Wiadomosci lekarskie最新文献

{"title":"Pathomorphological features of systemic manifestations of severe acute pancreatitis complicated by abdominal compartment syndrome.","authors":"Olexii I Dronov, Inna O Kovalska, Ivanna A Shchyhel, Tetiana P Shevchyk, Vitaliy R Balyak, Vadym O Kostiukevich","doi":"10.36740/WLek/203878","DOIUrl":"https://doi.org/10.36740/WLek/203878","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To classify systemic pathomorphologic changes in severe acute pancreatitis (SAP) and to identify histologic features associated with abdominal compartment syndrome (ACS).</p><p><strong>Patients and methods: </strong>Materials and Methods: The retrospective cohort examination of 53 patients with SAP, who died due to progressive organ failure. Microscopic specimens of the heart, lungs, liver, kidneys and intestines have been reviewed, divided by the proposed four levels of pathological changes and comparable between the two groups, depending on the presence of AСS (25 and 28 patients).</p><p><strong>Results: </strong>Results: When comparing in two groups the levels of lesions of each studied organ, according to given levels of change, a statistically significant difference between groups in the level of kidney and intestine lesions (P <0.05, Mann-Whitney U-Test) was obtained. The changes in moderate and severe levels were significantly dominating in the microscopic specimens of the kidneys and intestines of group A compared to group B (p <0.001).</p><p><strong>Conclusion: </strong>Conclusions: Histopathological changes in the examined organs of patients who died from severe acute pancreatitis complicated by abdominal compartment syndrome were characterized by more pronounced ischemic and inflammatory damage in the kidneys and intestines. The variability of extrapancreatic pathological changes in SAP patients depended on intra-abdominal pressure levels. Monitoring and timely correction of intra-abdominal hypertension aimed at preventing ACS in SAP patients may influence disease progression and treatment outcomes.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"760-767"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point prevalence study of antibiotics use in Ramadi hospitals.","authors":"Maysaa Ali Abdul Khaleq, Ammar Yasir Ahmed, Ahmed Kahlid Awad, Abdula Ahmed Fahed, Fahed Ahmed Fahed, Gada Safaa Ali, Tabark Mohammed Huwadi","doi":"10.36740/WLek/199783","DOIUrl":"10.36740/WLek/199783","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To describe antibiotic use in Al-Ramadi hospitals using the Biomérieux VITEK2 compact system.</p><p><strong>Patients and methods: </strong>Materials and Methods: A lot of different hospitals in Al- Ramadi were visited, checking Patients' illness profile. Information about antibiotics prescription pattern in Al-Ramadi hospitals had been collected from urinary tract infected patients using the Biomérieux VITEK2 compact system.</p><p><strong>Results: </strong>Results: Out of 67 specimens obtained from Urinary tract infection, fifty-two isolates were E. coli, eight isolates were Klebsiella pneumoniae, four were Burkholderia cepacian, and two were Raoultella spp and only one isolate Acetobacter aceti. The data analysis revealed that females had a higher prevalence of infection than males, with 41(68.30%) and 26(38.80%), respectively.</p><p><strong>Conclusion: </strong>Conclusions: Resistance rates have shown variations over the years, they have typically remained elevated for antibiotics commonly employed in the empirical management of urinary tract infections. For successful treatment, it will be crucial to adjust therapy based on culture results and to consider resistance rates during empirical treatment.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"396-401"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerobic skin microbiota study in patients with paratraumatic eczema developed as a result of combat injuries.","authors":"Svitlana Dzhoraieva, Yanina Kutasevych, Oksana Sokol, Valentina Honcharenko, Hanna Kondakova, Iryna Oliinyk, Olha Oliinyk","doi":"10.36740/WLek/197131","DOIUrl":"10.36740/WLek/197131","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To establish taxonomic composition, population level and microecological indicators of the \"macroorganism-microbiota\" ecosystem by determining the expression levels of individual pathogenicity factors of microorganisms isolated from the skin areas of patients with paratraumatic eczema developed as a result of combat injuries.</p><p><strong>Patients and methods: </strong>Materials and Methods: Studied microbiologically eczematous lesions content in 54 military men to determine the qualitative and quantitative composition of microbiocenosis to analyze the taxonomic composition, population-species level, microecological indicators and expression levels of individual pathogenicity factors.