Wiadomosci lekarskie最新文献_第5页

Current landscape of photosensitizers in photodynamic therapy: challenges and future perspectives - a literature review. 光动力疗法中光敏剂的现状：挑战和未来展望-文献综述。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/215319

Barbara Lipka, Michał Lipka, Mikołaj Rycerski, Małgorzata Toroń, Antoni Wołoszyn, Wojciech Tokarczyk, Jakub Mordarski

{"title":"Current landscape of photosensitizers in photodynamic therapy: challenges and future perspectives - a literature review.","authors":"Barbara Lipka, Michał Lipka, Mikołaj Rycerski, Małgorzata Toroń, Antoni Wołoszyn, Wojciech Tokarczyk, Jakub Mordarski","doi":"10.36740/WLek/215319","DOIUrl":"10.36740/WLek/215319","url":null,"abstract":"Objective: Aim: To provide an updated overview of photodynamic therapy (PDT), emphasizing the evolution of photosensitizers, their mechanisms of action, and current challenges and innovations aimed at improving therapeutic outcomes.Patients and methods: Materials and Methods: A structured literature review was conducted using PubMed, Scopus, and Embase databases to identify studies published between 2000 and 2025. Search terms included photodynamic therapy, photosensitizers, nanoparticles, reactive oxygen species, and drug delivery systems. Experimental studies, clinical trials, and review articles focused on photosensitizer development and applications were analyzed. Photosensitizers have advanced through three generations. First-generation agents such as Photofrin demonstrated clinical success but were hindered by shallow tissue penetration and prolonged photosensitivity. Second-generation compounds achieved stronger absorption within the therapeutic window (650-800 nm) and higher singlet oxygen yields but encountered solubility and delivery limitations. Third-generation systems integrate targeting ligands or nanocarriers, improving selectivity, bioavailability, and pharmacokinetics. Despite these advances, PDT remains limited by insufficient light penetration, tumor hypoxia, and non-specific toxicity, and is therefore used only in select clinical settings. Recent approaches, such as multifunctional theranostic photosensitizers, gene-encoded PSs, and combination therapies with immunotherapy or chemotherapy, aim to overcome these barriers.Conclusion: Conclusions: Continued innovation in photosensitizer chemistry, nanotechnology-based delivery, and combination strategies promises to enhance PDT's selectivity, depth, and clinical effectiveness across oncology, dermatology, and infectious disease treatment.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 2","pages":"408-416"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New diagnostic tools for obstructive sleep apnea. 阻塞性睡眠呼吸暂停新诊断工具。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/216754

Jakub Piotr Bundyra, Agata Sochocka, Alicja Sikorska, Julia Parda, Emil Mian, Zuzanna Zapart, Martyna Szepietowska, Nina Nowicka, Oliwia Zuzanna Gańska, Dominika Janik

{"title":"New diagnostic tools for obstructive sleep apnea.","authors":"Jakub Piotr Bundyra, Agata Sochocka, Alicja Sikorska, Julia Parda, Emil Mian, Zuzanna Zapart, Martyna Szepietowska, Nina Nowicka, Oliwia Zuzanna Gańska, Dominika Janik","doi":"10.36740/WLek/216754","DOIUrl":"10.36740/WLek/216754","url":null,"abstract":"Objective: Aim: To evaluate how multi-night home sleep apnea testing and other ambulatory monitoring strategies can complement or, in selected patients, replace single-night in-laboratory polysomnography when diagnosing obstructive sleep apnea, with emphasis on clinical decision-making, diagnostic accuracy, feasibility, and patient experience.Patients and methods: Materials and Methods: PubMed and Scopus were searched for English-language publications from 2015-2025. Selected landmark studies published before 2015, one American Academy of Sleep Medicine guideline and conference abstract were also included. Current evidence shows substantial night-to-night variability in the apnea-hypopnea index (AHI), driven by sleep position, alcohol use, and sleep-stage distribution. Single-night testing may misclassify a large proportion of mild-to-moderate cases. Modern home testing devices (e.g., peripheral arterial tonometry-based systems, accelerometry, radar, and under-mattress sensors) enable extended monitoring, reduce the first-night effect, and may improve diagnostic precision. Most patients prefer to perform tests at home due to convenience. However, it is worth emphasizing that clear instructions and easily accessible technical support are very important factors for them.Conclusion: Conclusions: For uncomplicated adults with a high pre-test probability of obstructive sleep apnea, multi-night home testing can be a pragmatic first-line option, especially around diagnostic thresholds. In-laboratory polysomnography remains preferred in patients with significant comorbidities, suspected coexisting sleep disorders, or when home testing is negative, inconclusive, or technically inadequate.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 2","pages":"433-439"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and outcomes of postoperative complications after liver cirrhosis - related surgery. 肝硬化相关手术术后并发症的发生率及结局。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/214416

