Veterinary Record Open最新文献

{"title":"Prevalence of antibody seroconversion to <i>Toxoplasma gondii</i> in uveitis and non-uveitis dogs.","authors":"Goran Kosec,&nbsp;Biljana Hacin,&nbsp;Philip G Sansom,&nbsp;Gereth Weaver,&nbsp;Emma Dewhurst,&nbsp;James W Carter","doi":"10.1136/vetreco-2018-000318","DOIUrl":"https://doi.org/10.1136/vetreco-2018-000318","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the prevalence of seroconversion to <i>Toxoplasma gondii</i> in dogs with uveitis and dogs without uveitis.</p><p><strong>Methods: </strong>In total, 135 dogs were evaluated: 51 dogs were diagnosed with uveitis, and 84 dogs were without uveitis. Latex agglutination tests were performed on all sera, and the results were evaluated.</p><p><strong>Results: </strong>Overall, 7.8 and 6.0 per cent of sera were positive for the presence of anti-<i>T gondii</i> antibodies (dilution ≥1:64) in the groups with uveitis and non-uveitis dogs, respectively. The frequency distribution of variables (positive and negative results in the uveitis and the non-uveitis group of dogs) was tested with Fisher's exact test. There was no statistically significant difference between groups (P=0.73).</p><p><strong>Clinical significance: </strong>These findings suggest that evidence of exposure to <i>T gondii</i> was not significantly different between uveitis and non-uveitis groups of dogs and that the possible association between exposure to <i>T gondii</i> and canine uveitis requires further investigation. This study is the first to report the seroprevalence of anti-<i>T gondii</i> antibodies in dogs in the UK population and the first to report the seroprevalence of anti-<i>T gondii</i> antibodies in dogs with uveitis.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":"6 1","pages":"e000318"},"PeriodicalIF":1.4,"publicationDate":"2019-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2018-000318","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37336930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of ceftiofur residues in cow milk using commercial screening test kits.","authors":"Luc Durel,&nbsp;Guglielmo Gallina,&nbsp;Terence Pellet","doi":"10.1136/vetreco-2018-000329","DOIUrl":"https://doi.org/10.1136/vetreco-2018-000329","url":null,"abstract":"<p><p>Ceftiofur, a third-generation cephalosporin, is one of the most used antibiotics in dairy industry. Intramuscular injection of 1 mg/kgBW ceftiofur hydrochloride (HCl) generally results in 0 hour withdrawal time for the milk in dairy cows. Nevertheless, farmers and dairy processors occasionally complain about ceftiofur-based products in case of positive result to a commercial rapid screening test for the presence of violative residues of antimicrobials (inhibitors) in the bulk milk tank. Six lactating cows were injected with a 50 mg/ml ceftiofur HCl-based product at the dosage regimen of 1 mg/kg, intramuscularly, once a day, for five consecutive days, as per label. Milk samples were then collected just before the very last injection (T₀) and then at 12, 24, 36, 48, 60, 72, 84 and 96 hours after the last injection. Individual milk samples were tested using three commercial screening test kits for inhibitor residues: DelvotestSP NT, SNAP Beta-Lactam ST Plus and ROSA MRL Beta-Lactam Test. Since bulk tank is screened in real operating conditions, samples were also diluted to 1:4, 1:10 and tested again. For the Delvotest SP NT, which lowest detected concentration is close the MRL of the ceftiofur (100 µg/kg), all results were negative. For the ROSA MRL Beta-Lactam Test and the SNAP Beta-Lactam ST Plus, several samples yielded positive and doubtful results at T₀ and T₁₂. However, after dilution to 1:10, all results were negative. Consequently, when used as officially instructed, the tested 50 mg/ml ceftiofur HCl-based injectable veterinary products are safe, and milk should be free of violative residues of ceftiofur. With consideration to the low specificity and the low positive predictive value of commercial screening tests, positive reactions of the bulk milk should be interpreted as false positive or another risky usage of β-lactam-based medicines in the farm must be investigated.