Veterinary Record Open最新文献

{"title":"Use of fever detection in combination with thoracic ultrasonography to identify respiratory disease, and compare treatments of antimicrobials and NSAID: a randomised study in dairy calves.","authors":"Sophie A Mahendran","doi":"10.1136/vetreco-2020-000415","DOIUrl":"https://doi.org/10.1136/vetreco-2020-000415","url":null,"abstract":"<p><strong>Background: </strong>This study explored the combined use of fever detection and thoracic ultrasonography to identify calves with early onset bovine respiratory disease (BRD). Thoracic ultrasonography was then used to assess the efficacy of antimicrobial and non-steroidal anti-inflammatory drug (NSAID) treatment for early onset BRD through a randomised study design.</p><p><strong>Methods: </strong>Calves were recruited from a single dairy farm in the UK, and fitted with a TempVerified FeverTag, which was activated when a calf developed fever (a temperature of 39.7°C for six hours). On identification of fever, a Wisconsin calf score was used to provide a diagnosis of BRD by exclusion of other causes. Calves were randomly assigned to experimental groups; group 1 (NSAID) received flunixin meglumine, group 2 (antimicrobial) received florfenicol, group 3 (both) received both drugs. A thoracic ultrasound was conducted within 48 hours of fever detection, and again 14 days later to assess lung pathology.</p><p><strong>Results: </strong>A total of 152 calves were recruited, with a relative BRD prevalence of 49 per cent (74/152). Thirty-two calves required a secondary treatment (due to continued fever), causing exclusion from statistical analysis of the change in ultrasound score and resulting in the study being underpowered for detecting statistical significance. Initial thoracic ultrasound scores were very low, with 70/74 calves scoring either 0 or 1, indicating few comet tails and no lung consolidation was seen and potential overdiagnosis of BRD. For assessment of therapy efficacy, no effect of experimental group was detected on average daily growth rates (mean 0.85 kg/day, P=0.89). Calves also displayed very few clinical signs at the time of fever detection. These factors combined suggest a high rate of false positive identification (low specificity) for BRD through fever detection alone. Calves given the NSAID only were more likely to require repeat treatments due to fever recurrence (OR=3.10 (95 per cent CI 0.86 to 11.15), P=0.083). Also calves affected by their first case of fever at an older age (21 v 28 days old) were less likely to go on to have further fever episodes (OR=0.95 (95 per cent CI 0.90 to 0.99), P=0.026).</p><p><strong>Conclusion: </strong>This study demonstrated calves given only an NSAID at occurrence of fever due to BRD may be more likely to require repeat treatments throughout the preweaning period. The use of fever detection alone for BRD indicated a low specificity for definitive diagnosis as shown by the low thoracic ultrasound scores and lack of clinical signs. The study was underpowered to assess the ultrasonic effects of the different treatment protocols on lung pathology.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7d/1b/vetreco-2020-000415.PMC7643518.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38614412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dexmedetomidine and ketamine simultaneous administration in tigers (<i>Panthera tigris</i>): pharmacokinetics and clinical effects.","authors":"Federica Di Cesare,&nbsp;Petra Cagnardi,&nbsp;Roberto Villa,&nbsp;Vanessa Rabbogliatti,&nbsp;Lorena Lucatello,&nbsp;Francesca Capolongo,&nbsp;Daniela Gioeni,&nbsp;Michele Capasso,&nbsp;William Magnone,&nbsp;Giuliano Ravasio","doi":"10.1136/vetreco-2020-000412","DOIUrl":"https://doi.org/10.1136/vetreco-2020-000412","url":null,"abstract":"<p><strong>Background: </strong>The study determines the pharmacokinetic profiles of dexmedetomidine (DEX), ketamine (KET) and its active metabolite, norketamine (NORKET), after simultaneous administration. Moreover, the study evaluates the sedative effects of this protocol, its influence on the main physiological variables and the occurrence of adverse effects.</p><p><strong>Methods: </strong>Eighteen captive tigers were initially administered with a mixture of DEX (10 µg/kg) and KET (2 mg/kg) by remote intramuscular injection. In case of individual and specific needs, the protocol was modified and tigers could receive general anaesthesia, propofol or additional doses of DEX and KET.