Wiadomosci lekarskie最新文献

{"title":"Rhinocerebral form of mucormycosis in a patient with post-COVID-19 syndrome and type 1 diabetes mellitus: clinical and morphological analysis of the case from practice.","authors":"Mykhailo S Myroshnychenko, Igor S Brodetskyi, Yevgen V Tytov, Alla M Bilovol, Olena O Pavlova, Yevheniia A Hromko, Liudmyla O Brodetska, Yuliia Ya Fedulenkova, Viktoriia O Bibichenko","doi":"10.36740/WLek/200319","DOIUrl":"10.36740/WLek/200319","url":null,"abstract":"<p><p>Mucormycosis is a serious life-threatening opportunistic infection which is characterized by various clinical and morphological manifestations, rapid progression, unpredictable course and high mortality. The development of mycormycosis depends on the metabolic and immune status of the human body. The authors conducted a clinical and morphological analysis of the case of rhinocerebral mucormycosis in a patient who was diagnosed lifetime, but despite a set of therapeutic and surgical measures led to death, which was due to the severity of the pathology, late hospitalization of the patient and the presence of comorbidities (type 1 diabetes mellitus and post-COVID-19 syndrome). The clinical case presented by the authors raises the issue of the need to increase physicians' awareness about the rhinocerebral form of mucormycosis, improve early diagnostic methods and find effective approaches to therapeutic and surgical treatment of this pathology.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"216-222"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of complex medicamental therapy in patients with silent myocardial ischemia of high risk after myocardial infarction.","authors":"Tetiana V Merhel, Tetiana V Naluzhna, Khrystyna V Levandovska","doi":"10.36740/WLek/201337","DOIUrl":"https://doi.org/10.36740/WLek/201337","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To determine the peculiarities of the course of silent myocardial ischemia (SMI) in patients with post-infarction cardiosclerosis depending on the risk factors (RFs); to reveal the interdependence between the presence of pathological turbulence of the heart rhythm and the peculiarities of the course of SMI in patients with post-infarction cardiosclerosis and the effectiveness of treatment applying S-amlodipine and enalapril in complex therapy.</p><p><strong>Patients and methods: </strong>Materials and Methods: There were observed 154 patients with SMI with a history of myocardial infarction, having received anti-anginal therapy. The diagnosis of SMI was made according to Holter ECG monitoring data. Among the additional indices of the severity of the patient's condition, the maximum value of the ST segment deviation amplitude was evaluated.</p><p><strong>Results: </strong>Results: It was determined that in patients with SMI with post-infarction cardiosclerosis, there is a positive correlation between the presence of RFs and Holter ECG monitoring indices, in particular, the average daily values of the number of ischemic episodes, the total daily duration of ST segment depression and the average duration of one ischemic episode. Enalapril and S-amlodipine are the effective means of pharmacotherapy in the SMI.</p><p><strong>Conclusion: </strong>Conclusions: The silent myocardial ischemia, which is associated with the presence of such Rfs as arterial hypertension, diabetes melitus, dyslipidemia or their combination, is characterized by a severe course of the disease, which is manifested by a worsening of the clinical condition, a decrease in tolerance to physical exertion, significant changes in hemodynamics.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"328-335"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of oral bacteria in patients with dentulous, partially edentulous and edentulous: A comparative study.","authors":"Janan M Al-Akeedi, Furqan Majid Kadhum, Zena Abdullah Khalaf","doi":"10.36740/WLek/201336","DOIUrl":"https://doi.org/10.36740/WLek/201336","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate distribution of oral bacteria among dentulous, partially edentulous, and edentulous patients while examining influence of age and gender on these conditions. It was designed to identify the prevalence of specific bacterial species in the oral cavity and their association with different dental statuses.</p><p><strong>Patients and methods: </strong>Materials and Methods: Samples were taken by rinse the mouth of 66 subjects divided into 3 groups: Dentulous n=49, Edentulous n=43, Partially Edentulous n=58. Ten types of bacteria were analyzed using gram staining and biochemical tests.