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":"6 1","pages":"e000329"},"PeriodicalIF":1.4,"publicationDate":"2019-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2018-000329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37340815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incomplete reporting of experimental studies and items associated with risk of bias in veterinary research.","authors":"Maxime Rufiange, Frédérik Rousseau-Blass, Daniel S J Pang","doi":"10.1136/vetreco-2018-000322","DOIUrl":"10.1136/vetreco-2018-000322","url":null,"abstract":"<p><p>In in vivo research, the reporting of core items of study design is persistently poor, limiting assessment of study quality and study reproducibility. This observational cohort study evaluated reporting levels in the veterinary literature across a range of species, journals and research fields. Four items (randomisation, sample size estimation, blinding and data exclusion) were assessed as well as availability of study data in publicly accessible repositories. From five general and five subject-specific journals, 120 consecutively published papers (12 per journal) describing in vivo experimental studies were selected. Item reporting was scored using a published scale (items ranked as fully, partially or not reported) according to completeness of reporting. Papers in subject-specific journals had higher median reporting levels (50.0 per cent vs 33.3 per cent, P=0.007). In subject-specific journals, randomisation (75.0 per cent vs 41.7 per cent, P=0.0002) and sample size estimation (35.0 per cent vs 16.7 per cent, P=0.025) reporting was approximately double that of general journals. Blinding (general 48.3 per cent, subject-specific 50.0 per cent, P=0.86) and data exclusion (general 53.3 per cent, subject-specific 63.3 per cent, P=0.27) were similarly reported. A single paper made study data readily accessible. Incomplete reporting remains prevalent in the veterinary literature irrespective of journal type, research subject or species. This impedes evaluation of study quality and reproducibility, raising concerns regarding wasted financial and animal resources.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":"6 1","pages":"e000322"},"PeriodicalIF":1.3,"publicationDate":"2019-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6b/8a/vetreco-2018-000322.PMC6541106.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37337402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of dogs in Hong Kong to human and canine influenza viruses.","authors":"Wen Su, Reimi Kinoshita, Jane Gray, Yue Ji, Dan Yu, Joseph Sriyal Malik Peiris, Hui-Ling Yen","doi":"10.1136/vetreco-2018-000327","DOIUrl":"10.1136/vetreco-2018-000327","url":null,"abstract":"<p><p>As a unique mammalian host for influenza A viruses, dogs support the transmission of canine influenza viruses (CIVs) of H3N8 and H3N2 subtypes and are susceptible to infection by avian and human influenza viruses. A cross-sectional serological study was performed to assess the exposure history of dogs in Hong Kong to CIV and human influenza viruses. Among 555 companion dogs sampled in 2015-2017, 1.3 per cent and 9.5 per cent showed hemagglutination inhibition (HI) antibody titre to CIV of H3N8 or H3N2 subtypes and to A(H1N1)pdm09 human influenza viruses, respectively. Among 182 shelter dogs sampled in 2017-2018, none showed HI titre to CIV and 1.1 per cent reacted to H3N2 human influenza virus. There was a poor correlation between ELISA and HI test results. The higher seropositive rates to human influenza viruses suggests that the contact dynamics of dogs under urban settings may affect the exposure risk to human influenza viruses and CIVs.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":"6 1","pages":"e000327"},"PeriodicalIF":1.4,"publicationDate":"2019-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/14/vetreco-2018-000327.PMC6541102.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37337403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autochthonous <i>Angiostrongylus vasorum</i> in Finland.","authors":"Valentina Tiškina,&nbsp;Eeva-Liisa Lindqvist,&nbsp;Anna-Clara Blomqvist,&nbsp;Merle Orav,&nbsp;Christen Rune Stensvold,&nbsp;Pikka Jokelainen","doi":"10.1136/vetreco-2018-000314","DOIUrl":"https://doi.org/10.1136/vetreco-2018-000314","url":null,"abstract":"<p><p><i>Angiostrongylus vasorum</i> has spread farther north in Europe. In this study, two autochthonous findings from dogs from Finland are described: in February 2014, the infection was diagnosed in a 10-month-old labrador retriever, and in February 2017, in a three-year-old French bulldog. These diagnoses