</p><p><strong>Results: </strong>Based on the immobilisation protocol, nine animals were assigned to the standard protocol group and the other nine to the non-standard protocol group. Higher area under the first moment curve (AUMC_0-last) and longer mean residence time (MRT_0-last) (P<0.05) were observed in the non-standard protocol group for DEX, KET and NORKET, and higher area under the concentration-time curve from administration to the last measurable concentration (AUC_0-last) only for KET. The KET metabolisation rate was similar (P=0.296) between groups. No differences between groups were detected in terms of stages of sedation and recoveries. All physiological variables remained within normality ranges during the whole observation period. During the hospitalisation period, no severe adverse reactions and signs of resedation were observed.</p><p><strong>Conclusion: </strong>The simultaneous administration of 10 µg/kg of DEX and 2 mg/kg of KET can be considered an effective protocol for chemical immobilisation of captive tigers, along with dosage adjusments or when other drugs are needed.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2020-000412","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38595464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thirteen-month duration of immunity of an oral canine vaccine against challenge with <i>Bordetella bronchiseptica</i>.","authors":"Maya Scott-Garrard,&nbsp;Xinshuo Wang,&nbsp;Yu-Wei Chiang,&nbsp;Frederic David","doi":"10.1136/vetreco-2020-000423","DOIUrl":"https://doi.org/10.1136/vetreco-2020-000423","url":null,"abstract":"<p><strong>Background: </strong>Very few studies have evaluated the duration of immunity of <i>Bordetella bronchiseptica</i> vaccines in dogs, and to date, no studies have been published on the duration of immunity of oral canine <i>Bordetella bronchiseptica</i> vaccines. This study was designed to determine the effectiveness of a single dose of an oral <i>B bronchiseptica</i> vaccine in dogs when challenged 13 months after vaccination.</p><p><strong>Methods: </strong>Two groups of approximately eight-week-old beagles were vaccinated once with 1 ml of placebo vaccine (oral, n=17) or 1 ml of Recombitek Oral Bordetella (oral, n=17). Thirteen months after vaccination, both groups were challenged with virulent <i>B bronchiseptica</i> via aerosolisation.</p><p><strong>Results: </strong>Thirteen of 17 dogs in the placebo group (76.5 per cent) and no dogs in the Recombitek Oral Bordetella vaccine group (0.0 per cent) developed spontaneous cough of two or more consecutive days (disease case definition). Dogs in the Recombitek Oral Bordetella group had a significantly lower prevalence of disease with prevented fraction of 1 (100 per cent prevention). In addition, the number of days coughing, duration of cough and prevalence of tracheal and nasal shedding were significantly lower for dogs vaccinated with Recombitek Oral Bordetella.</p><p><strong>Conclusions: </strong>The study demonstrated that vaccination with Recombitek Oral Bordetella is effective in preventing disease and reducing shedding 13 months after vaccination when compared with dogs vaccinated with a placebo.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2020-000423","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38623522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of potentially pathogenic bacteria from <i>Ixodes ricinus</i> carried by pets in Tuscany, Italy.","authors":"Valentina Chisu,&nbsp;Cipriano Foxi,&nbsp;Gabriella Masu,&nbsp;Barbara D' Amaddio,&nbsp;Giovanna Masala","doi":"10.1136/vetreco-2020-000395","DOIUrl":"https://doi.org/10.1136/vetreco-2020-000395","url":null,"abstract":"<p><strong>Background: </strong>Ticks are vectors of disease-causing pathogens that pose a serious threat to animals and people. Dogs and cats are exposed to tick infestation in multiple ways and can easily transport infected ticks into domestic environments and potentially transfer them to people. Pet owners are at increased risk of picking up ticks from their pets and developing tickborne diseases. This study aims to detect the presence of pathogens of potential public health interest in ticks removed from cats and dogs in Tuscany, Italy.</p><p><strong>Methods: </strong>The collected ticks were screened for the presence of protozoan (<i>Theileria</i> species and <i>Babesia</i> species) and bacterial (<i>Rickettsia</i> species, <i>Anaplasma</i> species, <i>Ehrlichia</i> species, <i>Chlamydia</i> species, <i>Bartonella</i> species and <i>Coxiella burnetii</i>) pathogens using PCR.