Wiadomosci lekarskie最新文献

{"title":"Practices of trauma-informed learning and their influence on the level of situational and personal anxiety of students who are studying face-to-face during hostilities.","authors":"Тetiana І Міyer, Borys І Palamar, Svitlana P Palamar, Olga V Kotenko, Hennadii L Bondarenko, Nataliia V Vyshnivska, Roksolana I Shpitsa","doi":"10.36740/WLek/197112","DOIUrl":"https://doi.org/10.36740/WLek/197112","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To reveal the essence of trauma-informed learning in the context of the functioning of a person's inner world and the impact on changing the levels of situational and personal anxiety.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study involved 900 people who are pursuing higher education during the military operations on the territory of Ukraine. Two parts of the Spielberger State-Trait Anxiety Inventory (STAI) questionnaire were used to determine low, medium, and high levels of situational and personal anxiety.</p><p><strong>Results: </strong>Results: Two groups of education seekers are studying face-to-face during hostilities. The first group includes students with a high level of creativity development who quickly adjust to the learning process after the \"Alarm Termination\" signal and show interest in communicating with the lecturer and classmates. The second group includes students with a low level of creativity, who, after the \"Alarm Termination\" signal, seek solitude, withdraw from studies, are depressed for a long time, and are quickly distracted by extraneous sounds.</p><p><strong>Conclusion: </strong>Conclusions: The repetitiveness of the process of experiencing situational anxiety without external supporting influence causes the formation of personal anxiety as a stable personal tendency in students. The use of preventive practices of trauma-informed learning (practices of focusing attention on breathing with a creative supplement, practices of supportive communication, practices of avoiding retraumatization, practices of \"Creative pauses\") helps to reduce the levels of situational and personal anxiety among students in face-to-face training during military operations.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 11","pages":"2289-2295"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specifics of barrier function impairment of the large intestine in patients with ulcerative collitis and joint damage.","authors":"Antonina V Varvarynets","doi":"10.36740/WLek/195166","DOIUrl":"https://doi.org/10.36740/WLek/195166","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To study the characteristics of barrier function impairments of the large intestine in patients with UC and concomitant joint damage.</p><p><strong>Patients and methods: </strong>Materials and Methods: At the clinical base of the Department of Therapy and Family Medicine, 80 patients with inflammatory bowel disease (IBD) were examined. Patients with IBD were divided into two groups. Group 1 (n=78) included patients with IBD and diagnosed with joint damage, namely spondylarthritis (SPA), and group 2 (n=40) included patients with IBD without joint damage. Patients were tested to determine the level of fecal calprotectin (FC), a1-antirpsin (a1-AT) and zonulin. Changes in the quantitative and qualitative composition of the colon microflora were assessed.</p><p><strong>Results: </strong>Results: Patients with UC have been diagnosed with large intestine dysbiosis (LID), which is more pronounced in patients of the 1st group. Stage 3 dysbiosis was 17,3 % (p<0.01) more likely to be found in patient of the 1st group, and stage 4 dysbiosis - 12,9 % (p<0.05) more likely. The level of zonulin, both in blood serum and in feces, was significantly higher in patients with UC compared to controls. In group I patients we found a significant increase in zonulin compared to group II patients (by 1.5 times in blood serum and by 1.4 times in feces, p<0.01). Identical results were observed when analyzing the levels of α1-AT in blood, feces, as well as its clearance (1.6 times (p<0.01), 1.3 times (p<0.05) and 1.4 times (p<0.01) accordingly).</p><p><strong>Conclusion: </strong>Conclusions: Increased levels of zonulin and a1-AT in blood serum and feces was found in patients with UC, which indicates an increased permeability of the intestinal wall in these patients. At the same time, more pronounced changes indicating intestinal barrier function impairment were found in patients with UC and SPA. In patients with UC and SPA, a direct correlation between the change in intestinal permeability and LID severity was established (fecal zonulin levels correlate with LID stages ІІІ and IV- r=0.94; р<0.01 та r=0.88; р<0.01 accordingly).