Wiadomosci lekarskie最新文献

{"title":"Pathomorphological features of systemic manifestations of severe acute pancreatitis complicated by abdominal compartment syndrome.","authors":"Olexii I Dronov, Inna O Kovalska, Ivanna A Shchyhel, Tetiana P Shevchyk, Vitaliy R Balyak, Vadym O Kostiukevich","doi":"10.36740/WLek/203878","DOIUrl":"https://doi.org/10.36740/WLek/203878","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To classify systemic pathomorphologic changes in severe acute pancreatitis (SAP) and to identify histologic features associated with abdominal compartment syndrome (ACS).</p><p><strong>Patients and methods: </strong>Materials and Methods: The retrospective cohort examination of 53 patients with SAP, who died due to progressive organ failure. Microscopic specimens of the heart, lungs, liver, kidneys and intestines have been reviewed, divided by the proposed four levels of pathological changes and comparable between the two groups, depending on the presence of AСS (25 and 28 patients).</p><p><strong>Results: </strong>Results: When comparing in two groups the levels of lesions of each studied organ, according to given levels of change, a statistically significant difference between groups in the level of kidney and intestine lesions (P <0.05, Mann-Whitney U-Test) was obtained. The changes in moderate and severe levels were significantly dominating in the microscopic specimens of the kidneys and intestines of group A compared to group B (p <0.001).</p><p><strong>Conclusion: </strong>Conclusions: Histopathological changes in the examined organs of patients who died from severe acute pancreatitis complicated by abdominal compartment syndrome were characterized by more pronounced ischemic and inflammatory damage in the kidneys and intestines. The variability of extrapancreatic pathological changes in SAP patients depended on intra-abdominal pressure levels. Monitoring and timely correction of intra-abdominal hypertension aimed at preventing ACS in SAP patients may influence disease progression and treatment outcomes.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 4","pages":"760-767"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point prevalence study of antibiotics use in Ramadi hospitals.","authors":"Maysaa Ali Abdul Khaleq, Ammar Yasir Ahmed, Ahmed Kahlid Awad, Abdula Ahmed Fahed, Fahed Ahmed Fahed, Gada Safaa Ali, Tabark Mohammed Huwadi","doi":"10.36740/WLek/199783","DOIUrl":"10.36740/WLek/199783","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To describe antibiotic use in Al-Ramadi hospitals using the Biomérieux VITEK2 compact system.</p><p><strong>Patients and methods: </strong>Materials and Methods: A lot of different hospitals in Al- Ramadi were visited, checking Patients' illness profile. Information about antibiotics prescription pattern in Al-Ramadi hospitals had been collected from urinary tract infected patients using the Biomérieux VITEK2 compact system.</p><p><strong>Results: </strong>Results: Out of 67 specimens obtained from Urinary tract infection, fifty-two isolates were E. coli, eight isolates were Klebsiella pneumoniae, four were Burkholderia cepacian, and two were Raoultella spp and only one isolate Acetobacter aceti. The data analysis revealed that females had a higher prevalence of infection than males, with 41(68.30%) and 26(38.80%), respectively.</p><p><strong>Conclusion: </strong>Conclusions: Resistance rates have shown variations over the years, they have typically remained elevated for antibiotics commonly employed in the empirical management of urinary tract infections. For successful treatment, it will be crucial to adjust therapy based on culture results and to consider resistance rates during empirical treatment.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 2","pages":"396-401"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formation of digital competence in the medical educational environment.","authors":"Vadym H Terentiyk, Pavlo V Mykytenko, Oleg M Vlasenko, Darya G Matukova, Inna I Kucherenko","doi":"10.36740/WLek/205381","DOIUrl":"https://doi.org/10.36740/WLek/205381","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To present theoretical and practical approaches to the development of digital competence among participants in the medical education environment based on the digitalization of Ukraine's healthcare system.</p><p><strong>Patients and methods: </strong>Materials and Methods: To achieve the research objective, general scientific theoretical and empirical methods were used, including: bibliosemantic method, system analysis method, conversations and interviews with participants in the educational process, modeling of the process of formation of digital competence.