Oleksii Petiunin, Vasyl Syplyviy, Kamel Jbarah Hammad Al Mashni, Dmytro Myroshnychenko, Vitaly Makarov, Anna Novikova, Bohdan Porovai-Nevoit

{"title":"Incidence and outcomes of postoperative complications after liver cirrhosis - related surgery.","authors":"Oleksii Petiunin, Vasyl Syplyviy, Kamel Jbarah Hammad Al Mashni, Dmytro Myroshnychenko, Vitaly Makarov, Anna Novikova, Bohdan Porovai-Nevoit","doi":"10.36740/WLek/214416","DOIUrl":"10.36740/WLek/214416","url":null,"abstract":"Objective: Aim: To investigate incidence and outcomes of postoperative complications after cirrhosis-related surgery.Patients and methods: Materials and Methods: Retrospective review of medical records of 344 liver cirrhosis (LC) patients who underwent cirrhosis-related surgical treatment was done. Types and incidence of postoperative complications, causes of death in operated patients, incidence of postoperative complications and mortality based on type of surgery were determined.Results: Results: Postoperative complications developed in 108 (31.4%) patients. Acute-on-chronic liver failure (ACLF) developed in 60 (17.4%) patients was the most common complication. ACLF was the main cause of death - 28 (49.1%) patients with developed complications died. The lowest number of postoperative complications and the lowest mortality were observed after extraperitonization of right hepatic lobe with intraoperative laser irradiation: complications developed in 3 (9.1%) patients, 1 (3.0%) patient died. Complications after endoscopic interventions developed in 10 (15.4%) patients, 6 (9.2%) died, after roentgen-endovascular interventions complications developed in 10 (15.4%) patients, all of them died. Devascularization and transection interventions complications developed in 31 (31.0%) patients, 21 (21%) died. In patients, who underwent distal splenorenal shunt - complications developed in 54 (66.7%) patients, 19 (23.4%) patients died.Conclusion: Conclusions: The most common complication of the early postoperative period after LC-related surgery is ACLF, which develops in 17.4% of patients and is the cause of death in 49.1% of cases. The incidence and outcomes of postoperative complications of cirrhosis-related surgery, depends on the liver function, timing and type of surgery.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 2","pages":"275-280"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iliotibial band and lumbar spine pain - a hidden connection. 髂胫束和腰椎疼痛——一个隐藏的联系。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218183

Beata Buczek, Klaudia Bartuzi, Vasu Duangudomdej, Mateusz Kaczmarski

引用次数: 0

Obesity as an interdisciplinary medical and social problem: Therapeutic opportunities. 肥胖症作为一个跨学科的医学和社会问题：治疗机会。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218280

Mirosław Jabłoński, Alina Stachyra, Agata Szynkaruk, Zeeshan Zulfiqar

{"title":"Obesity as an interdisciplinary medical and social problem: Therapeutic opportunities.","authors":"Mirosław Jabłoński, Alina Stachyra, Agata Szynkaruk, Zeeshan Zulfiqar","doi":"10.36740/WLek/218280","DOIUrl":"10.36740/WLek/218280","url":null,"abstract":"Objective: Aim: This review aimed to summarize current knowledge regarding overweight and obesity as chronic diseases. The health, social, and economic consequences were assessed. Diagnostic and therapeutic possibilities available in primary care practice were presented.Patients and methods: Materials and Methods: This work is a narrative review. Literature on the epidemiology, pathophysiology, and treatment of overweight and obesity was analyzed. Current guidelines from scientific societies were considered. Randomized trials, systematic reviews, and meta-analyses were included. Publications with significant clinical relevance were selected.Results: Results: Obesity is a multifactorial disease that leads to metabolic and cardiovascular complications. It increases the risk of type 2 diabetes and malignancies and impairs quality of life. The cornerstone of treatment is lifestyle modification, including caloric reduction and increased physical activity. In selected cases, pharmacotherapy or surgical intervention may be indicated. Acupuncture may serve as an adjunctive therapy.Conclusion: Conclusions: Obesity management requires a comprehensive and individualized approach. Long-term monitoring of treatment outcomes is essential. Primary care physicians play a pivotal role in the diagnosis and management of this condition.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 3","pages":"651-654"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of the MIND diet in prevention and treatment of Alzheimer's disease: A literature review. MIND饮食在预防和治疗阿尔茨海默病中的作用：文献综述。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/217286

Jan Krupa, Maciej Malinowski, Michał Krasowski, Alicja Kalinowska, Wiktoria Pietras, Adrian Kozieł, Zofia Kurek, Aleksander Jentkiewicz, Esmail Haj Obeid, Jakub Ulrych

