Veterinarni Medicina最新文献

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Additive effects of ceftiofur-neomycin combination against multidrug-resistant pathogenic Escherichia coli in a murine infection model. 头孢替福-新霉素联合用药对多重耐药致病性大肠杆菌小鼠感染模型的加性作用。
IF 0.8 4区 农林科学
Veterinarni Medicina Pub Date : 2026-01-26 eCollection Date: 2026-01-01 DOI: 10.17221/38/2025-VETMED
Kyung-Hyo Do, Min-Gyu Kim, Da-Hye Ryu, Hyun-Jung Ahn, Su-Bin Kim, You-Kyung Go, So Yeon Kim, Soochong Kim, Seung-Hun Lee, Do-Kyun Kim, Young-Eun Cho, Jihoon Kim, Young Kyung Park, Kounghwa Youn, Hanseul Oh, Kwang-Won Seo
{"title":"Additive effects of ceftiofur-neomycin combination against multidrug-resistant pathogenic <i>Escherichia coli</i> in a murine infection model.","authors":"Kyung-Hyo Do, Min-Gyu Kim, Da-Hye Ryu, Hyun-Jung Ahn, Su-Bin Kim, You-Kyung Go, So Yeon Kim, Soochong Kim, Seung-Hun Lee, Do-Kyun Kim, Young-Eun Cho, Jihoon Kim, Young Kyung Park, Kounghwa Youn, Hanseul Oh, Kwang-Won Seo","doi":"10.17221/38/2025-VETMED","DOIUrl":"10.17221/38/2025-VETMED","url":null,"abstract":"<p><p>This study aimed to evaluate the therapeutic efficacy of a ceftiofur-neomycin combination against a pathogenic multidrug-resistant <i>Escherichia coli</i> strain, KECS-0513, isolated from pigs, using a combination of genomic, <i>in vitro</i>, and <i>in vivo</i> approaches. The minimum inhibitory concentration, minimum bactericidal concentration, and checkerboard assays were performed. Time-kill assays were used to assess bactericidal activity over time, and a murine intraperitoneal infection model was used to evaluate survival outcomes following treatment with monotherapies or combination regimens. Whole genome sequencing indicated that KECS-0513 harboured multiple resistance genes, including <i>bla</i> <sub>TEM-1B</sub>, <i>sul3</i>, <i>aadA12</i>, <i>aad(3)-IVa</i>, <i>aph(3')-Ia</i>, and <i>aph(4)-Ia</i>. The resistance genes were localised within a mobile, element-rich plasmid. <i>In vitro</i> checkerboard assays revealed an additive interaction between ceftiofur and neomycin (fractional inhibitory concentration index = 1.0), and time-kill experiments demonstrated enhanced and sustained bacterial clearance with combination therapy. <i>In vivo</i> infection studies in mice demonstrated that the dual treatment resulted in a substantially higher survival rate (66.7%) compared to treatment with either agent alone (33.3% for each). These results support the practical application of ceftiofur-neomycin combination therapy for controlling swine-associated multidrug-resistant <i>E. coli</i> while minimising the risk of resistance emergence.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"71 1","pages":"18-26"},"PeriodicalIF":0.8,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12896122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Presumed atypical cor triatriatum dexter in a geriatric dog: A case report. 老年犬非典型右心房三裂:一例报告。
IF 0.8 4区 农林科学
Veterinarni Medicina Pub Date : 2026-01-26 eCollection Date: 2026-01-01 DOI: 10.17221/50/2025-VETMED
Yijin Jeong, Danbee Kwon, Kanghyo Park, Kichang Lee, Hakyoung Yoon
{"title":"Presumed atypical cor triatriatum dexter in a geriatric dog: A case report.","authors":"Yijin Jeong, Danbee Kwon, Kanghyo Park, Kichang Lee, Hakyoung Yoon","doi":"10.17221/50/2025-VETMED","DOIUrl":"10.17221/50/2025-VETMED","url":null,"abstract":"<p><p>Membranous structures within the right atrium (RA), such as the Chiari network, eustachian valve, Thebesian valve, and cor triatriatum dexter (CTD), can present with overlapping imaging features and complicated diagnoses. A 17-year-old male Maltese presented with a cardiac murmur, cough, anorexia, and exercise intolerance. Echocardiography revealed a mobile membrane in the RA, dividing it into two chambers. Computed tomography (CT) confirmed this finding, demonstrating differential attenuation