Veterinarni Medicina最新文献

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Effects of praziquantel on early life stages of Grass carp, Ctenopharyngodon idella. 吡喹酮对草鱼早期生命阶段的影响。
IF 0.6 4区 农林科学
Veterinarni Medicina Pub Date : 2025-03-24 eCollection Date: 2025-03-01 DOI: 10.17221/85/2024-VETMED
Josef Velisek, Alzbeta Strouhova, Marie Sandova, Eliska Zuskova, Petr Dvorak, Alzbeta Stara
{"title":"Effects of praziquantel on early life stages of Grass carp, <i>Ctenopharyngodon idella</i>.","authors":"Josef Velisek, Alzbeta Strouhova, Marie Sandova, Eliska Zuskova, Petr Dvorak, Alzbeta Stara","doi":"10.17221/85/2024-VETMED","DOIUrl":"https://doi.org/10.17221/85/2024-VETMED","url":null,"abstract":"<p><p>This study aimed to assess the toxicity of the anthelmintic drug praziquantel in the early life stages of grass carp (<i>Ctenopharyngodon idella</i>). The toxicity was evaluated based on mortality, early ontogeny development, growth, oxidative stress biomarkers, antioxidant enzymes and histopathology. Praziquantel at all tested concentrations (1, 2, 4 and 6 mg/l) showed no significant adverse effects on the hatching of grass carp. Concentrations of 2, 4 and 6 mg/l praziquantel caused significantly (<i>P < </i>0.01) higher mortality and slower growth compared with controls. Praziquantel at concentrations (4 and 6 mg/l) showed a significant (<i>P < </i>0.01) delay of early ontogeny of grass carp. Concentration of 2 mg/l praziquantel caused significantly (<i>P < </i>0.01) higher GST activity than controls. Among the groups, no histological changes were detected in tissues. For the early life of grass carp, praziquantel is safe at concentrations ≤1 mg/l.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 3","pages":"93-100"},"PeriodicalIF":0.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cor triatriatum sinister with partial atrioventricular septal defect in a cat. 猫三房心险恶伴部分房室间隔缺损。
IF 0.6 4区 农林科学
Veterinarni Medicina Pub Date : 2025-03-24 eCollection Date: 2025-03-01 DOI: 10.17221/91/2024-VETMED
Woohyun Go, Wonkyu Park, Gunha Hwang, Soyon An, Hee Chun Lee, Tae Sung Hwang
{"title":"Cor triatriatum sinister with partial atrioventricular septal defect in a cat.","authors":"Woohyun Go, Wonkyu Park, Gunha Hwang, Soyon An, Hee Chun Lee, Tae Sung Hwang","doi":"10.17221/91/2024-VETMED","DOIUrl":"https://doi.org/10.17221/91/2024-VETMED","url":null,"abstract":"<p><p>A 6-year-old female neutered Turkish Angora cat was referred due to tachypnoea. The patient was diagnosed with cardiomegaly at a local hospital during a health screening two years ago. Tachypnoea occurred one year ago. On physical examination, the patient presented with a respiratory rate of 72 breaths per minute and a systolic blood pressure of 70 mmHg. Thoracic radiographs revealed severe cardiomegaly, left atrium (LA) enlargement, right atrium (RA) enlargement, right ventricular enlargement, and dilation of pulmonary arteries and veins. An alveolar pattern was identified in the right and left cranial lung lobes. Echocardiography revealed a membrane that divided the LA into two chambers, a defect in the lower atrial septum, and elongation of anterior or posterior tricuspid valves (TV). However, septal TV was not observed. During systole, blood flow from LA to RA was confirmed through a defect in the atrial septum. During diastole, blood flow from LA to left ventricular was confirmed. These findings suggest cor triatriatum sinister (CTS) with partial atrioventricular septal defect (AVSD). This report describes echocardiographic diagnosis of CTS with partial AVSD in a cat.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 3","pages":"110-115"},"PeriodicalIF":0.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of glycerin-oxalic acid strips and essential oils in controlling Varroa destructor in honeybee. 甘油草酸条和精油对蜜蜂瓦螨的防治效果。
IF 0.6 4区 农林科学
Veterinarni Medicina Pub Date : 2025-03-24 eCollection Date: 2025-03-01 DOI: 10.17221/94/2024-VETMED
