Wiadomosci lekarskie最新文献

{"title":"Cranberry products in the prevention of recurrent urinary tract infections in adult women: Efficacy, safety, and place in non-antibiotic prophylaxis - literature review.","authors":"Julia Gładkowska, Marta Tokaj, Katarzyna Mórdas-Żylińska","doi":"10.36740/WLek/222496","DOIUrl":"https://doi.org/10.36740/WLek/222496","url":null,"abstract":"<p><p>Recurrent urinary tract infections are among the most frequent bacterial infections in adult women and are associated with impaired quality of life, like repeated medical consultations, and cumulative exposure to antibiotics. In the context of increasing antimicrobial resistance, non-antibiotic preventive strategies have attracted growing attention. Cranberry products remain one of the most commonly used and most extensively studied options. The aim of this review was to summarize current evidence regarding the efficacy, safety, and practical role of cranberry products in the prevention of recurrent urinary tract infections in adult women. Contemporary guidelines, systematic reviews, meta-analyses, and randomized clinical trials indicate that cranberry products may reduce recurrence risk, particularly in women with recurrent uncomplicated cystitis. However, cranberry should not be regarded as a single uniform intervention. The clinical effect appears to depend on formulation, proanthocyanidin content, and duration of administration. Preparations providing at least 36 mg of proanthocyanidins daily seem to offer the most consistent benefit, whereas non-standardized products yield heterogeneous and less reliable results. Cranberry products are generally safe and well tolerated, although adherence may be affected by palatability, pill burden, or uncertainty regarding product composition. Overall, cranberry may be considered a reasonable non-antibiotic prophylactic option for selected adult women, provided that counseling includes realistic discussion of expected benefits, limitations of the evidence, and the importance of using standardized preparations.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 6","pages":"1411-1420"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of lateral cephalometric parameters in determining vertical and horizontal maxillofacial growth patterns.","authors":"Myroslava S Drohomyretska, Yulia V Tkachenko, Olga V Garmash","doi":"10.36740/WLek/222584","DOIUrl":"https://doi.org/10.36740/WLek/222584","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To assess the diagnostic value of qualitative and quantitative lateral cephalometric parameters in determining vertical, horizontal, and neutral maxillofacial growth patterns in patients with orthodontic pathology.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study included 292 lateral cephalograms of patients aged 5 to 50 years who sought orthodontic consultation. Eleven quantitative cephalometric parameters were analysed in the full sample. In a randomised subgroup of 160 cephalograms, seven additional qualitative parameters were assessed. Growth pattern determination was performed using an integrated approach based on the absolute majority of diagnostic signs. In addition, 134 cephalograms were independently evaluated by 34 orthodontic trainees using qualitative characteristics only. The diagnostic performance of each parameter was assessed using balanced accuracy, sensitivity, specificity, and positive predictive value.</p><p><strong>Results: </strong>Results: Among 292 patients, 121 had a neutral growth pattern, 103 a vertical pattern, and 68 a horizontal pattern. Evaluation based only on qualitative signs resulted in correct classification in 60.45% of cases on average. Among quantitative parameters, ∠N-Go-Me demonstrated the highest diagnostic performance, with a positive predictive value of 82.9%, followed by ∠Ar-Go-Me and ∠Pn-MP. Among qualitative parameters, the mandibular angle, condylar process height, and contour of the lower mandibular border showed the highest diagnostic value.</p><p><strong>Conclusion: </strong>Conclusions: Quantitative cephalometric parameters, particularly ∠N-Go-Me, are more diagnostically reliable than isolated qualitative assessment for determining maxillofacial growth patterns. A combined approach may improve diagnostic accuracy in orthodontic treatment planning.