Veterinary Pathology最新文献_第4页

Pathology of "double scale" skin defect in farmed American alligators (Alligator mississippiensis) and the possible association with hepatic fibrosis. 养殖美洲鳄（Alligator mississippiensis）"双鳞 "皮肤缺损的病理及与肝纤维化的可能关联。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-03-29 DOI: 10.1177/03009858241238685

Ilaria M Piras, Annemarie Bezuidenhout, Josué Díaz-Delgado, Deirdre Slawski, Pamela A Kelly

{"title":"Pathology of \"double scale\" skin defect in farmed American alligators (Alligator mississippiensis) and the possible association with hepatic fibrosis.","authors":"Ilaria M Piras, Annemarie Bezuidenhout, Josué Díaz-Delgado, Deirdre Slawski, Pamela A Kelly","doi":"10.1177/03009858241238685","DOIUrl":"10.1177/03009858241238685","url":null,"abstract":"\"Double scale\" is a poorly characterized skin defect of crocodilians that drastically reduces the economic value of crocodilian skin. This study investigated the morphology and pathogenesis of double scale in a ranching farm of American alligators (Alligator mississippiensis). We compared the histopathology of skin and selected organs (liver, lung, kidney, heart, spleen, intestine, and brain) of alligators with double scale against healthy control animals, together with serum and liver vitamin and mineral levels. Skin affected with double scale had statistically significant hyperkeratosis, epidermal atrophy, and increased basal cell degeneration compared with control alligators (P < .0001). Interestingly, all alligators with double scale had varying degrees of hepatic fibrosis. Feed analysis showed that alligators that had double scale and hepatic fibrosis had prolonged dietary exposure to high levels of vitamin A, iron, and copper. Serum analysis indicated that levels of zinc (p < .0001), copper (P < .05), and vitamin E (P < .002) were significantly lower in alligators with hepatic fibrosis and double scale compared with controls. Finally, immunohistochemical analysis of skin with double scale showed a marked reduction in immunolabeling with the zinc-binding protein metallothionein. These results suggest that zinc deficiency, in combination with other micronutrient anomalies, may play a role in the pathogenesis of double scale in alligators with liver fibrosis.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"815-828"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal alterations in cats (Felis catus) housed in shelters and affected by systemic AA-amyloidosis: Clinicopathological data, histopathology, and ultrastructural features. 收容所中受全身 AA 淀粉样变性影响的猫（Felis catus）的肾脏变化：临床病理数据、组织病理学和超微结构特征。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-06-12 DOI: 10.1177/03009858241257903

Filippo Ferri, Silvia Ferro, Silvia Lucia Benali, Luca Aresu, Lorenza Muscardin, Federico Porporato, Francesco Rossi, Chiara Guglielmetti, Enrico Gallo, Carlo Palizzotto, Carolina Callegari, Stefano Ricagno, Maria Mazza, Luigi Michele Coppola, Gabriele Gerardi, Francesca Lavatelli, Serena Caminito, Giulia Mazzini, Giovanni Palladini, Giampaolo Merlini, Eric Zini

{"title":"Renal alterations in cats (Felis catus) housed in shelters and affected by systemic AA-amyloidosis: Clinicopathological data, histopathology, and ultrastructural features.","authors":"Filippo Ferri, Silvia Ferro, Silvia Lucia Benali, Luca Aresu, Lorenza Muscardin, Federico Porporato, Francesco Rossi, Chiara Guglielmetti, Enrico Gallo, Carlo Palizzotto, Carolina Callegari, Stefano Ricagno, Maria Mazza, Luigi Michele Coppola, Gabriele Gerardi, Francesca Lavatelli, Serena Caminito, Giulia Mazzini, Giovanni Palladini, Giampaolo Merlini, Eric Zini","doi":"10.1177/03009858241257903","DOIUrl":"10.1177/03009858241257903","url":null,"abstract":"AA-amyloidosis is frequent in shelter cats, and chronic kidney disease is the foremost cause of death. The aims were to describe kidney laboratory and microscopic findings in shelter cats with AA-amyloidosis. Cats were included if kidney specimens were collected post-mortem and laboratory data were available within 6 months before death. Renal lesions were evaluated with optical and electron microscopy. Mass spectrometry was used to characterize amyloid. Nine domestic short-hair cats were included; 4 females and 5 males with a median age of 8 years (range = 2-13). All cats had blood analyses and urinalyses available. Serum creatinine concentrations were increased in 6 cats and symmetric dimethylarginine was increased in all of the cats. All of the cats had proteinuria. Eight of 9 cats had amyloid in the medulla, and 9 had amyloid in the cortex (glomeruli). All cats had amyloid in the interstitium. Six cats had concurrent interstitial nephritis and 1 had membranoproliferative glomerulonephritis. All cats had extrarenal amyloid deposits. Amyloid was AA in each case. In conclusion, renal deposition of amyloid occurs in both cortex and medulla in shelter cats and is associated with azotemia and proteinuria. Renal involvement of systemic AA-amyloidosis should be considered in shelter cats with chronic kidney disease. The cat represents a natural model of renal AA-amyloidosis.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"771-782"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short beak and dwarfism syndrome among Pekin ducks: First detection, full genome sequencing, and immunohistochemical signals of novel goose parvovirus in tongue tissue. 北京鸭的短喙和侏儒症综合征：舌组织中新型鹅副病毒的首次检测、全基因组测序和免疫组化信号。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-05-07 DOI: 10.1177/03009858241249108