</p><p><strong>Results: </strong>PCR and sequencing analysis revealed that 3 per cent of the ticks were PCR-positive for the presence of <i>Rickettsia helvetica</i> DNA, 5 per cent of ticks were PCR-positive for <i>Bartonella henselae</i> DNA, and 46 per cent of ticks were PCR-positive for <i>Chlamydia psittaci</i> and <i>Chlamydia abortus</i> DNA. None of the examined ticks was PCR-positive for <i>Theileria</i> species, <i>Babesia</i> species, <i>Anaplasma</i> species, <i>Ehrlichia canis</i> or <i>Coxiella burnetii</i> DNA.</p><p><strong>Conclusion: </strong>The results of this preliminary study highlight the importance of monitoring companion animals as indicators to evaluate the health status of their owners. Preventive measures are necessary to limit the spread of zoonotic pathogens from companion animals to people within the home environment.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2020-000395","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38460938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A survey of biosecurity measures and serological status for bovine viral diarrhoea virus and bovine herpesvirus 1 on dairy cattle farms in north-west and north-east Spain.","authors":"Francisco J Villaamil, Ignacio Arnaiz, Alberto Allepuz, Miquel Molins, Mercedes Lazaro, Bibiana Benavides, Sebastián J Moya, Jordi Casal Fabrega, Eduardo Yus, Francisco J Dieguez","doi":"10.1136/vetreco-2020-000399","DOIUrl":"10.1136/vetreco-2020-000399","url":null,"abstract":"<p><strong>Background: </strong>Biosecurity is a key measure to reduce and prevent the introduction of diseases to farms and minimise spread of diseases within a herd. The aim of the study was to characterise the current application of biosecurity measures on dairy cattle farms in Spain along with their bovine viral diarrhoea and infectious bovine rhinotracheitis status.</p><p><strong>Methods: </strong>Data on biosecurity measures for 124 dairy herds were collected using a questionnaire. The sanitary status of these farms for bovine viral diarrhoea and infectious bovine rhinotracheitis was also assessed using antibody ELISA. Data were analysed using multiple correspondence analysis and a two-step cluster analysis.</p><p><strong>Results: </strong>Three main clusters of farms were identified: clusters 1 and 2 included herds of small and intermediate sizes. These, particularly cluster 1, showed the most deficiencies in the control of vehicles and visitors. However, laboratory tests were always performed on purchased animals. Cluster 3 had the largest herd sizes, with somewhat better biosecurity control of vehicles and visitors. However, farms in this cluster also purchased the most animals, sometimes without testing, and hired external workers more often.</p><p><strong>Conclusion: </strong>The study indicated that, in the study population, there are serious shortcomings in the application of biosecurity measures on dairy farms, exposing them to disease transmission. This survey also highlights regional and herd size-related differences in the implementation of biosecurity. Collecting data is an important first step to identification of specific weaknesses in different farm typologies, and an adequate follow-up is needed to ensure that measures are implemented correctly on farms.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/55/vetreco-2020-000399.PMC7497555.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38437023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper and zinc generated by the Aquascape IonGen pond clarifier system can be detrimental to koi (<i>Cyprinus carpio</i>) health.","authors":"Emily Tucker,&nbsp;Jamie Gerlach,&nbsp;Azais Curtean,&nbsp;Kent Passingham,&nbsp;Lisa Murphy,&nbsp;Gregory Lewbart","doi":"10.1136/vetreco-2020-000396","DOIUrl":"https://doi.org/10.1136/vetreco-2020-000396","url":null,"abstract":"<p><strong>Background: </strong>Copper is frequently used as an algicide, and copper ion generators such as the Aquascape IonGen claim to be safe for use in systems containing fish. In 2012, a die-off of koi (<i>Cyprinus carpio</i>) in a pond in Raleigh, North Carolina, occurred after the IonGen was added to the system.</p><p><strong>Methods: </strong>Physical and postmortem examinations suggested that heavy metal toxicity was the likely cause of morbidity and mortality. This was supported by a heavy metal screening of the owners' pond. Additional experiments were performed to determine if the IonGen produced toxic levels of copper and zinc.</p><p><strong>Results: </strong>The tank containing the IonGen had higher concentrations of copper and zinc, and copper levels exceeded those associated with toxicity in both hard and soft water.</p><p><strong>Conclusion: </strong>The results of this study indicate that ion generators might not be safe for fish, and copper should only be used as an algicide if concentrations are closely monitored.