Vascular Health and Risk Management最新文献

{"title":"Predictive Utility of PLR and Platelet-to-LDL Ratio for in-Stent Restenosis Following Carotid Artery Stenting.","authors":"Ling Ma, Hu Xu, Huatao Li, Dianwei Liu","doi":"10.2147/VHRM.S534400","DOIUrl":"10.2147/VHRM.S534400","url":null,"abstract":"<p><strong>Background: </strong>Carotid artery stenting (CAS) has been widely used to remodel the vascular structure and restore the blood flow for preventing ischemic stroke. However, in-stent restenosis (ISR) after CAS is extremely associated with an increased risk of ischemic stroke recurrence.</p><p><strong>Objective: </strong>The aim of this study was to explore potential predict biomarkers for ISR after CAS.</p><p><strong>Methods: </strong>In this study, data from 221 patients with CAS, which was divided into no-ISR group and ISR group, and 145 healthy controls were retrospectively analyzed. The ratios of neutrophil, lymphocyte, monocyte, platelet, glucose (Glu), and triglyceride (TG) to lymphocyte, HDL, and LDL were analyzed, respectively. In addition, the ratios of SII, SIRI, and AISI were analyzed as the following formulas: SII = platelet × neutrophil-to-lymphocyte ratio, SIRI = monocyte × neutrophil-to-lymphocyte ratio, and AISI = neutrophil × platelet × monocyte-to-lymphocyte ratio. ROC curve analysis was performed to analyze the predict roles of PLR and platelet/LDL for ISR.</p><p><strong>Results: </strong>The ratios of NLR, PLR, Glu/lymphocyte, TG/lymphocyte, NHR, PHR, Glu/HDL, TG/HDL, neutrophil/LDL, platelet/LDL, Glu/LDL, TG/LDL, and SII increased in patients with CAS, indicating the predict roles of these values in carotid artery stenosis. Most importantly, increased ratios of PLR and platelet/LDL before the first operation of CAS, but not the second operation, were found in ISR patients after CAS as compared with no-ISR group. ROC analysis showed a more effective role of PLR for predicting ISR. While PLR showed high specificity (96.95%), its modest sensitivity (35.29%) suggests the need for complementary biomarkers in clinical practice.</p><p><strong>Conclusion: </strong>These results indicate that ratios of PLR and platelet/LDL before the first CAS operation can act as the predict biomarkers of ISR.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"671-684"},"PeriodicalIF":2.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual and Cardiovascular Health: Factors Influencing on the Quality of Sexual Life of Coronary Heart Disease Patients - A Narrative Review [Response to Letter].","authors":"Magdalena Piegza, Joanna Smolarczyk, Jacek Piegza","doi":"10.2147/VHRM.S554668","DOIUrl":"https://doi.org/10.2147/VHRM.S554668","url":null,"abstract":"","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"669-670"},"PeriodicalIF":2.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Predictors of Temporary Epicardial Pacing Wires Use After Isolated Coronary Artery Bypass Grafting Surgery.","authors":"Nizar R Alwaqfi, Majd M AlBarakat, Rana B Altawalbeh, Hala R Qaryouti, Abdullah AlMomani, Ahmed S Obeidat, Ayah J Alkrarha, Khalid S Ibrahim, Qusai Aljarrah, Nisreen Yaghmour","doi":"10.2147/VHRM.S513921","DOIUrl":"https://doi.org/10.2147/VHRM.S513921","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery bypass grafting (CABG) is frequently associated with postoperative arrhythmias, often necessitating temporary cardiac pacing (TCP). The routine placement of temporary epicardial pacing wires (PWs) remains controversial due to potential complications. This study aimed to identify predictors for TCP after isolated CABG to guide selective PW use and improve perioperative outcomes.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 1,395 patients who underwent isolated CABG with cardiopulmonary bypass (CPB) at King Abdullah University Hospital, Jordan, between 2004 and 2022. Patients undergoing redo surgeries or presenting with high-grade atrioventricular block, ischemic ventricular septal defect, or missing data were excluded. Patients were grouped based on PW placement, and predictors for TCP were assessed using univariate and multivariate logistic regression.</p><p><strong>Results: </strong>Among the 1,395 patients, 887 received PWs, and 127 required TCP. Significant predictors for TCP included preoperative bundle branch block (BBB), intraoperative blood transfusion, prolonged vasoactive support, and mechanical ventilation exceeding 12 hours postoperatively. Preoperative beta-blocker use was associated with reduced risk of TCP. Demographics, comorbidities, and prolonged CPB or aortic cross-clamp times were not significant.