Wiadomosci lekarskie最新文献

{"title":"Clinical manifestation, laboratory and instrumental characteristics of infants born to mothers with a complicated anamnesis.","authors":"Olesya M Horlenko, Yuriy Yu Chuhran, Gabriella B Kossey, Viktoria V Ivano, Mariya A Derbak, Volodymyr D Symulyk, Lybov Yu Pushkash","doi":"10.36740/WLek/203889","DOIUrl":"https://doi.org/10.36740/WLek/203889","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To improve early diagnosis by analyzing the pathological pattern of ≪mother-newborn≫ in newborns.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study group included newborns with a diagnosis of \"Infection specific to the perinatal period, unspecified\" (P39,9, n=64), born to mothers (age 31,31 ± 2,08 years) with a complicated diagnosis and a control group (n=31) of infants.</p><p><strong>Results: </strong>Results: Clinical manifestations in newborns mainly included involvement of the central nervous system (57,8%), cardiovascular system (12,0%), congenital heart defects (2,8%), jaundice (11,0%), hepatosplenomegaly (5,2%), exanthema (9,0%), hypothermia (70,6%). Markers of inflammatory response confirmed an increase in the level of IL-1, a significant increase in IL-6 levels, the level of IL-8 in the studied contingent also significantly differs from the data of the control group, the level γ-IFN also exceeded the reference values by 2,4 times. Hypoxic-ischemic encephalopathy was detected in 63 infants (57,8%) and intracranial hemorrhage was diagnosed in 25 (22,9%) infants.</p><p><strong>Conclusion: </strong>Conclusions: The values of cytokine profile parameters (IL-1, IL-6, IL-8, IL-10) on the first day of life varied within the reference values, but with significant differences from the values of the control group, which were 9,24; 20; 11 times, respectively. The levels of inflammatory mediators (γ-IFN, procalcitonin, neopterin, TNF-α, Pg E2) significantly differed from the data of the control group and exceeded the upper limit of reference values by 2,4; 40; 8,9; 25; 3,5 times, respectively.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"783-789"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical experience in the surgical treatment of newborns with isolated gastrointestinal perforations based on scientific evidence.","authors":"Olga M Gorbatyuk, Taras V Martyniuk, Andrey A Momotov","doi":"10.36740/WLek/203901","DOIUrl":"https://doi.org/10.36740/WLek/203901","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To share first-hand experience in the surgical treatment of newborns with isolated gastrointestinal perforations.</p><p><strong>Patients and methods: </strong>Materials and Methods: This study examines 71 newborns with perforated peritonitis: 53 (74.65%) had necrotizing enterocolitis, 14 (19.72%) had isolated gastrointestinal perforations, and 4 (5.63%) had other intestinal perforations. Diagnosis involved clinical, laboratory, radiographic, ultrasound, and histological examinations of surgical and autopsy samples.</p><p><strong>Results: </strong>Results: The most significant risk factors for isolated perforations of the gastrointestinal tract in newborns were acute birth asphyxia and pathology of the respiratory system, which required tracheal intubation in 100% of children. Isolated perforations were localized in the stomach (n=6), jejunum (n=3), ileum (n=2), duodenum (n=1), colon (n=2). Morphological features of isolated perforations are as follows: a rapid muscle layer wasting of the wall, sometimes with the absence of muscle fragments; vascular malformations in the submucosal layer of the wall; ulcerous defect without necrotic changes; absence of pneumatosis of the intestinal wall. In isolated perforations, the operation of choice was closure of perforation in 11 children. In 2 patients direct interintestinal anastomoses were performed. Case mortality rate was 21.43% (3 newborns died).</p><p><strong>Conclusion: </strong>Conclusions: 1. Clinical and pathomorphological features of gastrointestinal perforations in newborns indicate that isolated perforations are a separate nosological entity. 2. Isolated perforations of the gastrointestinal tract in newborns are characterized by such clinical differences as distress syndrome, prematurity, early onset, local lesions of a hollow organ, moderate peritonitis, favorable course and prognosis. 3. Isolated perforations are secondary to fibromuscular dysplasia of the wall of a hollow organ, indicating congenital pathology. 4. The operation of choice for isolated perforations is the excision of the edges of the perforation and closure of the perforation. 5. The prognosis for the gastrointestinal isolated perforations is favorable. Mortality was 21,43%.