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 6","pages":"1312-1322"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of resocialisation policy for veterans with posttraumatic stress disorder as a factor of security and socioeconomic stability of Ukraine and the European Union.","authors":"Maryna V Spivak, Oleh М Dubina, Iryna L Bulyk, Lyudmyila Yo Shostak","doi":"10.36740/WLek/222575","DOIUrl":"10.36740/WLek/222575","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To substantiate the strategic role of the resocialisation of veterans with PTSD as a critical factor in the security of Ukraine and the EU; to analyse the clinical specificity of contemporary combat-related disorders; and to demonstrate the necessity of implementing inclusive governance models of rehabilitation at the community level to prevent cross-border social risks.</p><p><strong>Patients and methods: </strong>Materials and Methods: A comprehensive approach was applied, including statistical, comparative, and clinical-diagnostic analyses. The source base consisted of a secondary analysis of data from international organisations (GPI, GLOBSEC, UNODC) and departmental statistics for the period 2008-2025. A systematic selection of publications was carried out in the Web of Science Core Collection, Google Scholar, and the electronic catalogues of the V. I. Vernadskyi National Library of Ukraine using the keywords: resocialisation, veterans, PTSD. Of 68 identified sources (including 34 articles), 22 studies that fully met the criteria of scientific validity were included in the final analysis.</p><p><strong>Conclusion: </strong>Conclusions: It has been demonstrated that Ukraine's resocialisation policy represents a unique precedent for EU and NATO countries. It shows that the stability of the veteran community serves as an instrument for mitigating cross-border crime and social destabilisation in the region. Public administration bodies and local self-government play a decisive role in creating multi-level interventions. The transition from a punitive to a rehabilitative model proves its economic efficiency. Clinical advances by Ukrainian physicians in PTSD are fundamental for the European healthcare system, particularly in the context of rehabilitating foreign volunteers and preparing medical professionals for the challenges of modern conflicts.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 6","pages":"1397-1403"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting the progression of glaucomatous optic neuropathy after antiglaucoma surgery in patients with primary open-angle glaucoma.","authors":"Iryna V Shargorodska, Sergiy O Rykov, Yurii V Barinov, Olha S Sas, Dmytro I Chuhaiev, Liudmyla P Novak, Nataliia M Aleieva","doi":"10.36740/WLek/222588","DOIUrl":"10.36740/WLek/222588","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To identify and analyze the key clinical, structural, and functional factors influencing the progression of glaucomatous optic neuropathy after antiglaucoma surgical intervention in patients with POAG, as well as to determine their prognostic value for optimizing postoperative patient management.</p><p><strong>Patients and methods: </strong>Materials and Methods: A retrospective observational cohort study included 56 patients (56 operated eyes) with primary open‑angle glaucoma who underwent unilateral antiglaucoma surgery and were followed dynamically in the postoperative period. Based on follow‑up results, patients were divided into two groups: with postoperative disease progression (n = 20) and without progression (n = 36).</p><p><strong>Results: </strong>Results: Postoperative disease progression was not associated with age, sex, axial length, or phacomorphic syndrome. Besides, disease progression was significantly associated with elevated plasma LOX1 concentration (≥ 80.1 pg/mL), reduced neuroretinal rim area (< 0.7 mm²), and elevated preoperative IOP (> 25 mmHg). In multivariate logistic regression analysis, reduced neuroretinal rim area 0.7 mm² (OR = 12.9; 95% CI: 3.4-49.1; p < 0.05) and preoperative IOP > 25 mmHg (OR = 7.6; 95% CI: 1.9-29.4; p < 0.05) remained independent predictors of postoperative disease progression, while plasma LOX1 showed moderate discriminative performance (AUC = 0.664).</p><p><strong>Conclusion: </strong>Conclusions: Postoperative progression of glaucomatous optic neuropathy in patients with primary open‑angle glaucoma is determined by a combination of structural, biomechanical, and systemic vascular‑related factors. Preoperative IOP, neuroretinal rim morphology, and plasma LOX1 levels have prognostic significance and should be considered for postoperative risk stratification and individualized follow‑up.