</p><p><strong>Conclusion: </strong>Preoperative BBB and postoperative complications were associated with increased TCP risk, while beta-blocker use was protective. These findings support a risk-based strategy for PW placement after CABG to reduce complications and improve resource allocation. Prospective studies are needed to validate these predictors and refine perioperative protocols.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"655-666"},"PeriodicalIF":2.8,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurses Bridging Silence on Sexual Health in Cardiac Care: A Commentary on Piegza et al (2025) \"Sexual and Cardiovascular Health: Factors Influencing on the Quality of Sexual Life of Coronary Heart Disease Patients - A Narrative Review\" [Letter].","authors":"Sílvia Teixeira, Bruno Delgado, Paulo Alves","doi":"10.2147/VHRM.S551001","DOIUrl":"https://doi.org/10.2147/VHRM.S551001","url":null,"abstract":"","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"667-668"},"PeriodicalIF":2.8,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the Coagulation Factor V c.3865T>G Mutation with Genetic and Regional Susceptibility to Cerebral Venous and Sinus Thrombosis in Xiangyang.","authors":"Jun Zhang, Qian Liu, Chenglin Sun, Jun Yang","doi":"10.2147/VHRM.S518609","DOIUrl":"10.2147/VHRM.S518609","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the potential genetic and regional associations of a newly identified c.3865T>G mutation in the F5 gene (coagulation factor V) with cerebral venous and sinus thrombosis (CVST).</p><p><strong>Methods: </strong>Two groups of CVST cases associated with hereditary thrombophilia were analyzed. Genetic sequencing was performed to identify the patients' genetic profiles. A family pedigree analysis and a review of relevant literature were conducted to assess the pathogenic significance of the mutation.</p><p><strong>Results: </strong>Genetic analysis revealed the presence of a c.3865T>G mutation in the F5 gene in both cases. This mutation is distinct from the well-established Leiden mutation and has not been previously reported. Although the two patients' families had no direct blood relationship, both patients resided in the same geographic region, suggesting the possibility of shared environmental or genetic factors. Advances in diagnostic technologies have also facilitated the identification of hereditary thrombophilia as an increasingly recognized cause of CVST.</p><p><strong>Conclusion: </strong>The c.3865T>G mutation in the F5 gene may represent a novel genetic contributor to CVST. Its regional clustering points to a potential genetic and geographic association. These findings provide new insights into the etiology and diagnosis of CVST and underscore the importance of investigating regional genetic predispositions further.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"645-653"},"PeriodicalIF":2.8,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensified Multifaceted Education Improves the Implementation of Standard Atrial Fibrillation Care in Elderly Patients with Atrial Fibrillation in Rural China.","authors":"Shimeng Zhang, Ming Chu, Dechuan Lu, Youmei Shen, Xingxing Sun, Yaodongqin Xia, Shu Yang, Jinlong Gong, Li Hong, Mingfang Li, Gregory Y H Lip, Minglong Chen","doi":"10.2147/VHRM.S535313","DOIUrl":"10.2147/VHRM.S535313","url":null,"abstract":"<p><strong>Background: </strong>Exploring an integrated care management model to effectively deliver the standardized management to atrial fibrillation (AF) elderlies in rural China.</p><p><strong>Purpose: </strong>The objective of this study was to assess whether intensified multifaceted education (IME) targeting AF elderlies, their family members, and the village doctors (VD) can increase compliance for rural AF elderlies with integrated care based on the AF Better Care (ABC) pathway. Additionally, the capacity of VD to deliver integrated AF care was investigated.</p><p><strong>Patients and methods: </strong>This is a self-controlled cohort study before and after IME, including AF patients aged ≥65 years identified in phase-I of The Jiangsu Province Rural Community AF Project. The IME model was defined as 12 months of continuous knowledge education on integrated care management of AF based on the ABC pathway, delivered to AF patients, their family members and the village doctors. AF knowledge evaluation from VD and compliance with the ABC pathway before and after the IME model were evaluated.</p><p><strong>Results: </strong>A total of 810 AF patients (mean age 76.1 ± 5.9 years; 51.4% women) were enrolled. After 12 months, the AF knowledge score of VD was significantly improved [(65.0 ± 13.0) scores vs (53.1 ± 9.8) scores, <i>P</i> < 0.001]. Although the compliance of AF patients with the ABC pathway was improved statistically (4.3% vs 1.7%, <i>P</i> = 0.003), the absolute increase was small.