Wiadomosci lekarskie最新文献

{"title":"Clinical characteristics of temporomandibular disorders in a sample of Iraqi patients.","authors":"Rana Murtadha Hasan, Ameena Ryhan Diajil, Noor Mohammed Ali, Fawaz Aswad, Lina Ziyad Tariq","doi":"10.36740/WLek/197186","DOIUrl":"10.36740/WLek/197186","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To evaluate the symptoms and indicators that people with TMD experience and encourage them to seek treatment at an academic oral medicine clinic.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study includes temporomandibular joint patients who visited the oral medicine clinic at the University of Baghdad's College of Dentistry between October 2021 and May 2022. The information was gathered from temporomandibular joint patients' medical records.</p><p><strong>Results: </strong>Results: In the research herein, 323 patients in total were included, females 234(72.4%) and 89(27.6%) males, the patient's mean age was (31.38 ± 14.085), and there was no discernible gender difference in mean age. In this study, the most prevalent temporomandibular joint signs and symptoms were temporomandibular joint clicking 73.6% with no significant difference between females and males. In comparison, dislocation is the least prevalent and the most prevalent muscle spasm was the masseter muscle with a percentage of 50.4%) while the sternocleidomastoid muscle is the least one.</p><p><strong>Conclusion: </strong>Conclusions: The research results demonstrated a significant prevalence of temporomandibular joint disorder and the necessity of preventing it to improve the overall well-being of people in general.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"143-147"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological and social aspects of the life of patients with periodontal and maxillofacial diseases.","authors":"Tetiana O Timokhina, Olena V Anoprienko, Natalia I Gryg, Andrii A Boiko, Ihor M Kolodka","doi":"10.36740/WLek/197121","DOIUrl":"10.36740/WLek/197121","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To analyze the impact of concurrent periodontal and maxillofacial diseases on the mental state and quality of life of patients aged 18-60 years for future comprehensive rehabilitation.</p><p><strong>Patients and methods: </strong>Materials and Methods: A total of 61 patients (aged 28-60 years) with periodontal diseases and concomitant maxillofacial disorders were studied. All patients had a dental examination, accompanied by assessments of anxiety, depression, and self-esteem with the Hospital Anxiety and Depression Scale (HADS), the Dembo-Rubinstein self-assessment method, and the Chaban Quality of Life Scale (CQLS).</p><p><strong>Results: </strong>Results: The analysis of the HADS A score revealed that 31.1% of patients had a clinical level of anxiety, whereas 41% of patients had a subclinical level of anxiety. Based on the HADS D score, 21.3% of patients had a clinical level of depression, whereas 50.8% had a subclinical level of depression. The aspects of appearance, health, and confidence are highly correlated with patients' mental well-being. The quality of life assessment indicates that the majority of patients with concurrent periodontal and maxillofacial diseases experience a low or moderate quality of life.</p><p><strong>Conclusion: </strong>Conclusions: Patients with periodontal and maxillofacial diseases require not only dental care but also comprehensive rehabilitation, since appearance and physical health have a major impact on their quality of life.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects of osteosynthesis with fixators based on magnesium alloys, mechanical and physiological properties. The state of the problem at the current stage.","authors":"Bohdan A Kotelyukh, Oleksandr Movchan, Serhii Teslia, Dmitro Shtonda","doi":"10.36740/WLek/197141","DOIUrl":"10.36740/WLek/197141","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim of this work is to analyze the available scientific information regarding to the prospects of metal-osteosynthesis with biodegradable fixators based on magnesium alloys.</p><p><strong>Patients and methods: </strong>Materials and Methods: A set of general and special methods of scientific knowledge are used in the article. Search and analysis of full-text articles and scientific publications - carried out in databases of systematic reviews of MEDLINE, PubMed, Web of Science, Google Scholar, Scopus.</p><p><strong>Conclusion: </strong>Conclusions: Magnesium-based implants contribute to a tissue regeneration and healing during degradation and do not require removal. This allows you to avoid the second surgical intervention and reduces treatment costs. That is why the development and implementation of biodegradable fixators for osteosynthesis is of great importance.