{"title":"The role of the MIND diet in prevention and treatment of Alzheimer's disease: A literature review.","authors":"Jan Krupa, Maciej Malinowski, Michał Krasowski, Alicja Kalinowska, Wiktoria Pietras, Adrian Kozieł, Zofia Kurek, Aleksander Jentkiewicz, Esmail Haj Obeid, Jakub Ulrych","doi":"10.36740/WLek/217286","DOIUrl":"10.36740/WLek/217286","url":null,"abstract":"Objective: Aim: Recent research increasingly point to modifiable risk factors, especially dietary patterns, as potential tools to prevent or delay neurodegeneration. This review evaluates the impact of the MIND diet on the prevention and progression of AD and compares it with other dietary interventions.Patients and methods: Materials and Methods: A literature search was conducted using the PubMed and Google Scholar databases for articles published from January 2015 to January 2025, focusing on the influence of the MIND diet, as well as other dietary patterns, on AD progression and cognitive performance.Conclusion: Conclusions: While the MIND diet shows promise as a feasible non-pharmacological strategy, current evidence is largely observational and limited by population heterogeneity and inconsistent adherence definitions. Short-term randomized controlled trials are less conclusive. Long-term clinical trials are needed to establish causality. Despite these limitations, the MIND diet remains a practical and potentially effective approach to reducing cognitive decline and delaying the onset of AD.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 2","pages":"390-398"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current perspectives on 3D-printed casts. 目前对3d打印铸件的看法。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218282

Firoz Rizvi, Konrad Bełżek, Kinga Tracichleb, Jagoda Pałubska, Oliwer Műller, Aleksandra Bełżek, Karolina Turżańska

{"title":"Current perspectives on 3D-printed casts.","authors":"Firoz Rizvi, Konrad Bełżek, Kinga Tracichleb, Jagoda Pałubska, Oliwer Műller, Aleksandra Bełżek, Karolina Turżańska","doi":"10.36740/WLek/218282","DOIUrl":"10.36740/WLek/218282","url":null,"abstract":"Objective: Aim: Fractures of the distal radius and ulna are among the most common skeletal injuries and are traditionally treated with cast immobilization. However, conventional casting techniques have significant limitations. In recent years, three-dimensional (3D) printing technology has emerged as a promising alternative in the production of personalized post-traumatic stabilization devices. The aim of this review was to present current information and perspectives on the development of 3D-printed casts, with particular emphasis on the diversity of designs, material properties, and clinical applications.Patients and methods: Materials and Methods: A literature review was conducted using the PubMed and Google Scholar databases. The results of the analyzed studies indicate that additive technologies enable the production of lightweight, ventilated, individually tailored orthoses with high mechanical strength and improved moisture resistance compared to traditional casts and glass fiber casts.Conclusion: Conclusions: Materials such as polylactide (PLA) and PLA composites produced by Fused Filament Fabrication (FFF) demonstrate superior properties in static and dynamic tests. Furthermore, 3D-printed casts offer improved hygiene, greater comfort, a reduced risk of skin complications, such as wound healing, and high aesthetic acceptability. Clinical applications also include planning corrective osteotomies and the production of personalized surgical instruments. Although further research is needed on long-term durability and broad clinical outcomes, current reports indicate that 3D printing is a promising and increasingly viable alternative to traditional cast immobilization.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 3","pages":"615-619"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body mass index as a determinant of surgical outcomes in total hip arthroplasty. 体重指数作为全髋关节置换术手术结果的决定因素。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218174

Wiktoria Leja, Maciej Błaszczak, Katarzyna Latalska, Zeeshan Zulfiqar, Jakub Kot, Julia Zjawiony, Kacper Lee

{"title":"Body mass index as a determinant of surgical outcomes in total hip arthroplasty.","authors":"Wiktoria Leja, Maciej Błaszczak, Katarzyna Latalska, Zeeshan Zulfiqar, Jakub Kot, Julia Zjawiony, Kacper Lee","doi":"10.36740/WLek/218174","DOIUrl":"10.36740/WLek/218174","url":null,"abstract":"Body mass index is an important element influencing surgical outcomes after total hip arthroplasty. This review analyses how body mass index influences perioperative complications, infection rates, implant survival and functional results in patients undergoing this procedure. A literature review of the past decade was carried out using PubMed, Scopus and Web of Science, focusing on studies published between 2020 and 2026. Studies involving humans that examined the relationship between body mass index and outcomes of total hip arthroplasty were included if they reported perioperative complications, infections, revision rates, or patient-reported outcome measures. The evidence indicates that a higher body mass index is associated with an increased risk of wound complications, periprosthetic joint infection and the need for revision surgery. It is also associated with a lower possibility of achieving minimal clinically important differences in functional scores. The relationship follows a U-shaped pattern showing that, compared with normal weight, obesity and underweight status are associated with increased risk. Proposed mechanisms include technical surgical challenges, altered immune function, compromised wound healing and greater mechanical stress on implants. Preoperative optimization strategies consist of nonsurgical weight loss and bariatric surgery. They are promising but require more investigation. New pharmacological approaches using glucagon-like peptide-1 receptor agonists are a useful contribution to perioperative care. Future research should focus on finding biomarkers of obesity-related risk and on developing individualized strategies to improve outcomes across the body mass index spectrum.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 3","pages":"558-563"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomaterials in cartilage damage. 软骨损伤中的生物材料。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/217826

