Wiadomosci lekarskie最新文献_第5页

Medication nonadherence in osteoarthritis: Review of determinants, consequences and strategies. 骨关节炎的药物不依从：决定因素、后果和策略的回顾。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218186

Ariba Juayria Zubair, Abubakker Siddiq Mohamed Hameed, Sandhra Treesa Santhosh, Mamoun Abdulhamid Jarjouma, Parvathy Jyothish, Mateusz Kaczmarski, Silvija Ille

{"title":"Medication nonadherence in osteoarthritis: Review of determinants, consequences and strategies.","authors":"Ariba Juayria Zubair, Abubakker Siddiq Mohamed Hameed, Sandhra Treesa Santhosh, Mamoun Abdulhamid Jarjouma, Parvathy Jyothish, Mateusz Kaczmarski, Silvija Ille","doi":"10.36740/WLek/218186","DOIUrl":"https://doi.org/10.36740/WLek/218186","url":null,"abstract":"Osteoarthritis (OA), particularly of the knee, represents a leading cause of chronic pain and functional limitation worldwide. Although pharmacologic therapy remains central to symptom control, real-world treatment effectiveness is frequently compromised by suboptimal medication adherence. To synthesize contemporary evidence on the determinants, clinical consequences, and targeted strategies related to medication nonadherence in osteoarthritis. A narrative review of literature published between January 2021 and February 2026 was conducted using PubMed, Scopus, and supplementary sources. Studies examining determinants of nonadherence, associated outcomes, and adherence-enhancing interventions in OA were thematically integrated. Thirty-nine studies were included. Medication nonadherence in OA is multifactorial, reflecting the interaction of patient-related, therapy-related, and healthcare system determinants. Aging, multimorbidity, cognitive vulnerability, and polypharmacy contribute to unintentional nonadherence, whereas risk perception, safety concerns, and financial barriers frequently drive intentional dose modification or discontinuation. Inconsistent medication use is associated with persistent pain, functional limitation, reduced quality of life, and increased healthcare utilization. Emerging evidence supports patient-centered education, shared decision-making, regimen simplification, pharmacist-led interventions, and digital adherence tools as promising strategies. Medication nonadherence represents a clinically consequential yet underrecognized determinant of treatment effectiveness in osteoarthritis. Addressing adherence through integrated, patient-centered, and system-level strategies is essential to optimizing symptom control, functional outcomes, and healthcare resource utilization in OA populations.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 3","pages":"571-581"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 aggravates well tolerated spinal cord injury - related neuropathic pain. COVID-19加重了耐受性良好的脊髓损伤相关神经性疼痛。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/216216

Mohammed K Al-Chlaihawi, Akeel Abd Uljaleel Qyas, Muntadher Zyara, Salim Kadhim

{"title":"COVID-19 aggravates well tolerated spinal cord injury - related neuropathic pain.","authors":"Mohammed K Al-Chlaihawi, Akeel Abd Uljaleel Qyas, Muntadher Zyara, Salim Kadhim","doi":"10.36740/WLek/216216","DOIUrl":"10.36740/WLek/216216","url":null,"abstract":"Objective: Aim: To compare the intensity of the pain, medication requirements and the evolution of symptoms of neuropathic pain patients with or without COVID‑19 infection and to determine whether the severity of the infection influenced these variables.Patients and methods: Materials and Methods: In all, 400 adults with chronic neuropathic pain (≥3months duration) were included-200 positive and 200 negative for SARS‑CoV‑2. Baseline demographic and clinical characteristics were comparable between groups (age, sex, BMI, comorbidities, pain duration; all p>0.22) to meaningful outcome comparison. Pain severity, analgesic consumption, pain course and symptom deterioration were assessed pre-/post-COVID‑19 or similar follow-up for the controls.Results: Results: In COVID‑positive group score values raised from 4.6 ± 1.1 to 7.7 ± 1.4 (p<0.05), at a more significant extent in women (4.7-8.2, p<0.01) as in diabetic patients (4.6-8.1, p<0.001). The COVID-negative group had no significant change (4.2-4.3, p =0.42). Post-COVID, 72% of infected patients needed more analgesics and 65% of them other drugs, vs. 15% and 12%, respectively, in the negative group p<0.001. Pain curves trajectories evidenced steeper increments in COVID‑positive (85% vs. 25% in severe vs. mild COVID-19 worsening, p<0.001, revealing a directly related pain severity to the infection.Conclusion: Conclusions: SARS‑CoV‑2 infection is an aetiologic factor that independently leads to a substantial worsening of chronic neuropathic pain, an increase in analgesic needs, and a more severe symptom burden. The impact is most pronounced among women, diabetic patients and those with severe COVID‑19. These results highlight the significance of proactive pain management approaches and longitudinal tracking in this population.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 1","pages":"123-129"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Surgical Antimicrobial Prophylaxis Practices in a Tertiary Hospital in Iraq. 伊拉克一家三级医院外科抗菌预防措施评估。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/214269

