The role of the MIND diet in prevention and treatment of Alzheimer's disease: A literature review.

Q4 Medicine

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI:10.36740/WLek/217286

Jan Krupa, Maciej Malinowski, Michał Krasowski, Alicja Kalinowska, Wiktoria Pietras, Adrian Kozieł, Zofia Kurek, Aleksander Jentkiewicz, Esmail Haj Obeid, Jakub Ulrych

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引用次数: 0

Abstract

Objective: Aim: Recent research increasingly point to modifiable risk factors, especially dietary patterns, as potential tools to prevent or delay neurodegeneration. This review evaluates the impact of the MIND diet on the prevention and progression of AD and compares it with other dietary interventions.

Patients and methods: Materials and Methods: A literature search was conducted using the PubMed and Google Scholar databases for articles published from January 2015 to January 2025, focusing on the influence of the MIND diet, as well as other dietary patterns, on AD progression and cognitive performance.

Conclusion: Conclusions: While the MIND diet shows promise as a feasible non-pharmacological strategy, current evidence is largely observational and limited by population heterogeneity and inconsistent adherence definitions. Short-term randomized controlled trials are less conclusive. Long-term clinical trials are needed to establish causality. Despite these limitations, the MIND diet remains a practical and potentially effective approach to reducing cognitive decline and delaying the onset of AD.

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MIND饮食在预防和治疗阿尔茨海默病中的作用：文献综述。

目的：最近的研究越来越多地指出可改变的危险因素，特别是饮食模式，作为预防或延缓神经变性的潜在工具。本综述评估了MIND饮食对AD预防和进展的影响，并将其与其他饮食干预进行了比较。患者和方法：材料和方法：使用PubMed和谷歌Scholar数据库进行文献检索，检索2015年1月至2025年1月发表的文章，重点关注MIND饮食以及其他饮食模式对AD进展和认知表现的影响。结论：虽然MIND饮食显示出作为一种可行的非药物策略的希望，但目前的证据主要是观察性的，并且受到人群异质性和不一致的依从性定义的限制。短期随机对照试验则不那么具有决定性。需要长期临床试验来确定因果关系。尽管存在这些局限性，MIND饮食仍然是减少认知能力下降和延缓阿尔茨海默病发病的一种实用且潜在有效的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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