Hodias S de Oliveira Filho, José L Costa Duarte, Gabriel F Paranhos, João Paulo G da Silva, Paulo M da Nóbrega Neto, Bianca B Lins, Wellington M Dos Santos, Rafael L de Oliveira, Renato L Santos, Saulo Petinatti Pavarini, Mayra F Tsoi, Dalen Agnew, Jeann Leal de Araújo
{"title":"Clinicopathological findings of sustentacular cell tumors in 13 singing tournament passerine birds.","authors":"Hodias S de Oliveira Filho, José L Costa Duarte, Gabriel F Paranhos, João Paulo G da Silva, Paulo M da Nóbrega Neto, Bianca B Lins, Wellington M Dos Santos, Rafael L de Oliveira, Renato L Santos, Saulo Petinatti Pavarini, Mayra F Tsoi, Dalen Agnew, Jeann Leal de Araújo","doi":"10.1177/03009858261477048","DOIUrl":"https://doi.org/10.1177/03009858261477048","url":null,"abstract":"<p><p>Testicular tumors are rarely reported in passerine birds and are typically described as isolated cases. This study characterizes the clinical, pathological, immunohistochemical, and epidemiological features of 13 testicular neoplasms diagnosed in ultramarine grosbeaks (<i>Cyanoloxia brissonii; n</i> = 12) and a green-winged saltator (<i>Saltator similis; n</i> = 1), 2 South American passerine species commonly used in singing competitions. Clinical signs included coelomic distension, respiratory distress, pododermatitis, feather loss, cloacal prolapse, and decreased vocalization. Radiography demonstrated displacement of coelomic organs and, in some cases, markedly reduced gastrointestinal transit associated with tumor compression. Grossly, tumors were large, pale tan to yellow, frequently multilobulated, and caused compression of adjacent viscera. Histologically, all neoplasms were classified as sustentacular cell tumors (SCTs) based on established histomorphological criteria adapted for avian testes. Most tumors exhibited a tubular growth pattern (77%), whereas diffuse (15%) and mixed-type (7%) patterns were less common. Rare Call-Exner-like bodies and extensive contralateral testicular atrophy were observed. Immunohistochemically, KIT (CD117) and neuron-specific enolase were the most consistently expressed markers, whereas melan-A, calretinin, and GATA-4 showed sporadic labeling and inhibin-α, vimentin, and pancytokeratin were consistently negative. Liver metastases occurred in 2 ultramarine grosbeaks, demonstrating the malignant potential of SCTs in passerines. This study represents the largest series of testicular tumors reported in passerine birds and provides the first evidence that participation in singing competitions is significantly associated with the development of SCTs in ultramarine grosbeaks. Our results underscore the importance of including testicular neoplasia as a differential diagnosis in cases of coelomic distension in passerines.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858261477048"},"PeriodicalIF":2.3,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Systemic fibrinogen Aα-chain amyloidosis in a blue-winged kookaburra (<i>Dacelo leachii</i>): The first non-AA systemic amyloidosis in avians.","authors":"Tomoaki Murakami, Natsumi Kobayashi, Ayaka Shimmura, Mako Ikudome, Tomoki Motegi, Yoshiyuki Itoh, Yuki Satake, Kohji Nomura, Susumu Iwaide","doi":"10.1177/03009858261480622","DOIUrl":"https://doi.org/10.1177/03009858261480622","url":null,"abstract":"<p><p>Amyloidosis is a group of protein-misfolding disorders characterized by the deposition of insoluble fibrils in tissues. In birds, only systemic amyloid A (AA) amyloidosis and cerebral Aβ amyloidosis have been described to date, and non-AA systemic amyloidosis has not been reported. We describe the first case of non-AA systemic amyloidosis in an avian species, fibrinogen Aα-chain (FibA) amyloidosis, in an 8-year-old male blue-winged kookaburra (<i>Dacelo leachii</i>). Histologically, prominent amyloid deposits were observed in renal glomeruli and in arterial walls of multiple organs. Ultrastructurally, amyloid deposits consisted of non-branching fibrils. Amyloid isolated from multiple organs was consistently identified as FibA-derived by liquid chromatography-tandem mass spectrometry using a customized protein database constructed from hepatic transcriptomic data, enabling amyloid typing in a species lacking comprehensive genomic resources. Peptide mapping demonstrated predominant involvement of the FibA αC-connector region, which was further supported by immunohistochemical labeling of amyloid deposits with an antibody against this region. This case expands the spectrum of avian amyloidosis and highlights the evolutionarily conserved amyloidogenic vulnerability of FibA across vertebrate species.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858261480622"},"PeriodicalIF":2.3,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148809078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabrita De Zan, Claudia Zanardello, Lara Clapiz, Silvia Deotto, Monia Cocchi