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"894-899"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From efficacy to adversity: understanding the side effects of antidepressants - systematic review.","authors":"Vasyl Hrabar, Taras Studeniak, Mariana Pryima, Vitalii Kondratskyi","doi":"10.36740/WLek/197143","DOIUrl":"10.36740/WLek/197143","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate how and why antidepressant side effects occur, in order to use them effectively in clinical practice.</p><p><strong>Patients and methods: </strong>Materials and Methods: We have studied modern literary sources on the topic of side effects of antidepressant and presented in the form of a literature review in this article. Electronic Scopus and Pubmed databases were searched for articles on the studied topic. The review included original articles, research, and official recommendations from medical associations.</p><p><strong>Conclusion: </strong>Conclusions: Side effects of antidepressants can reduce treatment adherence and delay recovery. Therefore, it is extremely important to consider possible side effects when choosing a therapy. While there is no perfect antidepressant that works quickly and is completely free of side effects, newer antidepressants are safer, better tolerated, and associated with lower rates of treatment failure. Most side effects occur as a consequence of the basic mechanism of action of the drugs. Therefore, it is important to understand the neurobiology of side effects, their frequency and risks, ways to prevent them or use them to your advantage resources.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"187-196"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of dietary factors on the outcomes of rehabilitation in individuals diagnosed with sarcopenia.","authors":"Julia Szewczyk, Konrad Talarek, Paweł Szymonek, Michał Świta, Karolina Turżańska, Małgorzata Drelich, Agnieszka Posturzyńska","doi":"10.36740/WLek/202330","DOIUrl":"https://doi.org/10.36740/WLek/202330","url":null,"abstract":"<p><p>This review gives an overview of the current knowledge about the impact of nutrition on sarcopenia treatment effectiveness. We examined the outcomes of 11 individual clinical trials in conjunction with existing literature to assess the effectiveness of nutritional interventions. Our focus encompassed protein nutrition and its components, the provision of vitamin D. Furthermore, we explored the influence of these substances in addressing sarcopenia within the context of concurrent conditions like osteoporosis, fractures, stroke, or chronic kidney disease. Sarcopenia is a disease of the skeletal muscles that causes a decline in muscle function and mass, which affects mainly elderly people. A progressive course leads to multiple serious complications, such as increased mortality, falls, and co-morbidity. Sarcopenia treatment is limited to physical activity, mainly resistance exercise training and nutritional interventions... Our investigation underscores the significant role of proper nutrition in the treatment process. Finally, this review demonstrates the need for further high-quality research on nutrition and its impact on sarcopenia treatment outcomes.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"544-550"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The study of the base resin impact on planktonic growth of microorganisms of oral origin.","authors":"Yurij Kushnir, Roman Kutsyk, Mykola Rozhko, Tetyana Dmytryshyn, Roksolana Verbovska, Bohdan Pelekhan, Olena Rozhko","doi":"10.36740/WLek/197145","DOIUrl":"10.36740/WLek/197145","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To study the main differences in the intensity of growth of microbial strains of oral origin when they are cultivated in the presence of base resins that are widely used in the clinic of prosthetic dentistry.</p><p><strong>Patients and methods: </strong>Materials and Methods: 3 types of base resin samples were used to evaluate the impact on the growth of microorganisms. Strains of opportunistic pathogens representing the facultative anaerobic transient microflora of the oral cavity were used for the research. Microbial cultures were isolated from the oral mucosa of the patients with removable dentures. The optical density of the culture was determined using a multi-mode photometer. Control growth of the cultures was evaluated under similar cultivation conditions in test tubes with a nutrient medium without resin samples.</p><p><strong>Results: </strong>Results: All resins reduced the intensity of polyantibiotic-resistant S. aureus MRSA growth compared to control samples. The impact on S. epedermidis growth was different. Thus, Vertex and Вreflex reduced the growth intensity insignificantly, and Villacryl increased it to the level of 1.104 ±0.026 CU in comparison with glass constituting 1.178 ±0.033 CU. All studied resins inhibited the growth of polyantibiotic-resistant S. aureus MRSA. Villacryl resin had the least impact on the growth of S. epedermidis. Villacryl resin inhibited C. albicans growth only by 13.70%, and the other two resins inhibited it by 25% on average.