</p><p><strong>Results: </strong>Results: An analysis of self-assessment and the level of digital competence formation among healthcare representatives helped determine the criteria for updating educational programs on digital competence development as a result, steps were taken to introduce comprehensive training in digital competencies, covering previously unaddressed aspects and enabling healthcare professionals to acquire all necessary competencies. Therefore, we presented a model illustrating the interrelation of competency formation and learning outcomes (LOs) through the lens of qualification characteristics and higher education standards for the specialty, interpreted in the information-educational environment model NMU_DIGITAL.</p><p><strong>Conclusion: </strong>Conclusions: Medical and pharmaceutical education must adapt to modern standards and tools, regardless of whether they relate to treatment, prevention, rehabilitation, or management activities. Developing digital competence and using digital tools should begin at the earliest stages of professional orientation, be thoroughly studied at the pre-higher and higher education levels, and continue through lifelong professional development.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 5","pages":"1106-1111"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of a family doctor in the formation of a healthy lifestyle of young people in Ukraine.","authors":"Оlena S Shcherbinska, Nadiia Ya Zhylka, Nataliia О Serohina, Oksana V Zhdanova","doi":"10.36740/WLek/205367","DOIUrl":"https://doi.org/10.36740/WLek/205367","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Highlighting the main problems of forming a healthy lifestyle among the youth of Ukraine and determining the role of the family doctor in solving them.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study used bibliosemantic, statistical, analytical methods and descriptive modeling. Data processing was performed using the Microsoft ® Excel ® software package (trial version); statistical processing of results was performed using the statistical analysis software package Statsoft ®Statistica ® ver. 10 (STA999K347156-W) and IBM ® SPSS 25.0 (trial version).</p><p><strong>Results: </strong>Results: According to the results of the study, numerous health problems associated with an unhealthy lifestyle are observed in Ukraine: physical inactivity, bad habits (use of alcoholic beverages and psychoactive substances, smoking), excessive communication on social networks, lack of safe sexual behavior skills. To increase the level of awareness of young people about a healthy lifestyle, we modeled the administration of services for the formation of a healthy lifestyle in the field of primary health care by a family doctor.</p><p><strong>Conclusion: </strong>Conclusions: One of the main links in the formation of a healthy lifestyle is the professional approach of this family doctor in the framework of performing his direct functions of eliminating habits and behavior that pose a risk to health and forming healthy lifestyle skills. Public administration should ensure the effectiveness of the family doctor in providing services for the formation of a healthy lifestyle through the process of collective adoption and implementation of strategic decisions.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 5","pages":"1045-1051"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerobic skin microbiota study in patients with paratraumatic eczema developed as a result of combat injuries.","authors":"Svitlana Dzhoraieva, Yanina Kutasevych, Oksana Sokol, Valentina Honcharenko, Hanna Kondakova, Iryna Oliinyk, Olha Oliinyk","doi":"10.36740/WLek/197131","DOIUrl":"10.36740/WLek/197131","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To establish taxonomic composition, population level and microecological indicators of the \"macroorganism-microbiota\" ecosystem by determining the expression levels of individual pathogenicity factors of microorganisms isolated from the skin areas of patients with paratraumatic eczema developed as a result of combat injuries.</p><p><strong>Patients and methods: </strong>Materials and Methods: Studied microbiologically eczematous lesions content in 54 military men to determine the qualitative and quantitative composition of microbiocenosis to analyze the taxonomic composition, population-species level, microecological indicators and expression levels of individual pathogenicity factors.</p><p><strong>Results: </strong>Results: The results indicate that most eczematized areas are contaminated with S.aureus (48.1% ) with the highest level of quantitative dominance. The rate of quantitative dominance of other strains is significantly lower: S.epidermidis - 2.56 times, S.haemolyticus - 4.56 times, S.pyogenes - 5.86 times, E.faecalis and K.pneumoniae - 20.56 times. When determining the sensitivity of S. aureus clinical strains to antibacterial drugs, we established high levels of sensitivity to mupirocin, fusidic acid, and oxazolidinones - 95.1%, 90.2%, and 87.8%, respectively. Moreover, S. aureus dominated among the strains with a high ability to form biofilms - 68.2%, with an average ability - S epidermidis, 28.8%.