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 6","pages":"1179-1187"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of apixaban versus warfarin in LVAD patients: A propensity-matched analysis.","authors":"Laith Rhabneh, Ra'ed Ababneh, Abdallah Al-Muhtaseb, Shahd Qaddour, Mohammed Aloqaily, Khalid Hazaimeh, Abdel Rahman Alwardat","doi":"10.36740/WLek/216191","DOIUrl":"10.36740/WLek/216191","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The primary endpoint was the incidence of major HRAEs. Secondary endpoints included LVAD thrombosis, stroke, major bleeding, non-central nervous system thromboembolism, and all-cause mortality.</p><p><strong>Patients and methods: </strong>Materials and Methods: We conducted a multicenter retrospective cohort study using the TriNetX database, identifying LVAD patients receiving either warfarin or apixaban. Two cohorts were established based on anticoagulation regimen, and propensity score matching was employed to minimize baseline differences.</p><p><strong>Results: </strong>Results: After matching, 3,129 patients were included in each group. HRAEs occurred less frequently in the apixaban cohort (19.7%) than in the warfarin cohort (28.4%) (OR: 0.618; 95% CI: 0.513-0.744; P < 0.001). Apixaban was also associated with significantly fewer LVAD thrombosis events (OR: 0.088), strokes (OR: 0.721), and major bleeding events (OR: 0.528). Rates of non-CNS thromboembolism and all-cause mortality were similar between groups.</p><p><strong>Conclusion: </strong>Conclusions: Although warfarin remains the standard anticoagulant for LVAD recipients, apixaban demonstrated lower rates of major adverse events in this large retrospective analysis. Further prospective and randomized studies are warranted to confirm these findings and inform future clinical practice.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 5","pages":"978-988"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148340513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volitional qualities development in future law enforcement officers during various types of motor activity.","authors":"Tetyana M Snyatkova, Oksana M Mіroshnychenko, Igor M Bushai, Natalia E Penkova, Tetyana V Kondratyuk-Antonova, Olga G Marchenko, Ivan M Okhrimenko, Serhii M Zhembrovskyi","doi":"10.36740/WLek/217267","DOIUrl":"10.36740/WLek/217267","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate the impact of various types of motor activity on the development of cadets' indicators of volitional qualities during their training at higher educational institutions.</p><p><strong>Patients and methods: </strong>Materials and Methods: The research, conducted in the 2024-2025 academic year, involved 352 male cadets, who were divided into three groups: the HHC Group (n=54), whose cadets participated in hand-to-hand combat (HHC) during their sporting and mass participation events; the SC Group (n=91), whose cadets participated in various sports clubs of the academy; the K Group (n=207), whose cadets did not participate in additional sports. Research methods: analysis and generalization of literary sources, methods of assessing volitional qualities, and methods of mathematical statistics.</p><p><strong>Results: </strong>Results: It was found that the cadets of the HHC Group showed significantly better results in terms of volitional qualities in their senior training years than those in the K group, which indicates a more pronounced effect of HHC training sessions on the development of volitional qualities in future law enforcement officers. At the same time, no significant difference was found between the indicators of cadets in the HHC and SC groups, which indicates the effectiveness of additional sports activities in developing cadets' volitional qualities.</p><p><strong>Conclusion: </strong>Conclusions: The comprehensive impact of hand-to-hand combat training sessions on the volitional qualities of cadets has been proven. This emphasizes the advisability of wider introduction of hand-to-hand combat techniques into the physical training of cadets during their studies at higher educational institutions to improve the effectiveness of their future service and professional activities.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 1","pages":"46-53"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of histopathological results of the endometrium in breast cancer patients treated with tamoxifen. Preliminary report.","authors":"Małgorzata Toroń, Antoni Wołoszyn, Aleksandra Zielińska, Anna Kociszewska","doi":"10.36740/WLek/215320","DOIUrl":"10.36740/WLek/215320","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to compare histopathological outcomes of the endometrium in breast cancer patients treated with tamoxifen. The analysis included asymptomatic women referred for abnormal ultrasound findings and symptomatic women with abnormal uterine bleeding.