of contrast between the chambers. The vascular connections and anatomical relationships of the structure differed from those of previously reported CTD types. Although other sinus venosus valve remnants were considered, the findings supported a provisional diagnosis of atypical CTD. This case highlights the utility of multimodal imaging for the characterisation of right atrial membranous structures. In human medicine, a detailed anatomical comparison of sinus venosus valve remnants aids in the differential diagnosis. Applying a similar approach in veterinary medicine, especially in geriatric patients, may improve diagnostic accuracy. Comprehensive imaging evaluations, including echocardiography and CT, are recommended to assess RA membranes that may be misinterpreted as variants of the CTD or other embryological remnants.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"71 1","pages":"27-34"},"PeriodicalIF":0.8,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12896125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of a hydroalcoholic extract of liquorice (Glycyrrhiza glabra L.) root on the treatment of experimentally induced peritonitis in New Zealand male rabbits. 甘草根水酒精提取物对实验性新西兰雄性家兔腹膜炎的治疗作用。
IF 0.8 4区 农林科学
Veterinarni Medicina Pub Date : 2025-12-31 eCollection Date: 2025-12-01 DOI: 10.17221/31/2025-VETMED
Mohammad Ahmadi, Iraj Nowrouzian, Mostafa Norbakhsh, Mehrdad Yadegari, Mohsen Jafarian Dehkordi
{"title":"Evaluation of a hydroalcoholic extract of liquorice (<i>Glycyrrhiza glabra</i> L.) root on the treatment of experimentally induced peritonitis in New Zealand male rabbits.","authors":"Mohammad Ahmadi, Iraj Nowrouzian, Mostafa Norbakhsh, Mehrdad Yadegari, Mohsen Jafarian Dehkordi","doi":"10.17221/31/2025-VETMED","DOIUrl":"10.17221/31/2025-VETMED","url":null,"abstract":"<p><p>This experimental study evaluated the therapeutic potential of a liquorice-derived hydroalcoholic extract in managing experimentally induced peritonitis in New Zealand rabbits. The animals were randomly divided into six groups (<i>n</i> = 6): one control group, one negative control group (infected but untreated), three treatment groups that received the liquorice-derived extract at 0.5, 1, and 2 g/kg, and one positive control group treated with enrofloxacin. The confirmation of peritoneal infection relied on histopathological and radiographic tests. The effect of the liquorice extract on the peritoneal infection was evaluated using biochemical, haematological, and ultrasound analyses across the groups. The ultrasound examination, along with the haematological and biochemical evaluation on the 20<sup>th</sup> day after induction, showed significant differences between the groups. The results demonstrated that higher doses of 1 g/kg and 2 g/kg were more effective than the lower dose of 0.5 g/kg. The haematological and biochemical analyses revealed significant differences in several variables (including WBC, neutrophils, fibrinogen, and liver enzymes) between the treated and control groups, with the most pronounced improvements observed in the group receiving 2 g/kg of liquorice extract, suggesting a dose-dependent therapeutic effect. The administration of a hydroalcoholic extract of liquorice at different doses, along with the standard treatment with enrofloxacin, affected various haematological and biochemical variables in the context of peritoneal infection management. In conclusion, the effectiveness of the liquorice-derived extract is dose-dependent and could be used as an effective therapeutic agent in peritoneal infections in New Zealand rabbits. These findings showed that the liquorice-derived extract effectively improves the local inflammatory and structural changes associated with peritoneal infection without adversely affecting systemic biochemical homeostasis.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 12","pages":"432-441"},"PeriodicalIF":0.8,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of prebiotic supplementation on the zootechnical and health performance in broiler chickens. 添加益生元对肉鸡动物生产性能和健康性能的影响。
