The Impact of Triglyceride-Glucose Index Trajectories on Incidence and Recurrent Cardiovascular Events: Evidence from a Retrospective Cohort Study.

IF 2.8 Q2 PERIPHERAL VASCULAR DISEASE

Vascular Health and Risk Management Pub Date : 2025-07-12 eCollection Date: 2025-01-01 DOI:10.2147/VHRM.S532194

Yuan Xu, Gonglong Wu, Long Jiang, Xinlei Yang, Chengjin Wen, Yulan Yang, Hui Hu

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Abstract

Patients and methods: The study retrospectively collected 8086 clinical data from 2019 to 2021. Latent Class Trajectory Modeling (LCTM) was utilized to identify the longitudinal trajectories of the triglyceride-glucose index, and logistic regression was employed to analyze the relationship between different triglyceride-glucose trajectories and the incidence and recurrence of cardiovascular diseases.

Results: During the study period, 1484 patients in the cohort experienced cardiovascular events. Using LCTM, three distinct triglyceride-glucose index trajectories were identified. In the overall cohort of recurrent patients, as well as among those with higher triglyceride-glucose levels (triglyceride-glucose > 8.309) within it, a high-gradual-increase trajectory was found to be significantly associated with cardiovascular disease risk compared to a low-stable trajectory. Similar observations were seen in incidence patients with higher triglyceride-glucose levels (OR 1.179; 95% CI 1.017-1.368), which adjusted the demographic characteristics and the test indicators.

Conclusion: A high baseline level of triglyceride-glucose index with a high-gradual-increasing trajectory was significantly associated with incidence and recurrence of cardiovascular disease. Early identification of such populations can aid in the prevention of both incidence and recurrent cardiovascular diseases in the future.

Purpose: The triglyceride-glucose index is related to the cerebrovascular diseases. This study aimed to investigate the relationship between different triglyceride-glucose index trajectories and incidence and recurrence of cardiovascular disease.

Abstract Image

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甘油三酯-葡萄糖指数轨迹对心血管事件发生率和复发的影响：来自回顾性队列研究的证据。

患者和方法：回顾性收集2019 - 2021年8086例临床资料。利用潜类轨迹模型（Latent Class Trajectory Modeling， LCTM）识别甘油三酯-葡萄糖指数的纵向轨迹，采用logistic回归分析不同甘油三酯-葡萄糖轨迹与心血管疾病发病率和复发率的关系。结果：在研究期间，队列中有1484例患者发生心血管事件。使用LCTM，确定了三种不同的甘油三酯-葡萄糖指数轨迹。在整个复发患者队列中，以及甘油三酯-葡萄糖水平较高（甘油三酯-葡萄糖> 8.309）的患者中，与低稳定的轨迹相比，发现高逐渐增加的轨迹与心血管疾病风险显著相关。在甘油三酯-葡萄糖水平较高的患者中也有类似的观察结果(OR 1.179；95% CI 1.017-1.368)，调整了人口统计学特征和试验指标。结论：高基线水平的甘油三酯-葡萄糖指数与心血管疾病的发病率和复发率显著相关。早期识别这类人群有助于预防未来心血管疾病的发生和复发。目的：探讨甘油三酯-葡萄糖指数与脑血管疾病的关系。本研究旨在探讨不同甘油三酯-葡萄糖指数轨迹与心血管疾病的发病率和复发率之间的关系。

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来源期刊

Vascular Health and Risk Management PERIPHERAL VASCULAR DISEASE-

CiteScore

4.20

自引率

3.40%

发文量

109

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal of therapeutics and risk management, focusing on concise rapid reporting of clinical studies on the processes involved in the maintenance of vascular health; the monitoring, prevention, and treatment of vascular disease and its sequelae; and the involvement of metabolic disorders, particularly diabetes. In addition, the journal will also seek to define drug usage in terms of ultimate uptake and acceptance by the patient and healthcare professional.