{"title":"Diagnostic challenge in veterinary pathology: Late term abortion in a cow.","authors":"Gabrita De Zan, Claudia Zanardello, Lara Clapiz, Silvia Deotto, Monia Cocchi","doi":"10.1177/03009858261472494","DOIUrl":"https://doi.org/10.1177/03009858261472494","url":null,"abstract":"","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858261472494"},"PeriodicalIF":2.3,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148809100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Golnaz Jalalahmadi, Jennifer Cann, Elizabeth Hines, Igor Mikaelian, Rahul Dange, Nadine Swierzawski, Melissa Miles, Emily Ramirez, Richard Bouffard, Matthew Lawrence
{"title":"An artificial intelligence-driven workflow to detect the macula and quantify retinal ganglion cells in nonhuman primates.","authors":"Golnaz Jalalahmadi, Jennifer Cann, Elizabeth Hines, Igor Mikaelian, Rahul Dange, Nadine Swierzawski, Melissa Miles, Emily Ramirez, Richard Bouffard, Matthew Lawrence","doi":"10.1177/03009858261477045","DOIUrl":"https://doi.org/10.1177/03009858261477045","url":null,"abstract":"<p><p>The retinal ganglion cell layer integrates and transmits stimuli from photoreceptors to the central nervous system. Retinal ganglion cell loss is a hallmark of glaucoma and other retinopathies and neuropathies. Therefore, changes in this cell population define disease severity and therapeutic efficacy in patients and animal models. Artificial intelligence has demonstrated utility in automated quantification of whole-slide images, including hematoxylin and eosin-stained tissue sections. Hematoxylin and eosin is the most commonly used microscopy stain, easily implemented, highly reproducible, cost-effective, and able to delineate cellular details; however, manually counting cells is labor-intensive and subject to interobserver variability. We have applied artificial intelligence to automate detection of the macula and retinal ganglion cells at the level of the fovea in 4-µm-thick cross sections of African green monkey (<i>Chlorocebus sabaeus</i>) eyes. The workflow finds the parafoveal and perifoveal macula versus the peripheral retina and quantifies the number of retinal ganglion cells in the specific region of interest. Results were validated by comparing pathologist-guided manual annotations to the artificial intelligence outputs using accuracy and intersection over union (IoU). The macula-segmentation application achieved 97.1% accuracy and an IoU of 0.89, whereas the retinal ganglion cell counting application showed strong agreement with pathologist counts (<i>R</i><sup>2</sup> = .9986). This study provides a proof of concept for automated detection and quantitation of macula and retinal ganglion cells in hematoxylin and eosin-stained whole-slide images.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858261477045"},"PeriodicalIF":2.3,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erica A Suitor, Jamie L Rothenburger, John Scheels, Fabien Mavrot, Douglas P Whiteside, Lisa-Marie Leclerc, Susan J Kutz
{"title":"Incisor pathology in wild muskoxen (<i>Ovibos moschatus</i>) from the Canadian Arctic.","authors":"Erica A Suitor, Jamie L Rothenburger, John Scheels, Fabien Mavrot, Douglas P Whiteside, Lisa-Marie Leclerc, Susan J Kutz","doi":"10.1177/03009858261472491","DOIUrl":"https://doi.org/10.1177/03009858261472491","url":null,"abstract":"<p><p>Dental lesions are often painful and can impair digestive efficiency and fitness in mammals, consequently leading to systemic health complications. Although dental lesions are rarely described in wild herbivores, a high prevalence of incisor abnormalities was detected in wild muskoxen (<i>Ovibos moschatus</i>) using mandibles collected by Inuit hunters through the Community-Based Wildlife Health Surveillance program in the Canadian Arctic. Here, we present