Veterinarni Medicina最新文献_第2页

Meloxicam blood levels are not affected by sex-related hormones in male and female goats. 在雄性和雌性山羊中，美洛昔康血药浓度不受性激素的影响。

IF 1.3 4区农林科学

Veterinarni Medicina Pub Date : 2026-06-25 eCollection Date: 2026-06-01 DOI: 10.17221/103/2025-VETMED

Ayris Gokceoglu, Zeynep Ozdemir Kutahya, Gul Fatma Yarim, Petek Piner Benli, Cengiz Gokbulut

{"title":"Meloxicam blood levels are not affected by sex-related hormones in male and female goats.","authors":"Ayris Gokceoglu, Zeynep Ozdemir Kutahya, Gul Fatma Yarim, Petek Piner Benli, Cengiz Gokbulut","doi":"10.17221/103/2025-VETMED","DOIUrl":"10.17221/103/2025-VETMED","url":null,"abstract":"The present study aims to investigate the interaction between the non-steroidal anti-inflammatory (NSAID) drug meloxicam and sex hormones in seasonal polyoestrous male and female Saanen goats. It was hypothesised that sex hormones, both steroidal and peptide hormones, may influence the serum concentration of the lipophilic drug meloxicam. In the study, the relationship between plasma meloxicam concentration (μg/ml) and the levels of follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), testosterone, oestradiol (E2), and progesterone (P4) was evaluated. For this purpose, six male and six female Saanen goats aged one year were intravenously administered a 0.5 mg/kg dose of meloxicam, and blood samples were collected at different time points (0, 5, 30 min, and 2, 8, 24, 48 h) to obtain plasma and serum. The hormone levels were determined by ELISA, following the manufacturer's instructions, and drug concentrations were measured by HPLC-UV. While the study found no direct correlation between the meloxicam levels and the sex hormones, significant sex-related differences in the hormone levels underscore the importance of considering sex-related physiological differences in veterinary pharmacology. These results will establish a scientific basis for future research on species- and sex-specific dosage adjustments.","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"71 6","pages":"222-229"},"PeriodicalIF":1.3,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13394867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A reproducible rat model for warfarin studies: Prothrombin time assessment with minimal blood using the CoaguChek XS and determination of an effective warfarin dosage. 华法林研究的可重复大鼠模型：使用CoaguChek XS以最少血评估凝血酶原时间并确定华法林的有效剂量。

IF 1.3 4区农林科学

Veterinarni Medicina Pub Date : 2026-06-25 eCollection Date: 2026-06-01 DOI: 10.17221/4/2026-VETMED

Eyup Tolga Akyol, Mehmet Tolga Hekim, Muharrem Erol

{"title":"A reproducible rat model for warfarin studies: Prothrombin time assessment with minimal blood using the CoaguChek XS and determination of an effective warfarin dosage.","authors":"Eyup Tolga Akyol, Mehmet Tolga Hekim, Muharrem Erol","doi":"10.17221/4/2026-VETMED","DOIUrl":"10.17221/4/2026-VETMED","url":null,"abstract":"Warfarin research in rats is often challenged by methodological inconsistencies and large blood volume requirements. This study aimed to validate a refined, reproducible rat model for serial prothrombin time (PT) monitoring using the CoaguChek XS, in alignment with the 3R principles, and to determine an effective warfarin sodium dosage. Male Wistar albino rats received daily oral warfarin (0.125-0.750 mg/kg) for 5 days. PT was measured using the whole-blood CoaguChek XS and two laboratory plasma assays (Innovin, Thromborel S). Agreement was assessed using Bland-Altman and Passing-Bablok regression. The CoaguChek XS consistently yielded higher PT values than laboratory tests but showed strong agreement up to 25 seconds. A daily dose of 0.125 mg/kg resulted in a stable anticoagulant effect without mortality. Doses Doses of 0.250 mg/kg and higher were toxic, causing PT prolongation beyond the device's range and high mortality within 4-7 days after the initiation of treatment. In conclusion, the CoaguChek XS is a reliable tool for experiments requiring repeated measurements. Values remain reliable up to 25 s, and 0.125 mg/kg is a safe dose for short-term studies, effectively supporting animal welfare and the 3R principles.","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"71 6","pages":"245-253"},"PeriodicalIF":1.3,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13394869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of Loranthus tanakae Franch. & Sav. on allergic asthma induced by ovalbumin. 田中花的保护作用。和干腊肠。卵清蛋白致过敏性哮喘的研究。