Marwan Ibrahim Abdullah, Narmin Sayed Essa, Ahmed Khalil Al-Kubeisi, Mohammed Rajab Mohammed

{"title":"Assessment of Surgical Antimicrobial Prophylaxis Practices in a Tertiary Hospital in Iraq.","authors":"Marwan Ibrahim Abdullah, Narmin Sayed Essa, Ahmed Khalil Al-Kubeisi, Mohammed Rajab Mohammed","doi":"10.36740/WLek/214269","DOIUrl":"10.36740/WLek/214269","url":null,"abstract":"Objective: Aim: Surgical Antimicrobial Prophylaxis (SAP) is critical in reducing surgical site infections (SSIs). However, inappropriate antibiotic use remains common concern in many healthcare settings. Therefore, the aims was to assess the use of surgical antibiotic prophylaxis.Patients and methods: Materials and Methods: A retrospective cross-sectional study was conducted among 419 discharged surgical and gynecological patients at Al-Salam Teaching Hospital, Mosul, Iraq, during August 2023. Patient records were analyzed for SAP indication, antibiotic selection, timing, and duration according to international guidelines. This study aimed to assess both the prescribing patterns and the appropriateness of surgical antimicrobial prophylaxis practices.Results: Results: SAP was indicated for most patients; however, appropriate antibiotic selection was documented in only 35.1%. Ceftriaxone was predominantly prescribed (73.0%), followed by amoxicillin (8.6%), and cefotaxime (6.2%). Furthermore, most patients received antibiotics after surgical incision, and the duration exceeded 7 days in a significant proportion of cases, contrary to standard recommendations. Of 419 patients, 117 (27.9%) received appropriate prophylaxis and 302 (72.1%) inappropriate prophylaxis. The mean antibiotic cost per patient was 2.16 USD in the appropriate group compared with 4.85 USD in the inappropriate group. Inappropriate prophylaxis accounted for 85.3% of the total antibiotic expenditure.Conclusion: Conclusions: The study highlights substantial gaps in adherence to SAP guidelines, emphasizing inappropriate antibiotic selection, timing, and excessive duration. These findings underscore the urgent need for implementing antimicrobial stewardship interventions to optimize SAP practices and reduce potential antibiotic resistance and SSIs.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 1","pages":"87-94"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence for predicting adverse surgical outcomes: Challenges, limitations and implications for clinical translation - a narrative review. 预测手术不良结果的人工智能：临床翻译的挑战、限制和意义-一篇叙述性综述。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218217

Zain Ahmed, Tanvi Prem Kumar, Alina Stachyra

{"title":"Artificial Intelligence for predicting adverse surgical outcomes: Challenges, limitations and implications for clinical translation - a narrative review.","authors":"Zain Ahmed, Tanvi Prem Kumar, Alina Stachyra","doi":"10.36740/WLek/218217","DOIUrl":"https://doi.org/10.36740/WLek/218217","url":null,"abstract":"The rise in the number of surgeries per year has led to the development of many artificial intelligence models for predicting surgical complications. Despite their ever-growing use in healthcare, artificial intelligence is not up to the mark yet. We need to search and critically overcome the hurdles preventing their safe and reliable use in surgical care. This narrative review aims to find and analyze the main limitations and challenges of artificial intelligence in predicting surgical outcomes. Across the reviewed literature, key limitations were identified in four domains: data-related, methodological limitations, performance and generalizability, and barriers to clinical implementation. Common issues included missing and imbalanced datasets, small sample sizes, retrospective single-center designs, high risk of bias, and inadequate external validation. Although several studies reported high predictive performance, these findings were often derived from non-representative datasets and lacked prospective validation. Additional concerns included limited interpretability, ethical and privacy risks, workflow integration difficulties, and potential amplification of healthcare disparities. Despite their potential, AI models for surgical outcome prediction remain constrained by multiple challenges. Substantial improvements in data quality, transparency, fairness, and robust multicenter prospective validation are required before AI can be safely and reliably integrated into routine surgical decision-making.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 3","pages":"605-610"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise interventions for knee osteoarthritis: A narrative review of mechanisms, modalities, and clinical implementation. 膝关节骨性关节炎的运动干预：机制、方式和临床实施的叙述性回顾。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218218