</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 10","pages":"1989-1995"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The second week corneal changes in rodents model of streptozotocin-induced diabetes.","authors":"Oleksandr M Slobodian, Zoriana Z Masna, Yaroslav I Penishkevych, Khrystyna I Rudnytska, Ilona V Chelpanova, Olena V Smolkova, Kostyantyn I Voytsenko","doi":"10.36740/WLek/195141","DOIUrl":"https://doi.org/10.36740/WLek/195141","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Installation the changes of the microstructural rearrangement of the layers of the rat cornea at the end of the second week of experimental streptozotocin- induced diabetes.</p><p><strong>Patients and methods: </strong>Materials and Methods: The research was conducted on 15 sexually mature, outbred white male rats, weighing 120-130 g. Two groups of animals were used in the work: the first group with developing diabetes (2 weeks after administration of streptozotocin); the second group served as control and received injections of 0.9% physiological solution for 2 weeks.</p><p><strong>Results: </strong>Results: Basal cells were located loosely, lost their columnar shape, basal cells of a rounded shape were visualized. The cytoplasm of individual basal cells was swollen and contained small acidophilic granules. At the same time, the cells of the basal layer with lighted vacuolated cytoplasm were visualized. Epitheliocytes of the middle layer of the outer epithelium of the cornea were chaotically located in individual areas, lumps of intensively condensed chromatin were often visualized in their nuclei. Focal destruction of the cells of the surface layer of the cornea and focal layering of fine-grained acidophilic masses in such areas were observed in places. The endothelium of the anterior chamber of the eye was preserved in most areas of the cornea.</p><p><strong>Conclusion: </strong>Conclusions: At the end of the second week of experimental streptozotocin induced diabetes mellitus, we established pathomorphological manifestations indicating the initial phenomena of diabetic keratitis.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 10","pages":"1910-1915"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometrial hyperplasia as a consequence of mixed urogenital infections.","authors":"Nataliya Yu Bysaha, Oxana O Korchynska, Shtefanija Andrashchikova, Silvija Zhultakova, Alena Shlosserova","doi":"10.36740/WLek/195137","DOIUrl":"https://doi.org/10.36740/WLek/195137","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Investigation of hyperproliferative diseases of the female genital organs as a consequence of mixed urogenital infections.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study included 56 women of reproductive age who experienced discomfort in the external genital area in the form of excessive vaginal discharge and/or unpleasant odour of the discharge, itching in the external genital area (main group). The control group consisted of 30 somatically and gynaecologically healthy patients.</p><p><strong>Results: </strong>Results: The following complaints were noted in mixed infections: increased amount of vaginal discharge (28 women / 50% of the main group), unpleasant odour of discharge (19 women / 34%), less frequently - itching (10 women / 18%), burning (11 women / 20%), pain during intercourse (8 women / 14%), digestive tract disorders - bloating and irregular bowel movements (13 women / 23%). Two or more complaints were noted in 29 patients (52% of the main group). The microscopy revealed a small number or complete absence of lactobacilli, abundant polymorphic gram-negative and gram-positive bacillus and coccusmicroflora, and the presence of 'key cells'.</p><p><strong>Conclusion: </strong>Conclusions: Taking into account the information described above, it can be noted that mixed urogenital infections affect the pathogenesis of endometrial hyperplastic processes.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 10","pages":"1888-1891"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of postoperative acute pancreatitis of non-resection genesis in abdominal surgery.","authors":"Tetiana V Formanchuk, Maxym A Hudz, Оleg V Honcharenko, Hryhoriy V Lapshyn","doi":"10.36740/WLek/197078","DOIUrl":"https://doi.org/10.36740/WLek/197078","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To analyse in detail the incidence of POAP after urgent abdominal and endoscopic transpapillary surgical interventions.