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2020-000396","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38284582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of cytokine concentrations in a trehalose-stabilised lyophilised canine platelet product: a preliminary study.","authors":"Robert Goggs,&nbsp;Signe Cremer,&nbsp;Marjory B Brooks","doi":"10.1136/vetreco-2019-000366","DOIUrl":"https://doi.org/10.1136/vetreco-2019-000366","url":null,"abstract":"<p><strong>Background: </strong>Platelet transfusion is indicated for haemorrhage due to severe thrombocytopenia and for trauma associated coagulopathy. Febrile non-haemolytic transfusion reactions are a common complication of platelet transfusions in people and may be due to accumulated inflammatory cytokines. The present study aimed to determine the cytokine profile of a novel canine lyophilised platelet product following reconstitution, to assess the lyophilised platelets' activation response to physiological platelet agonists and to compare the cytokine profiles of basal and stimulated canine lyophilised platelets.</p><p><strong>Methods: </strong>Cell counts and biochemical analyses were conducted following reconstitution. Cytokine concentrations were measured with a canine-specific multiplex immunocapture assay and with an electrochemiluminescent ELISA. Aliquots of reconstituted product from three separate vials were activated for 10 minutes under non-stirred conditions using adenosine diphosphate, thrombin or convulxin and their cytokine concentrations compared with unactivated samples. Flow cytometry and light-transmission aggregometry were used to evaluate the product's ability to express a procoagulant surface, degranulate and aggregate. Fresh platelet-rich plasma was used as a positive control.</p><p><strong>Results: </strong>The product had a mean±SD particle count of 1.23±0.2×10⁹/ml, contained platelets that expressed surface phosphatidylserine before agonist stimulation and was capable of aggregation in response to thrombin stimulation suggesting that the product may have haemostatic potential following in vivo administration. Cytokine concentrations measured by the immunocapture assay were generally low, while twofold to threefold increases relative to published intervals were noted for several cytokines using the ELISA. Concentrations of chemokine (C-X-C) motif ligand 8 and tumour necrosis factor-α were significantly increased as measured by the ELISA, but not by the immunocapture assay, while concentrations of KC-like were significantly increased as measured by the immunocapture assay. Stimulation with platelet agonists did not affect measured cytokine concentrations.</p><p><strong>Conclusion: </strong>Further study of the effects of administration of this lyophilised platelet product is warranted.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2019-000366","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38284583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of hepatitis and fibrosis using Gd-EOB-DTPA MRI in dogs.","authors":"Toshiyuki Tanaka,&nbsp;Hidetaka Nishida,&nbsp;Keiichiro Mie,&nbsp;Hiroki Yamazaki,&nbsp;Lee-Shuan Lin,&nbsp;Hideo Akiyoshi","doi":"10.1136/vetreco-2019-000371","DOIUrl":"https://doi.org/10.1136/vetreco-2019-000371","url":null,"abstract":"<p><strong>Background: </strong>Gadoxetate sodium (Gd-EOB-DTPA) is taken into hepatocytes and excreted into the bile. Hepatocytes with reduced function or dysfunction due to hepatocellular carcinoma (HCC), hepatitis or hepatic fibrosis show impaired Gd-EOB-DTPA uptake. The purpose of the present retrospective case series was to assess the relationship between liver function and contrast enhancement using Gd-EOB-DTPA MRI.</p><p><strong>Methods: </strong>Sixteen dogs with a histopathological diagnosis of liver disease, including six with HCC, three with nodular hyperplasia, two with hepatocellular adenoma, two with liver fibrosis and three with hepatitis were included in the study along with three dogs with suspected liver disease but no histopathological diagnosis of liver disease. Relative signal intensities (RSI) of the common bile duct and gall bladder were calculated, and their relationship with the following serum biochemical parameters was assessed: total bilirubin, alanine transaminase, alkaline phosphatase and albumin (Alb). To assess anatomical liver function, relative contrast enhancement indices (RCEI) of the liver were calculated, and differences were assessed between normal and diseased liver.