IF 1.3 4区农林科学

Veterinarni Medicina Pub Date : 2026-05-27 eCollection Date: 2026-05-01 DOI: 10.17221/77/2025-VETMED

Sin-Hyang Park, So-Won Pak, Woong-Il Kim, Ba-Reun Jin, Young-Kwon Cho, Tae-Won Kim, Je-Won Ko, Joong-Sun Kim, Jong-Choon Kim, A Yeong Lee, In-Sik Shin

{"title":"Protective effect of Loranthus tanakae Franch. & Sav. on allergic asthma induced by ovalbumin.","authors":"Sin-Hyang Park, So-Won Pak, Woong-Il Kim, Ba-Reun Jin, Young-Kwon Cho, Tae-Won Kim, Je-Won Ko, Joong-Sun Kim, Jong-Choon Kim, A Yeong Lee, In-Sik Shin","doi":"10.17221/77/2025-VETMED","DOIUrl":"10.17221/77/2025-VETMED","url":null,"abstract":"Allergic asthma is a widespread disease with elevated eosinophil levels. Although corticosteroids are widely prescribed for allergic asthma, numerous patients experience limited sensitivity and side effects. Loranthus tanakae Franch. & Sav., a traditional herbal plant, has anti-inflammatory and antioxidant properties in pulmonary inflammation caused by Asian sand dust and cigarette smoke condensate. To assess the protective effects of L. tanakae, we examined the influence of an L. tanakae ethanol extract (LTE) in ovalbumin (OVA)-induced asthma. Mice received intraperitoneal sensitisation with OVA, and challenged using OVA inhalation. LTE was consecutively orally gavaged for 6 days. Following sacrifice, the bronchoalveolar lavage fluid (BALF) and lung tissue was analysed. The LTE treatment considerably reduced inflammatory cell counts, proinflammatory cytokine levels in the BALF, and immunoglobulin E, compared with the OVA group, along with a reduction in airway hyperresponsiveness. The LTE also improved airway inflammation and suppressed mucus hypersecretion in the lung tissues. Additionally, the expression of MMP-9 and activation of ERK, JNK, and p38 were notably diminished in the LTE groups. This study revealed reduced airway inflammation in OVA-induced asthma via suppressing the MMP-9 and mitogen-activated protein kinase-associated factors. Consequently, our findings demonstrated that LTE is suggested as a potential remedy for allergic asthma.","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"71 5","pages":"190-200"},"PeriodicalIF":1.3,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the effect of Mospilan SP and its active substance on Artemia franciscana. Mospilan SP及其活性物质对青蒿药效的比较。

IF 1.3 4区农林科学

Veterinarni Medicina Pub Date : 2026-05-27 eCollection Date: 2026-05-01 DOI: 10.17221/73/2025-VETMED

Marcel Falis, Katarina Benova, Michaela Spalkova, Lenka Leskova

{"title":"Comparison of the effect of Mospilan SP and its active substance on Artemia franciscana.","authors":"Marcel Falis, Katarina Benova, Michaela Spalkova, Lenka Leskova","doi":"10.17221/73/2025-VETMED","DOIUrl":"10.17221/73/2025-VETMED","url":null,"abstract":"Contaminants formed after the use of pesticides raise concerns for human health and aquatic ecosystems, i. a., due to their high persistence in surface waters and their further migration to other components of the environment. In our study, we compared the effect of the insecticide Mospilan SP and its active substance acetamiprid on the aquatic crustacean Artemia franciscana. The concentration was 367.44 mg/l for Mospilan SP LC50 after 120 h, and 102.82 mg/l after 144 hours. The concentration was 148.04 mg/l for the active substance acetamiprid LC20 after 144 h and 28.84 mg/l after 168 hours. The commercial insecticide Mospilan SP showed a significant suppressive effect on the measured morphological parameters (body length and body width), with statistically significant differences observed after 10 days of exposure. When comparing the changes after the application of the insecticide and the active substance, it is impossible to confirm the same effect on the morphological parameters within the given time intervals. The objective of the study was to examine morphological changes at sublethal concentrations, as these changes can provide a more sensitive indication of the adverse effects of commercial products and active substances on morphological parameters.","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"71 5","pages":"201-208"},"PeriodicalIF":1.3,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From grain to forage: A decade of mycotoxin contamination in ruminant feed in the Czech Republic (2013-2023). 从谷物到饲料：捷克共和国反刍动物饲料中霉菌毒素污染的十年（2013-2023）。