</p><p><strong>Patients and methods: </strong>Materials and Methods: A retrospective analysis of 52 clinical cases of POAP was done, among which 27 patients developed POAP after urgent abdominal interventions and 25 patients - after endoscopic transpapillary interventions.</p><p><strong>Results: </strong>Results: The incidence of POAP after urgent surgical interventions consisted 0,3%, after endoscopic transpapillary interventions - 18,25%. In the structure of urgent surgical interventions complicated by POAP, gastric and duodenal surgery - 25% (13) and splenectomy - 9,6% (5) were dominating. There was a significant predominance of men in the group of patients with POAP after abdominal interventions and a significant predominance of women in the group with endoscopic retrograde cholangiopancreatography induced POAP (ERCP-induced POAP). POAP can develop at any age; up to 70 years of age, there was an increase in the incidence of POAP with the age of patients, and after 70 years of age the incidence rate was decreasing. The dominant morphological form of POAP was edematous - 67,3% (35).</p><p><strong>Conclusion: </strong>Conclusions: The issue of a unified definition of POAP after operations on internal organs of nonresectional genesis is not resolved. The incidence rate of POAP after surgeries on internal organs, which have direct anatomical and functional relationship with the pancreas dominate.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 11","pages":"2119-2126"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of changes in proteins of the acute phase of inflammation in the postoperative period in patients with disseminated peritonitis.","authors":"Olga Bilyayeva, Ivan Karol, Vadim Kryzhevsky, Oksana Osadchay","doi":"10.36740/WLek202407115","DOIUrl":"https://doi.org/10.36740/WLek202407115","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To determine the effect of the developed complex treatment of patients with peritonitis on the dynamics of humoral factors of nonspecific reactivity in the course of the disease.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study included 124 patients with toxic and terminal stages of peritonitis, who were divided into 3 groups. Group I (main) included 39 patients whose complex treatment included cytochrome C. Group II (main) included 41 patients whose complex treatment included cytochrome C and a solution containing levocarnitine and arginine hydrochloride. The comparison group comprised 44 patients who did not receive the specified drugs. The patients underwent determination of the levels of fibronectin, ceruloplasmin, and procalcitonin in the serum during the course of the disease.</p><p><strong>Results: </strong>Results: In patients of the I and II main groups, the use of the proposed treatment contributed to the optimization of the production of acute phase proteins: a decrease in procalcitonin production during the study, optimization of ceruloplasmin and fibronectin production, especially in the II main group. In patients of the comparison group, decompensation in the production of humoral inflammatory factors was determined, associated with a significant increase in fibronectin production, a decrease in ceruloplasmin content, and an increase in procalcitonin throughout the entire period.</p><p><strong>Conclusion: </strong>Conclusions: The use of cytochrome C and a solution containing levocarnitine and arginine hydrochloride in the complex treatment of patients with disseminated peritonitis helps to optimize the production of acute phase proteins, which leads to a decrease in inflammation and the preservation of factors of nonspecific humoral activity at a subcompensated level.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 7","pages":"1409-1414"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and functional features of the colonic mucus barrier in patients with symptomatic uncomplicated diverticular disease and acute uncomplicated diverticulitis.","authors":"Hanna A Dorohavtseva, Andrey E Dorofieiev, Olena O Dyadyk, Mykhailo S Myroshnychenko","doi":"10.36740/WLek202407105","DOIUrl":"https://doi.org/10.36740/WLek202407105","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The purpose was to identify the morphological and functional features of the colonic mucus barrier in patients with symptomatic uncomplicated diverticular disease and acute uncomplicated diverticulitis.