Review of Chemical, Pharmacological, Biological Activities of Isatin and Its Derivatives – Part-2 (2002 To 2020)

Abstract

: Isatin is a naturally occurring substance identified in humans, animals, plants and coal tar. Isatin derivatives are reported to possess a wide range of activites. This review is in continuation of “Part-1 (1877-2002)” review published by our team. This review encompasses the most signigicant reports published during 2002 to 2020 on the biological & pharmacological activites of isatin and its derivatives. The review includes the various synthetic reactions of isatin and activites reported. The pharmacological and biological activites reported were antimicrobial, antineoplastic & related activities; analgesic, anti-inflammatory, anticonvulsant, antioxidant, activity against veterinary pathogen, effects on cardiac & vascular smooth muscles; transthyretin fibrillogenesis inhibitor and antiglycation activity of isatin compounds.