IF 1.3 4区农林科学

Veterinarni Medicina Pub Date : 2026-05-27 eCollection Date: 2026-05-01 DOI: 10.17221/74/2025-VETMED

Jana Cahova, Lucie Kvasnickova, Josef Illek, Tomas Palenik, Andrea Staffa, Veronika Vlasakova, Zdenka Svobodova, Lanto Ravonjison, Martin Svoboda

{"title":"From grain to forage: A decade of mycotoxin contamination in ruminant feed in the Czech Republic (2013-2023).","authors":"Jana Cahova, Lucie Kvasnickova, Josef Illek, Tomas Palenik, Andrea Staffa, Veronika Vlasakova, Zdenka Svobodova, Lanto Ravonjison, Martin Svoboda","doi":"10.17221/74/2025-VETMED","DOIUrl":"10.17221/74/2025-VETMED","url":null,"abstract":"This study is based on analytical data on mycotoxin contamination in ruminant feeds in the Czech Republic over a ten-year period (2013-2023), specifically deoxynivalenol (DON), zearalenone (ZEN), T-2 toxin (T-2/HT-2), and ochratoxin A (OTA). Analyses were performed in accredited State Veterinary Institutes using validated immunochemical and chromatographic methods. Samples included forage and concentrate feeds for dairy cows, calf feed, and fattening cattle feed. During the monitoring period, DON was detected at higher concentrations, reflecting the susceptibility of field crops to Fusarium infection under local environmental conditions. Forage feeds showed significantly higher concentrations of DON (472.6 ± 13.2 µg/kg), ZEN (61.7 ± 4.4 µg/kg), and T-2/HT-2 toxin (36.7 ± 2.7 µg/kg) than concentrates for dairy cows (P < 0.05). Additionally, ZEN levels differed significantly between concentrates for dairy cows (17.1 ± 2.3 µg/kg) and calf feed (16.2 ± 3.3 µg/kg) (P < 0.05). Although mycotoxin concentrations generally remained below recommended limits, a small proportion of samples exceeded guideline values for DON (0.13%) and ZEN (0.56%). These findings highlight the importance of continued monitoring and preventive strategies to manage mycotoxin risks.","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"71 5","pages":"180-189"},"PeriodicalIF":1.3,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drugs and products in beekeeping: Efficacy and perspectives of natural alternatives. 养蜂业中的药物和产品：天然替代品的功效和前景。

IF 1.3 4区农林科学

Veterinarni Medicina Pub Date : 2026-05-26 eCollection Date: 2026-05-01 DOI: 10.17221/88/2025-VETMED

Imrich Szabo, Lucia Sabova, Rastislav Sabo, Monika Sucik

{"title":"Drugs and products in beekeeping: Efficacy and perspectives of natural alternatives.","authors":"Imrich Szabo, Lucia Sabova, Rastislav Sabo, Monika Sucik","doi":"10.17221/88/2025-VETMED","DOIUrl":"10.17221/88/2025-VETMED","url":null,"abstract":"Honeybee health is a key factor in sustainable apiculture, with the most significant colony losses attributed to the mite Varroa destructor and microsporidia of the genus Nosema spp. The aim of this review article is to summarise current knowledge on the use of pharmaceuticals and preparations in the prevention and treatment of these diseases and to highlight promising alternatives to synthetic acaricides. Commonly used active substances such as amitraz and pyrethroids show decreased efficacy in many countries due to the development of resistance. Therefore, organic acids (formic, oxalic, and lactic), essential oils, and plant extracts are increasingly used as environmentally friendly, residue-free alternatives. Some plant preparations and extracts have been shown to be effective against Nosema ceranae. In addition to therapeutic interventions, the importance of preventive measures and immune support through supplements containing vitamins, amino acids, and probiotics is emphasised. The article highlights the need for integrated bee health management combining pharmacological, natural, and biotechnological approaches to limit resistance development, minimise residues in bee products, and promote overall colony vitality.","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"71 5","pages":"169-179"},"PeriodicalIF":1.3,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of Lactiplantibacillus plantarum probiotic supplement on rainbow trout challenged with Aeromonas salmonicida. 补充植物乳杆菌益生菌对虹鳟鱼致杀沙门氏气单胞菌的影响。

