Vascular Health and Risk Management最新文献

{"title":"Research Trends in Vascular Aging in the Last Decade: A Comprehensive Bibliometric Analysis.","authors":"Dandan Shi, Ziqi Ning, Yaoyao Zhang, Xiaochen Guo, Yun Wei, Meixia Liu","doi":"10.2147/VHRM.S517302","DOIUrl":"10.2147/VHRM.S517302","url":null,"abstract":"<p><strong>Background: </strong>In recent years, vascular aging has emerged as a hot topic in become an important direction of aging research, but a comprehensive bibliometric analysis has not been conducted.</p><p><strong>Methods: </strong>The Web of Science database was searched for articles and reviews on vascular aging from January 1, 2014, to August 20, 2024, and the literature was analyzed and knowledge maps were constructed using CiteSpace, VOSviewer, pajek and Scimago Graphica software for econometric analysis and knowledge graph construction of the literature.</p><p><strong>Results: </strong>A total of 38,910 authors from 7622 institutions in 111 countries published 7277 papers in 1344 academic journals, with a significant increase in publication volume. The United States is the country with the highest productivity and citation rates, and Mayo Clinic is the most active institution. Tarantini S published the most papers, while Csiszar A received the most citations. <i>Retina-The Journal of Retinal and Vitreous Diseases</i> journal published the most papers, and <i>Circulation</i> journal received the most citations. The main research aspects include age-related macular degeneration, arteriosclerosis, and oxidative stress, which are the main keywords in this field. In the last decade, the term c reactive protein has attracted great attention with its strongest citation explosion.</p><p><strong>Conclusion: </strong>In the past decade, the research focus on vascular aging has been increasing year by year. Age-related macular degeneration, arteriosclerosis, oxidative stress and vascular endothelial cells are the emerging research directions in this field.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"411-423"},"PeriodicalIF":2.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technical Efficacy and Safety of Outpatient Endovenous Laser Ablation of Varicose Veins Under Local Anesthesia.","authors":"Abdullah Alwahbi","doi":"10.2147/VHRM.S518681","DOIUrl":"10.2147/VHRM.S518681","url":null,"abstract":"<p><strong>Background: </strong>Endovenous Laser Ablation (EVLA) is the recommended method for treating varicose veins. It is commonly performed in an inpatient or as day surgery setting under either general or spinal anesthesia. The purpose of this study is to assess the technical efficacy and safety performing outpatient EVLA for varicose veins under local tumescent anesthesia for procedure success, complications, recovery time, and patient satisfaction.</p><p><strong>Methods: </strong>A retrospective review of 300 consecutive patients who underwent outpatient EVLA under local tumescent anesthesia from October 2014 to June 2019 was undertaken. Patients 25-55 years diagnosed with symptomatic varicose veins and Great Saphenous Vein (GSV) incompetence were enrolled. Patient demographics, clinical characteristics, procedure duration, complications, and follow-up outcomes were recorded.</p><p><strong>Results: </strong>A total of 331 limbs were treated. The mean procedure time was 36 minutes. Five procedures were aborted for technical reasons, resulting in an overall technical success rate of 98%. They were minor complications of bruising (13%) and phlebitis (5%), that were resolved and did not require further intervention. There were no significant complications, including deep vein thrombosis (DVT) or pulmonary embolism (PE). Patients were discharged and resumed normal activities within approximately seven days and were well satisfied.</p><p><strong>Conclusion: </strong>EVLA for varicose veins can be performed as an outpatient procedure under local tumescent anesthesia safely and with high technical efficiency. It offers the benefits of shorter recovery times, less risk of complications, and lower health care costs.