</p><p><strong>Conclusion: </strong>Conclusions: The conducted microbiological studies showed the diverse influence of base materials on such important indicators as the optical density of cultures grown in the presence of base resins and the growth inhibition index of cultures.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"110-115"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanohydroxyapatite as the key factor in bone regeneration.","authors":"Paweł Kamiński, Mateusz Kaczmarski, Marta Żerebiec, Natalia Saj, Aleksandra Bełżek, Zuzanna Rupeć, Karolina Turżańska, Małgorzata Drelich","doi":"10.36740/WLek/202331","DOIUrl":"https://doi.org/10.36740/WLek/202331","url":null,"abstract":"<p><p>Bone tissue is a complex material with remarkable durability, elasticity and resistance to mechanical forces, playing a key role in the musculoskeletal system. Hydroxyapatite, a naturally occurring bone-like mineral, is used in a variety of medical applications due to its compatibility with bone tissue. However, synthetic hydroxyapatite has some limitations, such as fragility and low resistance to mechanical straining. Recent developments in nanotechnology have led to the invention of nanohydroxyapatite, which improves bone regeneration and integration with surrounding tissues. The aim of the study is to draw attention to the growing potential of nanohydroxyapatite in clinical practice, especially in the treatment of bone defects. A comprehensive literature review was conducted using PubMed and Google Scholar based on specific criteria to identify relevant studies on the clinical application of nanohydroxyapatite and evaluate its effectiveness and applicability with other organic and inorganic materials. Nanohydroxyapatite has been extensively studied in vitro, in vivo and in clinical trials, showing enhanced bone regeneration and integration. Studies in animal models show promising results for nanohydroxyapatite in bone healing and infection prevention. Clinical studies also confirm its effectiveness in bone grafts, showing comparable results to autografts and fewer complications than other synthetic materials. Nanohydroxyapatite represents a promising biomaterial in modern medicine. Demonstrating effectiveness comparable to natural bone tissue in clinical applications, it exhibits great promise in bone regeneration, implant integration and tissue healing.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"551-558"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis E virus in pregnancy - vaccine and HEV reinforced with polymer.","authors":"Kamila Gorczyca, Maciej Paszkowski","doi":"10.36740/WLek/202543","DOIUrl":"https://doi.org/10.36740/WLek/202543","url":null,"abstract":"<p><p>The hepatitis E virus (HEV) causes self-limiting viral hepatitis. It is now global, both in developing and low-industrialized countries. With infection, the predominance of infections is asymptomatic but can cause death. Pregnant women are particularly vulnerable to severe complications. This article summarizes the current knowledge about HEV infection during pregnancy, focusing on immunology, transmission, complications in both pregnant and newborn women, and polymer-boosted vaccines. The development of a polymer-reinforced vaccine may in the future solve the problem of the HEV virus, which is particularly dangerous for pregnant women.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"621-625"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to physical activity counseling in primary health care: identifying gaps in training and implementation.","authors":"Artur Jakubiak, Kamila Kwiatkowska, Nataliia Fedorenko, Silvija Ille, Zuzanna Jakubiak","doi":"10.36740/WLek/202448","DOIUrl":"https://doi.org/10.36740/WLek/202448","url":null,"abstract":"<p><p>Physical activity (PA) is a key factor in the prevention and treatment of non-communicable diseases. Despite the proven effectiveness of various PA interventions, their implementation in real-world settings remains suboptimal. Numerous barriers hinder effective PA counseling, potentially preventing patients in PHC settings from achieving adequate levels of physical activity. The identified barriers include lack of time, insufficient knowledge, inadequate training in PA counseling, and lack of confidence among healthcare professionals. These challenges highlight a training gap in primary healthcare education. A systematic literaturę review was conducted, focusing on studies published between 2018 and 2024, with a particular emphasis on systematic reviews. Primary Health Care (PHC) provides an appropriate environment for PA counseling, as a significant portion of the population has regular contact with family physicians. Understanding the barriers to promoting PA at the PHC level is a crucial first step toward their elimination, ultimately contributing to improved health outcomes not only for individuals but also for the broader population.