the first comprehensive examination of incisor dental lesions and developmental anomalies in wild muskoxen. We examined 243 mandibles from harvested muskoxen and identified and described both gross and radiographic pathology. The most frequent lesion was enamel infractions, characterized by linear cracks along lingual enamel surfaces, which was present in 91.4% (222/243) of individuals. Incisor fractures, which featured at least one incisor with a complicated crown fracture, were present in 50.6% (123/243) of individuals. Labial enamel abrasions were present in 26.3% (64/243) of muskoxen in which wear extended to the dentin, and in severe cases to the pulp. Other common gross abnormalities included rotation (31.3%; 76/243), crowding (21.8%; 53/243), and unerupted fourth incisors (18.9%; 46/243). Radiographic analysis revealed congenitally absent teeth, root fractures, and endodontic-related lesions that correlated with gross incisor abnormalities in a subset of 136 animals. Other radiographic findings included hypercementosis, ankylosis, dilaceration, dental decay, and retained primary teeth. These results underscore the high prevalence and severity of incisor pathology in muskoxen and provide foundational data for subsequent assessment of lesion epidemiology and their association with muskox health.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858261472491"},"PeriodicalIF":2.3,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leonardo L Gorza, Ellen C Oliveira, Sóstenes A C Marcelino, Luana F M Cordeiro, Yhuri C Nóbrega, Eduardo J S Borges, Guilherme C Tavares, Marcelo P N Carvalho, Bruno Ferrante, Anelise C Nepomuceno, Larissa T M Vieira, Marcos E Coutinho, Felipe Pierezan
{"title":"Gross, microscopic, and imaging findings of congenital malformations in farmed caimans (<i>Caiman yacare</i>).","authors":"Leonardo L Gorza, Ellen C Oliveira, Sóstenes A C Marcelino, Luana F M Cordeiro, Yhuri C Nóbrega, Eduardo J S Borges, Guilherme C Tavares, Marcelo P N Carvalho, Bruno Ferrante, Anelise C Nepomuceno, Larissa T M Vieira, Marcos E Coutinho, Felipe Pierezan","doi":"10.1177/03009858261472501","DOIUrl":"https://doi.org/10.1177/03009858261472501","url":null,"abstract":"<p><p>Congenital malformations (CMFs) are structural disorders that arise during embryogenesis, and various forms of these abnormalities have been reported in reptiles. The yacare caiman (<i>Caiman yacare</i>) is widely used in commercial farms in the Pantanal region, and studies characterizing CMFs in these animals are scarce. This study describes the pathological and imaging findings of CMFs in farmed caimans. From February 2022 to February 2023, the incubation and maternity of a caiman commercial farm, operating in ranching and farming systems, were monitored. A total of 26 distinct CMFs were identified in 30 farmed caimans. All animals were classified as infantile (9.65 ± 2.69 cm snout-vent length). CMFs were grouped according to anatomical site, with craniofacial disorders (18 cases) being the most frequent findings, followed by spinal malformations (13 cases). Palatoschisis (PC) and cheiloschisis (CL) were reported in 6 yacare caimans, which also exhibited a malformed palatal velum and secondary aspiration pneumonia. Meningoencephalocele was diagnosed in 3 caimans, with brain hemorrhage being a typical secondary lesion in these cases. Anophthalmus, exophthalmos, and cyclopia represented the ocular CMFs. Spinal malformations (kyphosis and scoliosis) were detected in 13 yacare caimans and were thoroughly characterized by the X-ray radiographic analysis. Tail abnormalities were reported in 12 animals, including tail agenesia (1 case) and coiled tail (11 cases). Other sites of CMFs include the limbs, the coelomic wall, and the skin. Radiographic assessments were obtained from all 30 CMFs, providing detailed information on these lesions.