Parvathy Jyothish, Abubakker Siddiq Mohamed Hameed, Fajrul Sabana Jahubar Ali, Lina Yaseen, Nataliia Fedorenko

{"title":"Exercise interventions for knee osteoarthritis: A narrative review of mechanisms, modalities, and clinical implementation.","authors":"Parvathy Jyothish, Abubakker Siddiq Mohamed Hameed, Fajrul Sabana Jahubar Ali, Lina Yaseen, Nataliia Fedorenko","doi":"10.36740/WLek/218218","DOIUrl":"https://doi.org/10.36740/WLek/218218","url":null,"abstract":"Knee osteoarthritis (OA) is a chronic, multifactorial joint disorder involving cartilage degeneration, subchondral bone changes, synovial inflammation, and neuromuscular dysfunction. Exercise is first-line therapy, yet heterogeneity in modalities, dosing, and delivery limits practical guidance. A narrative review was conducted using PubMed, Scopus, Google Scholar, Frontiers, and ScienceDirect (2021-2026), focusing on aerobic, resistance, aquatic, and mind-body exercise studies. Data were extracted on type, intensity, frequency, duration, delivery, and outcomes, and synthesized narratively to provide clinically relevant insights. Exercise improves pain, function, and quality of life through enhanced muscle strength, joint stability, optimized loading, anti-inflammatory effects, and central pain modulation. Aerobic and resistance training enhance cardiovascular fitness, quadriceps and hip strength, and functional performance. Aquatic therapy reduces joint stress and improves adherence, while mind-body interventions support flexibility, balance, and stress reduction. Long-term, thrice-weekly protocols offer maximal benefit, and hybrid models combining supervised and home-based exercise optimize adherence and outcomes. Exercise is a cornerstone of knee osteoarthritis management. Individualized programs considering patient characteristics, modality-specific benefits, and delivery method are essential. Future research should refine exercise dosage, intensity, progression, and hybrid delivery strategies to maximize long-term clinical effectiveness.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 3","pages":"624-632"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional rehabilitation of the upper limb after righthemisphere stroke: evaluation of the effectiveness of methods. 右脑卒中后上肢功能康复：方法有效性评价。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218519

Yurii M Dido, Olena A Dulo, Viacheslav M Miroshnichenko, Olena B Lazarіeva, Oleksey O Pidmurnyak

{"title":"Functional rehabilitation of the upper limb after righthemisphere stroke: evaluation of the effectiveness of methods.","authors":"Yurii M Dido, Olena A Dulo, Viacheslav M Miroshnichenko, Olena B Lazarіeva, Oleksey O Pidmurnyak","doi":"10.36740/WLek/218519","DOIUrl":"10.36740/WLek/218519","url":null,"abstract":"Objective: Aim: To study the impact of physical and occupational therapies on upper limb function and the degree of limitations in patients with right-hemisphere ischemic stroke complicated by neglect.Patients and methods: Materials and Methods: The study involved 58 patients, including 29 females and 29 males. The patients had their first ischemic stroke in the right hemisphere of the brain and unilateral spatial neglect. The average age of the patients was 68.62±10.06 years. The patients were divided into the MG and the CG in 29 individuals. In order to assess the impact of upper limb impairment and the degree of limitations experienced by patients, we used the main section of the DASH questionnaire, which consisted of 30 questions.Results: Results: The recovery of the upper limb in patients in the MG was better than in the CG. The recovery of the upper limb in patients according to the DASH questionnaire in the CG improved by 22%, and in the MG by 43%. Thus, after six months of using rehabilitation programs in the CG and the MG, the recovery of upper limb activities occurred almost 2 times faster in the MG than in the CG.Conclusion: Conclusions: Thus, the study confirmed the positive effect of a combined program of physical and occupational therapies conducted with MG patients on the sensorimotor recovery of the upper limb.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 1","pages":"196-201"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Legal regulation of health care management based on forensic medical assessment of early in-hospital mortality. 基于院内早期死亡法医鉴定的医疗管理法律规制。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218721