Plamen Rangelov Hristov, Ivaylo Stefanov Hristakov, Atanas Zdravkov Atanasov, Presiyan Antoniov Zhelyazkov
{"title":"Effectiveness of glycerin-oxalic acid strips and essential oils in controlling <i>Varroa destructor</i> in honeybee.","authors":"Plamen Rangelov Hristov, Ivaylo Stefanov Hristakov, Atanas Zdravkov Atanasov, Presiyan Antoniov Zhelyazkov","doi":"10.17221/94/2024-VETMED","DOIUrl":"https://doi.org/10.17221/94/2024-VETMED","url":null,"abstract":"<p><p>The decline in the bee colony strength due to high levels of <i>Varroa destructor</i> infestations necessitates the development of new control methods. This study evaluates the effectiveness of glycerin-oxalic acid strips and essential oils in managing <i>Varroa destructor</i>. The experiment was conducted in 2022 at the experimental apiary in Debelec, part of the Institute of Animal Husbandry in Kostinbrod. Six experimental groups, each treated with a different preparation, were compared to a control group of untreated colonies. Treatments included Beevital Hiveclean (20 ml per colony), Varro Red (2 ml per frame), ammonium nitrate strips (1.3 mm), glycerin-oxalic acid strips (1.3 mm), and glycerin-oxalic acid strips of paper-cellulose (2.3 mm) or cellulose-cotton (2.3 mm). The control group remained untreated. The glycerin-oxalic acid strips made of cellulose and cotton (2.3 mm) showed the highest efficacy, reducing the mite infestation by 17.79% compared to the control. The glycerin-oxalic acid strips of paper-cellulose (2.3 mm) were also effective, achieving a 17.05% reduction in mite levels. These results provide valuable insights for beekeepers seeking alternative and sustainable methods for controlling <i>Varroa destructor</i> infestations.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 3","pages":"101-109"},"PeriodicalIF":0.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of silver nanoparticles in pigs - An invited review. 银纳米颗粒在猪体内的应用——特邀综述。
IF 0.6 4区 农林科学
Veterinarni Medicina Pub Date : 2025-03-24 eCollection Date: 2025-03-01 DOI: 10.17221/101/2024-VETMED
Nikola Hodkovicova, Miroslav Machacek, Jana Cahova, Jerico Consolacion, Andrzej Siwicki, Zygmunt Pejsak, Martin Svoboda
{"title":"The use of silver nanoparticles in pigs - An invited review.","authors":"Nikola Hodkovicova, Miroslav Machacek, Jana Cahova, Jerico Consolacion, Andrzej Siwicki, Zygmunt Pejsak, Martin Svoboda","doi":"10.17221/101/2024-VETMED","DOIUrl":"https://doi.org/10.17221/101/2024-VETMED","url":null,"abstract":"<p><p>Silver nanoparticles (AgNPs) have attracted significant interest in veterinary medicine due to their unique properties, including enhanced stability, greater antimicrobial efficacy, and reduced toxicity compared to traditional silver salts. Their applications span various areas of veterinary practice, such as dermatology, wound management, infection prevention, drug delivery, and disinfection. This review explores their use in pigs, highlighting their role as feed additives to prevent diarrhoea, as antibacterial agents in semen extenders, and veterinary dermatology. AgNPs possess broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria, positioning them as a promising alternative to antibiotics in addressing antibiotic resistance. Additionally, AgNPs have shown antiviral potential, though the exact mechanism of action remains unclear. The review examines the antibacterial and antiviral properties of AgNPs, their utility in facility sanitation, and their potential toxicity to pigs. While AgNPs offer significant benefits in veterinary applications, concerns about their toxicity persist. Efforts to reduce this toxicity, such as surface modifications or combining AgNPs with other substances, are under investigation. Further research is essential to fully understand the potential applications and safety of AgNPs in pig medicine.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 3","pages":"77-92"},"PeriodicalIF":0.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cryptosporidium parvum screening in young calves with diarrhoea in Sulaymaniyah Governorate, Iraq. 伊拉克苏莱曼尼亚省腹泻幼犊副隐孢子虫筛查。