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"162-167"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of estrogen receptor β gene polymorphisms on the atherogenic index and coronary artery disease in Iraqi population.","authors":"Rasha Farhood Medlool, Karar Nadhum Obaid Aljabry, Majid Kadhum Hussain","doi":"10.36740/WLek/199561","DOIUrl":"10.36740/WLek/199561","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To study the impact of the estrogen receptor beta polymorphisms rs4986938 (AluI) and rs1256049 (RsaI) on ischemic heart disease as well as the atherogenic index in Iraqi population.</p><p><strong>Patients and methods: </strong>Materials and Methods: A case-control research study was conducted on a sample of Coronary artery disease patients in addition to a group of normal individuals. Serum lipid concentrations were measured in the participants, and the ER gene (rs1256049, rs4986938) was genotyped by PCR- RFLP.</p><p><strong>Results: </strong>Results: Atherogenic serum lipid concentrations increased significantly in Coronary artery disease patients relative to the control group. Genotyping of the estrogen receptor β gene forrs4986938 SNP revealed a significant (OR=2.79, P=0.000) elevation of the GA genotype carriers in Coronary artery disease versus the control groups. The genotype analysis of thers1256049 SNP failed to exhibit a significant variation. Atherogenic index and serum lipid concentration markedly elevated with these polymorphisms.</p><p><strong>Conclusion: </strong>Conclusions: The polymorphisms of ESRβ rs4986938, (not for rs1256049) was associated with risk of Coronary artery disease and implicated in changes of serum lipid concentrations and atherogenic index in Iraqi population. Additional studies of ESRβ genetic variation and risk of CVD are warranted.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"148-155"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pharmacogenomic biomarkers and clinical effect of FSHR gene variants on female infertility.","authors":"Hameeda Hadi Abdulwahid, Abeer Hussein, Mazin Hamid Oda","doi":"10.36740/WLek/200331","DOIUrl":"10.36740/WLek/200331","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aims of this study are to detect the genetic polymorphisms of FSHR rs6166 (C> T) and rs6165 (C> T) gene particularly that associated with the response to FSH treatment and their effects on the pathogenesis of infertility in Iraqi women.</p><p><strong>Patients and methods: </strong>Materials and Methods: 210 Iraqi women, aged 20 to 34, who had just been diagnosed with infertility were included in this prospective case control research, whereas the control group consisted of 50 clinically healthy women who were free of any disorders. Following the guidelines for inclusion and exclusion in the study, each of the participating women saw a gynecologist to confirm. The time frame for this From November 2021 to June 2022, the investigation was carried out.</p><p><strong>Results: </strong>Results: The findings of this study in infertile women, clearly indicates that multiple genotypes of FSHR gene particularly (rs6166) (C>T) and (rs6165) (C>T), that include the homozygous wild genotype (CC), homozygous mutant (TT) and heterozygous (CT) genotype. The T allele was significantly increased (P<0.05) in poor responder infertile women for both rs6166 and rs6165 in FSHR which associated significantly with poor response to FSH in Iraqi infertile women.</p><p><strong>Conclusion: </strong>Conclusions: Polymorphisms in FSHR gene may be associated with decrease in response to FSH treatment and it was associated with pathogenesis of infertility in Iraqi women/ Kerbala province.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"90-99"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of different factors (duration of disease, gender, education, patients' history, job and age) in metformin response in type 2 diabetes mellitus patient.","authors":"Alaa Abd Al-Hussain Naem, Mona N Al-Terehi, Fadhaa Abdulameer Ghafil, Sahar Majeed, Najah Rayish Hadi, Defaf Al-Mudafer","doi":"10.36740/WLek202407108","DOIUrl":"10.36740/WLek202407108","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study aims to evaluate how various factors affect various aspects of glycemic control in individuals with type 2 diabetes who are undergoing metformin treatment.</p><p><strong>Patients and methods: </strong>Materials and Methods: A cross-sectional study involved 150 participants who met specific criteria, including being aged between 30 and 70, having a type 2 diabetes diagnosis, and using 1000 mg of metformin as the monotherapy for at least three months. Collected data encompassed various measures, such as levels of glycated hemoglobin (HbA1c), fasting blood glucose concentrations, fasting serum insulin levels, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), and insulin sensitivity.