Volume 5, Issue 4最新文献_第8页

Volume 5, Issue 4 Pub Date : 2020-07-30 DOI: 10.46243/jst.2020.v5.i4.pp238-247

引用次数: 3

Formulation, Development and Evaluation of Lopinavir LoadedPolymeric Micelles 洛匹那韦聚合物胶束的制备、开发与评价

Volume 5, Issue 4 Pub Date : 2020-07-30 DOI: 10.46243/jst.2020.v5.i4.pp173-187

{"title":"Formulation, Development and Evaluation of Lopinavir Loaded\u0000Polymeric Micelles","authors":"","doi":"10.46243/jst.2020.v5.i4.pp173-187","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp173-187","url":null,"abstract":"Lopinavir is the anti HIV drug which is used to treat the HIV-1 infection. In this study we used the single\u0000lopinavir drug to formulate the polymeric micelle. This study was done with the two main objectives as\u0000Objective:first to enhance the solubility and bioavailability of the BCS class IV drug and second to avoid the\u0000combination of lopinavir rand ritonavir and use single lopinavir to preparation of polymeric micelle also to avoid\u0000the disadvantages related to the oral administration. Method:The different pluronic (F188 &F127) and co-solvent\u0000(Tween80) were chosen & the micelles were prepared by using different Drug: polymer ratio with or without cosolvent and drug Lopinavir. Formulations were been characterized by critical micelle concentration(CMC) value,\u0000micellesize,DSC, XRD, loading efficiency, % drug loading and stability.Result:Mixed micelle (hydrophobic\u0000&hydrophilic) obtained from optimized batch shows the highest entrapment of 29%with the pluronic F68 with the\u0000use of co-solvent and the vesicle size of 0.156µm the DSC, FTIR, XRD study was also done for lopinavir and\u0000optimized formulation .Conclusion: The pluronic F68 with the co-solvent showed fairly high entrapment efficiency,\u0000loading capacity than the mixed Pluronic in combination","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79868959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Conception of open spaces- A Case of Delhi Courtyard Houses 开放空间的概念——以德里四合院为例

Volume 5, Issue 4 Pub Date : 2020-07-30 DOI: 10.46243/jst.2020.v5.i4.pp87-105

{"title":"Conception of open spaces- A Case of Delhi Courtyard Houses","authors":"","doi":"10.46243/jst.2020.v5.i4.pp87-105","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp87-105","url":null,"abstract":"Concerns for the future of our environment, with regards to climate change, scarcity of resources,\u0000population growth, and globalization are growing, we need alternative solutions as to how can we reduce the\u0000negative impact of all the above on the planet while catering the needs of the mass. Only recently has there been\u0000debates if or not vernacular and traditional aspects of architecture can be the key to the required change.\u0000Courtyards and open spaces are one of the attributes of vernacular architecture that needs to be discussed in the\u0000above context. The importance of these spaces had already been proven for different climatic conditions. However,\u0000there is a need to justify this kind of open space typology in the lights of contemporary architecture of a\u0000metropolitan city like Delhi which is having a diverse urban fabric, a high rate of influx, and also cultural\u0000diversification. Given that the most common and relatable architectural typology is the dwelling, and it is subjected\u0000to a rapid transformation concerning its built as well as use. The following case takes into consideration the\u0000residential open spaces of Delhi through a comparative study of residential courtyard spaces of Delhi hence, the\u0000paper tries to form a conception of open spaces in the residential typology of Delhi post-independence and hence,\u0000tries to study the dwellings of the same time dating from the 1950s till date it also provides the reader an insight to\u0000the reasoning of flattening of built forms that have emerged in today’s era, despite the heterogeneity of people and\u0000what are the possible solutions to this through the understanding of courtyard spaces and use its functional benefits\u0000like comfort and a sense of belongingness.","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"04 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88780860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of Chemical, Pharmacological, Biological Activities of Isatinand Its Derivatives – Part-2 (2002 To 2020) isatinin及其衍生物的化学、药理、生物活性综述(2002 - 2020)

Volume 5, Issue 4 Pub Date : 2020-07-30 DOI: 10.46243/jst.2020.v5.i4.pp288-307

引用次数: 0

Performance Evaluation of EMG Pattern Recognition TechniquesWhile Increasing The Number of Movement Classes 增加运动类数时肌电模式识别技术的性能评价

Volume 5, Issue 4 Pub Date : 2020-07-30 DOI: 10.46243/jst.2020.v5.i4.pp248-260

{"title":"Performance Evaluation of EMG Pattern Recognition Techniques\u0000While Increasing The Number of Movement Classes","authors":"","doi":"10.46243/jst.2020.v5.i4.pp248-260","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp248-260","url":null,"abstract":":In the past few years of research done in the field of myoelectric control, many researchers have proposed\u0000several models imploying a combination of different features and classifiers to increase the movement classes, but\u0000all that work fails to explain if there is any correlation between multi-class classification and its accuracy. This\u0000paper focuses on finding the factors that decide the limit of movement classes that machine learning algorithms can\u0000accurately differentiate and to evaluate the performance of pattern classification techniques using the sEMG signal\u0000when the number of movement classes is increased while keeping the simplicity of the system. The results were\u0000obtained for eight channels sEMG signal using 7 independent time-domain features and four feature set\u0000combinations over 4 classifiers (Support Vector Machine(SVM), K-Nearest Neighbour(K-NN), Decision Tree(DT),\u0000and Naïve Bayes(NB)). Then the number of classes was increased in the manner of 5, 7, 10, 12, and 15 classes to\u0000determine the highest number of movement classes that the sEMG system with above-described features can classify\u0000efficiently. And the effect of increasing the number of movement classes on system accuracy was observed. The\u0000highest accuracies for all five class progression were obtained for SVM with the MFL feature, and for DT using\u0000MAV, it was successfully observed that the NB classifier had minimum performance depletion for the features used\u0000in this work","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86257006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and Trends in Clinical Data Analytics 临床数据分析的挑战和趋势