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"403-409"},"PeriodicalIF":2.6,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Sarcopenia Index and Aortic Valve Sclerosis in Coronary Artery Disease Patients: Insights from a Retrospective Cross-Sectional Analysis and Animal Models.","authors":"Yifeng Zhang, Hui Chen, Zhongli Chen, Xihao Du, Jiawei Chen, Mirenuer Aikebaier, Shuyao Shan, Ling Yang, Anqi Zhao, Yanping Wang, Yehong Liu, Ke Yang","doi":"10.2147/VHRM.S520000","DOIUrl":"10.2147/VHRM.S520000","url":null,"abstract":"<p><strong>Background: </strong>The Sarcopenia Index (SI) is a recognized predictor of cardiovascular risk in patients with coronary artery disease (CAD), yet its association with aortic valve sclerosis (AVSc) remains insufficiently studied. This study aimed to examine the relationship between SI and AVSc in CAD patients.</p><p><strong>Methods: </strong>In this retrospective study, 1056 CAD patients at Shanghai Ruijin Hospital underwent SI assessment and Doppler echocardiography. SI was calculated as [serum creatinine (mg/dL)/cystatin C (mg/L)] × 100. Logistic regression, subgroup analyses, and restricted cubic splines evaluated the SI-AVSc association. ROC curves determined SI's diagnostic value and its addition to traditional AVSc factors. In parallel with clinical observations, aortic valve changes were analyzed in mice via hematoxylin and eosin, AlizarinRed S, and Masson's trichrome to assess valve thickness, fibrosis and calcification.</p><p><strong>Results: </strong>Patients with the lowest SI levels showed a higher prevalence of AVSc. Multivariate logistic regression revealed that SI was independently associated with AVSc (<i>P</i><0.001). The C-statistic for SI in identifying AVSc was 0.708 (95% CI: 0.671, 0.744), and it improved risk stratification when SI was added to traditional clinical models (C-statistic increased from 0.840 to 0.866). In the subgroup analysis, the discriminatory power of SI was enhanced among elderly patients. Findings from animal models supported these results, and Spearman correlation analyses revealed negative correlation between SI and peak systolic aortic valve flow velocity (Spearman's rho=-0.578, <i>P</i>=0.006). Histological analysis demonstrated that aortic valve leaflets in the low SI group were thicker and more fibrotic than those in the high SI group, and this complementary approach provided mechanistic insights into how sarcopenia may promote valve degeneration in elder mice.</p><p><strong>Conclusion: </strong>Lower Sarcopenia Index is associated with the presence of AVSc in CAD patients. SI improves risk stratification and acts as a valuable associated marker for AVSc, emphasizing its potential clinical utility in enhancing patient management.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"391-401"},"PeriodicalIF":2.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Compression of the Right Internal Carotid Artery by the Hyoid Bone in a Patient with Moyamoya Syndrome and Low Internal Carotid Artery Bifurcation: A Case Report.","authors":"Klinta Bicevska, Sigita Skrastina, Karlis Kupcs, Anita Raita, Arturs Balodis","doi":"10.2147/VHRM.S520022","DOIUrl":"10.2147/VHRM.S520022","url":null,"abstract":"<p><strong>Background: </strong>Functional compression of the internal carotid artery by hyoid bone is a rare but potentially serious condition that can lead to vascular complications, particularly when coexisting with intracranial vascular abnormalities. This case report describes a 48-year-old woman with acute cerebral ischemia due to a combination of functional right internal carotid artery compression by the hyoid bone, low carotid bifurcation, and coexisting Moyamoya syndrome.</p><p><strong>Case report: </strong>In this article, we describe the clinical case of a 48-year-old woman who presented with sudden-onset weakness in her left arm. Imaging studies demonstrated acute ischemia in the territory supplied by the right middle cerebral artery. Further evaluation with computed tomography angiography revealed compression of the right internal carotid artery by the hyoid bone. However, additional imaging studies, including digital subtraction angiography and carotid Doppler ultrasound, did not reveal any signs of internal carotid artery stenosis. This suggested that the compression was functional, occurring only in specific positions of the head or arms. The patient was also newly diagnosed with Moyamoya syndrome, characterized by progressive stenosis of the intracranial vessels. Prompt recognition of these findings enabled timely management, including the initiation of antiplatelet therapy.