</p><p><strong>Patients and methods: </strong>Materials and Methods: In the research, three groups were formed. Group 1 included fragments of the mucous membrane of the large intestine, which were collected from 12 people during autopsies. The results of autopsies and histological examination of the material did not reveal any gastrointestinal pathology. Group 2 included biopsies of the mucous membrane of the large intestine from the area of the diverticulum of 34 patients with symptomatic uncomplicated diverticular disease. Group 3 included biopsies of the mucous membrane of the large intestine of 26 patients with acute uncomplicated diverticulitis. Histological (hematoxylin and eosin staining), histochemical (PAS reaction) and immunohistochemical (mouse monoclonal antibodies to Mucin 2 (MUC2) and Mucin 4 (MUC4)) staining methods were used. A morphometric study was also carried out.</p><p><strong>Results: </strong>Results: In patients with diverticular disease, the authors identified disturbances in the morphofunctional state of the mucus barrier of the colon, the structure and function of goblet cells contained in its mucous membrane, characterized by a decrease in the thickness of the mucus layer covering the surface of the mucous membrane; a decrease in the size and number of goblet cells with a decrease in their mucus-producing ability; a change in the mucin profile, characterized by a violation of the content of MUC2 and MUC4. These changes were greatest in patients with acute uncomplicated diverticulitis compared with patients with symptomatic uncomplicated diverticular disease.</p><p><strong>Conclusion: </strong>Conclusions: The identified disturbances in the morphofunctional state of the mucus barrier of the colon, structural and functional changes in goblet cells may be one of the mechanisms for the development of acute uncomplicated diverticulitis and symptomatic uncomplicated diverticular disease.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 7","pages":"1331-1337"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of the hormonal background in women with abnormal uterine bleeding and extragenital disorders.","authors":"Liudmyla A Vygivska, Roman Y Blahoveshchenskyi, Yevgenii V Blahoveshchenskyi, Yevgeniia B Radzischevska, Iryna A Guz, Olena V Buhaiova, Olesia O Pliekhova","doi":"10.36740/WLek202407107","DOIUrl":"https://doi.org/10.36740/WLek202407107","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To establish the peculiarities of the hormonal background in women with abnormal uterine bleeding and extragenital disorders.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study involved examination of 100 women of reproductive age with concomitant ED and AUB (MG). CG included 50 healthy women. MG women were additionally divided into subgroups depending on the detected pathological changes in the uterine cavity. When examining the hormonal status, concentrations of FSH, LH, estradiol, progesterone, and leptin in BS were determined. Additionally, the level of 25-hydroxyvitamin D ((25-OH) D) was determined.</p><p><strong>Results: </strong>Results: The decrease in FSH level in subgroups of GP, PSL, EH, EHL was 1.8-2.4 times (KWT, p<0.01). LH in BS of MG patients was statistically lower than that of CG patients (MWT, p=0.0083). The lowest level of LH was registered in patients with EHL, which was 2 times lower than this indicator in CG. A statistically significant increase in the level of estradiol was registered in 73% of MG patients (MWT, p=0.044). The lowest level of progesterone was registered in patients with EHL - 8.40, which is 4.7 times lower than in CG (MWT, p=0.0021). A statistically significant increase in the level of leptin in BS was observed in MG patients (KWT, p=0.0021). The highest level of leptin was found in women with AFP, 2.3 times higher than CG indicators. A statistically significant correlation between the level of leptin and BMI (r=0.86, p=0.011) and a statistically significant (p=0.023) correlation between the level of leptin and estradiol in BS of patients of the examined groups (r=0.42) were revealed. In 87% of MG women, vitamin D deficiency was observed in BS (KWT, p=0.03). A statistically significant (p=0.01) negative correlation between the level of estradiol and vitamin D in the BS of female patients was revealed (r=-0.61, p=0.01).</p><p><strong>Conclusion: </strong>Conclusions: Women of reproductive age with AUB and ED were found to have disorders in the hypothalamic-pituitary-ovarian system. Most patients are characterized by an elevated level of leptin, the concentration of which is closely correlated with BMI, and an elevated level of estradiol is correlated with the level of vitamin D.