Veterinary Pathology最新文献_第5页

Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in canine tumors. 有丝分裂活动：关于犬肿瘤评估方法和预后价值的系统性文献综述。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-03-27 DOI: 10.1177/03009858241239565

Christof A Bertram, Taryn A Donovan, Alexander Bartel

{"title":"Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in canine tumors.","authors":"Christof A Bertram, Taryn A Donovan, Alexander Bartel","doi":"10.1177/03009858241239565","DOIUrl":"10.1177/03009858241239565","url":null,"abstract":"One of the most relevant prognostic indices for tumors is cellular proliferation, which is most commonly measured by the mitotic activity in routine tumor sections. The goal of this systematic review was to analyze the methods and prognostic relevance of histologically measuring mitotic activity that have been reported for canine tumors in the literature. A total of 137 articles that correlated the mitotic activity in canine tumors with patient outcome were identified through a systematic (PubMed and Scopus) and nonsystematic (Google Scholar) literature search and eligibility screening process. Mitotic activity methods encompassed the mitotic count (MC, number of mitotic figures per tumor area) in 126 studies, presumably the MC (method not specified) in 6 studies, and the mitotic index (MI, number of mitotic figures per number of tumor cells) in 5 studies. A particularly high risk of bias was identified based on the available details of the MC methods and statistical analyses, which often did not quantify the prognostic discriminative ability of the MC and only reported P values. A significant association of the MC with survival was found in 72 of 109 (66%) studies. However, survival was evaluated by at least 3 studies in only 7 tumor types/groups, of which a prognostic relevance is apparent for mast cell tumors of the skin, cutaneous melanoma, and soft tissue tumor of the skin and subcutis. None of the studies using the MI found a prognostic relevance. This review highlights the need for more studies with standardized methods and appropriate analysis of the discriminative ability to prove the prognostic value of the MC and MI in various tumor types. Future studies are needed to evaluate the influence of the performance of individual pathologists on the appropriateness of prognostic thresholds and investigate methods to improve interobserver reproducibility.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"752-764"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to "Eponyms in science: A proposal to minimize their use". 对 "科学中的外来语地名：关于尽量减少使用外来语地名的建议

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-07-23 DOI: 10.1177/03009858241262494

Grant Maxie

引用次数: 0

Embolic necrosuppurative pneumonia in domestic cats induced by a novel Neisseria species. 一种新型奈瑟菌诱发家猫栓塞性坏死性肺炎。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-03-05 DOI: 10.1177/03009858241235392

Christopher R Bolt, Vikash K Singh, Arno Wünschmann, Hallie C Richards, Kelly L Gehlhaus, Sunil K Mor

{"title":"Embolic necrosuppurative pneumonia in domestic cats induced by a novel Neisseria species.","authors":"Christopher R Bolt, Vikash K Singh, Arno Wünschmann, Hallie C Richards, Kelly L Gehlhaus, Sunil K Mor","doi":"10.1177/03009858241235392","DOIUrl":"10.1177/03009858241235392","url":null,"abstract":"Three cats, aged 2 to 11 years, presented to the University of Minnesota Veterinary Diagnostic Laboratory over a 3-year period following euthanasia or death due to respiratory distress. Thoracic radiographs revealed nodular, soft tissue opacities throughout the lung fields in all cases. On postmortem examination, approximately 60% to 80% of the lung parenchyma were expanded by multifocal to coalescing, well-demarcated, beige, semi-firm nodules. Histologically, large numbers of neutrophils, fewer macrophages, fibrin, and cellular and karyorrhectic debris effaced the pulmonary parenchyma. The inflammatory foci contained aggregates of gram-negative cocci. 16s rRNA Sanger sequencing and whole-genome sequencing identified the bacteria isolated from the lung of all cats under aerobic conditions as a novel Neisseria spp. Based on whole-genome sequence analysis, all 3 sequences shared 92.71% and 92.67% average nucleotide identity with closely related Neisseria animaloris NZ LR134440T and Neisseria animaloris GCA 002108605T, respectively. The in silico DNA-DNA hybridization identity compared to our isolates was 46.6% and 33.8% with strain DSM Neisseria zoodegmatis 21642 and strain DSM 21643, respectively. All 3 sequences have less than 95% average nucleotide identity and less than 70% DNA-DNA hybridization identity, suggesting that the 3 isolates are a novel species of the genus Neisseria. Infection with Neisseria spp. induces an embolic pneumonia in cats that radiographically and pathologically resembles a metastatic neoplastic process and should be considered among the etiologic differential diagnoses in cases of infectious pulmonary disease with a disseminated, nodular lung pattern.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"783-791"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eponyms in science: A proposal to minimize their use. 科学中的外来语地名：关于尽量减少使用外来语地名的建议。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-05-09 DOI: 10.1177/03009858241252408