Alina O Pletenetska, Anzhela B Berzina, Ruslan A Volynets, Oksanа O Cherniak, Oleksandr V Felyk, Valentyn V Halunko

{"title":"Legal regulation of health care management based on forensic medical assessment of early in-hospital mortality.","authors":"Alina O Pletenetska, Anzhela B Berzina, Ruslan A Volynets, Oksanа O Cherniak, Oleksandr V Felyk, Valentyn V Halunko","doi":"10.36740/WLek/218721","DOIUrl":"https://doi.org/10.36740/WLek/218721","url":null,"abstract":"Objective: Aim: To analyze the legal regulation of health care management based on the analysis of forensic medical examinations concerning the quality of medical care in cases of early in-hospital mortality.Patients and methods: Materials and Methods: A retrospective forensic medical examination was conducted of 51 cases of patient mortality occurring within the first 24 hours after hospital admission in a multidisciplinary hospital in Kyiv. Organizational and legal aspects of medical care delivery were analyzed for compliance with legislation and clinical protocols.Results: Results: Systemic deficiencies included the absence of electrocardiographic examination in 90,2 ± 4,2% of cases, regardless of diagnostic accuracy. Significant trends were identified as the hospital stay duration increased: the absence of oxygen therapy showed a downward trend (from 86,7 ± 8,8% to 38,5 ± 13,5%; ptrend = 0,006), while diagnostic discrepancies demonstrated an upward trend (from 6,7 ± 6,4% to 46,2 ± 13,8%; ptrend = 0,016). The median number of deficiencies doubled from 2 (1-3) in the <3 h group to 4 (3-4) in the 12-24 h group (p = 0,002). A moderate direct correlation was established between patient age and the total number of deficiencies (ρ = 0,462; p < 0,001).Conclusion: Conclusions: The identified deficiencies correlate with non-compliance with mandatory regulatory requirements. The accumulation of medical errors with increasing length of stay and patient age indicates systemic violations of organizational and legal standards, necessitating stricter public administration control over medical care quality.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 2","pages":"355-361"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamics of cadets' morphofunctional development in the process of their academic training for law enforcement activities. 学员在执法活动学术训练过程中的形态功能发展动态。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218720

Zoriana R Kisil, Natalia E Miloradova, Halyna V Katolyk, Volodymyr P Ostapovich, Sergii M Myronets, Ihor Y Hnyp, Ivan M Okhrimenko

{"title":"Dynamics of cadets' morphofunctional development in the process of their academic training for law enforcement activities.","authors":"Zoriana R Kisil, Natalia E Miloradova, Halyna V Katolyk, Volodymyr P Ostapovich, Sergii M Myronets, Ihor Y Hnyp, Ivan M Okhrimenko","doi":"10.36740/WLek/218720","DOIUrl":"https://doi.org/10.36740/WLek/218720","url":null,"abstract":"Objective: Aim: To study the dynamics of morphofunctional development indicators in female cadets - future law enforcement officers - in the process of engaging in various types of motor activity during their academic training.Patients and methods: Materials and Methods: The research involved 56 female cadets in their first to third training years. Two groups of female cadets were formed: an experimental group (EG, n = 27), whose members attended the university's CrossFit sports club, and a control group (CG, n = 29), whose members did not engage in additional sports activities, but only participated in the traditional program during their sporting and mass-participation activities (SMPAs). Research methods: theoretical methods, biomedical methods, statistical methods.Results: Results: It was found that in female cadets who practiced CrossFit, all the parameters studied were significantly (p ≤ 0.05-0.001) better at the end of the research than in female cadets who practiced using the traditional SMPAs method by the BMI - 1.07 kg/m2, the SI - 4.36 %, the VI - 4.14 ml/kg, the RI - 2.99 c. u., HRRI - 7.4 s, HSTI - 6.8 c. u., PWC - 103.1 kgm/min, BF - by 0.4 %, and SHL - by 3.16 points. The analysis of the dynamics of the studied indicators during the academic training period showed that in the EG, unlike the CG, all studied indicators have a stable tendency to improve.Conclusion: Conclusions: The data we obtained indicate that CrossFit training sessions effectively contribute to the improvement of the morphofunctional development of female cadets during their academic training for future law enforcement activities.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 2","pages":"328-335"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dose adjustment of oral thyroxine in patients consuming dairy products: A cohort retrospective study. 乳制品患者口服甲状腺素的剂量调整：一项队列回顾性研究。