</p><p><strong>Patients and methods: </strong>The study included 85 patients hospitalized between 2013 and 2024 at the Medical University of Warsaw. Group I (n=41) comprised patients with abnormal ultrasonographic findings, while Group II (n=44) included women with abnormal uterine bleeding. All patients underwent hysteroscopy with subsequent histopathological tissue analysis.</p><p><strong>Results: </strong>The most frequent histopathological diagnosis in both groups was the presence of endometrial polyps (Group I: 51.22%; Group II: 36.36%). Endometrial cancer was diagnosed in 7.32% of Group I and 9.09% of Group II patients, indicating a comparable prevalence of serious pathology. Statistically significan differences (p < 0.05) were noted between the groups only for non-atypical hyperplasia and proliferative endometrium.</p><p><strong>Conclusion: </strong>The findings confirm that endometrial polyps are the most frequent pathology associated with tamoxifen use in this cohort. This preliminary report underscores the critical need for further targeted research focusing on population-specific factors and menopausal status to develop clear, personalized clinical guidelines for screening and surveillance, particularly for premenopausal women, independent of symptomatic presentation.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 1","pages":"242-246"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of using modern oral iron formulations for the correction of iron deficiency conditions in women of reproductive age.","authors":"Valentyna K Kondratiuk, Iryna M Nikitina, Natalia Y Нorban, Kateryna O Kondratiuk, Natalia P Dzis","doi":"10.36740/WLek/217270","DOIUrl":"10.36740/WLek/217270","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Aim: To scientifically justify the use of the FERRO-EURIKA™ food supplement as a corrective agent for iron deficiency (ID) in women of reproductive age.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patients and methods: &lt;/strong&gt;Materials and Methods:The study involved 120 women aged 18 to 35 years (median age: 29 years; interquartile range: 24-33 years) with laboratory-confirmed iron deficiency (ID) and iron deficiency anaemia (IDA) related to chronic blood loss (ICD-10 N 92.0 - Excessive and frequent menstruation with regular cycles). In addition to evaluating changes in peripheral blood parameters and iron stores, we analysed the participants' complaints and clinical manifestations of iron deficiency conditions (sideropenic and anaemic syndromes). All subjects were divided into two representative groups of 60 women each. Women of Group 1 (main group, n = 60) received iron bisglycinate 157 mg (equivalent to 30 mg of elemental bivalent iron) in combination with glucosamine salt of (6S)-5-methyltetrahydrofolate - 740 µg (equivalent to 400 µg of folic acid), one capsule twice daily, 30 minutes before meals, for pathogenetically justified correction of ID conditions. Women of Group 2 (comparison group, n = 60) received ferrous sulfate 247.25 mg (equivalent to 80 mg of elemental bivalent iron), one capsule twice daily, 30 minutes before meals. The treatment duration for both groups was 90 days.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Results: We analysed clinical manifestations of iron deficiency conditions and laboratory parameters in women of reproductive age both before the initiation of iron therapy and during correction (on Days 21, 60, and 90 of treatment). Dynamic analysis of clinical symptoms and haematologic indicators in both groups demonstrated a significant decrease in subjective complaints, accompanied by normalization of laboratory parameters, confirming the positive effects of the interventions. Safety and tolerability analyses of the correction of ID conditions were performed to evaluate adherence to long-term iron supplementation among women. An analysis of the causes of treatment discontinuation revealed gastrointestinal adverse effects associated with iron intake: nausea occurred in 5 (8.3%) women of Group 1 and 13 (24.1%) of Group 2; constipation in 2 (3.3%) of Group 1 and 7 (13.0%) of Group 2; and abdominal pain in 2 (3.3%) of Group 1 and 9 (16.7%) of Group 2. These complaints in Group 1 were mild in intensity and resolved by Day 60, allowing all participants in this group to successfully complete the full treatment course. In contrast, gastrointestinal symptoms persisted in Group 2 at Days 60 and 90, resulting in reduced adherence to therapy, with approximately 30% of patients discontinuing further intake of the prescribed iron preparation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Conclusions: 