were based on direct detection of the larvae from faeces of the dogs. The dogs had no history of travel to or import from abroad; the first lived in Southern Finland and the other in Western Finland, about 150 km apart. The dogs had no clinical signs attributable to angiostrongylosis. An online questionnaire was used to survey the extent to which veterinarians in Finland have self-reportedly observed canine <i>A vasorum</i> infections. A total of 38 veterinarians authorised to work in Finland answered the questionnaire in December 2017, and 9 (24%) of them reported having seen one or more dogs with <i>A vasorum</i> infection in Finland. The results suggest that at least five individual dogs with <i>A vasorum</i> infection would have been seen in Finland, three of which had an apparently autochthonous infection. While the geographical distribution of <i>A vasorum</i> in Finland remains largely unknown, findings have started to appear from domestic dogs. It remains possible that some veterinarians could have misdiagnosed, for example, <i>Crenosoma vulpis</i> larvae as those of <i>A vasorum</i>, and the findings without confirmation using antigen test could be due to coprophagy and passage of ingested larvae; however, this does not change the main conclusion that can be made: <i>A vasorum</i> is already multifocally present in Finland. Increasing awareness about <i>A vasorum</i> is important in areas where it is emerging and spreading.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":"6 1","pages":"e000314"},"PeriodicalIF":1.4,"publicationDate":"2019-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2018-000314","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37162809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the specificity of a gamma-interferon test performed with specific antigens to detect bovine tuberculosis, after non-negative results to intradermal tuberculin testing.","authors":"Anne Praud,&nbsp;Clémence Bourély,&nbsp;Maria-Laura Boschiroli,&nbsp;Barbara Dufour","doi":"10.1136/vetreco-2019-000335","DOIUrl":"https://doi.org/10.1136/vetreco-2019-000335","url":null,"abstract":"<p><p>In cattle herds in France, cervical skin tests (STs) using simple intradermal tuberculin (SIT) are performed to detect bovine tuberculosis (bTB). When positive results are found on ST screening, the herd is considered to be 'under suspicion' and confined, raising economic issues. The suspicion can be lifted by carrying out a single intradermal cervical comparative test (SICCT) at least six weeks later. The authors conducted an experimental study in France between 2013 and 2015 to assess the accuracy of the gamma-interferon test (IFN-γ), used in series after a non-negative result to ST screening, and to study the possibility of replacing the SICCT performed six weeks later by an IFN performed within a few days. Data were collected concerning 40 infected and 1825 bTB-free animals from herds with non-negative results to ST screening. This study showed that the IFN-γ test based on specific antigens and performed within a few days of a non-negative result to the ST has higher sensitivity than the SICCT performed six weeks later and equal specificity. The IFN test is more convenient to perform; however, it is more expensive. The IFN-γ test based on MIX antigens may be a useful alternative to the SICCT, to shorten the confinement period of suspect herds without underdetecting bTB.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":"6 1","pages":"e000335"},"PeriodicalIF":1.4,"publicationDate":"2019-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2019-000335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37162718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low frequency of pre-treatment and post-treatment haematological abnormalities in dogs with non-infectious meningoencephalitis treated with cytosine arabinoside and prednisolone.","authors":"Sarah Keegan,&nbsp;Jeremy H Rose,&nbsp;Zohra Khan,&nbsp;Francois-Xavier Liebel","doi":"10.1136/vetreco-2018-000315","DOIUrl":"https://doi.org/10.1136/vetreco-2018-000315","url":null,"abstract":"<p><strong>Background: </strong>Cytosine arabinoside (CA) and prednisolone are drugs commonly used together in the management of canine non-infectious meningoencephalitis (NIME). The aim of this study was to report the haematological findings before and after CA and prednisolone treatment and identify any adverse haematological events in this clinical setting, following the veterinary cooperative oncology group established common terminology criteria for recording adverse events following administration of chemotherapy or biological antineoplastic therapy.