</p><p><strong>Conclusion: </strong>In cases of acute brain ischemia, it is crucial to consider both intracranial and extracranial vascular conditions. This case report underscores the significance of identifying anatomical variations in the relationship between the hyoid bone and the internal carotid artery, as it can lead to arterial compression and potentially trigger acute ischemic strokes, especially in combination with Moyamoya syndrome. Understanding these anatomical nuances is essential for early diagnosis and appropriate management.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"383-389"},"PeriodicalIF":2.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constructing a Predictive Model to Evaluate the Risk of CHD Based on New Metabolic Indicators.","authors":"Wenqiang Wang, Zonghan Du, Peng Xie","doi":"10.2147/VHRM.S521822","DOIUrl":"https://doi.org/10.2147/VHRM.S521822","url":null,"abstract":"<p><strong>Objective: </strong>Constructing a predictive model to evaluate the risk of coronary heart disease (CHD) for early identification of patients with CHD risk based on new metabolic indicators.</p><p><strong>Methods: </strong>A retrospective analysis was conducted based on NHANES databases. Collect general information, cardiovascular comorbidities, new metabolic indicators (BMI, Triglycerides/Glucose, Waist Circumference-to-Height ratio, Cholesterol/HDL, Triglycerides/HDL, Cardiometabolic index, Neutrophil percentage-to-albumin ratio, etc). The least absolute shrinkage and selection operator (LASSO) regression model and multivariate logistic regression were performed to analyze the risk factors of CHD and develop a CHD risk predictive model using R software.</p><p><strong>Results: </strong>A total of 3741 individuals were included and 160 (4.3%) individuals had CHD. According to the results of the LASSO regression model and multivariate logistic regression, 9 factors were related to CHD such as Hypertension (Yes), Cardiometabolic index (≥0.672), Mean arterial pressure (<70 mmHg), Gender (male), COPD (Yes), Age (>69), Neutrophil percentage-to-albumin ratio (≥1.465), Thyroid problem (Yes) and Stroke (Yes), which were developed a CHD risk prediction nomogram. The nomogram presented good discrimination with a C-index value of 0.869 (95% confidence interval: 0.82196-0.91604), AUC (0.868) and good calibration. Based on the maximum point of the Youden index, the individuals with a score greater than 136.5 are at high risk for CHD.</p><p><strong>Conclusion: </strong>A risk prediction model for CHD has been developed based on new metabolic indicators in this study and boasts a relatively high accuracy in the early identification of patients with CHD risk. It may help clinicians develop strategies to prevent CHD and improve care quality.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"371-382"},"PeriodicalIF":2.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Clinical Features and Outcomes in Patients with Acute Coronary Syndrome Treated with Bifurcation Stenting Using the Double-Kissing Culotte and Culotte Technique - 1-year Follow-up.","authors":"Piotr Włodarczak, Mateusz Barycki, Szymon Włodarczak, Łukasz Furtan, Andrzej Giniewicz, Anita Chudaś, Waldemar Banasiak, Adrian Doroszko, Maciej Lesiak, Adrian Włodarczak, Piotr Rola","doi":"10.2147/VHRM.S513926","DOIUrl":"https://doi.org/10.2147/VHRM.S513926","url":null,"abstract":"<p><strong>Purpose: </strong>Sex differences in the clinical course of coronary artery disease (CAD) particularly in Acute Coronary Syndrome (ACS), have been extensively hypothesized. Although coronary bifurcations account for approximately 20% of ACS cases, data concerning potential sex disparities in the outcomes of percutaneous interventions (PCI) remain scarce. Several data suggest the double kiss (DK) Culotte may provide advantages in bifurcation PCI. Therefore, we evaluate potential sex differences in relation to the Culotte technique.</p><p><strong>Patients and methods: </strong>This study retrospectively analyzes sex disparities following PCI interventions in ACS patients using the DK-Culotte or Culotte technique for bifurcation lesions. The primary endpoint was Target Lesion Failure (TLF), a composite of cardiovascular death, target vessel myocardial infarction, or clinically driven target lesion revascularization (TLR). The secondary endpoint included major adverse cardiac events MACE (myocardial infarction, cardiac death, and target lesion revascularization).</p><p><strong>Results: </strong>There were no significant differences between sexes regarding TLF (DK-Culotte: Females 10.3% vs Males 5.7%; p=0.401; Culotte: Females 16.2% vs Males 11.8%; p=0.481) or MACE (DK-Culotte: Females 13.8% vs Males 12.5%; p=0.771; Culotte: Females 24.3% vs Males 17.6%; p=0.370) after a 1-year follow-up for both bifurcation techniques.