</p><p><strong>Results: </strong>Results: Staphylococcus aureus is most prevalent in the edentulous group, accounting for 27.91%, compared to 15.52% in the Partially Edentulous and 10.20% in the dentulous group. This suggests a possible increase in its presence with tooth loss. Staphylococcus albicans and Streptococcus are more common in the Dentulous and Partially Edentulous groups, with the dentulous group having the highest percentage of Staphylococcus albus at 22.45%. Diplococcus pneumoniae shows an increased frequency in the edentulous group 16.28% compared to the other groups, which may indicate a higher risk of pneumonia-related bacteria in patients without teeth. There was a significant association between age and tooth loss. Gender did not show any relationship neither to tooth loss nor to oral cavity bacteria.</p><p><strong>Conclusion: </strong>Conclusions: Edentulism was most prevalent in individuals aged 50 years and older, emphasizing the role of aging in tooth loss. No significant gender differences were observed, indicating equal impact on males and females. Certain bacteria, like Staphylococcus aureus and Streptococcus, were more common in edentulous patients.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"257-264"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Ovo evaluation effects of normal saline on cardiovascular system development.","authors":"Rafid A Doulab, Esraa A Qory","doi":"10.36740/WLek/200333","DOIUrl":"https://doi.org/10.36740/WLek/200333","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To estimate the effect of normal saline on early development stage of embryo during pregnancy after LD50 dose determination and to record of heart electrocardiogram ECG for chick embryo and make histopathological sections for the heart to find if it suitable for pregnant women.</p><p><strong>Patients and methods: </strong>Materials and Methods: Novel data- acquisition record for embryo ECG, vision findings as well as histopathological study for 42h of development can support the exact harm and sudden death causes for embryo during first months of pregnancy.</p><p><strong>Results: </strong>Results: LD50 results show significant variation (p<0.05) between dose 2μl and other lethal doses and ECG show same variation according to recording in amplitude, QRS, and heart rate on the other hand the histopathological slides show clear teratology signs of veins malformation specially in dose 6, 8, and 10 μl and heart muscle rupture with sign of edema and pathological apoptosis.</p><p><strong>Conclusion: </strong>Conclusions: Due to harmful effect of normal saline on chick embryo development especially heart and veins which lead to sudden death, they must not use for pregnant women during first 4 months or before pregnancy.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"388-395"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meeting Highlights The 4th Marie Skłodowska-Curie Symposium on cancer research and care: Mechanisms of support for regional & international collaborations.","authors":"Pawel Kalinski, Kathleen M Kokolus, Indu Ahluwalia, Mihaela Balu, Łukasz Balwicki, Brygida Baran, Loretta Beine, Mikhail Berezin, Ioana Berindan-Neagoe, Andriy Beznosenko, Blanka Borowiec, Szabolcs Bozsányi, Jonathan Bramson, Brian Czerniecki, Rūta Everatt, Wojciech Fendler, Peter Forsyth, Jeffrey E Gershenwald, Maciej Goniewicz, Khurshid Guru, Andrew Hyland, Smitha James, Iva Kirac, Pawel Koczkodaj, Leszek Kotula, Maciej Łuba, Iwona Ługowska, Elizabeth Luke, Cristian Lungulescu, Sandro Matosevic, Kaushal Nanavati, Michael Nemeth, Karolina Nowak, Katia Noyes, Mark Parascandola, Waldemar Priebe, Piotr Rutkowski, Mukund Seshadri, Christine E Sheffer, Ioana-Miruna Stanciu, Joanna Stanson, Telisa Stewart, Edita Sužiedėlienė, Kęstutis Sužiedėlis, Iryna Tanasiichuk, Anda M Vlad, Wei-Zen Wei, Dylan Williams, Malgorzata Wojtowicz, Tomasz Zdrojewski","doi":"10.36740/WLek/202370","DOIUrl":"https://doi.org/10.36740/WLek/202370","url":null,"abstract":"<p><p>The Marie Skłodowska-Curie Symposia on Cancer Research and Care (MSCS-CRC) promote collaborations between cancer researchers and care providers in the United States, Canada and Central and Eastern European Countries (CEEC) to accelerate the development of new cancer therapies, new strategies for early detection and prevention, and improve cancer care and the quality of life for patients and their families. The 4th MSCS-CRC (September 25-27, 2024, Buffalo, New York) brought together 147 participants from the US, Canada, Croatia, Czechia, Lithuania, Poland, Romania and Ukraine, and involved representatives of the US Centers for Disease Control and Prevention (CDC), National Cancer Institute (NCI) and their counterparts from Poland, Ukraine Lithuania and other CEECs. They were accompanied by