</p><p><strong>Results: </strong>While 48 patients with a presumptive diagnosis of NIME had pretreatment haematology results, only 12 patients met the inclusion criteria of also having post-treatment haematology results available for review after being treated with prednisolone and CA at a standard dose (200 mg/m²) in a single referral hospital in the UK. Forty-nine post-treatment haematology results were available for these 12 patients.</p><p><strong>Conclusions: </strong>Four adverse haematological events were identified in four patients. None of these events were convincingly attributable to CA administration.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":"6 1","pages":"e000315"},"PeriodicalIF":1.4,"publicationDate":"2019-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2018-000315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37162717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of iatrogenic diseases in cattle requiring admission to a veterinary hospital.","authors":"Giulia Sala,&nbsp;Antonio Boccardo,&nbsp;Eleonora Fantinato,&nbsp;Eleonora Coppoletta,&nbsp;Valerio Bronzo,&nbsp;Pietro Riccaboni,&nbsp;Angelo Giovanni Belloli,&nbsp;Davide Pravettoni","doi":"10.1136/vetreco-2017-000254","DOIUrl":"https://doi.org/10.1136/vetreco-2017-000254","url":null,"abstract":"<p><p>Iatrogenic diseases in veterinary medicine are often related to malpractice or lack of skill. For this retrospective study, 4262 clinical records of cattle admitted to the veterinary teaching hospital of the University of Milan between 2005 and 2017 were analysed, and 121 cases (2.8 per cent), referred for an iatrogenic-related disease, were selected. The findings showed that iatrogenic diseases were more often caused by farmers (92.6per cent) than by bovine practitioners (7.4 per cent). Iatrogenic diseases were caused mainly by the improper administration of drugs (43.0 per cent), forced extraction during calving (19.8 per cent), forced milk or colostrum feeding, which was often performed by awkward administration using a nipple bottle (14.9 per cent) or by oral oesophageal tubing (15.7 per cent). Moreover, farmers often performed medical, nursing and zootechnical procedures without adequate training. The role of the practitioner is fundamental in farmer education. Clinicians, especially in some professional branches such as neonatology, should not delegate medical procedures to untrained farmers. Effective tutoring and good communication with farmers play a key role in dairy herd health and consequently in public health. This then can lead to a decrease in improper drug administration, the prevention of antibiotic resistance and the reduction of treatment costs.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":"6 1","pages":"e000254"},"PeriodicalIF":1.4,"publicationDate":"2019-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2017-000254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37162808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying subclinical trauma associated with calving difficulty, vigour, and passive immunity in newborn beef calves.","authors":"Jennifer M Pearson,&nbsp;Elizabeth R Homerosky,&nbsp;Nigel A Caulkett,&nbsp;John R Campbell,&nbsp;Michel Levy,&nbsp;Edmond A Pajor,&nbsp;M Claire Windeyer","doi":"10.1136/vetreco-2018-000325","DOIUrl":"https://doi.org/10.1136/vetreco-2018-000325","url":null,"abstract":"<p><p>This cross-sectional study quantifies subclinical trauma associated with calving difficulty, calf vigour, and passive immunity (PI) in newborn beef calves. The degree of calving difficulty was categorised as: unassisted, easy assist (one or two people manually pulling to deliver the calf) and difficult assist (more than two people pulling, a fetal extractor (ie, calf jack), or caesarean section). Vigour assessment occurred at 10 minutes and blood sampling at 24 hours after birth in 77 beef calves. The measured blood parameters associated with trauma were creatine kinase (CK), aspartate aminotransferase (AST), and haptoglobin. Serum IgG concentration was measured, and an IgG concentration at least 24 g/l was considered as adequate PI. Calving difficulty was associated