</p><p><strong>Conclusion: </strong>Conclusions: S.aureus is the leading pathogen in the infectious-allergic process with paratraumatic eczema according to the constancy index of each taxon, frequency of manifestation, Margalef's species richness index, Whittaker's species diversity, the value of Simpson's and Berger-Parter's species dominance indices, as well as the population level of each taxon, the coefficient of quantitative dominance and the coefficient of significance. We should consider this fact when prescribing therapy.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extrinsic black staining of teeth: a review.","authors":"Inessa I Yakubova, Volodymyr Ostrianko, Yurii Skrypnyk, Roman Volovodovskiy","doi":"10.36740/WLek/197130","DOIUrl":"10.36740/WLek/197130","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Discovering of the prevalence, causes and consequences of the Extrinsic black staining(EBS) of teeth in pediatric population.</p><p><strong>Patients and methods: </strong>Materials and Methods: Upon completion of the scientific search, the review included 47 scientific articles from the electronic databases, reference lists of articles, and selected textbooks in the time interval from 1976 to 2023.</p><p><strong>Conclusion: </strong>Conclusions: The results show that EBS is a possible protective factor against early childhood caries. Dental plaque and gut microbiome may be related to EBS in the temporary dentition. The literature suggests a decreased caries prevalence in the presence of EBS which associated with low incidence of caries in children. The nature of the black pigmentation is suggested to be a form of bacterial plaque with an insoluble ferric salt. Tabaco smoke, food and antibiotics that can be also a risk factors for EBS. There are some clinical and localization features that dentist have to pay attention for. Many diseases of various systems and organs are directly related to black plaque. With this review, we wanted to encourage dentists to identify the problem in childhood and collaborate in a multidisciplinary team to improve treatment efficiency and speed up the selection of the right tactics for the most person-centered approach to avoid worsening the problem in adulthood.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"210-215"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender dimorphism of neurodynamic and cognitive functions of sub-elite and elite athletes (on the example of sports acrobatics).","authors":"Nataliia Veronika Bachynska, Dmytro Anisimov, Oleksandr Zhuravel, Dmytro Kaznacheiev, Vadym Fursa, Nataliia Martynova, Liudmyla Lysenko","doi":"10.36740/WLek/197138","DOIUrl":"10.36740/WLek/197138","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To evaluate the impact of a specific acrobatic load on the neurodynamic and cognitive functions of acrobats, as well as to study how these functions change depending on the gender, age and level of sports qualification of athletes (sub-elite and elite athletes).</p><p><strong>Patients and methods: </strong>Materials and Methods: Athletes specializing in pair and group acrobatics, of two age categories: 1. Sub-elite - athletes of puberty age, which included: girls (n=32), average age 13.96±1.02 years; boys (n=36), average age 14.88±2.32 years. 2. Youth acrobats (elite athletes): girls (n=30), average age 19.36±2.86 years; young men (n=34), average age 20.38±2.89. The computer program \"Diagnost-1\" was used in researches.</p><p><strong>Results: </strong>Results: In female acrobats, the latency period of simple visual-motor information, the latent period of the visual-motor reaction to choosing two out of three stimuli are statistically different from those of young acrobats. Boys acrobats are faster in terms of functional mobility of nervous processes than girls in both age categories (at p<0.05). A greater amount of processed information was found in acrobat boys than in adolescent girls. According to the indicators of cognitive characteristics features of sexual dimorphism between acrobats of different age categories were revealed due to different information processing strategies taking into account sexual characteristics.</p><p><strong>Conclusion: </strong>Conclusions: Boys-acrobats of puberty and adolescence showed more effective processing of simple and complex visual-motor information compared to girls-acrobats of the same age categories. The indicators of neurodynamic and cognitive functions of young acrobats are better than those of pubescent athletes and different by gender (p<0.05).