F Yvonne Schulman, Daniel R Rissi

引用次数: 0

Splenic rupture in dairy cattle: Report of 24 cases. 奶牛脾破裂：24 例报告

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-08-27 DOI: 10.1177/03009858241273172

Vitor W Horn, Fernanda F Perosa, Anderson H Gris, Manoela M Piva, C Robert Stilz, Érica Boldori, Mateus E Gabriel, Giovana Pelisser, Saulo P Pavarini, Teane M A Gomes, Ricardo E Mendes

{"title":"Splenic rupture in dairy cattle: Report of 24 cases.","authors":"Vitor W Horn, Fernanda F Perosa, Anderson H Gris, Manoela M Piva, C Robert Stilz, Érica Boldori, Mateus E Gabriel, Giovana Pelisser, Saulo P Pavarini, Teane M A Gomes, Ricardo E Mendes","doi":"10.1177/03009858241273172","DOIUrl":"https://doi.org/10.1177/03009858241273172","url":null,"abstract":"Splenic rupture in cattle is scarcely described in the literature. The aim of this work was to report the occurrence of splenic rupture in cattle in southern Brazil as well as to describe the causes of the condition. Between 2013 and 2022, 24 of the 1769 bovine necropsies performed in southern Brazil were due to splenic rupture, accounting for 1.36% of the diagnoses. Animals died due to hemoperitoneum caused by a rupture in the splenic capsule, typically associated with marked splenomegaly and a large hematoma between the capsule and the parenchyma. Clinical signs were described in a subset of cases (11 of 24 cases, 46%) and included apathy, abdominal pain, mucosal pallor, tachycardia, and respiratory distress. However, the majority (13 of 24 cases, 54%) presented as sudden death. The underlying cause of splenic rupture was established as follows: 16 cases (67%) secondary to babesiosis, 4 cases (17%) due to lymphoma, 1 case (4%) due to a thrombus, 1 case (4%) due to external trauma, 1 case due to a ruptured nodular lymphoid hyperplasia (4%), and 1 case of undetermined cause (4%). Hypovolemic shock caused by splenic rupture is an important cause of death of dairy cattle, and babesiosis and bovine leukemia virus-associated lymphoma are among the most common etiologic diagnoses (84% of cases). The description of the causes of this condition is important to clarify the pathogenesis and occurrence of splenic rupture in dairy cattle.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241273172"},"PeriodicalIF":2.3,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokeratin AE1/AE3 immunolabeling in epithelioid hemangiosarcoma. 上皮样血管肉瘤中的细胞角蛋白AE1/AE3免疫标记。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-08-20 DOI: 10.1177/03009858241273268

Daniel Felipe Barrantes Murillo, Tatiane Terumi Negrão Watanabe, Dominique J Wiener, Andrew Miller, Daniel R Rissi, Maninder Sandey