with elevated levels of CK (P=0.002) and AST (P=0.01), weak suckle reflex (P=0.001), abnormal mucous membrane colour (P<0.0001), and decreased odds of adequate PI (P=0.004). Elevated levels of CK and AST were associated with abnormal mucous membrane colour, incomplete tongue withdrawal and weak suckle reflex at birth (P<0.001). An incomplete tongue withdrawal (P=0.005) and weak suckle reflex (P=0.02) were associated with decreased IgG concentrations. Abnormal mucous membrane colour, incomplete tongue withdrawal, and a weak suckle reflex were associated with decreased odds of having adequate PI (P<0.05). Haptoglobin was not associated with any of the parameters measured. Subclinical trauma was associated with calving difficulty, decreased vigour and decreased odds of having adequate PI. Understanding the impacts of a traumatic birth may aid the development of management strategies for compromised newborn beef calves.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":"6 1","pages":"e000325"},"PeriodicalIF":1.4,"publicationDate":"2019-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2018-000325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36543922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producing <i>Escherichia coli</i> in veterinary hospital staff and students.","authors":"Alexandra Royden,&nbsp;Emma Ormandy,&nbsp;Gina Pinchbeck,&nbsp;Ben Pascoe,&nbsp;Matthew D Hitchings,&nbsp;Samuel K Sheppard,&nbsp;Nicola J Williams","doi":"10.1136/vetreco-2018-000307","DOIUrl":"https://doi.org/10.1136/vetreco-2018-000307","url":null,"abstract":"<p><p>Extended-spectrum β-lactamase (ESBL)-producing bacteria causing clinical infections are often also multidrug-resistant (MDR; resistance to ≥3 antimicrobial drug classes), therefore treatment options may be limited. High carriage rates of these potentially zoonotic bacteria have been found in livestock and companion animals. Therefore, people working in veterinary hospitals may be a high-risk population for carriage. This is the first study to determine the prevalence and longitudinal carriage of antimicrobial-resistant (AMR) and ESBL-producing faecal <i>Escherichia coli</i> in veterinary hospital staff and students. Prevalence of faecal AMR and ESBL-producing <i>E coli</i> was determined in 84 staff members and students in three UK veterinary hospitals. Twenty-seven participants were followed for six weeks to investigate longitudinal carriage. Antimicrobial susceptibility and phenotypic ESBL production were determined and selected isolates were whole genome sequenced. ESBL-producing <i>E coli</i> were isolated from five participants (5.95 per cent; 95 per cent CI 0.89 to 11.0 per cent); two participants carried ESBL-producing <i>E coli</i> resistant to all antimicrobials tested. Carriage of MDR <i>E coli</i> was common (32.1 per cent; 95per cent CI 22.2 to 42.1 per cent) and there was a high prevalence of ciprofloxacin resistance (11.9 per cent; 95 per cent CI 4.98 to 18.8 per cent). ESBL-producing <i>E coli</i> were isolated from seven longitudinal participants (25.9 per cent; 95 per cent CI 9.40 to 42.5 per cent); two participants carried ESBL-producing <i>E coli</i> for the entire study period. Twenty-six participants (96.3 per cent; 95 per cent CI 89.2 to 100) carried ≥1 MDR <i>E coli</i> isolate during the six-week period, with seven participants (25.9 per cent) carrying ≥1 MDR isolate for at least five out of six weeks. The prevalence of faecal ESBL-producing <i>E coli</i> in cross-sectional participants is similar to asymptomatic general populations. However, much higher levels of carriage were observed longitudinally in participants. It is vital that veterinary hospitals implement gold-standard biosecurity to prevent transmission of MDR and ESBL-producing bacteria between patients and staff. Healthcare providers should be made aware that people working in veterinary hospitals are a high-risk population for carriage of MDR and ESBL-producing bacteria, and that this poses a risk to the carrier and for transmission of resistance throughout the wider community.</p>","PeriodicalId":23565,"journal":{"name":"Veterinary Record Open","volume":"6 1","pages":"e000307"},"PeriodicalIF":1.4,"publicationDate":"2019-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/vetreco-2018-000307","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36902638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}