</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"61-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential cardioprotective effect of trimetazidine in mice model of endotoxemia: role of AMPK-Nrf2.","authors":"Alaa Kadhum Mosa, Sahar Majeed, Fadhaa Abdulameer Ghafil, Najah Rayish Hadi","doi":"10.36740/WLek/190820","DOIUrl":"10.36740/WLek/190820","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To clarify the potential cardioprotective effect of Trimetazidine against experimentally sepsis-caused endotoxic cardiac injury damage in mice.</p><p><strong>Patients and methods: </strong>Materials and Methods: 24 Mice were divided into four groups (n=6): Sham group, CLP group DMSO group, trimetazidine-treated group 50 mg/kg IP, 1hr before CLP, then the animals were sacrificed 24 hr after CLP and tissue sample was taken for measurement of TNF-α, TNF-αr1, IL-1β, HO-1, MPO, caspase-11, F2-isoprostane and serum troponin by ELISA and gene expression of AMPK-Nrf2 by qpcr and histopathological study.</p><p><strong>Results: </strong>Results: trimetazidine treated group showed significant changes as compared with clp group regarding TNF-α, TNF-αr1, IL-1β, HO-1, MPO, CASPASE-11, F2-ISOPROSTANE as well as affect tissue mRNA expression of AMPK-Nrf2 genes p<0.05.</p><p><strong>Conclusion: </strong>Conclusions: We evaluate that Trimetazidine has cardio protective effects due to its anti-inflammatory and anti-oxidative action. Also, trimetazidine showed a cardio-protective effect as they affect tissue mRNA expression of AMPK-Nrf2 genes.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"35-44"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From efficacy to adversity: understanding the side effects of antidepressants - systematic review.","authors":"Vasyl Hrabar, Taras Studeniak, Mariana Pryima, Vitalii Kondratskyi","doi":"10.36740/WLek/197143","DOIUrl":"10.36740/WLek/197143","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate how and why antidepressant side effects occur, in order to use them effectively in clinical practice.</p><p><strong>Patients and methods: </strong>Materials and Methods: We have studied modern literary sources on the topic of side effects of antidepressant and presented in the form of a literature review in this article. Electronic Scopus and Pubmed databases were searched for articles on the studied topic. The review included original articles, research, and official recommendations from medical associations.</p><p><strong>Conclusion: </strong>Conclusions: Side effects of antidepressants can reduce treatment adherence and delay recovery. Therefore, it is extremely important to consider possible side effects when choosing a therapy. While there is no perfect antidepressant that works quickly and is completely free of side effects, newer antidepressants are safer, better tolerated, and associated with lower rates of treatment failure. Most side effects occur as a consequence of the basic mechanism of action of the drugs. Therefore, it is important to understand the neurobiology of side effects, their frequency and risks, ways to prevent them or use them to your advantage resources.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 1","pages":"187-196"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of dietary factors on the outcomes of rehabilitation in individuals diagnosed with sarcopenia.","authors":"Julia Szewczyk, Konrad Talarek, Paweł Szymonek, Michał Świta, Karolina Turżańska, Małgorzata Drelich, Agnieszka Posturzyńska","doi":"10.36740/WLek/202330","DOIUrl":"https://doi.org/10.36740/WLek/202330","url":null,"abstract":"<p><p>This review gives an overview of the current knowledge about the impact of nutrition on sarcopenia treatment effectiveness. We examined the outcomes of 11 individual clinical trials in conjunction with existing literature to assess the effectiveness of nutritional interventions. Our focus encompassed protein nutrition and its components, the provision of vitamin D. Furthermore, we explored the influence of these substances in addressing sarcopenia within the context of concurrent conditions like osteoporosis, fractures, stroke, or chronic kidney disease. Sarcopenia is a disease of the skeletal muscles that causes a decline in muscle function and mass, which affects mainly elderly people. A progressive course leads to multiple serious complications, such as increased mortality, falls, and co-morbidity. Sarcopenia treatment is limited to physical activity, mainly resistance exercise training and nutritional interventions... Our investigation underscores the significant role of proper nutrition in the treatment process. Finally, this review demonstrates the need for further high-quality research on nutrition and its impact on sarcopenia treatment outcomes.</p>","PeriodicalId":23643,"journal":{"name":"Wiadomosci lekarskie","volume":"78 3","pages":"544-550"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}