New York State (NYS) and local representatives of the NYS Empire State Development, and of the Translational Research Consortium of Cancer Centers (TRCCC), involving 13 cancer centers from the Northeastern US and Canada, as well as several Pharma and Biotech companies. The 4th Meeting focused on prevention and early detection of smoking- and HPV-related cancers, reducing disparities in cancer detection-, care and outcomes, and increasing the feasibility and reducing costs of high-end treatments, such as cell therapies for patients with advanced cancers. The second focus area were the available sources of funding of regional and international collaborations in these areas. The relevance of the successful model TRCC to promoting the oncology training and research collaborations in the CEE Countries was discussed. The 5th MSCR-CRC meeting will take place September 3-5, 2025, in Warsaw, Poland.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"232-247"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial infection disease diagnosis and treatment by artificial intelligence.","authors":"Laith M Abbas Al-Huseini, Nisreen Jawad Kadhim, Mohammed Salih Mahdi, Raed H Ogaili, Orooba Al-Hammood","doi":"10.36740/WLek/200511","DOIUrl":"https://doi.org/10.36740/WLek/200511","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The main objective of this study was to examine current perspectives on initiatives to identify viable approaches for more accurate diagnosis of infectious diseases.</p><p><strong>Patients and methods: </strong>Materials and Methods: Indexed databases, such as EMBASE, Scopus, and PubMed/Medline, and online searches were performed. Cross-referencing of important articles led to additional references. This study reviews important clinical applications and provides an overview of several Artificial intelligence algorithms used in diagnosis of diseases caused by pathogenic microorganisms.</p><p><strong>Conclusion: </strong>Conclusions: Artificial intelligence technologies could be used in nearly every area of medicine. Before these new technologies may be used in actual clinical settings, more carefully planned clinical trials are required.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"442-447"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified radical mastectomy under local anesthesia using Tumescent Technique experience of Teaching Hospitals in Iraq.","authors":"Nasser M Meazher, Haider Nadum Obaid, Osama Abdul-Razaq Twayej, Fadhil Abbas Al-Janabi, Samer Makki Mohamed Al Hakkak, Alaa Abood Al Wadees","doi":"10.36740/WLek/197197","DOIUrl":"https://doi.org/10.36740/WLek/197197","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To evaluate the advantages, disadvantages, safety, and restrictions of local anaesthetic against general anesthesia for mastectomy.</p><p><strong>Patients and methods: </strong>Materials and Methods: In this prospective clinical trial, which was carried out at Al-Sader teaching hospital from October 2020 to September 2023, 25 patients (LA group) with a mean age of 64.0±6.3 years (range 55-76 years) underwent a unilateral total mastectomy for breast cancer under local anesthesia using tumescent technique (by manual infiltration technique), and an additional 25 patients (GA group) as a control group with a mean age of 64.9±6.9 years (range 55-75 years) underwent a unilateral mastectomy.</p><p><strong>Results: </strong>Results: With use of light sedation for 6 patients, anesthetic is sufficient for all 25 patients. The amount of blood loss intraoperatively measured by number of gauze used during the procedure, approximately 3 gauze, 20 cc of blood for each gauze was significantly lower in LA group than GA group, 2.7±0.4, 5.4±0.4 gauze respectively P<0.001. More than 8 hours after surgery, patients are pain-free. No postoperative complications like necrosis of skin flap, wound infection, or hematoma, when compared to GA group, surgery took substantially longer in LA group 48.9±14.3 minutes than in GA group 38.2±2.9 minutes; P<0.001. The day after the surgery, the patient was discharged.</p><p><strong>Conclusion: </strong>Conclusions: The use of tumescent anesthesia (which is safe and effective) is an attractive alternative method for general anesthesia in properly selected candidates (class IV according to American society of anesthesia).</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"311-315"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The level of use of cardiovascular interventions in the treatment of patients with acute myocardial infarction in Ukraine.","authors":"Gennadiy O Slabkiy, Victoria J Bilak-Lukyanchuk, Rostislav L Kartavtsev, Vitalii Kondratskyi, Svitlana V Dudnik","doi":"10.36740/WLek/200415","DOIUrl":"https://doi.org/10.36740/WLek/200415","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate the level of use of cardiovascular interventions during the treatment of patients with acute myocardial infarction in Ukraine.