</p><p><strong>Results: </strong>Results: The results indicate that most eczematized areas are contaminated with S.aureus (48.1% ) with the highest level of quantitative dominance. The rate of quantitative dominance of other strains is significantly lower: S.epidermidis - 2.56 times, S.haemolyticus - 4.56 times, S.pyogenes - 5.86 times, E.faecalis and K.pneumoniae - 20.56 times. When determining the sensitivity of S. aureus clinical strains to antibacterial drugs, we established high levels of sensitivity to mupirocin, fusidic acid, and oxazolidinones - 95.1%, 90.2%, and 87.8%, respectively. Moreover, S. aureus dominated among the strains with a high ability to form biofilms - 68.2%, with an average ability - S epidermidis, 28.8%.</p><p><strong>Conclusion: </strong>Conclusions: S.aureus is the leading pathogen in the infectious-allergic process with paratraumatic eczema according to the constancy index of each taxon, frequency of manifestation, Margalef's species richness index, Whittaker's species diversity, the value of Simpson's and Berger-Parter's species dominance indices, as well as the population level of each taxon, the coefficient of quantitative dominance and the coefficient of significance. We should consider this fact when prescribing therapy.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extrinsic black staining of teeth: a review.","authors":"Inessa I Yakubova, Volodymyr Ostrianko, Yurii Skrypnyk, Roman Volovodovskiy","doi":"10.36740/WLek/197130","DOIUrl":"10.36740/WLek/197130","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Discovering of the prevalence, causes and consequences of the Extrinsic black staining(EBS) of teeth in pediatric population.</p><p><strong>Patients and methods: </strong>Materials and Methods: Upon completion of the scientific search, the review included 47 scientific articles from the electronic databases, reference lists of articles, and selected textbooks in the time interval from 1976 to 2023.</p><p><strong>Conclusion: </strong>Conclusions: The results show that EBS is a possible protective factor against early childhood caries. Dental plaque and gut microbiome may be related to EBS in the temporary dentition. The literature suggests a decreased caries prevalence in the presence of EBS which associated with low incidence of caries in children. The nature of the black pigmentation is suggested to be a form of bacterial plaque with an insoluble ferric salt. Tabaco smoke, food and antibiotics that can be also a risk factors for EBS. There are some clinical and localization features that dentist have to pay attention for. Many diseases of various systems and organs are directly related to black plaque. With this review, we wanted to encourage dentists to identify the problem in childhood and collaborate in a multidisciplinary team to improve treatment efficiency and speed up the selection of the right tactics for the most person-centered approach to avoid worsening the problem in adulthood.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"210-215"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender dimorphism of neurodynamic and cognitive functions of sub-elite and elite athletes (on the example of sports acrobatics).","authors":"Nataliia Veronika Bachynska, Dmytro Anisimov, Oleksandr Zhuravel, Dmytro Kaznacheiev, Vadym Fursa, Nataliia Martynova, Liudmyla Lysenko","doi":"10.36740/WLek/197138","DOIUrl":"10.36740/WLek/197138","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To evaluate the impact of a specific acrobatic load on the neurodynamic and cognitive functions of acrobats, as well as to study how these functions change depending on the gender, age and level of sports qualification of athletes (sub-elite and elite athletes).</p><p><strong>Patients and methods: </strong>Materials and Methods: Athletes specializing in pair and group acrobatics, of two age categories: 1. Sub-elite - athletes of puberty age, which included: girls (n=32), average age 13.96±1.02 years; boys (n=36), average age 14.88±2.32 years. 2. Youth acrobats (elite athletes): girls (n=30), average age 19.36±2.86 years; young men (n=34), average age 20.38±2.89. The computer program \"Diagnost-1\" was used in researches.