{"title":"Cytokeratin AE1/AE3 immunolabeling in epithelioid hemangiosarcoma.","authors":"Daniel Felipe Barrantes Murillo, Tatiane Terumi Negrão Watanabe, Dominique J Wiener, Andrew Miller, Daniel R Rissi, Maninder Sandey","doi":"10.1177/03009858241273268","DOIUrl":"https://doi.org/10.1177/03009858241273268","url":null,"abstract":"Epithelioid hemangiosarcoma (EH), a rare histological variant of hemangiosarcoma, is reported in various animal species, including humans, dogs, cows, horses, and cats. Epithelioid hemangiosarcomas are composed of highly pleomorphic epithelioid cells arranged in cords, islands, nests, or solid cellular areas, similar to epithelial neoplasms. Moreover, in humans, approximately 50% of EHs have cytoplasmic immunolabeling for cytokeratin AE1/AE3 (CK AE1/AE3), making it challenging to distinguish them from carcinomas. This retrospective study assessed the CK AE1/AE3 immunolabeling in canine EH cases from 5 veterinary institutions. Immunohistochemistry for CD31 and CK AE1/AE3 was performed on 30 cases. CK AE1/AE3 immunolabeling was detected in 43% (13/30) of cases, with cytoplasmic labeling ranging from 5% to 100% of neoplastic cells. All tumors consistently had membranous immunolabeling for CD31. The CK AE1/AE3 immunolabeling pattern in canine EHs closely resembled those documented in humans, indicating a similar diagnostic challenge. Therefore, it is recommended to include a vascular immunohistochemistry marker, such as CD31, whenever EH is suspected, particularly in small incisional cutaneous and subcutaneous biopsies.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241273268"},"PeriodicalIF":2.3,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testicular tumors in commercial boars with infertility: A gross, histologic, and immunohistochemical study. 不育商品公猪的睾丸肿瘤：大体、组织学和免疫组织化学研究。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-08-16 DOI: 10.1177/03009858241269836

Raquel Ausejo, María Victoria Falceto, Olga Mitjana, Ana María Garrido, Juan José Badiola, Bernardino Moreno

{"title":"Testicular tumors in commercial boars with infertility: A gross, histologic, and immunohistochemical study.","authors":"Raquel Ausejo, María Victoria Falceto, Olga Mitjana, Ana María Garrido, Juan José Badiola, Bernardino Moreno","doi":"10.1177/03009858241269836","DOIUrl":"https://doi.org/10.1177/03009858241269836","url":null,"abstract":"Tumors in boars are uncommon, and testicular tumors even rarer. This study describes the pathological and immunohistochemical characteristics of a case series of testicular tumors in commercial boars with fertility problems. Tumors were detected in 19 of 333 animals (19/333, 5.9%). Macroscopically, tumors were observed in 13 (13/19, 68%) boars, while 6 cases (6/19, 32%) were only detected by microscopic examination. Testicular enlargement was observed in 1 boar, while in the others, tumors were only observed after removal of the scrotal skin or after sectioning of the testis. Histologically, tumors were classified as seminomas (16/19, 84%), mixed germ cell-stromal tumors (2/19, 11%), and B-cell lymphoma (1/19, 5%). Seminomas had 3 different growth patterns: intratubular (6/16, 38%), diffuse (4/16, 25%), and intratubular/diffuse (6/16, 38%). All tumors that were not evident on macroscopic examination were intratubular seminomas. Intratesticular metastases were observed in 2 cases and extratesticular metastases, located in the pampiniform plexus, were observed in 1 case. In 1 seminoma, the rete testis was also involved. By immunohistochemistry, all intratubular seminomas were negative for c-kit, cytokeratin, and vimentin. In diffuse seminomas, c-kit and cytokeratin were also negative, while vimentin showed granular or perinuclear cytoplasmic labeling in some areas. PAX-5 and CD-3 antibodies classified the lymphoma as a B-cell lymphoma. This study suggests that testicular tumors in boars may be more common than previously reported, especially when microscopic examination is performed. It also shows that testicular tumors in pigs are predominantly seminomas.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241269836"},"PeriodicalIF":2.3,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and characterization of polyglucosan bodies in the cerebella of montserrat orioles (Icterus oberi). 蒙特塞拉特黄鹂（Icterus oberi）小脑中多葡聚糖体的发生率和特征。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-08-15 DOI: 10.1177/03009858241270000

Simon Spiro, Marta Pereira, Kieran A Bates, Zane Jaunmuktane, David J Everest, Mark F Stidworthy, Daniela Denk, Alejandro Núñez, Ethan Wrigglesworth, Andrew Theodoulou, Alberto Barbon, Emma Nye, Yan Liu, Adrian L Smith, Steven Fiddaman