IF 0.6 4区 农林科学
Veterinarni Medicina Pub Date : 2025-02-26 eCollection Date: 2025-02-01 DOI: 10.17221/60/2024-VETMED
Saeed Abdulqader, Abdullah Kaya, Hardi Marif, Basim Ali, Dana Ismaeel
{"title":"<i>Cryptosporidium parvum</i> screening in young calves with diarrhoea in Sulaymaniyah Governorate, Iraq.","authors":"Saeed Abdulqader, Abdullah Kaya, Hardi Marif, Basim Ali, Dana Ismaeel","doi":"10.17221/60/2024-VETMED","DOIUrl":"10.17221/60/2024-VETMED","url":null,"abstract":"<p><p>The parasitic protozoan <i>Cryptosporidium parvum</i> causes cryptosporidiosis in young calves, leading to diarrhoea and financial losses in the farming industry. This study aimed to examine the occurrence of <i>C. parvum</i> in preweaning calves suffering from diarrhoea in Sulaymaniyah, Iraq, using both enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) methods. Faecal samples were obtained from 80 young calves categorised into various groups according to age, breed, sex, and geographic origin. Notably, a greater occurrence of <i>C. parvum</i> infection was observed in female calves, those in the 5-30 days age group, and those of the Friesian breed. Furthermore, the highest infection rate was reported in the Zarayan region. A strong correlation was observed between the ELISA and PCR findings. The molecular analysis detected both <i>C. parvum</i> and <i>C. ryanae</i>, with <i>C. ryanae</i> documented for the first time in Iraq. <i>C. parvum</i> infection considerably affects physiological indicators, particularly in younger calves, including body temperature, heart rate, and respiratory rate. PCR positivity in our study was substantially correlated with dehydration. Overall, this study highlights the need for prompt identification and intervention for the management of <i>C. parvum</i> infections in young calves.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 2","pages":"45-53"},"PeriodicalIF":0.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Claw diseases are the dominant cause of lameness in dairy cows and a risk factor for mastitis. 爪病是奶牛跛足的主要原因,也是乳腺炎的危险因素之一。
IF 0.6 4区 农林科学
Veterinarni Medicina Pub Date : 2025-02-24 eCollection Date: 2025-02-01 DOI: 10.17221/56/2024-VETMED
Vladimir Hisira, Jana Zahumenska, Marian Kadasi, Robert Klein, Pavol Mudron, Frantisek Zigo
{"title":"Claw diseases are the dominant cause of lameness in dairy cows and a risk factor for mastitis.","authors":"Vladimir Hisira, Jana Zahumenska, Marian Kadasi, Robert Klein, Pavol Mudron, Frantisek Zigo","doi":"10.17221/56/2024-VETMED","DOIUrl":"10.17221/56/2024-VETMED","url":null,"abstract":"<p><p>Lameness and mastitis are two of the most economically important issues for the dairy industry. This study aimed to obtain a clearer analysis of the link between mastitis and lameness in dairy cows using the Mastitis Score and detecting the pathogens that predominate in dairy cows' milk samples with claw diseases. During routine claw trimming, milk samples were collected from dairy cows in two Slovak dairy farms. Out of 558 cows presented for claw trimming, 144 cows (25.8%) exhibited lameness from claw diseases. The most prevalent disease in our study was digital dermatitis (43.1%), followed by toe necrosis (41.7%), and Rusterholz ulcer (15.3%). Udder inflammation in clinical form was diagnosed based on clinical examination of individual udder quarters, and sensory evaluation of milk from each quarter and in the subclinical form by the CMT. Mastitis was detected in 80 cows with claw diseases, clinical mastitis in 14 cows (17.5%), and subclinical mastitis in 66 cows (82.5%). On both farms, Mastitis Scores were significantly higher in dairy cows affected by claw diseases than in the non-lame ones. In mastitic cows affected by claw diseases, environmental pathogens dominated the infected milk samples. Our findings showed that cows with claw disease were more likely to have mastitis.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 2","pages":"35-44"},"PeriodicalIF":0.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and risk factors of Cryptosporidium spp. and Giardia infestation in cattle and in broiler chickens in Algeria. 阿尔及利亚牛和肉鸡隐孢子虫和贾第虫感染的流行及危险因素。