</p><p><strong>Conclusion: </strong>Although VD have the potential to serve as AF integrated care management providers, the impact of the IME model used to improve the standard AF care in rural elderly AF population was small.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"633-644"},"PeriodicalIF":2.8,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiological Findings of Retrograde Venous Cerebral Air Embolism Infarcts: A Case Report and Literature Review.","authors":"Sabīne Teifurova, Kārlis Rācenis, Ģirts Freijs, Sigita Skrastina, Arturs Balodis","doi":"10.2147/VHRM.S537865","DOIUrl":"10.2147/VHRM.S537865","url":null,"abstract":"<p><strong>Background: </strong>Cerebral air embolism infarction (CAEI) is a rare but life-threatening condition that can affect the venous or arterial blood supply to the brain. Its aetiology is mostly iatrogenic, often resulting from complications of cardiothoracic or neurosurgical procedures, as well as manipulations with peripheral or central catheters. If undiagnosed and untreated, cerebral air embolism infarction can lead to long-term neurological consequences or even death. Diagnosis relies on clinical presentation and neuroimaging findings from CT and MRI, which are time-sensitive and not well described in the current literature.</p><p><strong>Case presentation: </strong>We present a rare case of cerebral infarction as a complication of retrograde cerebral venous air embolism following haemodialysis catheter removal in a young patient, with management leading to a favourable outcome. The diagnosis was confirmed based on clinical manifestations and neuroimaging findings, with air emboli identified in the subarachnoid space on the CT scan, followed by characteristic MRI changes defined for cerebral air embolism infarcts. Timely diagnosis allowed for the rapid initiation of hyperbaric oxygen therapy and the rehabilitation process, resulting in positive outcomes.</p><p><strong>Conclusion: </strong>Timely neuroimaging-particularly CT within the first 2 hours-is critical for diagnosing CAEI. MRI findings, including cytotoxic and vasogenic oedema in a distal vascular distribution and leptomeningeal enhancement, further support diagnosis. Early identification and treatment initiation are essential for improving patient outcomes.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"617-631"},"PeriodicalIF":2.8,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Cardio-Ankle Vascular Index (CAVI) and the Severity of Coronary Artery Lesions: A Case-Control Study.","authors":"Le Van Dung, Pham Nguyen Son, Kieu Ly Thi Nguyen, Dinh Cong Pho, Nguyen Manh Thang, Dao Chien Thang, Pham Truong Son","doi":"10.2147/VHRM.S542595","DOIUrl":"10.2147/VHRM.S542595","url":null,"abstract":"<p><strong>Introduction: </strong>The cardio-ankle vascular index (CAVI) is an important metric for evaluating arterial stiffness (AS). In this study, we used cardio-ankle vascular index (CAVI) to predict CAD severity of coronary artery lesions.</p><p><strong>Methods: </strong>This case-control study was conducted between October 2019 and December 2022. There were 222 patients divided into two groups: those with chronic coronary artery disease (CAD group), with 160 patients and a control group (non-CAD group) with 62 patients. The CAVI measurement and severity of coronary artery lesion parameters were evaluated (severity of stenosis, number of coronary artery diseases, syntax scores, and Gensini scores).</p><p><strong>Results: </strong>The CAVI in the CAD group (9.21 ± 0.79) was significantly higher than that in the non-CAD group (8.48 ± 0.62) (p < 0.001). CAVI, with a cut-off point ≥8.83, was a significant predictor of chronic CAD (OR = 9.6; 95% CI: 4.0-18.8) with an area under the curve (AUC) of 0.796 (95% CI: 0.736-0.856; p < 0.001). CAVI was significantly higher in severe stenosis (≥75%) compared to moderate stenosis (9.41 ± 0.81 vs 9.02 ± 0.75, p = 0.002). CAVI was higher in multivessel disease compared to single-vessel disease (9.43 ± 0.80 vs 8.90 ± 0.70, p < 0.001). CAVI increased with higher SYNTAX scores (mild, moderate, and severe: 9.09 ± 0.65, 9.80 ± 1.05, and 9.45 ± 0.46, respectively; p < 0.001) and Gensini scores (mild, moderate, and severe: 8.90 ± 0.65, 9.37 ± 0.95, and 9.43 ± 0.59, respectively; p < 0.001).</p><p><strong>Conclusion: </strong>CAVI is higher in chronic CAD and can predict chronic CAD with a cut-off point of ≥8.83. The CAVI is higher in patients with severe stenosis, multivessel coronary artery disease, higher syntax scores, and higher Gensini scores.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"607-615"},"PeriodicalIF":2.