</p><p><strong>Results: </strong>Results: In female acrobats, the latency period of simple visual-motor information, the latent period of the visual-motor reaction to choosing two out of three stimuli are statistically different from those of young acrobats. Boys acrobats are faster in terms of functional mobility of nervous processes than girls in both age categories (at p<0.05). A greater amount of processed information was found in acrobat boys than in adolescent girls. According to the indicators of cognitive characteristics features of sexual dimorphism between acrobats of different age categories were revealed due to different information processing strategies taking into account sexual characteristics.</p><p><strong>Conclusion: </strong>Conclusions: Boys-acrobats of puberty and adolescence showed more effective processing of simple and complex visual-motor information compared to girls-acrobats of the same age categories. The indicators of neurodynamic and cognitive functions of young acrobats are better than those of pubescent athletes and different by gender (p<0.05).</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"61-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential cardioprotective effect of trimetazidine in mice model of endotoxemia: role of AMPK-Nrf2.","authors":"Alaa Kadhum Mosa, Sahar Majeed, Fadhaa Abdulameer Ghafil, Najah Rayish Hadi","doi":"10.36740/WLek/190820","DOIUrl":"10.36740/WLek/190820","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To clarify the potential cardioprotective effect of Trimetazidine against experimentally sepsis-caused endotoxic cardiac injury damage in mice.</p><p><strong>Patients and methods: </strong>Materials and Methods: 24 Mice were divided into four groups (n=6): Sham group, CLP group DMSO group, trimetazidine-treated group 50 mg/kg IP, 1hr before CLP, then the animals were sacrificed 24 hr after CLP and tissue sample was taken for measurement of TNF-α, TNF-αr1, IL-1β, HO-1, MPO, caspase-11, F2-isoprostane and serum troponin by ELISA and gene expression of AMPK-Nrf2 by qpcr and histopathological study.</p><p><strong>Results: </strong>Results: trimetazidine treated group showed significant changes as compared with clp group regarding TNF-α, TNF-αr1, IL-1β, HO-1, MPO, CASPASE-11, F2-ISOPROSTANE as well as affect tissue mRNA expression of AMPK-Nrf2 genes p<0.05.</p><p><strong>Conclusion: </strong>Conclusions: We evaluate that Trimetazidine has cardio protective effects due to its anti-inflammatory and anti-oxidative action. Also, trimetazidine showed a cardio-protective effect as they affect tissue mRNA expression of AMPK-Nrf2 genes.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"35-44"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic challenges of Lisfranc joint injuries: A review of imaging methods.","authors":"Konrad Talarek, Michał Świta, Julia Szewczyk, Anna Szuciak, Karolina Turżańska","doi":"10.36740/WLek/202333","DOIUrl":"https://doi.org/10.36740/WLek/202333","url":null,"abstract":"<p><p>Lisfranc injuries, which affect the tarsometatarsal joint and are relatively rare, have a 20% misdiagnosis rate. This can result in serious complications such as foot instability, degeneration, or chronic pain. Due to the absence of clear diagnostic guidelines, this article reviews existing literature and research to propose an algorithm for identifying potential Lisfranc injuries. The literature review summarizes information on diagnostic methods for Lisfranc complex injuries. It was executed using PubMed, Web of Science, and Google Scholar databases. Scientific publications published between 2016 and 2024 were counted in review and scientific before this period. Lisfranc complex injuries, especially subtle cases, are frequently missed due to both patient oversight and physician error. In diagnostic trials, tools like traditional X-rays or CT scans are commonly employed, however MRIs and ultrasounds are often overlooked. Weight-bearing X-rays and weight-bearing CT could be promising due to their high sensitivity. Appropriate patient interview and physical examination along with imaging are essential points for making an accurate diagnosis. It is important to diagnose Lisfranc injuries to prevent the development of serious complications. Greater patient awareness and a comprehensive diagnostic approach by doctors are key to improving detection rates. Subtle Lisfranc injuries are the greatest diagnostic challenge. Weight-bearing CT scans and radiographs could be very helpful in identifying these injuries. Further research is needed to optimize the use of these imaging methods.