isatinin及其衍生物的化学、药理、生物活性综述(2002 - 2020)

Volume 5, Issue 4 Pub Date : 2020-07-30 DOI:10.46243/jst.2020.v5.i4.pp288-307

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引用次数: 0

摘要

Isatin是一种天然存在的物质，存在于人类、动物、植物和煤焦油中。据报道，Isatinderivatives具有广泛的活性。这篇综述是我们小组发表的“Part-1(1877-2002)”综述的延续。本综述涵盖了2002年至2020年间发表的关于isatin及其衍生物的生物学和药理学活性的最重要的报告。综述了isatin的各种合成反应和已报道的活性。所报道的药理和生物活性为抗菌、抗肿瘤及相关活性;镇痛、抗炎、抗惊厥、抗氧化、抗兽用病原体、对心脏血管平滑肌的作用;胰脏素化合物的转甲状腺素纤维生成抑制及抗糖化活性。

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Review of Chemical, Pharmacological, Biological Activities of Isatin and Its Derivatives – Part-2 (2002 To 2020)

: Isatin is a naturally occurring substance identified in humans, animals, plants and coal tar. Isatin derivatives are reported to possess a wide range of activites. This review is in continuation of “Part-1 (1877-2002)” review published by our team. This review encompasses the most signigicant reports published during 2002 to 2020 on the biological & pharmacological activites of isatin and its derivatives. The review includes the various synthetic reactions of isatin and activites reported. The pharmacological and biological activites reported were antimicrobial, antineoplastic & related activities; analgesic, anti-inflammatory, anticonvulsant, antioxidant, activity against veterinary pathogen, effects on cardiac & vascular smooth muscles; transthyretin fibrillogenesis inhibitor and antiglycation activity of isatin compounds.

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来源期刊

Volume 5, Issue 4

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