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Disease-Modifying Antirheumatic Drugs on Cardiovascular Risk in Inflammatory Joint Diseases: Current Evidence and Uncertainties.","authors":"Olena Garmish, Svitlana Smiyan, Fedir Hladkykh, Bohdan Koshak, Roman Komorovsky","doi":"10.2147/VHRM.S523939","DOIUrl":"10.2147/VHRM.S523939","url":null,"abstract":"<p><p>Patients with inflammatory joint diseases, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, have an elevated risk of cardiovascular complications due to systemic inflammation, immune-mediated endothelial dysfunction, and associated metabolic changes. Disease-modifying antirheumatic drugs (DMARDs) influence cardiovascular risk through their effects on inflammation, lipid metabolism, and endothelial function. Methotrexate has demonstrated cardioprotective properties, likely mediated through anti-inflammatory mechanisms rather than direct metabolic effects. However, other conventional DMARDs, such as sulfasalazine and hydroxychloroquine, also continue to play a role in routine practice; their cardiovascular effects appear more heterogeneous and less well established. Biologic DMARDs, particularly tumor necrosis factor (TNF) inhibitors, are associated with a reduction in major cardiovascular events despite inducing lipid profile alterations. However, data on newer biologic agents, such as interleukin (IL)-17 and IL-23 inhibitors, remain limited. Janus kinase (JAK) inhibitors present concerns regarding dyslipidemia and thrombotic risk, necessitating individualized cardiovascular risk assessment. Nonsteroidal anti-inflammatory drugs (NSAIDs) remain controversial due to their potential to exacerbate cardiovascular risk, particularly with long-term use. Given the variability in drug effects, treatment strategies must balance effective disease control with cardiovascular safety. This narrative review summarizes current evidence on the impact of both conventional and biologic DMARDs on cardiovascular risk, drawing from randomized clinical trials and real-world observational data. The review also compares available data across different inflammatory joint diseases and highlights areas of uncertainty that remain in clinical decision-making. A multidisciplinary and individualized approach remains essential for optimizing long-term cardiovascular outcomes in these patients.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"593-605"},"PeriodicalIF":2.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Recovery Systolic Blood Pressure After Spot Marching Exercise and Vascular Function in Middle-Aged Adults.","authors":"Teonchit Nuamchit, Weerapong Chidnok, Tomon Thongsri, Nuttanit Rodvinit, Thanaphon Chaitawong, Noppawit Rattanawan, Nisakan Juntarach, Noppakoon U-Suwan, Sorrawee Lamoonkit, Nannalat Onchaiya, Paniwara Borirakwanich, Suwiporn Kawila, Pussadee Paensuwan, Wanvisa Treebuphachatsakul, Duangduan Siriwittayawan, Piyanuch Thitiwuthikiat","doi":"10.2147/VHRM.S533735","DOIUrl":"10.2147/VHRM.S533735","url":null,"abstract":"<p><strong>Purpose: </strong>Blood pressure (BP) response observed during exercise stress tests has been recognized as a predictor of the onset of hypertension and arterial stiffness. However, access to such testing is often limited to specialized clinical settings. The purpose of this study was to assess the utility of a simple, equipment-free exercise, self-paced spot marching exercise (SME), along with the subsequent recovery BP in evaluating vascular functions.</p><p><strong>Patients and methods: </strong>A cross-sectional study was conducted with 107 participants aged 40-59 years, including those with and without hypertension. During the 6-min recovery period following SME, systolic BP (SBP) and diastolic BP (DBP) were measured every 2 min. Flow-mediated dilation (FMD) and cardio-ankle vascular index (CAVI) were used to evaluate endothelial function and arterial stiffness. Pearson's correlation and multiple linear regression analyses were performed to assess the associations between recovery BP and vascular parameters.</p><p><strong>Results: </strong>Among total participants, 4-min recovery SBP was independently associated with FMD, whereas resting BP showed no such association. CAVI was not correlated with any recovery BP. In non-hypertensive individuals, 4-min recovery SBP remained independently associated with FMD, whereas age and resting SBP were linked to CAVI.</p><p><strong>Conclusion: </strong>These findings suggest that recovery SBP following SME reflects early endothelial dysfunction and vascular impairment. Therefore, using recovery SBP after the SME demonstrates the potential to be a tool for the early detection of vascular risk in middle-aged adults.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"581-592"},"PeriodicalIF":2.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}