IF 0.8 4区 农林科学
Veterinarni Medicina Pub Date : 2025-12-19 eCollection Date: 2025-12-01 DOI: 10.17221/37/2025-VETMED
Maroua Mansouri, Nabila Hammami, Achour Yahia, Khelaf Saidani, Zoubida Boumahdi, Dalila Tarzaali, Nora Mimoune
{"title":"Impact of prebiotic supplementation on the zootechnical and health performance in broiler chickens.","authors":"Maroua Mansouri, Nabila Hammami, Achour Yahia, Khelaf Saidani, Zoubida Boumahdi, Dalila Tarzaali, Nora Mimoune","doi":"10.17221/37/2025-VETMED","DOIUrl":"10.17221/37/2025-VETMED","url":null,"abstract":"<p><p>This study aimed to evaluate the effectiveness of mannan-oligosaccharides (MOSs) in broiler chicken feed throughout the complete rearing cycle, focusing on zootechnical performance and lactic acid bacteria. Over a period of 49 days, a total of one thousand and eighty (1 080) day-old ISA 15 chicks were divided into two (control and experimental) groups of 540 subjects each (9 replicates of 60 chicks per treatment). They were fed the same basic diet, but only the experimental group received a yeast cell wall extract-based prebiotic (AGRIMOS<sup>®</sup>, France), administered continuously at a dose of 2 g/kg throughout the different rearing phases. Under our local conditions, the prebiotic supplementation resulted in a significant increase in body weight gain (<i>P</i> < 0.01), reaching 1 559.82 ± 41.47 g during the growth phase and 913.20 ± 72.58 g during the finishing phase. Moreover, a significant reduction in the feed conversion ratio was observed throughout the rearing cycle (<i>P</i> < 0.05). Across all segments of the analysed intestinal tract (duodenum, ileum, and caecum), the data showed that chickens supplemented with the prebiotic had a significantly higher number of lactic acid bacteria than the control group at the start, growth, and finishing phases (<i>P</i> < 0.01). Our findings demonstrated a clear impact of the prebiotic on the feed utilisation under our rearing conditions, which required further studies to elucidate the underlying mechanisms of action.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 12","pages":"442-451"},"PeriodicalIF":0.8,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebellar hypoplasia in an Amur leopard cat (Prionailurus bengalensis euptilura) with feline panleukopenia virus infection. 猫泛白细胞减少症病毒感染的黑龙江豹猫小脑发育不全。
IF 0.8 4区 农林科学
Veterinarni Medicina Pub Date : 2025-12-19 eCollection Date: 2025-12-01 DOI: 10.17221/29/2025-VETMED
Jang-Hee Han, Jeong-Seop Oh, Seung Yoon Ahn, Jinyoung Kim, Do Na Lee, Young Deok Suh, Dae-Yong Kim, Junghee Yoon, Seong-Chan Yeon
{"title":"Cerebellar hypoplasia in an Amur leopard cat (<i>Prionailurus bengalensis euptilura</i>) with feline panleukopenia virus infection.","authors":"Jang-Hee Han, Jeong-Seop Oh, Seung Yoon Ahn, Jinyoung Kim, Do Na Lee, Young Deok Suh, Dae-Yong Kim, Junghee Yoon, Seong-Chan Yeon","doi":"10.17221/29/2025-VETMED","DOIUrl":"10.17221/29/2025-VETMED","url":null,"abstract":"<p><p>Cerebellar hypoplasia caused by feline panleukopenia virus (FPV) is well documented in domestic cats. Still, it remains unreported in wild felid species, including the Amur leopard cat (<i>Prionailurus bengalensis euptilura</i>). Understanding the impact of such viral diseases on wild populations is crucial for advancing conservation efforts and protecting wildlife. An orphaned Amur leopard cat exhibiting idiopathic ataxia was rescued. Initial diagnostics, including physical examination, radiography, and blood analysis, yielded no remarkable findings, though its clinical signs indicated an underlying neurological problem. Subsequent real-time polymerase chain reaction tests detected