Marta Żerebiec, Weronika Woźnica, Natalia Kołodyńska, Zuzanna Kołodyńska, Natasza Jankowska, Lena Sobiech, Vivek Vasudevan, Katarzyna Jóźwik, Karolina Turżańska, Małgorzata Drelich

{"title":"Biomaterials in cartilage damage.","authors":"Marta Żerebiec, Weronika Woźnica, Natalia Kołodyńska, Zuzanna Kołodyńska, Natasza Jankowska, Lena Sobiech, Vivek Vasudevan, Katarzyna Jóźwik, Karolina Turżańska, Małgorzata Drelich","doi":"10.36740/WLek/217826","DOIUrl":"10.36740/WLek/217826","url":null,"abstract":"Objective: Aim: Cartilage tissue degradation is a common symptom of diseases affecting the musculoskeletal system. Impairment of its function can occur due to numerous factors, both external and internal. Thanks to advances in imaging techniques, identifying pathologies in cartilage tissue is becoming increasingly common, leading to a search for optimal treatment methods. Human cartilage has a limited capacity for self-repair. Treatments such as transplants have many limitations, which is why biocompatible materials are becoming increasingly popular. This article presents selected biomaterials that may be useful in the treatment of cartilage pathologies. Current research on the use of biomaterials in cartilage regeneration was analyzed.Patients and methods: Materials and Methods: The research material consisted of scientific publications describing the use of natural and synthetic scaffolds in animal models and clinical trials. Particular attention was paid to gelatin, silk fibroin, polylactic acid, polycaprolactone, poly(lactic-co-glycolic acid), and commercial biomimetic scaffolds. Methods included analysis of mechanical properties, biocompatibility, and the ability to support chondrogenesis.Conclusion: Conclusions: The study results indicate that appropriately modified biomaterials can effectively support cartilage regeneration and improve its structure and function. Further research is needed to improve the treatment of cartilage injuries and diseases, and to optimize biomaterials used in cartilage tissue engineering.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 3","pages":"541-547"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The analysis of cervicovaginal microbiota and immune mediators in patients with adenomyosis. 子宫腺肌症患者宫颈阴道菌群及免疫介质分析。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218754

Mykola Shcherbina, Liliya Potapova, Oksana Lipko, Lrina Shcherbina, Anastasiia Chekhunova, Olga Mertsalova

{"title":"The analysis of cervicovaginal microbiota and immune mediators in patients with adenomyosis.","authors":"Mykola Shcherbina, Liliya Potapova, Oksana Lipko, Lrina Shcherbina, Anastasiia Chekhunova, Olga Mertsalova","doi":"10.36740/WLek/218754","DOIUrl":"https://doi.org/10.36740/WLek/218754","url":null,"abstract":"Objective: Aim: To determine and characterise changes associated with microbial, inflammatory and immune factors in patients with adenomyosis.Patients and methods: Materials and Methods: 115 female patients were enrolled in the study, including 85 patients with adenomyosis and 30 healthy individuals. Vaginal cleanliness was assessed by collecting vaginal samples and plating on solid bacterial agar. Urogenital infections were determined by the PCR analysis of the cervicovaginal samples. The immunological characterisation was performed using enzyme immunoassay to analyse cervicovaginal lavage for β-defensin-2 and a defined set of cytokines. Antibody titers were quantified in patients' serum using nephelometry.Results: Results: Patients with adenomyosis displayed disrupted cervicovaginal microflora that was characterised by elevated levels of pro-inflammatory cytokines and antimicrobial peptide β-defensin-2. Serum analysis of patients with adenomyosis revealed higher concentration of IgG, IgM and IgA antibodies compared to healthy control groups.Conclusion: Conclusions: Analysis of inflammatory and immunological parameters in patients with adenomyosis revealed distinct features of the pathophysiology of adenomyosis. Specifically, patients with adenomyosis had disrupted cervicovaginal microflora with higher prevalence of anaerobic species. Furthermore, patients with adenomyosis had elevated levels of pro-inflammatory cytokines and interleukins in cervicovaginal lavage, and higher levels of IgG, IgM and IgA antibody serum titres. The analysis presented in the paper represents an important step towards determining precise diagnostic parameters and effective therapies to treat adenomyosis.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 7","pages":"1493-1499"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0