IF 1.3 4区农林科学

Veterinarni Medicina Pub Date : 2026-04-30 eCollection Date: 2026-04-01 DOI: 10.17221/101/2025-VETMED

Ivana Mikulikova, Zuzana Lepkova, Hana Bandouchova, Jana Blahova, Ivana Papezikova, Hana Novotna, Ivona Toulova, Katerina Kobelkova, Klara Odehnalova, Eva Postulkova, Marija Radojicic, Jan Mares, Dagmar Mudronova, Miroslava Palikova

{"title":"The effect of Lactiplantibacillus plantarum probiotic supplement on rainbow trout challenged with Aeromonas salmonicida.","authors":"Ivana Mikulikova, Zuzana Lepkova, Hana Bandouchova, Jana Blahova, Ivana Papezikova, Hana Novotna, Ivona Toulova, Katerina Kobelkova, Klara Odehnalova, Eva Postulkova, Marija Radojicic, Jan Mares, Dagmar Mudronova, Miroslava Palikova","doi":"10.17221/101/2025-VETMED","DOIUrl":"10.17221/101/2025-VETMED","url":null,"abstract":"Two probiotic (Lactiplantibacillus plantarum) supplementation strategies (continuous and cyclic) were evaluated for their ability to enhance resistance of rainbow trout (Oncorhynchus mykiss) to Aeromonas salmonicida infection. Neither of these strategies improved post-challenge survival. Instead, cyclic administration resulted in a significantly higher mortality rate (73%) compared with continuous supplementation (52%) and the control group (46%). One week post-challenge, most haematological, plasma biochemical, and immune parameters showed no significant difference between treatments, though fish receiving cyclic supplementation did exhibit a reduced lymphocyte count. However, three weeks post-challenge, this same group showed a significant decrease in total phagocyte number and in the proportion of phagocytes within white blood cells. IgM concentrations were significantly lower in both probiotic-supplemented groups than in the control group. In the cyclic group, reductions in interleukin-10 and elevations in total protein levels were also observed. Microbiome analysis of gut content three weeks post-challenge revealed a marked decline in microbial diversity in both probiotic-treated groups. These findings indicate that, under the experimental conditions, probiotic supplementation did not provide protection against A. salmonicida infection and that cyclic administration may disrupt immune homeostasis and intestinal microbial stability, ultimately compromising host resilience.","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"71 4","pages":"156-168"},"PeriodicalIF":1.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13173405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro comparison of anthelmintic efficacy across Gyrodactylus species. 旋毛虫不同种驱虫效果的体外比较。

IF 1.3 4区农林科学

Veterinarni Medicina Pub Date : 2026-04-30 eCollection Date: 2026-04-01 DOI: 10.17221/79/2025-VETMED

Marketa Ondrackova, Jitka Kolarova, Katerina Skocovska

{"title":"In vitro comparison of anthelmintic efficacy across Gyrodactylus species.","authors":"Marketa Ondrackova, Jitka Kolarova, Katerina Skocovska","doi":"10.17221/79/2025-VETMED","DOIUrl":"10.17221/79/2025-VETMED","url":null,"abstract":"Gyrodactylosis, caused by monogenean parasites of the genus Gyrodactylus, poses a significant threat to aquaculture, particularly under intensive farming conditions. This study evaluated the in vitro effectiveness of three veterinary anthelmintics - fenbendazole (FBZ), levamisole hydrochloride (LHC), and ivermectin (IVM) - against four Gyrodactylus species collected from wild cyprinid hosts. Parasite survival was monitored over 48 h at 6-7 °C. LHC showed the highest efficacy at both tested concentrations (30 and 50 mg/l), achieving near-complete mortality within 8 hours. FBZ and IVM were significantly less effective, with 23% and 33% of parasites surviving, respectively. Species-specific differences in drug susceptibility were observed, particularly with FBZ and IVM, with G. carassii showing consistently higher sensitivity than G. laevis, G. rutilensis, and G. vimbi. Lower water temperatures probably contributed to reduced drug efficacy and prolonged parasite survival. These findings highlight the importance of species-level evaluation and temperature considerations when selecting anthelmintic treatments for gyrodactylosis. In vitro testing under controlled conditions offers valuable insights into parasite susceptibility and complements in vivo approaches. Further research incorporating broader parasite diversity, temperature ranges, and pharmacological profiles is recommended to optimise treatment strategies in aquaculture.","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"71 4","pages":"129-138"},"PeriodicalIF":1.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13173408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of a 24-hour praziquantel bath on the haematological and biochemical profile and selected parameters of oxidative stress in grass carp (Ctenopharyngodon idella). 吡喹酮24小时浸泡对草鱼血液学和生化特征及氧化应激选定参数的影响