</p><p><strong>Results: </strong>RSI showed no significant differences between dogs without and with a histopathological diagnosis of liver disease (P=0.88) although they were significantly correlated with Alb (<i>ρ</i>=0.57, P=0.02) in dogs with a histopathological diagnosis of liver disease. RCEI was significantly higher in normal liver tissue than that in livers with hepatitis/fibrosis (P=0.048) and HCC (P=0.03) but not nodular hyperplasia/hepatocellular adenoma (P=0.51).</p><p><strong>Conclusions: </strong>Gd-EOB-DTPA MRI may be potentially useful in the assessment of anatomical liver function in dogs with liver disease.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2019-000371","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38281680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of fentanyl on intraocular pressure and pupil size in medetomidine-methadone premedicated dogs: a pilot study.","authors":"Maria Isabel Gomez-Martinez, Oscar Varela-Lopez, Jose Luis Fontalba-Navas, Antonio González-Cantalapiedra","doi":"10.1136/vetreco-2019-000391","DOIUrl":"10.1136/vetreco-2019-000391","url":null,"abstract":"<p><strong>Background: </strong>This is a pilot study to evaluate the effects of fentanyl on intraocular pressure (IOP) and pupil size (PS) in dogs premedicated with medetomidine and methadone.</p><p><strong>Methods: </strong>Sixteen dogs with a median (first quartile-third quartile) age of 3.5 (1.25-6) years and a mean (sd) weight of 18.6 (9.2) kg were included. Baseline readings of IOP and PS were recorded before all dogs were premedicated intramuscularly with medetomidine (10 µg/kg) and methadone (0.5 mg/kg). Both measurements were repeated 15 and 30 minutes later. Following this, the dogs were randomly assigned into two groups. The fentanyl group received intravenous fentanyl (10 µg/kg), while the control group received the same volume of saline solution intravenously. IOP and PS measurements were measured and recorded in both groups at one, five and ten minutes after intravenous injection. Data were analysed with one-way and two-way repeated-measures analysis of variance or their non-parametric equivalents.</p><p><strong>Results: </strong>PS was significantly decreased 15 and 30 minutes following intramuscular premedication and IOP was significantly increased in the fentanyl group at all time points following intravenous administration.</p><p><strong>Conclusions: </strong>Medetomidine, methadone and fentanyl combinations are not recommended for use in patients where an increase in IOP or decrease in PS is undesirable.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/85/vetreco-2019-000391.PMC7388883.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38267842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-reactive protein in dogs with suspected bacterial diskospondylitis: 16 cases (2010-2019).","authors":"George Nye,&nbsp;Francois-Xavier Liebel,&nbsp;Tom Harcourt-Brown","doi":"10.1136/vetreco-2019-000386","DOIUrl":"https://doi.org/10.1136/vetreco-2019-000386","url":null,"abstract":"<p><strong>Objectives: </strong>C-reactive protein (CRP) is an acute phase protein used in multiple canine inflammatory conditions including steroid responsive meningitis-arteritis, immune-mediated polyarthritis and bronchopneumonia. The aim of this study was to assess whether serum CRP is elevated in cases of diskospondylitis.</p><p><strong>Methods: </strong>Medical records from 2010 to 2019 were searched to identify dogs diagnosed with diskospondylitis based on findings consistent on CT or MRI and with CRP tested.</p><p><strong>Results: </strong>A total of 16 dogs met the inclusion criteria. All cases had back pain. Fourteen cases had elevated CRP, with a median value of 100.7 mg/l (reference range for CRP values: 0-10 mg/l), 12 were pyrexic and six had leucocytosis. The two dogs with normal CRP were normothermic and did not have leucocytosis. CRP was measured four to six weeks into antimicrobial treatment in eight of 14 dogs and was normal in all cases. One dog developed a suspected bacterial empyema diagnosed on MRI; this occurred two weeks after antibiotic treatment was discontinued based on a normal CRP level at follow-up.</p><p><strong>Conclusions: </strong>Serum CRP is elevated in cases of diskospondylitis and may be clinically more useful to screen dogs with back pain than pyrexia or leucocytosis alone. Further long-term clinical evaluation in a prospective study is needed to assess its use as a treatment monitoring tool and in decision making.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2019-000386","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38185437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}