations of pro-inflammatory cytokines and β2-microglobulin with indicators of changes in the functional state of kidneys in patients with diabetic nephropathy, to determine different degrees of chronic renal failure.Patients and methods: Materials and Methods: 80 patients with type 1 and type 2 diabetes, complicated by diabetic nephropathy, at different levels of the functional state of the kidneys were examined.Results: Results: It has been shown that the level of tumor necrosis factor α (TNFα) in the blood of patients with diabetic nephropathy (DN) is increased already with sufficient kidney function, decreases with chronic renal failure (CRF) of the I degree and reaches maximum values with CRF of the II and III degrees. Which indicates the degree of progression of fibroplastic and sclerotic processes in the kidneys with DN. The level of interleukin-1α (IL-1α) in the blood of patients with DN begins to decrease with sufficient kidney function, increases with CRF of the II degree, but remains below the values of the control group and is minimal in patients with CRF of the III degree, which reflects a decrease in the intensity of the acute-phase inflammatory process in the development of CRF.Conclusion: Conclusions: The development and progression of CRF is accompanied by an increase in the excretion of β2-microglobulin in the urine in parallel with changes in the cytokine profile in the blood.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"248-256"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the psychological well-being among adolescent and children. 青少年和儿童的心理健康评估。

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/197184

Adil Ali Hussein, Amer Abdullah Sachit, Hajer S Essa

{"title":"Assessing the psychological well-being among adolescent and children.","authors":"Adil Ali Hussein, Amer Abdullah Sachit, Hajer S Essa","doi":"10.36740/WLek/197184","DOIUrl":"10.36740/WLek/197184","url":null,"abstract":"Objective: Aim: To assess the psychological well-being of children and adolescents, socio demographic distribution data of parents and children and to find out the relationship between psychological well-being of children and adolescents and their socio demographic characteristics.Patients and methods: Materials and Methods: A descriptive cross- sectional study to assess the psychological well-being of children and adolescents in AI-Nasiriyah schools. The study period was extended (from December 1, 2023 to April 1, 2024). A non- probability (purposive sample) consist of (200) children and adolescents.Results: Results: Results revealed That children and adolescent in current study have moderate levels of Psychological Well-Being, our study revealed that is significant correlation (between participants' age and Psychological Well-being, difference in psychological wellbeing between history of school fail, difference in psychological Well-being among between mother educational groups and difference in Psychological well-being among father job groups) and no statistically Significant ( between difference psychological well-being and school history, difference in psychological well- being Among socioeconomic status groups, difference in psychological well-being among father level of education Groups and difference in psychological wellbeing among father job groups).Conclusion: Conclusions: Study provides valuable insights into factors influencing the psychological well- being of children and adolescents, highlighting the complex interaction between age, social status, parental education, and parental occupation. Academic performance and school experiences play a significant role in psychological well-being, especially in cases of academic failure.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"130-135"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic pain of the musculoskeletal system - point of view for general practitioner. 肌肉骨骼系统的慢性疼痛-全科医生的观点。

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/202549

Iwona Morawik, Mirosław Jabłoński

{"title":"Chronic pain of the musculoskeletal system - point of view for general practitioner.","authors":"Iwona Morawik, Mirosław Jabłoński","doi":"10.36740/WLek/202549","DOIUrl":"https://doi.org/10.36740/WLek/202549","url":null,"abstract":"Pain is subjective unpleasant feeling of varied origin and once it is chronic (lasting more than 6 month) it could be responsible for significantly decreased quality of life. Pivotal role in pain suffering plays both peripheral and central nervous system and at these levels its intensity could be decreased by several pharmacological and non-pharmacological means. Rationale of chronic management of musculoskeletal pain. This article is a review of contemporary bibliography in order to assess pathomechanism and causes of pain to successfully cope with the condition. Of utmost importance in managing pain is proper diagnosis and identification of its sources. Once this condition is met it is easier to apply diagnosis-specific treatments even including surgeries. In various clinical situations especially in chronic aged patients with multiple comorbidities personalized approach is mandatory. Armamentarium then encompasses complex actions with the use of simple counseling, medical treatment, physiotherapy, orthotics and preferably mini-invasive but also major surgical interventions. Proper management of chronic musculoskeletal pain demands detailed analysis of complex clinical situation basing on medical history, examination and combining these data with possible imaging investigations. Often cooperation of several specialists is mandatory.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"634-638"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in morphological and immunohistochemical parameters of tumors during neoadjuvant hormone therapy in postmenopausal patients with luminal type of breast cancer. 绝经后腔型乳腺癌患者新辅助激素治疗期间肿瘤形态学和免疫组化参数的变化。