IF 0.6 4区 农林科学
Veterinarni Medicina Pub Date : 2025-02-24 eCollection Date: 2025-02-01 DOI: 10.17221/82/2024-VETMED
Ratiba Baazizi, Messaouda Taibi, Nour Senouci, Djamel Baroudi, Sarah Khodja, Redha Belala, Djamel Khelef, Nora Mimoune
{"title":"Prevalence and risk factors of <i>Cryptosporidium</i> spp. and <i>Giardia</i> infestation in cattle and in broiler chickens in Algeria.","authors":"Ratiba Baazizi, Messaouda Taibi, Nour Senouci, Djamel Baroudi, Sarah Khodja, Redha Belala, Djamel Khelef, Nora Mimoune","doi":"10.17221/82/2024-VETMED","DOIUrl":"10.17221/82/2024-VETMED","url":null,"abstract":"<p><p>Cryptosporidiosis and giardiasis are zoonotic protozoan diseases with significant public health and economic concerns. In Algeria, epidemiological data on these parasites in livestock are limited. This study aimed to estimate the prevalence of <i>Cryptosporidium</i> spp. and <i>Giardia</i> in dairy calves and broiler chickens and to identify the associated risk factors. A microscopic analysis of 200 faecal samples revealed a <i>Cryptosporidium</i> spp. prevalence of 56% in calves and 60% in broiler chickens, while the <i>Giardia</i> prevalence was 8% in calves and absent in chickens. In cattle, the data showed that age constituted a potential risk factor for both parasites (<i>P</i> < 0.000 1 for <i>Cryptosporidium</i>; <i>P</i> < 0.000 5 for <i>Giardia</i>). Interestingly, the risk of a <i>Cryptosporidium</i> infection decreased with age, while the <i>Giardia</i> infestation risk increased. The sex was not a significant factor for <i>Cryptosporidium</i> (<i>P</i> = 0.115 0), but was impactful for <i>Giardia</i> (<i>P</i> < 0.000 1), with males at higher risk. These results highlighted the distinct epidemiological characteristics of <i>Cryptosporidium</i> and <i>Giardia</i> infestations in Algerian livestock. The contrasting age-related risks and sex-specific susceptibility to <i>Giardia</i> underline the need for targeted, age and sex prevention strategies. This study provides valuable data to inform public health policies and to improve livestock management practices in Algeria, contributing to the wider understanding of these zoonotic parasites in North African agricultural farming.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 2","pages":"68-76"},"PeriodicalIF":0.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and microbiological evaluation of foot diseases in small ruminants in Siirt province (Türkiye) and its districts. 对土耳其锡尔特省及其地区小型反刍动物蹄病的临床和微生物学评估。
IF 0.6 4区 农林科学
Veterinarni Medicina Pub Date : 2025-02-24 eCollection Date: 2025-02-01 DOI: 10.17221/81/2024-VETMED
Ali Gulaydin, Ozgul Gulaydin, Muazzez Yesilyurt, Nihat Sindak, Mustafa Baris Akgul, Onur Yildirim
{"title":"Clinical and microbiological evaluation of foot diseases in small ruminants in Siirt province (Türkiye) and its districts.","authors":"Ali Gulaydin, Ozgul Gulaydin, Muazzez Yesilyurt, Nihat Sindak, Mustafa Baris Akgul, Onur Yildirim","doi":"10.17221/81/2024-VETMED","DOIUrl":"10.17221/81/2024-VETMED","url":null,"abstract":"<p><p>Foot diseases are one of the leading health problems that lead to significant yield losses in small ruminant breeding. This study aimed to clinically evaluate foot diseases in sheep and goats reared in Siirt province of Türkiye and its surrounding districts. Molecular methods were used to investigate the presence of <i>Dichelobacter nodosus</i> serogroups and <i>Treponema</i> spp. phylogroups in cases with identified lesions. Clinical examination of 4 111 sheep and goats identified foot diseases in 402 animals, affecting a total of 410 feet. Contagious ovine digital dermatitis (CODD) and digital dermatitis (DD) cases were identified in 66.82% and 26.82% of diseased feet, respectively. Footrot lesions were found in 4.87% of the feet in which the disease was identified. <i>D.