FPV. Magnetic resonance imaging (MRI) revealed brain lesions, including reduced cerebellar parenchyma and cerebrospinal fluid occupying the space where the cerebellum should be located. These findings suggested cerebellar hypoplasia caused by in utero FPV infection. The Amur leopard cat was euthanised owing to its permanent disability, and the necropsy confirmed a markedly shrunken cerebellum. At the same time, histopathology identified decreased cellularity of the molecular and granular layers of the cerebellar cortex. These results coincided with the MRI findings. This report suggests that cerebellar hypoplasia caused by FPV can occur in wild felid species.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 12","pages":"452-459"},"PeriodicalIF":0.8,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of vatinoxan co-administered with medetomidine on intraocular pressure and pupil diameter in healthy dogs. 瓦替诺森与美托咪定合用对健康犬眼压和瞳孔直径的影响。
IF 0.8 4区 农林科学
Veterinarni Medicina Pub Date : 2025-12-19 eCollection Date: 2025-12-01 DOI: 10.17221/47/2025-VETMED
Petr Rauser, Marketa Mrazova, Alena Sabatova, Karolina Jiraskova
{"title":"Effect of vatinoxan co-administered with medetomidine on intraocular pressure and pupil diameter in healthy dogs.","authors":"Petr Rauser, Marketa Mrazova, Alena Sabatova, Karolina Jiraskova","doi":"10.17221/47/2025-VETMED","DOIUrl":"10.17221/47/2025-VETMED","url":null,"abstract":"<p><p>Medetomidine, an alpha-2 adrenoreceptor agonist, is used for sedation. This study aimed to determine the influence of the alpha-2 adrenoreceptor antagonist vatinoxan, co-administered with medetomidine, on healthy dogs' intraocular pressure (IOP) and pupil diameter (PD). A prospective, randomised, masked clinical study was performed. A total of 40 conscious dogs were allocated to one of two groups: medetomidine 0.01 mg/kg with vatinoxan 0.2 mg/kg intravenously (MV-group, <i>n = </i>20) or medetomidine 0.01 mg/kg intravenously (M-group, <i>n</i> = 20). The IOP, PD, heart rate, and mean arterial pressure were measured prior to baseline and 5, 10, and 20 min after drug administration. Data were analysed using one- and two-way repeated measures ANOVA or their non-parametric equivalents (<i>P</i> < 0.05). No significant differences in IOP within or between groups were recorded. In the MV-group, PD remained unchanged compared to baseline. In the M-group, PD significantly (<i>P</i> = 0.007, <i>P</i> < 0.001, <i>P</i> < 0.001) decreased compared to baseline at all observation times. PD was significantly (<i>P</i> = 0.010, <i>P</i> < 0.001, <i>P</i> < 0.001) smaller in the M-group at all observation times compared to the MV-group. Vatinoxan co-administered with medetomidine, as well as medetomidine alone, did not significantly influence IOP. Vatinoxan with medetomidine did not affect PD, while medetomidine alone significantly reduced it.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 12","pages":"427-431"},"PeriodicalIF":0.8,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coagulation profile in bitches with pyometra: Standard tests and thromboelastography. 脓脓症母狗的凝血特征:标准试验和血栓弹性成像。
IF 0.8 4区 农林科学
Veterinarni Medicina Pub Date : 2025-11-28 eCollection Date: 2025-11-01 DOI: 10.17221/16/2025-VETMED
Alice Ramesova, Katerina Machackova, Ivana Vanova, Marie Lacinova, Alena Bartoskova, Robert Novotny, Roman Vitasek, Kristina Rehakova, Jaroslav Doubek