{"title":"Incidence and characterization of polyglucosan bodies in the cerebella of montserrat orioles (Icterus oberi).","authors":"Simon Spiro, Marta Pereira, Kieran A Bates, Zane Jaunmuktane, David J Everest, Mark F Stidworthy, Daniela Denk, Alejandro Núñez, Ethan Wrigglesworth, Andrew Theodoulou, Alberto Barbon, Emma Nye, Yan Liu, Adrian L Smith, Steven Fiddaman","doi":"10.1177/03009858241270000","DOIUrl":"https://doi.org/10.1177/03009858241270000","url":null,"abstract":"Polyglucosan bodies are accumulations of insoluble glucose polymers and proteins that form intracytoplasmic inclusions in the brain, large numbers of which can be indicative of neurodegenerative diseases such as Lafora disease. Montserrat orioles (Icterus oberi) are an icterid passerine endemic to Montserrat with conservation populations maintained in captivity abroad. We demonstrate that polyglucosan bodies are unusually abundant in the cerebellar molecular and Purkinje cell layers and cerebellar peduncles of captive-bred and wild-caught Montserrat orioles. The bodies are periodic acid-Schiff positive and diastase resistant and label with concanavalin A and for ubiquitin, consistent with those seen in humans. We found no association of the polyglucosan bodies with concurrent neurological lesions or clinical signs, nor with EPM2A and EPM2B gene mutations associated with Lafora disease. We conclude that an abundance of cerebellar polyglucosan bodies may be a normal finding in aged Montserrat orioles and not a threat to the captive breeding population.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241270000"},"PeriodicalIF":2.3,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral fibrolipoma in dogs: Retrospective case series study and comparative review. 犬口腔纤维脂肪瘤：回顾性病例系列研究和比较综述。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-08-15 DOI: 10.1177/03009858241273238

Daniel Felipe Barrantes Murillo, Alexis Berrocal, Cynthia Bell, Daniel R Rissi, Linden E Craig, Erin A Graham, Emily J Brinker, Tatiane Terumi Negrão Watanabe

{"title":"Oral fibrolipoma in dogs: Retrospective case series study and comparative review.","authors":"Daniel Felipe Barrantes Murillo, Alexis Berrocal, Cynthia Bell, Daniel R Rissi, Linden E Craig, Erin A Graham, Emily J Brinker, Tatiane Terumi Negrão Watanabe","doi":"10.1177/03009858241273238","DOIUrl":"https://doi.org/10.1177/03009858241273238","url":null,"abstract":"Fibrolipoma is defined as a typical lipoma transected by variable amounts of paucicellular and collagenous fibrous components. Oral and lingual fibrolipomas are well-recognized histological entities in human medicine that are slightly more prevalent in females, occur most commonly after the fourth decade, and arise from the buccal mucosa. The documentation of this neoplasm in the oral cavity is lacking in veterinary medicine. Through a multi-institutional retrospective compilation of cases submitted to diagnostic pathology services, here we describe the clinical and pathologic features of oral fibrolipomas in dogs. A total of 112 cases of oral fibrolipomas in dogs were retrieved. The mean age was 10.1 years (range 2-16 years, ±2.63 years standard deviation), with an average tumor size of 1.7 cm (range 0.2-8 cm, ±1.1 cm standard deviation). The most common location was the tongue (57.1%, 64/112), followed by the buccal mucosa (15.2%, 16/112), sublingual area (8.0%, 9/112), gingiva and lip (4.5%, 5/112 each), and palate (1 case). The anatomical location of oral fibrolipomas only differed significantly among the dog breeds (P < .001) but not among sex, age, anamnesis, or reason for submission. The tumor was most commonly reported in males (69.7%, 78/112), and in 62.5% (70/112) of the cases, the tumor was an incidental finding. Fibrolipoma should be considered a differential diagnosis when considering benign lingual and other oral soft tissue masses in dogs.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241273238"},"PeriodicalIF":2.3,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rosettes and pseudorosettes in veterinary neuropathology. 兽医神经病理学中的玫瑰花瓣和假花瓣。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-08-14 DOI: 10.1177/03009858241269877

Daniel R Rissi, Andrew D Miller

引用次数: 0