</p><p><strong>Results: </strong>Results: Our research reveals that when it comes to factors such as several socio-demographic variables, there is no statistically significant difference (p-value ≥ 0.05) between patients who exhibit a positive response to metformin and those who do not. Nevertheless, distinctions were noted in patients' previous history and the duration of their illness, which did influence their treatment response.</p><p><strong>Conclusion: </strong>Conclusions: Glycemic parameters in individuals with type 2 diabetes can be impacted by a range of factors, such as age, gender, and occupation also it's important to note that these outcomes influenced by additional variables like the adherence for medication, and the existence of diabetes-related complications.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 7","pages":"1356-1363"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors for low- and high grade squamous intraepithelial lesions in histological preparations following LLETZ procedure.","authors":"Yonka Ivanova, Yavor Kornovski, Stoyan Kostov, Stanislav Slavchev, Dimitar Metodiev, Angel Yordanov","doi":"10.36740/WLek202408105","DOIUrl":"https://doi.org/10.36740/WLek202408105","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate the influence of the following prognostic factors: age, parity, hormonal status (premenopausal, postmenopausal), histological result from targeted biopsy (LSIL, HSIL), adequacy of colposcopic examination (satisfactory, unsatisfactory colposcopy), type of TZ (type 1, 2, 3), type of cervical lesions (type 1, 2, 3), the colposcopic impression (diagnosis) of the cervical lesion (LSIL, HSIL/Ca colli uteri in situ), lesion size (up to 1/3; up to 2/3; more than 2/3 of the cervical circumference) for the occurrence of LSIL and HSIL/Ca colli uteri in situ in the final histological result after LLETZ procedure.</p><p><strong>Patients and methods: </strong>Materials and Methods: This is a prospective study (01.01.2017 - 31.07. 2021) including 189 patients with cervical precancerous lesions received LLETZ treatment One gynaecologic oncologist performed video colposcopy, targeted biopsy, and LLETZ. One histopathologist diagnosed histological specimens from the biopsy and LLETZ procedure.</p><p><strong>Results: </strong>Results: We found a statistically significant correlation between the histological result of the targeted biopsy factor and the colposcopic diagnosis factor concerning the final histological result of LLETZ. The cervical lesion size factor and cervical lesion type factor have prognostic significance for the histological outcome following LLETZ.</p><p><strong>Conclusion: </strong>Conclusions: The histological result of targeted biopsy and colposcopic diagnosis are significant factors for the final histological result after LLETZ. Cervical lesion invasion into the endocervical canal is a prognostic factor for HSIL, and its invisible borders - for carcinoma (in situ or microinvasive/invasive). Lesion size up to 1/3 of the cervix is a prognostic factor for LSIL and large lesions (2/3 of the cervix) - for HSIL and cervical cancer (in situ, microinvasive/invasive).</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 8","pages":"1562-1568"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Index assessment of periodontal status in patients on the background of administering a drug with circadian activity.","authors":"Maryna Y Vasko, Iryna M Tkachenko, Yaroslav Y Vodoriz, Anna V Dvornyk, Oleh A Pysarenko","doi":"10.36740/WLek202407104","DOIUrl":"https://doi.org/10.36740/WLek202407104","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim of this study was to determine the effect of application of drug with circadian activity (pioglitazone) for treatment of patients with periodontist.</p><p><strong>Patients and methods: </strong>Materials and Methods: Group I - 18 individuals with healthy periodontium. Group II - 12 participants with stage II, grade B periodontitis treated with a standard treatment protocol. Group III - 12 participants with stage II, grade B periodontitis, treated with a regimen that included the standard protocol along with the administration of pioglitazone prescribed at recommended times of intake. Group IV - 12 participants with stage II, grade B periodontitis treated with the standard protocol and pioglitazone against the recommended intake hours.</p><p><strong>Results: </strong>Results: The Simplified Oral Hygiene Index in Group I was 0.406±0.034. In Group II, it was 2.5±0.06. In Group III, the hygiene index was 2.633±0.056 and in Group IV it was 2.5±0.059. The Papillary-Marginal-Alveolar Index in Group I was 0.033±0.004. In Group II, it was 0.366±0.011. For Group III, the PMA index was 0.38±0.012 and for Group IV it was 0.378±0.01. The Russell's Periodontal Index in Group I was 0.111±0.008. In Group II, it was 4.668±0.155. For Group III - 4.708±0.132 and for Group IV it was 4.575±0.089. The Gingival Bleeding Index (GBI) in Group I was 0.031±0.003, while in Group II, it was 0.266±0.009, in Group III, it was 0.273±0.007 and in Group IV it was 0.278±0.006.