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 7","pages":"1346-1353"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota as an efficacy marker of surgical treatment of obesity.","authors":"Olexandr Y Ioffe, Pavlo A Kobzar, Oleg V Shvets, Mykola S Kryvopustov, Olexandr P Stetsenko, Tetiana V Tarasiuk, Olena V Dema","doi":"10.36740/WLek202407122","DOIUrl":"https://doi.org/10.36740/WLek202407122","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To study the impact of bariatric interventions on changes in the parameters of the intestinal microbiome.</p><p><strong>Patients and methods: </strong>Materials and Methods: The research method is a prospective observational cohort monocentric study. 112 patients were included in the study. All patients had indications for surgical obesity treatment due to IFSO criteria. All patients were offered surgical treatment. 53 patients who consented to the operation formed the study group. 59 patients who refused surgical treatment formed the control group. The result of the study was evaluated one year after the start of treatment. The studied group of patients underwent bariatric interventions. The control group consisted of 59 obese patients who were treated conservatively.</p><p><strong>Results: </strong>Results: evaluating criteria was: %EWL (percentage of excess weight loss), comorbidity regression, life quality improvement. Overwhelming majority of surgically treated patients with gut microbiome composition improvement reached %EWL≥50. Patients who didn't have improvements in gut microbiota composition had insufficient efficacy of surgical treatment.</p><p><strong>Conclusion: </strong>Conclusions: 1) Surgical treatment of obesity leads to the positive changes in the gut microbiota. 2) Operated patients, who had positive dynamics in changes of gut microbiota demonstrated sufficient efficacy of surgical treatment due to %EWL. 3) Firmicutes/Bacteriodetes ratio and Bacterioidetes/Faecalibacterium ratio can be one of the criteria of the efficacy of surgical treatment of obesity. 4) Patients of the control group, had positive dynamics of changes in gut microbiota much rarely than operated patients and the effectiveness of obesity treatment was insufficient.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 7","pages":"1464-1469"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indicators of biochemical control of diabetes mellitus during limited availability of health service in the context of hypoglycemic therapy.","authors":"Marcin Kleibert, Beata Mrozikiewicz-Rakowska, Klaudia Korycka, Iga Płachta, Patrycja Małgorzata Bąk, Daniel Bałut, Jakub Zieliński, Wojciech Zgliczyński","doi":"10.36740/WLek202407103","DOIUrl":"https://doi.org/10.36740/WLek202407103","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Type 2 diabetes mellitus (T2DM) is a widespread disease that leads to many complications if not adequately controlled. The pandemic and its limitations on healthcare access impaired the management of chronic conditions. The aim of our study was to examine its effects in context of different antidiabetic therapies on key health related factors in patients with T2DM.</p><p><strong>Patients and methods: </strong>Materials and Methods: To the study we enrolled 598 adult patients with diagnosed T2DM treated in diabetology outpatient department of the University Clinical Centre (UCC) of the Medical University of Warsaw. Data on body weight, glycated hemoglobin (HbA1c), and creatinine concentration were collected throughout the first COVID-19 pandemic wave and compared to the results obtained before the 4th of March, 2020 (1st confirmed COVID-19 case in Poland).</p><p><strong>Results: </strong>Results: The HbA1c mean baseline level was 7.15% (±1.39) and increased significantly (7.34% (±1.37), p=0.02) during observation. Importantly, the attendance of patients for HbA1c testing decreased by 57.82% in comparison to the pre-pandemic period. Similarly, creatinine concentrations increased (from 1.27 mg/dl (±0.76) to 1.34 mg/dl (±1.02), (p=0.004)). The increase in creatinine concentration was significantly lower in the group treated with regimens including metformin compared to other regimens. Somewhat surprisingly, the mean body mass remained unchanged.</p><p><strong>Conclusion: </strong>Conclusions: The pandemic period had a significant impact on the tested biochemical parameters. The lesser changes of renal parameters in the group of patients treated with metformin confirms its nephroprotective effect and its value as a first-line treatment in T2DM.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"77 7","pages":"1318-1324"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}