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/216217

Zahraa Al-Isawi, Ammar Azzam, Mohammed Sh Sachit, Fadhil Abdulameer Wdaah Alsailawi, Salim Kadhim

{"title":"Dose adjustment of oral thyroxine in patients consuming dairy products: A cohort retrospective study.","authors":"Zahraa Al-Isawi, Ammar Azzam, Mohammed Sh Sachit, Fadhil Abdulameer Wdaah Alsailawi, Salim Kadhim","doi":"10.36740/WLek/216217","DOIUrl":"https://doi.org/10.36740/WLek/216217","url":null,"abstract":"Objective: Aim: Hypothyroidism management with levothyroxine might be affected by a range of factors, including diet. Dairy sources are rich in calcium and proteins which may interfere with the absorption of thyroxine so dose adaptability might be required. This study assesses the effect of dairy intake on levothyroxine dose and clinical outcomes.Patients and methods: Materials and Methods: Retrospective cohort study over 14 months in an endocrinology center in Najaf, included 150 adult patients with primary hypothyroidism on stable oral levothyroxine therapy. We classified individuals into high, medium and low dairy consumers. A comparative approach was performed between these groups on terms of the dose, time to stabilization, dose response, clinical outcome, and economic outcome.Results: Results: After multivariable analysis, we found that participants who consumed one or more servings of dairy products per day were 6.8 times more likely to report taking their medications at least once with inadequate preparation p<0.001. These findings suggest that dietary interventions targeting dairy intake could stabilize treatment and reduce healthcare costs.Conclusion: Conclusions: Dietary intake of dairy has a major impact on both the absorption and dosing of levothyroxine in hypothyroid patients. Given the healthcare burden arising from dose adjustments, clinicians should consider dietary counselling and timing strategies to improve therapy.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 2","pages":"362-369"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential predictors of chronic liver disease among adults: Key determinants for promoting healthy aging. 成人慢性肝病的潜在预测因素：促进健康老龄化的关键决定因素

Wiadomosci lekarskie Pub Date : 2026-01-01 DOI: 10.36740/WLek/218230

Mohammed Isham Shiju, Benzil Binu, Aadith Soorya Arun Kumar, Jessica James Stanley, Abhinandh Uthaman, Abrar Allahyari, Tatjana Ille, Abdulsalam Al Mujamee, Mohammed Ahmed Elshobary, Sneha Reji

{"title":"Potential predictors of chronic liver disease among adults: Key determinants for promoting healthy aging.","authors":"Mohammed Isham Shiju, Benzil Binu, Aadith Soorya Arun Kumar, Jessica James Stanley, Abhinandh Uthaman, Abrar Allahyari, Tatjana Ille, Abdulsalam Al Mujamee, Mohammed Ahmed Elshobary, Sneha Reji","doi":"10.36740/WLek/218230","DOIUrl":"https://doi.org/10.36740/WLek/218230","url":null,"abstract":"Objective: Aim: This study aimed to find out predictors of chronic liver disease (CLD) in adults and evaluate key determinants that may influence healthy aging.Patients and methods: Materials and Methods: A case-control study was conducted among adults who were receiving care at a tertiary care center. Demographics, lifestyle factors, and clinical variables like BMI were collected. Statistical analysis was performed using chi-square testing for association and logistic regression analysis to identify independent factors that predict CLD, p-value of <0.05 was used to identify significance for all information collected.Results: Results: Significant links were found between CLD and several factors. Males were significantly more affected with CLD (78.5%, p < 0.001), making gender one of the factors that predict CLD. Similarly, age was a significant factor, with those aged 40-60 being the most affected (33%, p = 0.039). Abnormal BMI was strongly associated with CLD, found in 84.6% cases (p = 0.008). Alcohol consumption demonstrated a marked association with chronic liver disease (p < 0.001), with former and current alcohol use substantially more common among cases. After logistics regression analysis, male gender, abnormal BMI, and alcohol consumption are significant independent predictors of CLD.Conclusion: Conclusions: The study highlights gender (male), age (40-60), abnormal BMI and alcohol consumption as significant predictors of CLD in the studied population. These findings emphasize the urgent need for targeted screening and lifestyle-based preventive interventions, particularly focusing on metabolic health and weight management, to mitigate the rising burden of liver disease and promote healthy aging.","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"79 3","pages":"491-499"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0