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"565-570"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate diaphragmatic relaxation effect on mobility and pain threshold in smartphone users with non-specific cervical spine pain: a randomized placebo-controlled trial.","authors":"Agata Czępińska, Magdalena Zawadka, Izabela Dąbkowska","doi":"10.36740/WLek/202427","DOIUrl":"https://doi.org/10.36740/WLek/202427","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To compare the manual diaphragmatic relaxation technique and placebo intervention on selected parameters in the neck in smartphone users with non-specific neck pain.</p><p><strong>Patients and methods: </strong>Materials and methods: A randomized placebo-controlled trial included 38 women. Neck range of motion and pressure pain threshold were assessed in participants who were assigned to the Therapy group or a Placebo group. The intervention consisted of a single manual relaxation of the diaphragm in the supine position. Repeat measurements were taken after the intervention.</p><p><strong>Results: </strong>Results: There was a statistically significant effect of therapy on range of motion in both studied groups (p < 0.001; partial η2= 0.58. Statistically significant improvement in the range of motion concerned three planes of movement and all analyzed measurements. There were no statistically significant differences in range of motion between groups. Comparison of pressure pain threshold at the level of the 4th cervical vertebra before and after therapy showed significant differences only in the Therapy group (p=0.04, d=0.45). No statistically significant differences in pressure pain threshold were found between the groups either before or after therapy.</p><p><strong>Conclusion: </strong>Conclusions: Global summary of results does not allow for drawing final conclusions regarding the effect of manual diaphragm release on neck parameters in smartphone users with non-specific neck pain, taking into account the results of other researchers, diaphragm therapy is recommended for people with neck pain.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"522-530"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in 3D printed orthotics for rehabilitation.","authors":"Aleksandra Bełżek, Marta Żerebiec, Natalia Saj, Zuzanna Rupeć, Paweł Kamiński, Mateusz Kaczmarski, Karolina Turżańska","doi":"10.36740/WLek/202602","DOIUrl":"https://doi.org/10.36740/WLek/202602","url":null,"abstract":"<p><p>3D printing technology has revolutionized medicine, particularly in orthopedic oncology and rehabilitation, by enabling the creation of customized implants, prostheses, and surgical tools. Its ability to produce complex, patient-specific structures with precise mechanical properties has significantly improved surgical outcomes and treatment effectiveness. Additionally, advancements in digital imaging and computer-aided design/computer-aided manufacturing (CAD/CAM) technologies have streamlined the design and manufacturing process, reducing production time while enhancing comfort and functionality. The continuous development of materials and printing techniques ensures further innovations in personalized medical solutions, making 3D printing a key tool in modern healthcare.The aim of this review is to evaluate the usefulness and development of 3D printing in rehabilitation, focusing on its impact on prosthetics and orthotics. The review of contemporary literature confirms that 3D printing significantly enhances the customization, efficiency, and accessibility of prosthetics and orthotics in rehabilitation. Studies indicate that 3D-printed devices provide comparable or superior biomechanical performance and comfort compared to traditionally manufactured solutions. Additionally, advancements in digital imaging and CAD/CAM technologies have optimized the design and production process, reducing manufacturing time while maintaining precision. 3D printing has emerged as a groundbreaking technology in rehabilitation, offering highly customizable and cost-effective solutions for prosthetics and orthotics. The integration of digital imaging and CAD/CAM technologies further refines the design process, ensuring greater precision. As research and material advancements continue, 3D printing is expected to play an increasingly significant role in rehabilitation, improving patient care and quality of life.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"539-543"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}