</p><p><strong>Conclusion: </strong>The study found no significant differences in clinical outcomes between sexes following PCI for bifurcation lesions in the ACS cohort, regardless of whether the two-stent techniques (DK- Culotte or Culotte) were used.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"361-370"},"PeriodicalIF":2.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Inflammatory Response Index Is a More Promising Prognostic Index Than Systemic Immune Inflammation Index in Critically Ill Heart Failure Patients: A Retrospective Cohort Analysis of the MIMIC-IV Database.","authors":"Xueqing Wang, Sheng Zhang, Xinxin Wang, Xiaojun Shen, Lei Huang","doi":"10.2147/VHRM.S523798","DOIUrl":"https://doi.org/10.2147/VHRM.S523798","url":null,"abstract":"<p><strong>Aim: </strong>The incidence of heart failure (HF) remains high throughout the world, posing a serious threat to human health, with inflammation being a pivotal factor in the entire pathophysiologic process. Systemic inflammatory response index (SIRI) and systemic immune inflammation index (SII) are novel indicators for poor prognosis of HF. This paper aimed to ascertain the connection between SIRI and mortality in critically ill HF patients and to compare the prognostic value with SII.</p><p><strong>Methods: </strong>All data on HF patients were sourced from MIMIC-IV. Cox proportional hazards analysis, restricted cubic spline, and Kaplan-Meier survival analysis were utilized to determine the link between SIRI or SII and in-hospital mortality. Receiver operating characteristic curve, area under the curve (AUC), and Youden index were employed to compare the prognostic value of SIRI and SII. Subgroup analysis was conducted to confirm the predictive capability of SIRI on mortality. Propensity score matching was utilized to reveal the connection between SIRI and secondary outcomes.</p><p><strong>Results: </strong>754 patients were included and 45 patients (6.0%) died. There was a positive link between SIRI and in-hospital mortality in both unadjusted (<i>p</i> < 0.001) and adjusted models (<i>p</i> < 0.001 and <i>p</i> = 0.001, respectively), outperforming SII in all models (<i>p</i> > 0.05 in all models). SIRI had a higher AUC and Youden index than SII, indicating better prognostic power. In addition, hospital stay was shorter in the low SIRI group (<i>p</i> = 0.034).</p><p><strong>Conclusion: </strong>SIRI predicts in-hospital mortality in critically ill HF patients, and the prognostic power is superior to SII.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"345-360"},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of Fruits to Improve Dyslipidemias: A Pilot Review.","authors":"Miguel Angel Flores Flores, Luis Antonio Flores Flores, Serafín Dernali Romero Yupanqui","doi":"10.2147/VHRM.S488465","DOIUrl":"https://doi.org/10.2147/VHRM.S488465","url":null,"abstract":"<p><p>Dyslipidemia is a condition characterized by excessive lipids in the blood plasma, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and decreased levels of high-density lipoprotein cholesterol (HDL-C), which is generated mostly due to obesity. This study aims to summarize research conducted on rats and humans regarding the potential of eight fruits in reducing dyslipidemia and their associated health benefits (eg, reduction of free radicals, hypoglycemic effects, weight reduction, lowering of blood pressure, and anti-inflammatory properties). The studied fruits include pomegranate, star fruit, Rosa roxburghii, pineapple, tree tomato, coffee, apple, and passion fruit. Various parts of these fruits, such as the root, leaves, stem, peel, and pulp, were analyzed for their effects. These fruits are edible, widely available, and cost-effective when purchased during the harvest season (Graphical abstract).</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"327-343"},"PeriodicalIF":2.