Association of toll-like receptor 4 gene (Thr399Ile) polymorphism with type II diabetes mellitus patients.

Q4 Medicine

Wiadomosci lekarskie Pub Date : 2025-01-01 DOI:10.36740/WLek/207378

Ahmed J Mohammed, Atheer Mohammed Jasim Al-Zurfi, Shaden M H Mubarak

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引用次数: 0

Abstract

Objective: Aim: This study investigates the association of the TLR4 Thr399Ile (rs4986791) polymorphism with T2DM in Iraqi patients and its influence on clinical parameters.

Patients and methods: Materials and Methods: A case-control study was conducted on 200 participants (100 T2DM cases and 100 healthy controls). Phenotypic analyses included fasting blood glucose, HbA1c, lipid profiles, and insulin sensitivity indices. Genotyping of the TLR4 Thr399Ile polymorphism was performed using PCR-RFLP. Statistical analyses were conducted using SPSS.

Results: Results: The CT and TT genotypes were significantly more frequent in T2DM patients, associated with higher odds ratios (OR=2.40, p=0.003; OR=5.33, p=0.04, respectively). HDL levels were significantly lower in variant genotypes (p = 0.01). Other clinical parameters showed no significant genotype-specific differences.

Conclusion: Conclusions: The TLR4 Thr399Ile polymorphism is significantly associated with increased T2DM risk and altered HDL levels in Iraqi patients, highlighting its potential as a genetic marker for early risk assessment.

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toll样受体4基因（Thr399Ile）多态性与2型糖尿病患者的关系

目的：探讨TLR4 Thr399Ile （rs4986791）多态性与伊拉克T2DM患者的关系及其对临床参数的影响。患者与方法：材料与方法：对200名参与者进行病例对照研究（100例T2DM患者和100例健康对照）。表型分析包括空腹血糖、糖化血红蛋白、脂质谱和胰岛素敏感性指数。采用PCR-RFLP对TLR4 Thr399Ile多态性进行基因分型。采用SPSS进行统计分析。结果：CT和TT基因型在T2DM患者中更为常见，且优势比较高（OR=2.40, p=0.003； OR=5.33, p=0.04）。不同基因型患者HDL水平显著降低（p = 0.01）。其他临床参数没有明显的基因型特异性差异。结论：TLR4 Thr399Ile多态性与伊拉克患者T2DM风险增加和HDL水平改变显著相关，突出了其作为早期风险评估遗传标记的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wiadomosci lekarskie Medicine-Medicine (all)

CiteScore

0.80

自引率

0.00%

发文量

482