DNA repair RAD 18 rs373572 and OGG1 rs1052133 genes polymorphisms association with histological characterization of renal cell carcinoma.

Q4 Medicine

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI:10.36740/WLek/217773

Iftikhar Khdhair Abbas Altemimi, Binan Adil Mohammed Ameen, Mona N Al-Terehi, Liwaa Mahdi Hussein

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引用次数: 0

Abstract

Objective: Aim: Validate the association RAD18 Arg302Gln (rs373572) and OGG1 Ser326Cys (rs1052133) - with Renal Cell Carcinoma (RCC) susceptibility and histopathological characterization.

Patients and methods: Materials and Methods: present study compromised of 37 patients with RCC and control group consisted of 28 healthy apparently individuals. A case control study was conducted using Hand E staining and allele-specific PCR for genes genotyping.

Results: Results: The cohort comprised cases with subtypes clear cell, chromophobe, and variant RCC. A significant link was detected between OGG1 rs1052133 and RCC risk (p = 0.006), with the GG genotype being strongly linked to disease p=0.005. Haplotype demonstrated a significant relations of the GC with RCC (p=0.013). LD test revealed a significant association between RAD18 and OGG1 loci (χ2 = 9.214, p = 0.027), with r- value of 0 in cases and 0.14 in controls. Histopathological correlations revealed that OGG1 rs1052133 genotypes demonstrated a highly significant association with RCC p<0.001. RAD18 rs373572 genotypes were significantly closed link with tumor stage p=0.001. TNM classification revealed a significant relationship with RAD18 genotypes p=0.017.

Conclusion: Conclusions: A significant relationship between OGG1 rs1052133 and both RCC susceptibility and cancer histological subtype, proposed a potential role in the pathogenesis of disease. RAD18 rs373572 showed relevance to tumor stage and TNM classification, indicating a possible impact in disease progression rather than initiation.

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DNA修复RAD 18 rs373572和OGG1 rs1052133基因多态性与肾细胞癌组织学特征的关系

目的：验证RAD18 Arg302Gln （rs373572）和OGG1 Ser326Cys (rs1052133) -与肾细胞癌（RCC）易感性和组织病理学特征的关系。患者与方法：材料与方法：本研究纳入了37例肾细胞癌患者，对照组28例健康个体。病例对照研究采用Hand E染色和等位基因特异性PCR进行基因分型。结果：该队列包括透明细胞、憎色细胞和变异型RCC亚型的病例。OGG1 rs1052133与RCC风险之间存在显著联系（p = 0.006）， GG基因型与疾病密切相关p=0.005。单倍型显示GC与RCC有显著的相关性（p=0.013）。LD检验显示，RAD18与OGG1位点存在显著相关性（χ2 = 9.214, p = 0.027），病例r值为0，对照组r值为0.14。结论：OGG1 rs1052133基因型与RCC易感性和肿瘤组织学亚型均存在显著相关性，可能在RCC发病机制中发挥潜在作用。RAD18 rs373572与肿瘤分期和TNM分类相关，表明可能影响疾病进展而非起始。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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