IF 1.3 4区农林科学

Veterinarni Medicina Pub Date : 2026-04-27 eCollection Date: 2026-04-01 DOI: 10.17221/89/2025-VETMED

Radka Dobsikova, Petr Marsalek, Josef Velisek, Jana Blahova

{"title":"Effect of a 24-hour praziquantel bath on the haematological and biochemical profile and selected parameters of oxidative stress in grass carp (Ctenopharyngodon idella).","authors":"Radka Dobsikova, Petr Marsalek, Josef Velisek, Jana Blahova","doi":"10.17221/89/2025-VETMED","DOIUrl":"10.17221/89/2025-VETMED","url":null,"abstract":"This study assessed the effect of a 24-hour bath with praziquantel (2 and 4 mg/l) on grass carp (Ctenopharyngodon idella) by monitoring the haematological parameters, plasma biochemical profile, and oxidative stress indices. Fish were sampled at 24-, 48-, 72-, and 96-hours post-exposure (hpe). The haematological analysis revealed a significant increase (P < 0.05) in the white blood cell count immediately after treatment at both concentrations, with no subsequent changes. Within the plasma biochemical profile, a significant decrease (P < 0.05) was observed only in chloride (24 hpe at 2 mg/l; 72 hpe at both concentrations) and in magnesium (48 hpe at 2 mg/l). The oxidative stress responses indicated that the gill was the most responsive tissue. In the gill, the catalase and glutathione-S-transferase activities increased significantly (P < 0.05) at 48 hpe at 4 mg/l. Lipid peroxidation in the gill decreased at 48 hpe but increased at 72 hpe following exposure to 4 mg/l. In the hepatopancreas, the glutathione peroxidase activity significantly decreased at 48 hpe at 2 mg/l. In the plasma, significant changes (P < 0.05) were detected only in the ceruloplasmin activity, which decreased at 72 hpe in the 2 mg/l group. These findings provide essential baseline data supporting the potential future application of praziquantel in aquaculture.","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"71 4","pages":"147-155"},"PeriodicalIF":1.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13173407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral efficacy of controlled-release doxycycline against Ichthyophthirius multifiliis infestation in salmonids. 多西环素口服控释对鲑鱼中多filifius侵染的防治效果。

IF 1.3 4区农林科学

Veterinarni Medicina Pub Date : 2026-04-27 eCollection Date: 2026-04-01 DOI: 10.17221/104/2025-VETMED

Zuzana Mikulkova, Katerina Matejickova, Jitka Motlova, Pavlina Ginterova, Martin Jerabek, Lubomir Pojezdal

{"title":"Oral efficacy of controlled-release doxycycline against Ichthyophthirius multifiliis infestation in salmonids.","authors":"Zuzana Mikulkova, Katerina Matejickova, Jitka Motlova, Pavlina Ginterova, Martin Jerabek, Lubomir Pojezdal","doi":"10.17221/104/2025-VETMED","DOIUrl":"10.17221/104/2025-VETMED","url":null,"abstract":"Ichthyophthiriosis, caused by Ichthyophthirius multifiliis, is a major threat in salmonid aquaculture. This study evaluated the efficacy of orally administered standard doxycycline and controlled-release doxycycline formulations in experimentally infected brook trout (Salvelinus fontinalis). Fish received medicated feed for 10 days starting seven days post-infection. Controlled-release doxycycline achieved the highest survival rate (84.2%), followed by standard doxycycline (73.7%), while no control fish survived after day 25 post-infection. Both drug formulations eliminated trophonts from the skin and gills by 20 days post-treatment. Despite a 2.5-fold lower dietary dose, the controlled-release doxycycline achieved a tissue concentration equivalent to ~32% of that of standard doxycycline, with similar retention rates. Levels of doxycycline residues in water declined over time for both groups, indicating limited environmental release. These results demonstrate the effective mitigation of ichthyophthiriosis with orally administered doxycycline and the enhancement of antiparasitic efficacy and reduction of drug load in tissues and the environment via controlled-release technology, supporting its potential as a sustainable medicated feed strategy in salmonid aquaculture.","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"71 4","pages":"139-146"},"PeriodicalIF":1.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13173406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0