</p><p><strong>Conclusion: </strong>Conclusions: The administration of pioglitazone (the drug with circadian activity) according to its circadian stage indeed has a positive effect on the periodontal status changes of patients with stage II, grade B periodontitis.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 7","pages":"1325-1330"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The private-legal nature of the application of the methods of assisted reproductive technologies in Ukraine.","authors":"Viktoriia V Nadon, Arsen N Isaiev, Olena O Ruban, Tetiana I Brovchenko","doi":"10.36740/WLek202407124","DOIUrl":"https://doi.org/10.36740/WLek202407124","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Analyze the legislation, judicial practice of Ukraine and EU countries, scientific views on surrogacy, as well as the procedure for legal regulation and registration of the procedure of surrogacy.</p><p><strong>Patients and methods: </strong>Materials and Methods: The following materials were used to write the scientific work: the practice of a number of countries was analyzed; scientific works have been studied; some methods of assisted reproductive technologies are described; the practice of the European Court of Human Rights is analyzed. When conducting the research, a methodology was used that embodies an interdisciplinary approach, which allows for a systematic analysis of theoretical and practical aspects of legal relations arising from the provision of medical services.</p><p><strong>Conclusion: </strong>Conclusions: At the legislative level, the provision of medical services (surrogate motherhood services) is partially regulated, therefore the basis of the legal relationship between the performers (surrogate mother) and the customers (genetic parents) is the contract concluded and signed by the parties on the provision of surrogate motherhood services. A contract in defined legal relations is a source of law. This contract is bilateral, paid and consensual.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 7","pages":"1476-1484"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of healthcare-associated endometritis after surgical abortion in Ukraine: results a multicenter study.","authors":"Aidyn G Salmanov, Lidiya V Suslikova, Yaroslav V Stepanets, Sergiy Yu Vdovychenko, Svitlana M Korniyenko, Victor O Rud, Orusia A Kovalyshyn, Igor V Kokhanov, Victoria Ye Butska, Alexander G Tymchenko","doi":"10.36740/WLek202405103","DOIUrl":"10.36740/WLek202405103","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To determine the current prevalence of healthcare-associated endometritis after surgical abortion and antimicrobial resistance of responsible pathogens in Ukraine.</p><p><strong>Patients and methods: </strong>Materials and Methods: We performed a prospective, multicentre cohort study was based on surveillance data of healthcare-associated endometritis after legal induced surgical abortion. Women who underwent induced surgical abortion at gynecological departments of 16 regional hospitals between 2020 and 2022 are included in the study. Definitions of endometritis were adapted from the CDC/NHSN. Antibiotic susceptibility was done by the disc diffusion test as recommended by EUCAST.</p><p><strong>Results: </strong>Results: Among 18,328 women who underwent surgical abortion, 5,023 (27.4%) endometritis were observed. Of all post-abortion endometritis cases, 95.3% were detected after hospital discharge. The prevalence of endometritis in different types surgical abortion was: after vacuum aspiration at < 14 weeks, 23.8%, and after dilatation and evacuation at ≥ 14 weeks, 32%. The most responsible pathogens of post-abortion endometritis are Escherichia coli (24.1%), Enterococcus spp. (14.3%), Enterobacter spp. (12,8%), Pseudomonas aeruginosa (8.3%), Proteus mirabilis (6.6%), Serratia marcescens (6.2%), Staphylococcus aureus (5.9%), and Stenotrophomonas maltophilia (5.7%). A significant proportion these pathogens developed resistance to several antimicrobials, varying widely depending on the bacterial species, antimicrobial group.</p><p><strong>Conclusion: </strong>Conclusions: Results this study suggest a high prevalence of endometritis after surgical abortion in Ukraine. A significant proportion of women were affected by endometritis caused by bacteria developed resistance to several antimicrobials. Optimizing the antibiotic prophylaxis may reduce the burden of endometritis after surgical abortion, but prevention is the key element.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 5","pages":"894-901"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}