{"title":"Coagulation profile in bitches with pyometra: Standard tests and thromboelastography.","authors":"Alice Ramesova, Katerina Machackova, Ivana Vanova, Marie Lacinova, Alena Bartoskova, Robert Novotny, Roman Vitasek, Kristina Rehakova, Jaroslav Doubek","doi":"10.17221/16/2025-VETMED","DOIUrl":"10.17221/16/2025-VETMED","url":null,"abstract":"<p><p>This study aimed to determine coagulation changes in bitches with pyometra based on a series of coagulation tests and thromboelastography (TEG), and to assess the incidence of disseminated intravascular coagulation (DIC). Eighteen bitches with pyometra and thirty-four control bitches were examined. Haematological, biochemical, and following haemostasis parameters were measured, including: prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin activity (AT), and levels of fibrinogen (FBG), d-dimers (DD), tissue factor (TF), plasminogen (PLG), tissue plasminogen activator inhibitor 1 (TPAI-1), and thromboelastography. DIC was considered present if three or more of these parameters were abnormal: platelet count (<153 × 10<sup>9</sup>/l), PT (>8.1 s), aPTT (>25.5 s), FBG (<0.6 g/l), DD (>0.2 mg/l), and AT (<107%). Significant differences were found in the PT, aPTT, FBG, DD, TPAI-1, clotting time, α-angle, and maximal amplitude. According to our scoring system, two patients were DIC positive. The study found alterations in several coagulation tests and hypercoagulable TEG tracings in bitches with pyometra, which point to excessive activation of coagulation, delayed fibrinolysis, and the presence of DIC. No patient bled abnormally, which may suggest that DIC is not overt in the majority of pyometra patients.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 11","pages":"408-416"},"PeriodicalIF":0.8,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of a new ready-to-use PCV2 and Mycoplasma hyopneumoniae vaccine under field conditions. 一种新的即用型PCV2和肺炎支原体疫苗在野外条件下的效果。
IF 0.8 4区 农林科学
Veterinarni Medicina Pub Date : 2025-11-27 eCollection Date: 2025-11-01 DOI: 10.17221/25/2025-VETMED
Peter Trampus, Attila Csagola, Tamas Szalai, Nimrod Palmai, Adam Toth, Nora Terenyi, Zoltan Nagy, Nikoletta-Agnes Szeplaki, Gergely Somogyi, Eniko Rausch, Zoltan Penzes, Roman Krejci
{"title":"Efficacy of a new ready-to-use PCV2 and <i>Mycoplasma hyopneumoniae</i> vaccine under field conditions.","authors":"Peter Trampus, Attila Csagola, Tamas Szalai, Nimrod Palmai, Adam Toth, Nora Terenyi, Zoltan Nagy, Nikoletta-Agnes Szeplaki, Gergely Somogyi, Eniko Rausch, Zoltan Penzes, Roman Krejci","doi":"10.17221/25/2025-VETMED","DOIUrl":"10.17221/25/2025-VETMED","url":null,"abstract":"<p><p>Coinfection of porcine circovirus type 2 (PCV2) with <i>Mycoplasma hyopneumoniae</i> (<i>M. hyo</i>) causes major worldwide economic losses within the swine industry. This study aimed to assess the safety and efficacy of a single dose of a bivalent vaccine containing PCV2d and <i>M. hyo</i> antigen (Cirbloc<sup>®</sup> M Hyo) under field conditions. Two studies were performed under the GCP (Good Clinical Practice) requirements on farrow-to-finish farms in Hungary and Cyprus. On both farms, the presence of both PCV2 and <i>M. hyo</i> infection was demonstrated. For both studies, safety parameters were observed and measured from inclusion at 21 (±3) days of age until 14 days after vaccination. Efficacy parameters were observed and measured from inclusion until slaughter. Administration of the vaccine was safe in both studies, as no general, immediate, or local reactions were observed. The efficacy of the vaccine was confirmed in both studies as the following parameters were significantly reduced in the vaccinated groups compared to the control groups: viraemia, faecal shedding, viral load in lungs and in all collected lymphoid tissues, <i>M. hyo</i>-specific lung lesions, and average daily body weight gain. These results collectively support the vaccine's potential as an effective tool for disease control.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 11","pages":"401-407"},"PeriodicalIF":0.8,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seasonal dynamics and nutritional risk factors of gastric ulcers in fattening pigs: Results from a one-year field study in Slovakia. 育肥猪胃溃疡的季节性动态和营养危险因素:斯洛伐克一项为期一年的实地研究结果。
IF 1.3 4区 农林科学