</i> <i>nodosus</i> was detected in 66.23% of swab samples collected from 77 CODD cases, whereas <i>Treponema</i> spp. was identified in 2.59% of the samples. Among DD cases (<i>n</i> = 110), <i>D. nodosus</i> was found in 35.45% and <i>Treponema</i> spp. in 17.27% (Group 1 = 1.81%, Group 2 = 15.45%). The majority of <i>D. nodosus</i> strains identified in the cases (<i>n</i> = 90) were classified as serogroup A (37.77%) and serogroup D (60.00%). This study revealed that CODD is a major problem in small ruminant breeding in the Siirt province and its districts. It was determined that <i>D.</i> <i>nodosus</i> serogroup A, D and <i>Treponema</i> spp<i>.</i> Group 2 strains played an important role in the aetiology of foot diseases in sheep and goats. This study represents the first comprehensive investigation of foot diseases in sheep and goats in the Siirt province and marks a significant milestone as the first study in Türkiye to identify and analyse the aetiology causes of CODD in the literature.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 2","pages":"54-67"},"PeriodicalIF":0.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biochemical and antioxidant responses of common carp (Cyprinus carpio) exposed to sublethal concentrations of the antiepileptic and analgesic drug gabapentin. 暴露于亚致死浓度的抗癫痫和镇痛药物加巴喷丁对鲤鱼的生化和抗氧化反应。
IF 0.6 4区 农林科学
Veterinarni Medicina Pub Date : 2025-01-20 eCollection Date: 2025-01-01 DOI: 10.17221/75/2024-VETMED
Jana Blahova, Premysl Mikula, Petr Marsalek, Zdenka Svobodova
{"title":"Biochemical and antioxidant responses of common carp (<i>Cyprinus carpio</i>) exposed to sublethal concentrations of the antiepileptic and analgesic drug gabapentin.","authors":"Jana Blahova, Premysl Mikula, Petr Marsalek, Zdenka Svobodova","doi":"10.17221/75/2024-VETMED","DOIUrl":"10.17221/75/2024-VETMED","url":null,"abstract":"<p><p>The present study aimed to evaluate the biochemical and antioxidant responses of common carp after exposure to the antiepileptic and analgesic drug gabapentin at concentrations of 0.1, 1, 10, and 100 μg/l for 4 weeks. The exposure to the highest two concentrations resulted in significant changes in plasma indices such as glucose (only group 100 μg/l), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), lipase, creatine kinase (CK), amylase as well as butyrylcholinesterase (BChE). Similar trends were found in both groups exposed to the environmentally relevant concentrations (i.e., 0.1 and 1 μg/l). In addition, a significant increase in the ferric-reducing power of the plasma was noted in all treated groups. Numerous changes in antioxidant enzymes, superoxide dismutase, catalase, glutathione-S-transferase, as well as lipid peroxidation, were observed especially in the caudal kidney in the group exposed to 100 μg/l. Significant findings were also confirmed in the group exposed to an environmentally relevant concentration (1 μg/l), with a decrease in superoxide dismutase in the gill and an increased lipoperoxidation in the caudal kidney. Our research shows that subchronic exposure to gabapentin may pose a significant risk to non-target aquatic organisms, such as disruption of metabolic pathways or induction of oxidative stress, even at environmentally relevant concentrations.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 1","pages":"20-29"},"PeriodicalIF":0.6,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the accuracy of patient-specific drilling guides for cervical (C5-C6) and lumbar (L4-L5) vertebrae in cats. 评估猫颈椎(C5-C6)和腰椎(L4-L5)患者特异性钻孔指南的准确性。
IF 0.6 4区 农林科学
Veterinarni Medicina Pub Date : 2025-01-20 eCollection Date: 2025-01-01 DOI: 10.17221/73/2024-VETMED
Rodrigo Casarin Costa, Gabriel Godoi de Moraes, Rafaela Gerbasi Ferreira, Renato Barroco Neto, Matheus Nobile, Thiago Andre Salvitti de Sa Rocha, Luciano Pereira de Barros, Bruno Watanabe Minto, Luis Gustavo Gosuen Goncalves Dias
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