</p><p><strong>Patients and methods: </strong>Materials and Methods: Materials: statistical data of the National Health Service of Ukraine for the period 2021-2023 in regional aspect. Methods: bibliosemantic, medico-statistical, of structural-and-logical analysis.</p><p><strong>Conclusion: </strong>Conclusions: In Ukraine, there is a tendency to increase the level of use of these technologies in the treatment of patients with acute myocardial infarction. Reliable differences in the level of use of cardiovascular interventions in the treatment of patients with acute myocardial infarction across the regions of Ukraine were reveale. A critically low level of use of these technologies is observed in the territories temporarily occupied by Russian troops since 2014 - Donetsk and Luhansk regions.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"456-462"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of treatment of sexual dysfunction in men with premature ejaculation, injured as a result of hostilities.","authors":"Mykola Vorobets, Dmytro Vorobets, Viktor Chaplyk, Oksana Melnyk, Olena Onufrovych, Zinoviy Vorobets, Roman Fafula","doi":"10.36740/WLek/197136","DOIUrl":"https://doi.org/10.36740/WLek/197136","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To evaluate the effectiveness of selective serotonin reuptake inhibitors (SSRIs) to the treatment of patients with premature ejaculation who have been affected by combat actions.</p><p><strong>Patients and methods: </strong>Materials and Methods: Results of an examination of 50 men injured as a result of hostilities, with sexual dysfunction and complaints of premature ejaculation. Patients were divided into smaller subgroups depending on the selected serotonin reuptake inhibitors, which they received for at least 1.5 months: sertraline (n=14), paroxetine (n=12), citalopram (n=12), venlafaxine (n=12).</p><p><strong>Results: </strong>Results: After treatment with all serotonin reuptake inhibitors, reactive and personal anxiety symptoms, as assessed by the Spielberger-Hanan scale, were objectively reduced in men. Only treatment with paroxetine and citalopram resulted in a likely reduction in depressive symptoms in men with premature ejaculation, Paroxetine and sertraline appeared to be relatively balanced drugs with moderate efficacy but relatively few side effects. The lack of a «gold standard» among serotonin reuptake inhibitor drugs for the treatment of premature ejaculation on the Ukrainian market necessitates the search for new, more effective drugs with the possibility of flexible use.</p><p><strong>Conclusion: </strong>Conclusions: The study demonstrates that the neurotransmitter serotonin plays a key role in the modulation of ejaculation, as the use of reuptake inhibitors increases the intravaginal latency to ejaculation. Among the selective serotonin reuptake inhibitors, venlafaxine was found to be the most effective.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"265-272"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience in implementing effective programs of colorectal cancer screening for the development of an appropriate model in Ukraine - a literature review.","authors":"Oleh Lyubinets, Yaroslav Hrzhybovskyy, Andrii Koval","doi":"10.36740/WLek/197139","DOIUrl":"https://doi.org/10.36740/WLek/197139","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To explore the potential for preventing cancer development through CRC screening programmes.</p><p><strong>Patients and methods: </strong>Materials and Methods: A number of foreign articles, international guidelines were analysed using PubMed, Google Scholar, Web of Science, and information from national government websites about the aspects of CRC screening programmes in countries with high rates of participation of the average-risk population as well as the stages of their implementation for national colorectal cancer screening program development in Ukraine.</p><p><strong>Conclusion: </strong>Conclusions: The final goal of CRC screening is to decrease mortality by detecting disease at an early stage, which increases treatment effectiveness and provides a better prognosis, as well as reducing incidence in the long term. This decrease in CRC incidence is the result of massive detection of early asymptomatic cases before they progress to later stages.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"425-434"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}