1. The results of the study indicate that the FERRO-EURIKA™ food supplement may be an effective oral agent for correcting iron deficiency conditions i","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary tract infections in patients undergoing orthopaedic procedures: A contemporary review (2021-2026).","authors":"Mateusz Kaczmarski, Zeeshan Zulfiqar, Vasu Duangudomdej, Jakub Kot, Joanna Niezbecka-Zając, Silvija Ille","doi":"10.36740/WLek/218250","DOIUrl":"10.36740/WLek/218250","url":null,"abstract":"<p><p>Urinary tract infections are one of the most frequent healthcare-associated infections representing a relevant postoperative complication in orthopedics patients. These infections are associated with increased morbidity, prolonged hospitalizations, and higher rates of readmission. In selected settings, they may coexist with or precede surgical site infections, including periprosthetic joint infections. This review aims to summarize and evaluate recent evidence from the last five years in regards to epidemiology, risk factors, clinical consequences, and preventative strategies for patients undergoing orthopaedic interventions. A narrative literature review was conducted using the PubMed/MEDLINE database utilizing English-language publications from January 2021 to February 2026. Particular emphasis was placed on systematic reviews, meta-analyses, cohort studies, and large database analyses related to hip fracture surgery, total joint arthroplasty, and spine surgery. These studies indicate that urinary tract infections remain particularly common among the geriatric population undergoing hip fracture surgery. Major modifiable risk factors include urinary catheterization and postoperative urinary retention. Symptomatic urinary tract infections briefly prior to surgery are associated with an increased risk of postoperative complications compared to asymptomatic bacteriuria. Avoidance of unnecessary urinary catheterization and routine urine testing in asymptomatic patients reduces the use of unnecessary antibiotics while preserving surgical outcomes. Urinary tract infections continue to represent a significant clinical issue in orthopaedic patients. Evidence supports catheter stewardship, targeted diagnostic strategies, and integrated preventive approaches to reduce infection-related complications.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 3","pages":"564-570"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147655148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA repair RAD 18 rs373572 and OGG1 rs1052133 genes polymorphisms association with histological characterization of renal cell carcinoma.","authors":"Iftikhar Khdhair Abbas Altemimi, Binan Adil Mohammed Ameen, Mona N Al-Terehi, Liwaa Mahdi Hussein","doi":"10.36740/WLek/217773","DOIUrl":"10.36740/WLek/217773","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Validate the association RAD18 Arg302Gln (rs373572) and OGG1 Ser326Cys (rs1052133) - with Renal Cell Carcinoma (RCC) susceptibility and histopathological characterization.</p><p><strong>Patients and methods: </strong>Materials and Methods: present study compromised of 37 patients with RCC and control group consisted of 28 healthy apparently individuals. A case control study was conducted using Hand E staining and allele-specific PCR for genes genotyping.</p><p><strong>Results: </strong>Results: The cohort comprised cases with subtypes clear cell, chromophobe, and variant RCC. A significant link was detected between OGG1 rs1052133 and RCC risk (p = 0.006), with the GG genotype being strongly linked to disease p=0.005. Haplotype demonstrated a significant relations of the GC with RCC (p=0.013). LD test revealed a significant association between RAD18 and OGG1 loci (χ2 = 9.214, p = 0.027), with r- value of 0 in cases and 0.14 in controls. Histopathological correlations revealed that OGG1 rs1052133 genotypes demonstrated a highly significant association with RCC p<0.001. RAD18 rs373572 genotypes were significantly closed link with tumor stage p=0.001. TNM classification revealed a significant relationship with RAD18 genotypes p=0.017.</p><p><strong>Conclusion: </strong>Conclusions: A significant relationship between OGG1 rs1052133 and both RCC susceptibility and cancer histological subtype, proposed a potential role in the pathogenesis of disease. RAD18 rs373572 showed relevance to tumor stage and TNM classification, indicating a possible impact in disease progression rather than initiation.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 2","pages":"317-327"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}