Volume 5, Issue 4 Pub Date : 2020-07-30 DOI: 10.46243/jst.2020.v5.i4.pp348-360

{"title":"Challenges and Trends in Clinical Data Analytics","authors":"","doi":"10.46243/jst.2020.v5.i4.pp348-360","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp348-360","url":null,"abstract":":Today’s technological advancements facilitated the researcher in collecting and organizing various forms\u0000of healthcare data. Data is an integral part of health care analytics. Drug discovery for clinical data analytics forms\u0000an important breakthrough work in terms of computational approaches in health care systems. On the other hand,\u0000healthcare analysis provides better value for money. The health care data management is very challenging as 80%\u0000of the data is unstructured as it includes handwritten documents, images; computer-generated clinical reports such\u0000as MRI, ECG, city scan, etc. The paper aims at providing a summary of work carried out by scientists and\u0000researchers who worked in health care domains. More precisely the work focuses on clinical data analysis for the\u0000period 2013 to 2019. The organization of the work carried out is specifically with concerned to data sets,\u0000Techniques, and Methods used, Tools adopted, Key Findings in clinical data analysis. The overall objective is to\u0000identify the current challenges, trends, and gaps in clinical data analysis. The pathway of the work is focused on\u0000carrying out on the bibliometric survey and summarization of the key findings in a novel way.","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88123657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sphingosomes: A Novel Lipoidal Vesicular Drug Delivery System 鞘体:一种新型脂质囊状给药系统

Volume 5, Issue 4 Pub Date : 2020-07-30 DOI: 10.46243/jst.2020.v5.i4.pp261-267

S. Chaudhari, Sneha U. Gaikwad

{"title":"Sphingosomes: A Novel Lipoidal Vesicular Drug Delivery System","authors":"S. Chaudhari, Sneha U. Gaikwad","doi":"10.46243/jst.2020.v5.i4.pp261-267","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp261-267","url":null,"abstract":"Vesicular drug delivery system has various advantages thereby improving therapeutic efficacy and by\u0000sustaining and controlling action of drugs. Liposomes, sphingosomes, ethosomes, cubosomes, pharmacasomes,\u0000niosomes, transferosomes are the newly developed vesicular drug delivery system. This review article mainly deals\u0000with the sphingosomal drug delivery system. Sphingosomes are vesicular drug delivery systems in which an aqueous\u0000volume is enclosed with sphingolipid bilayer membranes. Sphingosomes has an enhanced area of interest because of\u0000their applicability in improving the in vivo delivery of various chemotherapeutic agents, biological macromolecules\u0000and diagnostics. Sphingosome has major advantages over other vesicular drug delivery systems like high stability,\u0000more in vivo circulation time, high tumor loading efficacy in case of cancer therapy as compared to liposomes,\u0000niosomes etc. Sphingosomes are clinically used vesicular delivery system for chemotherapeutic agent, biological\u0000macromolecule and diagnostics. This review concluded that sphingosome represents a promising vesicular drug\u0000delivery system for a range of possible therapeutic applications.","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85285872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Frequency Based Damage Detection and Localization of PropellerShaft of a Ship Using Experimental Modal Analysis 基于实验模态分析的舰船螺旋桨轴频率损伤检测与定位

Volume 5, Issue 4 Pub Date : 2020-07-30 DOI: 10.46243/jst.2020.v5.i4.pp188-198

引用次数: 1

Formulation and Characterization of Tranylcypromine loadedPolymeric Micellar In-Situ Nasal Gel for treatment of Depression 三酰环丙胺负载聚合物胶束原位鼻凝胶治疗抑郁症的制备及表征

Volume 5, Issue 4 Pub Date : 2020-07-30 DOI: 10.46243/jst.2020.v5.i4.pp149-165

引用次数: 1

Review on Smart Bottle Dispenser And Filling Plant UsingIndustrial IoT 应用工业物联网的智能瓶分配器和灌装设备综述

Volume 5, Issue 4 Pub Date : 2020-07-30 DOI: 10.46243/jst.2020.v5.i4.pp143-148

{"title":"Review on Smart Bottle Dispenser And Filling Plant Using\u0000Industrial IoT","authors":"","doi":"10.46243/jst.2020.v5.i4.pp143-148","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp143-148","url":null,"abstract":"Up to yet, there are so many industries are working on manual process. But due to an increase in\u0000technology and automation, most of the industries are now becomes worker less i.e. fully automated. There is the\u0000requirement of the laborers which makes the industries full of errors and decreases work rate to improve it and\u0000reduce errors automation are used. Most of which is performed by pneumatic actuators with electrical and\u0000automation control. there are lots of difference between a traditional factory and fully automated industry 4.0 based\u0000factory In the current industry environment, providing high-end quality service or product with the least cost is the\u0000key to success and industrial factories are trying to achieve as much performance as possible to increase their profit\u0000as well as their reputation in current industries there is the utilization of data, finding errors in the system, analysis\u0000of system performance are done very efficiently but there is lots of contrast between the traditional industry and\u0000industry 4.0 based industry is that in the industry not only data analysis can be done but also in addition to\u0000condition monitoring and fault diagnosis, components and systems able to get self-based awareness, this will\u0000provide management system with insights for the status of the factory. Hence it will provide the best performance\u0000with better management and controlling processes with better time management.\u0000This paper describes the automation process of dispensing and filling the bottles of different sizes using Industrial\u0000IoT. This process can be used for industrial purposes.","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87190525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0