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858261472501"},"PeriodicalIF":2.3,"publicationDate":"2026-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Localization of feline gammaherpesvirus 1 in lymphoid tissues and pulmonary fibrotic lesions of naturally infected cats.","authors":"Chutchai Piewbang, Magdalena Novia Devina Putri, Aisyah Nikmatuz Zahro, Panitnan Punyathi, Sitthichok Lacharoje, Tanit Kasantikul, Somporn Techangamsuwan","doi":"10.1177/03009858261472500","DOIUrl":"https://doi.org/10.1177/03009858261472500","url":null,"abstract":"<p><p>Feline gammaherpesvirus 1 (FcaGHV1) is a recently identified member of the <i>Gammaherpesvirinae</i> detected in domestic cats; however, its tissue distribution and pathological relevance remain incompletely defined. This study investigated the localization of FcaGHV1 in naturally infected cats and evaluated potential relationships between viral presence and histopathologic lesions. Fresh tissues from 42 domestic cats submitted for routine necropsy in Thailand were screened for FcaGHV1 using quantitative polymerase chain reaction targeting the <i>glycoprotein B</i> gene, followed by sequencing confirmation. Corresponding formalin-fixed tissues were examined histologically, and viral localization was assessed using chromogenic <i>in situ</i> hybridization (ISH). FcaGHV1 was detected in 4 of 42 cats (10%). Viral loads were highest in lymph nodes and spleens, and ISH localized viral nucleic acids to histiocytes and small lymphocytes within lymphoid tissues. In 2 infected cats, pulmonary lesions characterized by interstitial fibrosis and vascular remodeling were observed, and viral hybridization signals were detected within infiltrating mononuclear cells, spindle-shaped interstitial cells, and vascular-associated stromal cells in affected regions. Based on this observation, an additional retrospective cohort of 18 cats with histologically diagnosed pulmonary fibrosis was examined using ISH. Viral hybridization signals were detected in 3 of 18 lungs (17%) and were primarily localized within fibrotic areas. Together, these findings demonstrate tissue-level evidence of FcaGHV1 localization in lymphoid organs and pulmonary lesions of naturally infected cats. The repeated detection of viral nucleic acids within fibrotic lung lesions across independent cohorts suggests an association between FcaGHV1 localization and pulmonary remodeling; however, the biological significance of this observation remains uncertain.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858261472500"},"PeriodicalIF":2.3,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mayane Faccin, Carolyn M Malinowski, Susanne Je-Han Lin, Sarah E Dysart, Selin N Atakan, Martha E Hensel
{"title":"Histological and immunohistochemical characterization of salivary pleomorphic adenomas in aged rhesus macaques (<i>Macaca mulatta</i>).","authors":"Mayane Faccin, Carolyn M Malinowski, Susanne Je-Han Lin, Sarah E Dysart, Selin N Atakan, Martha E Hensel","doi":"10.1177/03009858261472495","DOIUrl":"https://doi.org/10.1177/03009858261472495","url":null,"abstract":"<p><p>While pleomorphic adenoma (PA) is the most common salivary neoplasm in human medicine, it appears to be rare in animals and has only recently been reported in a rhesus macaque. We gathered 6 cases of PAs affecting aged rhesus macaques and summarized their gross, histological, and immunohistochemical characteristics. Affected animals ranged from 19 to 32 years, were predominantly male, and the neoplasm was an incidental finding at necropsy. The neoplasms affected the submandibular salivary gland (5/6) and the parotid gland (1/6). Neoplasms were round to ovoid, tan, well-demarcated, and firm. Histologically, the masses had an epithelial and a myoepithelial component supported by a hyalinized fibrous stroma. Immunohistochemistry (IHC) was performed in 5 cases. Pancytokeratin expression was diffuse in the epithelial component. Pleomorphic adenoma gene 1 (PLAG1), a specific nuclear IHC marker for human PAs, was negative in all but 1 case, where rare myoepithelial cells had false-positive cytoplasmic immunolabeling. Calponin and smooth muscle actin (SMA) highlighted the myoepithelial component, with calponin showing stronger expression than SMA in both the number and distribution of immunolabeled myoepithelial cells. Three cases had less than or equal to 5% of cells expressing Ki-67; in 2 cases that were larger with areas of necrosis, expression ranged from 10% to 20% of cells. In summary, salivary PAs in rhesus macaques are usually incidental and apparently affect mainly the submandibular salivary gland in aged males. Immunohistochemistry for PLAG1 is not helpful in the diagnosis, which instead relies primarily on gross and histological findings.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858261472495"},"PeriodicalIF":2.3,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Silvia Ferro, Margherita Orlandi, Paola Roccabianca, Silvia Lucia Benali, Giovanni Martino, Maria Massaro, Francesca Abramo