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/203842

Yevhen S Hotko, Diana Stryzhak, Svyatoslav V Zhero, Viktor Ya Ihnatko

{"title":"Changes in morphological and immunohistochemical parameters of tumors during neoadjuvant hormone therapy in postmenopausal patients with luminal type of breast cancer.","authors":"Yevhen S Hotko, Diana Stryzhak, Svyatoslav V Zhero, Viktor Ya Ihnatko","doi":"10.36740/WLek/203842","DOIUrl":"https://doi.org/10.36740/WLek/203842","url":null,"abstract":"Objective: Aim: Breast cancer (BC) remains the most common malignant disease among women in Ukraine and worldwide. The indication for neoadjuvant hormone therapy (NAHT) is HR+/HER2- breast cancer of stage II-III. However, there are currently insufficient data on its impact on the IHC biological characteristics of tumors and clinical outcomes.Patients and methods: Materials and Methods: The study was conducted at the Uzhhorod Treatment and Diagnostic Oncology Center during 2015-2023. At the diagnostic stage, morphological verification and IHC profile were determined based on trephine biopsy material. The study included 28 patients with HR+/HER2- BC, aged from 38 to 75 years old. All patients were prescribed NAHT with the use of aromatase inhibitors for 6.10±2.23 months. The expression levels of ER, PR, Ki-67, category G were assessed before and after NAHT using histological and IHC analyses.Results: Results: After NAHT, we observed a decrease in Ki-67 levels from 25.31% to 10.25%, ER expression levels from 97% to 84%, and PR expression levels from 87% to 11%. There were changes in category G: G1 was observed in 45.83% of patients, G2 in 54.17%. The staging of BC also decreased. A moderate degree of curative tumor pathomorphosis was achieved in 76.47% of patients, and complete regression (pCR) in 5.88%.Conclusion: Conclusions: Neoadjuvant hormone therapy demonstrated high efficacy in the treatment of patients with luminal HR+/HER2- BC of stage II-III. In most cases, it was possible to reduce the proliferative activity of the tumor, which was accompanied by a decrease in tumor staging. This made it possible to perform organpreserving surgeries in 60.71%, which confirms the feasibility of using NAHT as an alternative to chemotherapy in certain groups of patients.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"710-716"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of life in patients with chronic slow-transit constipation according to the PAC-QOL scale one year after surgical treatment: comparison with preoperative data and reference values. 慢性慢传输型便秘患者术后1年PAC-QOL生活质量：与术前数据及参考价值比较

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI: 10.36740/WLek/203846

Ivan M Leshchyshyn, Leonid Yu Markulan, Olga I Okhotska, Yaroslav M Susak, Pavlo L Byk

{"title":"Quality of life in patients with chronic slow-transit constipation according to the PAC-QOL scale one year after surgical treatment: comparison with preoperative data and reference values.","authors":"Ivan M Leshchyshyn, Leonid Yu Markulan, Olga I Okhotska, Yaroslav M Susak, Pavlo L Byk","doi":"10.36740/WLek/203846","DOIUrl":"https://doi.org/10.36740/WLek/203846","url":null,"abstract":"Objective: Aim: To assess the impact of surgical treatment on quality of life in patients with chronic slow transit constipation according to the PAC-QOL scale one year after surgery.Patients and methods: Materials and Methods: PAC-QOL scores were studied in 107 patients with chronic slow-transit constipation (main group) before and one year after total colectomy (57), subtotal colectomy (29) and colectomy with low rectal resection (21). 70 patients were included into the reference group. Open surgery was performed in 70 (65.4%) patients, while laparoscopic access - in 37 (34.6%) patients.Results: Results: Despite the long-term conservative treatment PAC-QOL scores for all subscales significantly exceeded the reference values in all patients before surgery (all p<0,05). After surgery PAC-QOL scores decreased to reference values and were statistically lower than preoperative values (all p<0.01): physical component - from 2.78±0.52 to 1.01±0.32; psychological component - from 1.90±0.48 to 0.83±0.41; warries and concerns - from 1.99±0.31 to 0.72±0.34; the satisfaction component - from 2.35±0.60 to 0.84±0.47; total PAC-QOL score - from 2.14±0.23 to 0.82±0.35.Conclusion: Conclusions: Surgical treatment - total or subtotal colectomy in patients with chronic slow-transit constipation resistant to conservative treatment provides a significant reduction of all PAC-QOL scores to reference values and provides full social and functional adaptation.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"726-734"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0