Amal A M Eid, Mohamed A Lebdah, Sarah S Helal, Mohamed G Seadawy, Abdelgalil El-Gohary, Mohamed R Mousa, Ayman H El-Deeb, Fakry F Mohamed, Reham M ElBakrey

{"title":"Short beak and dwarfism syndrome among Pekin ducks: First detection, full genome sequencing, and immunohistochemical signals of novel goose parvovirus in tongue tissue.","authors":"Amal A M Eid, Mohamed A Lebdah, Sarah S Helal, Mohamed G Seadawy, Abdelgalil El-Gohary, Mohamed R Mousa, Ayman H El-Deeb, Fakry F Mohamed, Reham M ElBakrey","doi":"10.1177/03009858241249108","DOIUrl":"10.1177/03009858241249108","url":null,"abstract":"Novel goose parvovirus (NGPV) is continuously threatening the global duck industry, as it causes short beak and dwarfism syndrome among different duck breeds. In this study, we investigated the viral pathogenesis in the tongue of affected ducks, as a new approach for deeper understanding of the syndrome. Seventy-three, 14- to 60-day-old commercial Pekin ducks were clinically examined. Thirty tissue pools of intestine and tongue (15 per tissue) were submitted for molecular identification. Clinical signs in the examined ducks were suggestive of parvovirus infection. All examined ducks had short beaks. Necrotic, swollen, and congested protruding tongues were recorded in adult ducks (37/73, 51%). Tongue protrusion without any marked congestion or swelling was observed in 20-day-old ducklings (13/73, 18%), and no tongue protrusion was observed in 15-day-old ducklings (23/73, 32%). Microscopically, the protruding tongues of adult ducks showed necrosis of the superficial epithelial layer with vacuolar degeneration. Glossitis was present in the nonprotruding tongues of young ducks, which was characterized by multifocal lymphoplasmacytic aggregates and edema in the propria submucosa. Immunohistochemical examination displayed parvovirus immunolabeling, mainly in the tongue propria submucosa. Based on polymerase chain reaction, goose parvovirus was detected in 9 out of 15 tongue sample pools (60%). Next-generation sequencing confirmed the presence of a variant goose parvovirus that is globally named NGPV and closely related to Chinese NGPV isolates. Novel insights are being gained from the study of NGPV pathogenesis in the tongue based on molecular and immunohistochemical identification.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"829-838"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage polarization in lymph node granulomas from cattle and pigs naturally infected with Mycobacterium tuberculosis complex. 自然感染结核分枝杆菌复合体的牛和猪淋巴结肉芽肿中的巨噬细胞极化。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-03-01 DOI: 10.1177/03009858241231606

Fernanda Larenas-Muñoz, Mohamed G Hamed, Inés Ruedas-Torres, José María Sánchez-Carvajal, Javier Domínguez, Francisco José Pallarés, Librado Carrasco, Irene M Rodríguez-Gómez, Jaime Gómez-Laguna