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"626-633"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression in older adults.","authors":"Kamila Kwiatkowska, Nataliia Fedorenko, Silvija Ille, Artur Jakubiak","doi":"10.36740/WLek/202719","DOIUrl":"https://doi.org/10.36740/WLek/202719","url":null,"abstract":"<p><p>Depression is an increasingly common disease in elderly. It affects almost every sphere of senior life and is a socio-medical challenge for the modern world. Unfortunately, it is rarely diagnosed in this age group, which concerns the use of pharmacological and therapeutic intervention. The complex etiology and comorbidity of somatic diseases makes diagnosis difficult because depressive symptoms are attributed to the underlying disease. Often, the lack of treatment and ignoring the symptoms by the patient and their relatives can contribute to suicide behavior of seniors. The phenomenon of population aging is observed all over the world. The average lifespan of people is increasing, which means an increase in the number of people in senior age. Depression affects more and more elderly people. Lack of interest from family and society, illnesses, loneliness, isolation make seniors experience depressive disorders more often. It is worth taking a closer look at the problem of depression among the elderly and implementing appropriate actions to minimize the problem. The key role is played by educating society about the characteristic symptoms of depression in old age and preventing its occurrence, among others by activating the elderly.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"639-642"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational program to asses and promote knowledge of Al-Zahraa hospital nurses about trichomoniasis disease, Al-Najaf city.","authors":"Wijdan Dhaidan Shnain Al-Abbas, Rehab Lafta Mohammad, Kawther Alqaseer, Ohood Aqeed Radhi","doi":"10.36740/WLek/201339","DOIUrl":"10.36740/WLek/201339","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study included implementing an educational program to evaluate and promote nurses' knowledge of trichomoniasis disease which caused by Trichomonas vaginalis parasite.</p><p><strong>Patients and methods: </strong>Materials and Methods: 100 randomly samples of nurses working in different units in Al-Zahraa Hospital - Najaf City, Iraq. This semi-experimental study was performed. The study was conducted from December 2023 until April 2024. It included a sample of different ages, gender and experience, working in different units in the hospital, married and unmarried, as well as those living in urban and rural areas.</p><p><strong>Results: </strong>Results: The results show the total rating of sample knowledge concerning Trichomoniasis in primary test was a moderate with a mean (0.57) and the mean of next test was a good (0.84), also the results observed a highly significant difference (P <0.01) between pre-test and post-test assessments. In addition, according to their Socio-Demographic Characteristics, the study showed no significant difference in the knowledge scores in the next test.</p><p><strong>Conclusion: </strong>Conclusion: This study concluded that there was an improvement in knowledge after the program for all nurses.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"316-327"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical and pathogenetic manifestations of gastroesophageal reflux disease and obesity and approaches to their diagnosis, treatment, and prevention: current state of the problem (literature review).","authors":"Taras I Griadil, Bohdana V Bezushko, Oleksandr O Dutko, Mykhailo M Lopit","doi":"10.36740/WLek/203909","DOIUrl":"https://doi.org/10.36740/WLek/203909","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The purpose of this study is to review the literature to determine the common pathogenetic mechanisms (PM) between gastroesophageal reflux disease (GERD) and obesity, as well as to analyze the impact of one disease on the other, followed by a review of the basic principles of diagnosis and treatment of patients with a combination of these comorbidities.</p><p><strong>Patients and methods: </strong>Materials and Methods: The literature review included an analysis of articles from the Scopus and Web of Science databases, with a focus on pathogenesis, clinical data, diagnosis and treatment of GERD and obesity. The following keywords were used to find relevant materials on the research topic: \"GERD\", \"obesity\", \"pathogenesis\", \"treatment\", \"clinical trials\".</p><p><strong>Conclusion: </strong>Conclusions: A series of studies have shown that there are risk factors that increase the development of GERD: stress, bad habits, excessive body mass index (BMI), advanced age and lifestyle. At the same time, obesity has similar risk factors to GERD, which in turn prompts the search for correction of common PM, new ways of diagnosis and comprehensive personalized treatment.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"937-942"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}