{"title":"Novel labial adnexal sebaceous basaloid proliferation associated with sebaceous epitheliomas and adenocarcinomas in Labrador retrievers.","authors":"Silvia Ferro, Margherita Orlandi, Paola Roccabianca, Silvia Lucia Benali, Giovanni Martino, Maria Massaro, Francesca Abramo","doi":"10.1177/03009858261472498","DOIUrl":"https://doi.org/10.1177/03009858261472498","url":null,"abstract":"<p><p>A distinctive peritumoral epithelial proliferation was identified exclusively in the labial region of Labrador retrievers in association with sebaceous neoplasms. To characterize this lesion, 515 sebaceous neoplasms diagnosed in dogs of different breeds between 2017 and 2025 were retrospectively reviewed. Among these, 2 of 255 epitheliomas (0.7%) and 22 of 41 adenocarcinomas (54%) arising in the lips exhibited a distinctive peripheral basaloid epithelial proliferation. The lesion was observed only in the lower lip of Labrador retrievers, occurring in association with either solitary or multifocal neoplastic nodules. No similar proliferations were identified after examining 103 labial lesions of other histotypes diagnosed in the same timeframe. Histologically, the proliferations consisted of 1- to 2-cell-thick epithelial cords surrounding pre-existing adnexal units. The cells showed minimal atypia and low mitotic activity. Immunohistochemically, they exhibited a cytokeratin (CK)5+/p63+/alpha-smooth muscle actin-/CK7- phenotype, supporting derivation from basal reserve cells of cutaneous glands and excluding differentiation toward mature apocrine epithelial or myoepithelial cells. The exclusive occurrence in Labrador retrievers suggests a possible breed-related predisposition. Although the biological behavior of this novel lesion is unknown, its recognition may be important in diagnostic pathology to avoid misinterpretation with an invasive adenocarcinoma.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858261472498"},"PeriodicalIF":2.3,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emely Rosbach, Jonas Ammeling, Christof A Bertram, Andreas Riener, Marc Aubreville
{"title":"Cognitive biases in AI-assisted medical decision making: A structured review as a primer for veterinary and human pathology.","authors":"Emely Rosbach, Jonas Ammeling, Christof A Bertram, Andreas Riener, Marc Aubreville","doi":"10.1177/03009858261472493","DOIUrl":"https://doi.org/10.1177/03009858261472493","url":null,"abstract":"<p><p>Cognitive biases are systematic patterns of error in human thinking. While artificial intelligence (AI)-based decision support systems offer great potential to enhance diagnostic accuracy and efficiency in pathology, collaboration between medical professionals and AI can also introduce or amplify these biases. This review aims to identify cognitive biases and their modes of manifestation in human-computer interaction (HCI) within pathology and to extrapolate potential manifestations of biases not yet explored in this domain but reported in HCIs across other medical specialties. We conducted a structured literature review (19 August 2025) across the ACM, IEEE, and PubMed databases. Studies were eligible if they operationalized cognitive biases during expert-machine interaction in diagnostic decision-making using qualitative or quantitative methods, including review articles citing primary studies that met these criteria. The final corpus comprised 24 studies (8 primary studies and 16 review articles). From these review articles, 18 additional primary studies were extracted and used in their place solely for analysis purposes. A narrative synthesis of the identified primary research revealed 12 cognitive biases reported in AI-assisted medical decision-making, with only one study originating from pathology. For each bias, definitions and hypothetical pathology-specific examples were derived. This review is intended as a primer for the veterinary and human pathology communities and strives to contribute to the safe and effective integration of AI into diagnostic practice.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858261472493"},"PeriodicalIF":2.3,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}