{"title":"Macrophage polarization in lymph node granulomas from cattle and pigs naturally infected with Mycobacterium tuberculosis complex.","authors":"Fernanda Larenas-Muñoz, Mohamed G Hamed, Inés Ruedas-Torres, José María Sánchez-Carvajal, Javier Domínguez, Francisco José Pallarés, Librado Carrasco, Irene M Rodríguez-Gómez, Jaime Gómez-Laguna","doi":"10.1177/03009858241231606","DOIUrl":"10.1177/03009858241231606","url":null,"abstract":"Tuberculosis in animals is caused by members of the Mycobacterium tuberculosis complex (MTC), with the tuberculous granuloma being the main characteristic lesion. The macrophage is the main cell type involved in the development of the granuloma and presents a wide plasticity ranging from polarization to classically activated or pro-inflammatory macrophages (M1) or to alternatively activated or anti-inflammatory macrophages (M2). Thus, this study aimed to analyze macrophage polarization in granulomas from cattle and pig lymph nodes naturally infected with MTC. Tuberculous granulomas were microscopically categorized into four stages and a panel of myeloid cells (CD172a/calprotectin), M1 macrophage polarization (iNOS/CD68/CD107a), and M2 macrophage polarization (Arg1/CD163) markers were analyzed by immunohistochemistry. CD172a and calprotectin followed the same kinetics, having greater expression in late-stage granulomas in pigs. iNOS and CD68 had higher expression in cattle compared with pigs, and the expression was higher in early-stage granulomas. CD107a immunolabeling was only observed in porcine granulomas, with a higher expression in stage I granulomas. Arg1+ cells were significantly higher in pigs than in cattle, particularly in late-stage granulomas. Quantitative analysis of CD163+ cells showed similar kinetics in both species with a consistent frequency of immunolabeled cells throughout the different stages of the granuloma. Our results indicate that M1 macrophage polarization prevails in cattle during early-stage granulomas (stages I and II), whereas M2 phenotype is observed in later stages. Contrary, and mainly due to the expression of Arg1, M2 macrophage polarization is predominant in pigs in all granuloma stages.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"792-802"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139997565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic challenge in veterinary pathology: Tri-cavitary effusion in a cat with systemic pyogranulomatous inflammation. 兽医病理学诊断难题：一只患有全身化脓性炎症的猫的三腔积液。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-01-21 DOI: 10.1177/03009858241226648

Sai Fingerhood, Pradeep Neupane, Edward B Breitschwerdt, Eunju April Choi

引用次数: 0

A brief history of the American College of Veterinary Pathologists (2009-2024). 美国兽医病理学家学会简史（2009-2024 年）。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-07-23 DOI: 10.1177/03009858241265038

Krista M D La Perle

引用次数: 0

Image challenge in Veterinary Pathology, answers: Pulmonary diseases. 兽医病理学中的图像挑战，答案：肺部疾病。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 DOI: 10.1177/03009858241257926

引用次数: 0

Image challenge in Veterinary Pathology. 兽医病理学中的图像挑战。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 DOI: 10.1177/03009858241257895

引用次数: 0

Assessment of SOX10 expression in 437 canine neoplasms of different embryologic origins. 评估 437 种不同胚胎起源的犬肿瘤中 SOX10 的表达。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-02-17 DOI: 10.1177/03009858241231562

Sophie Nelissen, Andrew D Miller

{"title":"Assessment of SOX10 expression in 437 canine neoplasms of different embryologic origins.","authors":"Sophie Nelissen, Andrew D Miller","doi":"10.1177/03009858241231562","DOIUrl":"10.1177/03009858241231562","url":null,"abstract":"Several members of the SRY-related HMG-box (SOX) protein family are implicated in tumorigenesis, metastasis, and regulation of the tumor microenvironment. SOX10, which is involved in neural crest cell migration and differentiation, has long been recognized a sensitive and specific immunohistochemical (IHC) marker in the diagnosis of melanoma in humans. However, expression of SOX10 in other tumor types has infrequently been evaluated in humans until recently and has not been thoroughly investigated in the dog. Our aim was to characterize the expression of SOX10 in canine neoplasms to objectively assess its value as a diagnostic IHC marker. Immunohistochemistry for SOX10 was performed on 437 archived, formalin-fixed paraffin-embedded tissues from representative canine neoplasms of ectodermal (15 tumor types), mesodermal (13 tumor types), endodermal (8 tumor types), and mixed/unknown (7 tumor types) embryologic origin. Oral and cutaneous tumors of melanocytic origin were used as positive controls. Intense SOX10 immunolabeling was observed in most tumors of ectodermal origin, including consistent expression in mammary carcinomas, and gliomas. Embryonal and hair follicle neoplasms inconsistently exhibited strong nuclear immunolabeling. Oral fibrosarcomas and undifferentiated oral sarcomas both inconsistently exhibited moderate to strong nuclear immunolabeling. Neoplasms of mesodermal and endodermal origin lacked immunolabeling. Salivary carcinomas, representing an unknown/mixed embryologic origin, were strongly labeled. SOX10 expression is not limited to melanomas, but is expressed by canine tumors of diverse tissues and embryologic derivation. Importantly, expression of SOX10 by a subset of oral sarcomas impairs its value as a marker for spindle cell oral melanomas.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"704-711"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139747522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From cutting-edge liquid biopsy to the evolving landscape of antibody drug conjugates and emerging trends in digital and computational pathology: Award-winning presentations await you at the 2024 ACVP/ASVCP annual meeting. 从前沿的液体活检到不断发展的抗体药物共轭物，以及数字和计算病理学的新兴趋势：2024 年 ACVP/ASVCP 年会将为您奉上屡获殊荣的精彩演讲。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-07-26 DOI: 10.1177/03009858241266946

Sanjeev Gumber

引用次数: 0