Veterinarni Medicina Pub Date : 2025-11-27 eCollection Date: 2025-11-01 DOI: 10.17221/44/2025-VETMED
Zuzana Krepelkova, Katarina Bardova, Frantisek Zigo, Arpad Csorgo, Jaroslav Novotny
{"title":"Seasonal dynamics and nutritional risk factors of gastric ulcers in fattening pigs: Results from a one-year field study in Slovakia.","authors":"Zuzana Krepelkova, Katarina Bardova, Frantisek Zigo, Arpad Csorgo, Jaroslav Novotny","doi":"10.17221/44/2025-VETMED","DOIUrl":"10.17221/44/2025-VETMED","url":null,"abstract":"<p><p>This study aimed to comprehensively evaluate the prevalence, severity, and risk factors associated with gastric lesions in fattening pigs across all four seasons in Slovakia. A total of 1 944 porcine stomachs were examined post-mortem at commercial slaughterhouses, focusing on the non-glandular region (<i>pars oesophagea</i>). A macroscopic evaluation was conducted using a standardised scoring system (0-3), in which gastric lesions, including parakeratosis, erosions, and ulcerations, were observed in 48% of the examined stomachs. Significant seasonal variation was detected, with the highest lesion prevalence recorded during the summer months, likely due to heat stress and reduced feed intake, and the lowest incidence of pathological changes seen in autumn. The gastric fullness had a notable impact: empty and liquid-filled stomachs were more frequently associated with severe mucosal damage, while full stomachs exhibited a protective effect. Furthermore, the feeding regimen played a crucial role: the pigs receiving wet feed had a significantly lower prevalence of gastric lesions than those on a dry feeding regimen. These results underscore the multifactorial nature of gastric ulceration in pigs and highlight the importance of nutritional and environmental management strategies in intensive production systems.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 11","pages":"393-400"},"PeriodicalIF":1.3,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental ultrasound stimulator for improving the diffusion of exosomes and drugs into lung tissue. 用于改善外泌体和药物向肺组织扩散的实验性超声刺激器。
IF 0.8 4区 农林科学
Veterinarni Medicina Pub Date : 2025-11-27 eCollection Date: 2025-11-01 DOI: 10.17221/41/2025-VETMED
Jaroslav Prucha, Josef Skopalik, Tomas Parak, Petr Bratka, Julie Cuprova
{"title":"Experimental ultrasound stimulator for improving the diffusion of exosomes and drugs into lung tissue.","authors":"Jaroslav Prucha, Josef Skopalik, Tomas Parak, Petr Bratka, Julie Cuprova","doi":"10.17221/41/2025-VETMED","DOIUrl":"10.17221/41/2025-VETMED","url":null,"abstract":"<p><p>Pulmonary fibrosis is not only a consequence of the recent COVID-19 pandemic, but is increasingly recognised by both human and veterinary healthcare providers. Pulmonary fibrosis is a progressive condition that leads to a decline in respiratory function and even death. In this work, we compared MSC-derived exosomes with conventional anti-inflammatory drug treatments. Exosomes from stimulated MSCs displayed higher miRNA concentrations (in particular, miRNA-30b was significantly increased). A set of rats with induced lung fibrosis were divided into four groups: NC (control - no treatment), A2 (exosome infusion), A3 (exosome infusion combined with ultrasound stimulation), and F1 (tamoxifen/metformin drug treatment). The rats' lungs were subjected to histological analysis; the fibrosis scores for groups F1 and A3 were very similar and decreased significantly compared with group NC. Ultrasound-facilitated diffusion of exosomes from the capillaries into the lung tissue could represent an innovative therapeutic approach for slowing fibrosis and prolonging the active life of the organism.</p>","PeriodicalId":23532,"journal":{"name":"Veterinarni Medicina","volume":"70 11","pages":"417-426"},"PeriodicalIF":0.8,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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