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Pemafibrate on Cardio-Ankle Vascular Index (CAVI) in Patients with Type 2 Diabetes or Ischemic Heart Disease: A 24-Week Observational Study.","authors":"Yasuhiro Watanabe, Shoya Nonaka, Shuhei Yamaoka, Shoko Nakamura, Osamu Horikawa, Takashi Yamaguchi, Shuji Sato, Shunsuke Todani, Yuta Sugizaki, Takuro Ito, Hiroshi Mikamo, Mao Takahashi, Daiji Nagayama, Kazuhiro Shimizu, Atsuhito Saiki","doi":"10.2147/VHRM.S506642","DOIUrl":"10.2147/VHRM.S506642","url":null,"abstract":"<p><strong>Purpose: </strong>Pemafibrate is a novel selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) that improves lipid profile, but its effects on cardiovascular events remain unproven. This study examined changes in the cardio-ankle vascular index (CAVI), a marker of arterial stiffness, in high-risk patients with type 2 diabetes mellitus (T2DM) or ischemic heart disease (IHD) treated with pemafibrate.</p><p><strong>Patients and methods: </strong>In this single-center, prospective, observational study, 95 patients with T2DM and/or IHD, who had hypertriglyceridemia (≥150 mg/dL) and started pemafibrate (0.2 mg/day) were analyzed. CAVI was measured at baseline and after 24 weeks of treatment as an indicator of arterial stiffness, along with comprehensive assessment of lipid parameters including triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, and apolipoproteins.</p><p><strong>Results: </strong>No significant change in CAVI was observed after 24 weeks of treatment (median [interquartile range (IQR)]; baseline vs 24 weeks: CAVI 9.4 [8.8-10.6] vs 9.6 [8.9-10.8], p=0.715). However, pemafibrate significantly reduced triglycerides (233 mg/dL [171-329] to 143 mg/dL [111-187], p<0.001), apolipoprotein C-II (8.1 mg/dL [6.1-10.2] to 6.3 mg/dL [5.3-8.3], p<0.001), apolipoprotein C-III (15.3 mg/dL [12.2-18.3] to 11.6 mg/dL [9.3-14.2], p<0.001) and liver enzymes; and increased HDL-C (45 mg/dL [39-52] to 50 mg/dL [40-60], p<0.001), LDL-C (92 mg/dL [70-111] to 103 mg/dL [79-128], p<0.001), apolipoprotein A-I and apolipoprotein A-II (both p<0.05). Calculated small dense low-density lipoprotein cholesterol also decreased significantly (40 mg/dL [31-49] to 36 mg/dL [28-45], p=0.002).</p><p><strong>Conclusion: </strong>While pemafibrate improves lipid profile and liver enzymes, its short-term impact on vascular stiffness, as measured by CAVI, appears limited. Extended follow-up studies are needed to clarify its cardiovascular benefits in high-risk patients.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"293-304"},"PeriodicalIF":2.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apelinergic System in the Left Ventricle Adverse Remodeling After Myocardial Infarction: A Preliminary Study.","authors":"Rafał Wyderka, Bogusława Ołpińska, Dorota Diakowska, Anna Leśków, Łukasz Osuch, Michał Borger, Barbara Brzezińska, Maria Łoboz-Rudnicka, Joanna Jaroch","doi":"10.2147/VHRM.S507783","DOIUrl":"https://doi.org/10.2147/VHRM.S507783","url":null,"abstract":"<p><strong>Background: </strong>Despite a growing evidence from the animal models of the cardioprotective function of the apelinergic system in the setting of myocardial infarction, little is known on the role of apelinergic system in the development of post- infarction adverse left ventricle remodeling in humans.</p><p><strong>Methods: </strong>The study group consisted of 49 patients with first-time ST-segment elevation myocardial infarction of anterior wall treated invasively. Echocardiography was performed on index hospitalization and on one-year check-up, with categorizing the study population into group with adverse LV remodeling defined as an increase of LV end diastolic volume by >20% (n = 12) and the group without adverse remodeling (n = 29). ELA, AP-17, AP-13 and APJ receptor levels were measured on one-year follow-up.</p><p><strong>Results: </strong>Patients with adverse LV remodeling presented significantly higher plasma level of apelin-13 (85.63 [75.43-96.13] vs 65.43 [57.35-69.35], p = 0.001) and apelin-17 (69.36 [42.61-77.04] vs 30.04 [25.97-41.95], p = 0.004). In a univariable logistic regression analysis, higher LVEDV and LVEDV1, higher LVESV and LVESVi, lower LVEF, higher WMSI score, higher SYNTAX score, higher levels of hs-CRP during index hospitalization and higher levels of AP-13 and AP-17 on the one-year check-up were associated with adverse LV remodeling. In multivariable logistic regression analysis, only AP-17 level was independently associated with adverse LV remodeling (p = 0.050).</p><p><strong>Conclusion: </strong>Apelinergic system may be involved in the development of post- infarction adverse left ventricle remodeling.</p>","PeriodicalId":23597,"journal":{"name":"Vascular Health and Risk Management","volume":"21 ","pages":"279-291"},"PeriodicalIF":2.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}